Symptoms Of Type 2 Diabetes Creative Commons https://youtu.be/d8fBlTgn1_U This is always a surprising situation for most people around, who just go for regular check up to the doctor and end up knowing that they are suffering from one of the most common disease “diabetes “or “pre diabetes” condition. Even your doctor keep on warning you for the diabetes before or give you the idea that all such symptoms may lead to such terrible non ending disease. This thing is also so common that even if you are paying a lot of your attention on your body still it wouldn’t be an astonishing outcome that you are one of the victims of diabetes. Here are listed some highly observed warning signs for diabetes. 1. Need of Water Your body remains dehydrated and you always feel a need of water. Your mouth and lips dry out and you feel like drinking a huge amount of water all the time. Dehydration is linked with linked with your brain instead of your mouth. It is that even your mouth is dry and you don’t get any message from your brain you will never want the water. The brain cells always need a regular transfer of glucose beside the other part of your bodies. So; the system is followed as if your brain is overly concentrated with sugar water, it will order the supply of fluid from any other form to get diluted unease fluid surrounding each cell. In this way, your brain gets the water supply from other cells and leads towards the dehydration. This is the reason your body want to acquire more and more water. Most of the people have this misunderstanding that if you take soda you will remain hydrated. While soda is one of dangerous intake. So, if you feel the dehydrated most of the time, it means you need to get a checkup for diabetes. 2. Trips to the bathroom When you are taking a large amount of water supply in your body, then this is so sure that you need to urine. This also one of the alarming situations, which you need to take seriously because there is too much sugar in the blood vessel. All the water you take in will fill up your bladder and give you the feeling to pee. After which you feel thirsty and dehydrated again. This process of dehydration and hydration continue. Kidneys in this way release the excess amount of glucose from your body. And if the kidney can’t filter the waste properly, it means it is collecting toxins in your blood vessels. This condition can also damage the kidney on major level. 3. Weakness and Fatigue Sometimes you didn’t work out much and still your body is tired and exhausted, and you will never realize that this is cause of your diabetes which you are carrying inside. The actual problem lies here is that you can’t consume the glucose from your meals, the glucose is not readily enter into your cells. From all this less consumption of glucose and energy turn you weak and lazy. As you don’t gain energy from your meal, you still feel hungry after a while again. Here goes one more vital sign of diabetes. You should focus on each and every little aspect of your healthy and its related issues. 4. Lose Weight When you are suffering from diabetes, you start losing the weight in a specific pattern without any efforts of losing weight. If you are losing the weight, which even you are taking proper meals and food then it is one of the alarming condition. This kind of weight loss causes you to lose muscle mass. It happens in the part of the body which is looking for some energy and it breaks down the muscles of the cells. This is one of the clear symptoms of fatal diabetes. 5. Vision Disorder In the case, if the blood levels increase high ,it will drain all the fluid from all over body tissues .This also include you’re fluid fro Well come to our Channel: ''HEALTH & FITNESS'' Our channel ''HEALTH & FITNESS'' give us a lot of information about health and fitness. HEALTH & FITNESS is a most important for Healthy life. So keep watching to our channel for more videos HEALTH & FITNESS. Thanks For Subscribe ,Like and Share to our channel: https://goo.gl/UDorwZ Follow us on social media: Facebook https://goo.gl/vsGuJG Instagram https://goo.gl/F16iqI Youtube https://goo.gl/UDorwZ Google Plus https://goo.gl/pkrpC6 Disclaimer: The materials and the information contained on Natural Cures channel are provided for general and educational purposes only and do not constitute any legal, medical or other professional advice on any subject matter.None of the information on our videos is a substitute for a diagnosis and treatment by your health professional. Always seek the advice of your physician or other qualified health provider prior to starting any new diet or treatment and with any questions you may have regarding a medical condition. If you have or suspect that you have a medical problem, promptly contact your health care provider.
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This video was created for the contest " anatomy by students, international contest" Category 5. ENT, ophthalmology, General Practice This video by Hershko Sarah is licensed under the Creative Commons Attribution ShareAlike 4.0 International license, or later version, see: https://creativecommons.org/licenses/by-sa/4.0/
Brain action published via YouTube.com
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Introduction to The Anatomy of The Heart
Introduction to the anatomy of the heart, with explanation of the pericardium, myocardium, and endocardium.
