Interactions between animals and plants exist on a spectrum that ranges from completely antagonistic relationships to those of obligatory mutualism, as seen in the pollination of certain tropical orchid species. In fact, these relationships are highly conditional and can change radically depending on variations in environmental conditions such as temperature, rainfall, and fluctuations in the populations of other interacting species.
MDPI - Multidisciplinary Digital Publishing Institute
Protection and Prevention Approaches in Occupational Health and Safety
Developments in working life have also brought about occupational health and safety (OHS) problems. While the development of technology and protective equipment has created a safer working environment over time, new risks that pose a danger have also emerged. OHS aims to prevent the deterioration of employees' health in all occupational groups, protect employees from the hazards and risks in the environment, and provide environments that will allow individuals to continue to work at the highest level physiologically and spiritually.
This Special Issue focuses on feeding and feed technology advances and challenges in aquaculture. These are of particular interest since aquaculture and fisheries are considered crucial sources of animal protein in human diets, providing around 17% of global edible animal protein.
Mal-Nutrition documents how maternal health interventions in Guatemala are complicit in reproducing poverty. Policy makers speak about how a critical window of biological growth around the time of pregnancy—called the ""first 1,000 days of life""—determines health and wealth across the life course. They argue that fetal development is the key to global development.
Nutritional Value of Meat and Meat Products and Their Role in Human Health
Meat and meat products are among the most nutrient-dense food sources in the human diet. They fulfill most of our bodily requirements, acting as important sources of energy and a variety of essential nutrients needed for metabolic functions. Meat and meat products may also contain non-nutritive components, such as sodium, saturated fat, nitrites, heterocyclic aromatic amines, and polycyclic aromatic hydrocarbons, which are associated with negative health-related outcomes.
Nutritional Status and Interventions for Patients with Cancer
Cancer is one of the leading causes of morbidity and mortality worldwide. The World Cancer Research Fund determined that the diet and nutrition conditions of the individuals are modifiable risk factors in the development of several cancers and a predominant component in the recovery and effectiveness of the treatments. Nutritional intervention is critical, but nutritional support is not widely accessible to all individuals, leading to potential nutritional risk and nutrition wasting.
Annisa Triyanti (editor) Mochamad Indrawan (editor)
Enabling and Optimising Recovery from COVID-19
This textbook provides readers with up to date knowledge about the assessment, management and support of people experiencing Long COVID. Learning activities draw upon personas co-authored with people with Long COVID.
Danielle Hitch, Genevieve Pepin, Kelli Nicola-Richmond, Valerie Watchorn,
Council of Australian University Librarians
The book Advances in Hematologic Malignancies presents new knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic, and genomic changes that have influenced the current outlook toward hematological malignancies.
This compilation gathers OER sources on body weight, nutrition, and movement, and it also problematizes the cultural meaning of these readings. Roughly, this anthology is divided into two parts--informational and theoretical--in depicting how medical research and journalism influence and are influenced by social stereotypes, constructed ideas about bodies, food, and individual choices within social systems.
Stress is a feeling you get when faced with a challenge. In small doses, stress can be good for you because it makes you more alert and gives you a burst of energy. For instance, if you start to cross the street and see a car about to run you over, that jolt you feel helps you to jump out of the way before you get hit. But feeling stressed for a long time can take a toll on your mental and physical health. Even though it may seem hard to find ways to de-stress with all the things you have to do, it’s important to find those ways. Your health depends on it.
Community interventions in obesity-related chronic diseases
The rate of obesity continues to climb in the United States in all age groups. National reports, including the Trust for America’s Health annual report State of Obesity: Better Policies for a Healthier America, highlight key findings and policy recommendations. The need to continue to work towards stabilization of the obesity epidemic could not be more important as consequences of this chronic disease can be dire, potentially affecting physical health with an increase in risk for chronic diseases including cardiovascular disease, type 2 diabetes and several types of cancer as well as potentially affecting behavioral health.
Sherri M. Cirignano, Sara A. Elnakib, Karen Ensle. et al
Advancing the Science of Cancer in Latinos
This open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos.
Ramirez, Amelie G. (editor) Trapido, Edward J. (editor)
All-Optical Methods to Study Neuronal Function
This open access volume provides an overview of the latest methods used to study neuronal function with all-optical experimental approaches, where light is used for both stimulation and monitoring of neuronal activity. The chapters in this book cover topics over a broad range, from fundamental background information in both physiology and optics in the context of all-optical neurophysiology experiments, to the design principles and hardware implementation of optical methods used for photoactivation and imaging. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
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21st Century Media and Female Mental Health
This open access book examines the conversations around gendered mental health in contemporary Western media culture. While early 21st century-media was marked by a distinct focus on happiness, productivity and success, during the 2010s negative feelings and discussions around mental health have become increasingly common in that same media landscape. This book traces this turn to sadness in women’s media culture and shows that it emerged indirectly as a result of a culture overtly focused on happiness.