Andrew Wolf published via YouTube.com
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Psych9B. Psychology Fundamentals. Lecture 1:
UCI Psych 9B: Psych Fundamentals (Fall 2015) Lec 01. Psych Fundamentals View the complete course: http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html Instructor: Mark Steyvers, Ph.D. License: Creative Commons CC-BY-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This one of the three courses that are a part of a three-quarter series, cross-listed as "Social Ecology Psy Beh P11 A, B, C" or "Social Sciences Psych 9 A, B, C." All three courses are offered every quarter and can be taken in any oder. The series is designed to give students a strong foundation in the major research areas of psychology, including such areas as human cognitive and social development, memory, language, emotional and social behavior, psychopathology, and neuroscience. This course sequence is required for students majoring in Psychology and Social Behavior in the School of Social Ecology and for students majoring in Psychology in the School of Social Sciences. These courses can also be taken by non-majors. In this course specifically, referred to as "Psy Beh P11B" or "Psych 9B," topics to be covered include memory, thinking, language, learning, and cognitive development Recorded on September 24, 2015. Required attribution: Steyvers, Mark. Psych Fundamentals 9B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/deed.en_US).
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Psych9B. Psychology Fundamentals. Lecture 2:
UCI Psych 9B: Psych Fundamentals (Fall 2015) Lec 02. Psych Fundamentals View the complete course: http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html Instructor: Mark Steyvers, Ph.D. License: Creative Commons CC-BY-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This one of the three courses that are a part of a three-quarter series, cross-listed as "Social Ecology Psy Beh P11 A, B, C" or "Social Sciences Psych 9 A, B, C." All three courses are offered every quarter and can be taken in any oder. The series is designed to give students a strong foundation in the major research areas of psychology, including such areas as human cognitive and social development, memory, language, emotional and social behavior, psychopathology, and neuroscience. This course sequence is required for students majoring in Psychology and Social Behavior in the School of Social Ecology and for students majoring in Psychology in the School of Social Sciences. These courses can also be taken by non-majors. In this course specifically, referred to as "Psy Beh P11B" or "Psych 9B," topics to be covered include memory, thinking, language, learning, and cognitive development Recorded on September 29, 2015. Required attribution: Steyvers, Mark. Psych Fundamentals 9B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/deed.en_US).
MIT 5.07SC Biological Chemistry, Fall 2013 View the complete course: http://ocw.mit.edu/5-07SCF13 Instructor: John Essigmann In this video, Professor Essigmann explores ketone bodies – what they are, how they are made, and how they are used in the body. He describes in detail the role ketone bodies play in diabetes and starvation scenarios. License: Creative Commons BY-NC-SA More information at http://ocw.mit.edu/terms More courses at http://ocw.mit.edu
MIT OpenCourseWare published via YouTube.com
Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Nauroz Syed. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/preterm-labor?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/uterine-inversion?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Lifestyle approaches aren’t just safer and cheaper. They can work better, because you’re treating the actual cause of the disease. Input by Sofia Nelly Subscribe to Dr. Greger’s free nutrition newsletter at http://www.nutritionfacts.org/subscribe and get a free excerpt from his latest NYT Bestseller HOW NOT TO DIE. (All proceeds Dr. Greger receives from the sales of his books, DVDs, and speaking engagements go to support the 501c3 nonprofit that runs NutritionFacts.org.) You can imagine how overwhelming NutritionFacts.org might be for someone new to the site. With videos on more than 2,000 health topics, where do you even begin? Imagine someone stumbling onto the site when the new video-of-the-day is about how some spice can be effective in treating a particular form of arthritis. It would be easy to miss the forest for the trees. That’s why I created this new series of overview videos, which are basically taken straight from my hour-long live 2016 presentation How Not to Die: Preventing, Arresting, and Reversing Our Top 15 Killers (http://nutritionfacts.org/video/how-not-to-die). Stay tuned for: • How Not to Die from Cancer (http://nutritionfacts.org/video/how-not-to-die-from-cancer/) • How Not to Die from Diabetes (http://nutritionfacts.org/video/how-not-to-die-from-diabetes/) • How Not to Die from Kidney Disease (http://nutritionfacts.org/video/how-not-to-die-from-kidney-disease/) • How Not to Die from High Blood Pressure (http://nutritionfacts.org/video/how-not-to-die-from-high-blood-pressure) If this video inspired you to learn more about the role diet may play in preventing and treating heart disease, check out some of these other popular videos on the topic: • Heart