A Practical Guide on Behaviour Change Support for Self-Managing Chronic Disease
This open access book is a valuable resource for students in health and other professions and practicing professionals interested in supporting effective change in self-management behaviors in chronic disease, such as medication taking, physical activity and healthy eating. Developed under the auspices of the Train4Health project, funded by the Erasmus+ program of the European Union, the book contains six chapters written by international contributors from different disciplines. Chapter one introduces the competencies necessary for delivering effective behavior change support, based on an established program of work, and related learning outcomes.
Guerreiro, Mara Pereira, Brito Félix, Isa . Moreira Marques, Marta
Introduction to Neuroscience is designed for undergraduate students enrolled in introductory neuroscience courses. This book specifically targets students enrolled in Introduction to Neuroscience 1 and Introduction to Neuroscience 2 at Michigan State University and primarily contains topics covered in those courses. This first edition will guide students through the structure and function of nervous system cells and nervous system structures, signaling within the nervous system, and introduce various sensory systems.
Pulmonary Pathophysiology for Pre-Clinical Students
Pulmonary Pathophysiology for Pre-Clinical Students is an undergraduate medical-level resource for foundational knowledge of pulmonary pathophysiology. This text is designed for a course pre-clinical undergraduate medical curriculum and it is aligned to USMLE(r) (United States Medical Licensing Examination) content guidelines. The text is meant to provide the essential information in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience
Roles of NF-κB in Cancer and Their Therapeutic Approaches
Although mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity.
Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients.
Janna L. Morrison --- Timothy R.H. Regnault
Malnutrition in people with liver disease is a challenging issue due to its multifactorial nature, which includes hypermetabolism, increased energy needs, malabsorption, and anorexia. Despite advances in both assessment and management, correct nutritional support is still an often-unanswered need in the care of these patients to avoid poor outcomes. One of the central issues remains how to improve muscolar mass of sarcopenic chronically malnourished individuals with end stage liver diseases and cirrhosis, as only a correct nutritional assessment and subsequent nutritional handling may enhance quality of life and disease outcome.
Pietro Vajro (Ed.) --- Claudia Mandato (Ed.)
The development and treatment of cancer presents a complex interaction between tumor and host. Provision of nutrients not only enables the maintenance of nutritional status, but also provides substrates and signals for immunity, tumor metabolism and protection of the host from treatment toxicities. Fat is one dietary element that has been explored for its role in cancer development. While the bulk of these studies have been observational or experimental, the evidence assembled suggests that dietary lipids behave uniquely to prevent or promote cancers
The purpose of this Special Issue, “Nutrition and Allergic Diseases”, is to provide an overview of the role of nutrition in allergy. The prevalence of asthma, rhinitis, and food allergy has increased tremendously over the last few decades. Is there a role for nutrition to help managing this global challenge? This Special Issue touches upon the many aspects that relate to nutrition and allergy and focuses on two fundamental questions: 1) Can nutrition play a role in allergy prevention and induction? 2) Can nutrition play a role in managing allergies?
Joost van Neerven (Ed.) --- Huub Savelkoul (Ed.)
Nutrients, Infectious and Inflammatory Diseases
Foodborne disease like salmonellosis and toxoplasmosis are amongst the most significant causes of hospitalization in the U.S. and globally. Gastrointestinal infections alter gut microbiomes and increase permeability to toxins. Various invasions by microbial, fungal, viral and parasitic agents stimulate inflammation, a defensive mechanism of the body’s immune system. Other stimuli include environmental stimuli, oxidative stress, aging and the physiological process. A long-lasting, persistent and excessive inflammatory response is a significant risk factor for developing various chronic inflammatory and infectious diseases.
Infants are not just small adults; they have a complex set of nutrient requirements and interactions to account for the high metabolic rate, growth, immunological and cognitive development, etc. Each year there are 138 million births, including 30 million from the least developed countries, where health is most at risk. Nutrition during infancy establishes growth patterns and development which moderate short term and long term health and life expectancy. There is continuing progress in understanding the nutrient composition of breastmilk and the importance nutritious and timely complementary foods.
Colin Binns (Ed.) --- Mi Kyung Lee (Ed.) --- Masaharu Kagawa (Ed.)
New Lipid Lowering Therapies for Cardiovascular and Metabolic Diseases: Lessons from the Past and Future Challenges
This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.
Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia
This Special Issue focuses on recent research on the important emerging and neglected tropical diseases (NTDs) in South and South East Asia and Northern Australia. This region stretches from Afghanistan in the west to Papua New Guinea in the east, and includes the Indian subcontinent, mainland South-East Asia (Indo China), maritime South East Asia, and the tropical regions of Australia. Many of these areas are highly endemic for important NTDs and emerging infectious diseases including lymphatic filariasis, leprosy, soil-transmitted helminthiases (hookworm, Trichuris, Ascaris, and Strongyloides), food-borne trematodiases, schistosomiasis, dengue/chikungunya/zika, leptospirosis, meloidosis, scabies, trachoma, and yaws. Several of these diseases are targeted for elimination or enhanced control by the World Health Organization in the next 5 to 10 years, although some have chronic lasting sequelae needing lifelong management.
Patricia Graves (Ed.) --- Thewarach Laha (Ed.) --- Peter A. Leggat (Ed.) --- Khin Saw Aye (Ed.)
Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs.
Mitochondrial Dysfunction in Ageing and Diseases
The past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors. Impairment of the mitochondria may be caused by mutations or deletions in nuclear or mitochondrial DNA. Hallmarks of mitochondrial dysfunction include decreased ATP production, decreased mitochondrial membrane potential, swollen mitochondria, damaged cristae, increased oxidative stress, and decreased mitochondrial DNA copy number.
[Selective and quantitative detection of different kinds of biocomponents plays an important role in biomedical applications, clinical diagnostics, environmental monitoring, toxicology, regenerative medicine and drug delivery. Therefore, multidisciplinary area of magnetic biosensing have been extensively developed in recent years, aiming to create compact analytical devices for non-expensive and low time consuming analysis provided at the point of care by non-skilled personnel.
Magnesium is universally recognized as an essential nutrient for human life and health. Indeed, magnesium plays an important physiologic role in every organ of the human body. Disturbances of Mg homeostasis have been implicated in the pathophysiology of several diseases, and Mg supplementation has been evaluated in numerous large-scale clinical trials. The World Health Organization has listed magnesium as among those essential nutrients that are consumed in suboptimal amounts by the general population.
Federica Wolf (Ed.) --- Valentina Trapani (Ed.)
In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD.
Gluten Related Disorders: People Shall not Live on Bread Alone
Once upon a time, gluten was not part of the human diet, and therefore, there were no gluten-related disorders. With the advent of agriculture 10,000 years ago, the introduction of gluten-containing grains in the human diet created conditions for human diseases related to gluten exposure. These diseases, including celiac disease, non-celiac gluten sensitivity, and wheat allergy, have distinct pathophysiological mechanisms, serological markers, and long-term treatments, but similar, often overlapping clinical presentations.
Diagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain.
Chemical and Molecular Approach to Tumor Metastases
Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies.
Gianni Sava (Ed.) --- Alberta Bergamo (Ed.)
The Biology and Treatment of Myeloid Leukaemias
There has been an observed decrease in the global mortality from cancer, mostly atributable to improved, particularly early, detection and prevention. For many carcinomas and leukaemias in adults, once the disease has reached a certain stage there are no therapies that are able to erradicate the cancer cells and cure patients. There has been progress in the treatment of acute myeloid leukaemia (AML) and remissions are achievable; however, the presence of chemoresistent blast cells leads to most patients relapsing, and relapse is difficult to treat and thus patients die due to their disease
Geoffrey Brown (Ed.) --- Ewa Marcinkowska (Ed.)
This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Caws, Maxine --- Marais, Ben --- Heemskerk, Dorothee --- Farrar, Jeremy
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book.
Akinori Akaike --- Shun Shimohama --- Yoshimi Misu
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field.
Hormones, Metabolism and the Benefits of Exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism.
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers
Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
his volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration
Toshio Nakanishi --- Roger R. Markwald --- H.Scott Baldwin --- Bradley B. Keller --- et al.
The Poetics and Politics of Alzheimer’s Disease Life-Writing
The introduction gives an overview on sociopolitical and research-related developments regarding dementia, and attempts explanations for why the interest in dementia of critical scholarship continues to be very limited and particularly focused on caregiver accounts. It illustrates that an understanding of the obvious neglect of dementia patient narratives sheds some light onto the ethical implications and challenges of critically reading such narratives: these narratives seem least of all fit to match classical survivor illness literature, and serious impairment in the ability to tell or understand stories has been taken as motivation to neglect patient narratives.
Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-3 FA-enriched oral nutritional supplement (ONS) providing 2.0 g of eicosapentaenoic acid (EPA) and 1.0 g of docosahexaenoic acid (DHA) per day or a standard ONS for seven days before surgery. On the day of operation, there was a significant increase in the production of leukotriene B5 (LTB5) (p < 0.01) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p < 0.01), a significant decrease in the production of leukotriene B4 (LTB4) (p < 0.01) and a trend for a decrease in the production of 5-hydroxyeicosatetraenoic acid (5-HETE) (p < 0.1) from stimulated neutrophils in the active group compared with controls. There was no association between LTB4 values and postoperative complications. In conclusion, oral n-3 FA exerts anti-inflammatory effects in surgical patients, without reducing the risk of postoperative complications.
Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book
his open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
Applications of STEM (Science, Technology, Engineering and Mathematics) tools in microbiology of infectious diseases
Science, technology, engineering, and mathematical (STEM) tools and approaches are expected to become a critical component for the prevention, control, and eradication of animal diseases at a global scale in the near future. In the last decades the amount of information that is being generated in all scientific disciplines, including microbiological studies applied to infectious diseases, has increased exponentially, becoming a problem in itself due to the lack of tools and expertise to analyze data. The formulation and parameterization of such a body of empirical knowledge combined with theoretical knowledge into mathematical models
Lyme Disease: Recent Advances and Perspectives
he interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging.
Tanja Petnicki Ocwieja, - Catherine A Brissette
Breaking the cycle: Attacking the malaria parasite in the liver
Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular eﬀector mechanisms capable of eliminating Plasmodium from the liver. However, malaria liver stage immunity is complex. The anatomic site of priming of naive Plasmodium-speciﬁc CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may in fact determine the speciﬁcity of the eﬀector CD8 T cells. The participation of particular antigenpresenting cells (Corradin and Levitskaya, 2014) and tissue signatures that inﬂuence the activation of intrahepatic CD8 T cells against malaria sporozoites (Morrot and Rodrigues, 2014) are still incompletely understood. Similarly, how eﬀector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.
Ute Frevert, Urszula Krzych , Thomas L. Richie
Rabies Symptoms, Diagnosis, Prophylaxis and Treatment
Rabies is an acute, progressive, incurable viral encephalitis found throughout the world. Despite being one of the oldest recognized pathogens, its impact remains substantial in public health, veterinary medicine, and conservation biology. Thus, it is Essential to apply existing tools and to seek new methods to improve upon prevention, control, selective variant elimination, and treatment efforts. Advances in diagnosis, vaccinology, pathobiology, and related research techniques continue to afford enhanced insights on rabies. Although rabies is not a candidate for eradication, the results of these innovative communications provide further knowledge to deﬁne a more optimal approach to understanding and managing this complex infectious disease of nature on a global basis in a One Health context.
Charles Rupprecht (Ed.), Bernhard Dietzschold (Ed.)
Metastatic Extramammary Paget's Disease: Pathogenesis and Novel Therapeutic Approach
Metastatic Extramammary Paget's Disease, Pathogenesis and Novel Therapeutic Approach
Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.
1. A variety of different malignancies fall into the category of “Head and. Neck Cancers”. This chapter focuses on upper aerodigestive tract cancer. 2. Tobacco and alcohol use and human papillomavirus infection are common causes of head and neck cancers. 3. Most head and neck cancers are squamous cell carcinomas. 4. Treatment of head and neck cancers commonly requires some combination of surgery, radiation, and chemotherapy. Close cooperation between otolaryngologists, radiation oncologists, and medical oncologists is mandatory for successful treatment of these cancers. 5. Preservation of organ function in addition to cure of cancer, is an important goal of treatment. 6. Any patient with persistent symptoms of sore throat, hoarseness, difficulty swallowing or an enlarged cervical lymph node should be evaluated for possible head and neck cancer.
James Liebmann, MD, Ali Akalin MD, PhD., Liana Puscas, MD, MHS., Andrew Chen MD., Richard S. Pieters, MD
Stigmatization, discrimination and illness
“She was given her own plate, her own cup, everything of her own, even when she just touched a cloth then nobody wanted to touch it again.” (Halima, HIV-seropositive) The book sheds light on the profound influence of an HIV-seropositive diagnosis on the lives of women and their social environment in the United Republic of Tanzania. The author, a medical doctor and social anthropologist, tells the story of six Tanzanian HIV-seropositive women, focusing on their negotiation and perception of illness and disease. Furthermore, the high levels of discrimination and stigmatization in the context of HIV-seropositivity that they experience are presented in detail, weaving together the impacts of an HIV-seropositive diagnosis with results analyzed both from a Medical Anthropology and Public Health perspective. Despite a new era of antiretroviral treatment, available in Tanzania free of cost, that has given cause for hope in a change in how the disease is perceived, the book impressively underlines that being HIV-seropositive remains a great challenge and heavy burden for women in Tanzania.