Disease Starts in Childhood (http://nutritionfacts.org/video/heart-disease-starts-in-childhood) • Lifestyle Medicine: Treating the Causes of Disease (http://nutritionfacts.org/video/lifestyle-medicine-treating-the-causes-of-disease) • The Actual Benefit of Diet vs. Drugs (http://nutritionfacts.org/video/the-actual-benefit-of-diet-vs-drugs) • Optimal Cholesterol Level (http://nutritionfacts.org/video/optimal-cholesterol-level) • Physicians May Be Missing Their Most Important Tool (http://nutritionfacts.org/video/physicians-may-be-missing-their-most-important-tool) • Oxygenating Blood with Nitrate Rich Vegetables (http://nutritionfacts.org/video/oxygenating-blood-with-nitrate-rich-vegetables) • Is Fish Oil Just Snake Oil? (http://nutritionfacts.org/video/is-fish-oil-just-snake-oil) • Does Cholesterol Size Matter? (http://nutritionfacts.org/video/does-cholesterol-size-matter) • When Low Risk Means High Risk (http://nutritionfacts.org/video/when-low-risk-means-high-risk) • Low Carb Diets and Coronary Blood Flow (http://nutritionfacts.org/video/low-carb-diets-and-coronary-blood-flow) • Fully Consensual Heart Disease Treatment (http://nutritionfacts.org/video/fully-consensual-heart-disease-treatment) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-not-to-die-from-heart-disease and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-not-to-die-from-heart-disease. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Google+: https://plus.google.com/+NutritionfactsOrgMD • Podcast: http://nutritionfacts.org/audio/
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Hypotension is low blood pressure, especially in the arteries of the systemic circulation. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Hypotension is generally considered if systolic blood pressure less than 90 millimeters of mercury (mm Hg) or diastolic less than 60 mm Hg. However, in practice, blood pressure is considered too low only if noticeable symptoms are present. Hypotension is the opposite of hypertension, which is high blood pressure. It is best understood as a physiological state, rather than a disease. It is often associated with shock, though not necessarily indicative of it. For some people who exercise and are in top physical condition, low blood pressure is a sign of good health and fitness. For many people, excessively low blood pressure can cause dizziness and fainting or indicate serious heart, endocrine or neurological disorders. Severely low blood pressure can deprive the brain and other vital organs of oxygen and nutrients, leading to a life-threatening condition called shock. Input by Sofia Nelly
The Audiopedia published via YouTube.com
In the past, before modern dentistry, people use to treat a tooth pain naturally because they had no other option. Nowadays, modern medicine has its own solutions, but there still several natural toothache remedies that people use just to avoid the visit to the dentist. There a few well-known causes of tooth pain, like Infected gums/ Gum Disease, Tooth Decay, Tooth eruption, An abnormal bite, Abscessed Tooth, Tooth Fracture or a damaged filling and all of them can cause pain, fever, headache, and swelling around the teeth. In this video, we represent 12 effective Home Toothache Remedies that will help you to get rid of the pain! Raw Garlic Garlic effectively fights fungi, bacteria, and viruses. You should crush the clove, leave it for a couple of minutes to activate its compounds, add some salt, and apply it on the painful tooth. You can also chew clove several times daily using the affected tooth. Ice To soothe the swelling and pain before going to the dentist, Apply an ice or a cold compress on the cheek. Salt Water Gargle Add a teaspoon of salt to a cup of boiling water, and as soon as it cools, gargle it for half a minute. This will alleviate pain and infections, remove debris, and ease the swelling. Chewing Gum The area around a broken tooth, or around a tooth which lacks the filling is irritated and painful. To relieve this pain, chew a gum on the opposite side of the mouth and apply it onto the painful tooth. Peppermint Tea A 2013 study found that peppermint oil has potent antiseptic properties which are useful against oral pathogens. You should drink peppermint tea with a teaspoon of peppermint leaves steeped for 15-20 minutes, to treat bad breath and toothaches. Clove Oil Clove oil is high in eugenol, which has powerful antiseptic and anesthetic properties that destroy germs and relieve gum pain. Studies have found that it is as effective as benzocaine in numbing pain. You should combine a few drops of this oil with a teaspoon of coconut oil, and use a cotton ball, apply the mixture on the painful area. When the place is numb, remove it, and wash the mouth. You can also chew a few cloves using the painful side of the mouth. Vanilla Extract The scent of vanilla soothes the anxiety linked to a toothache, and its alcohol content numbs the pain. Therefore, dab vanilla extracts on the finger and rub it onto the painful tooth twice daily to relieve the pain. Turmeric Paste Mix a teaspoon of turmeric powder, several drops of peppermint oil, and a tablespoon of coconut oil, and prepare a paste. Then, brush the teeth and leave it to act for a few minutes. And rinse. It has strong antiviral and antibacterial properties and will help you fight bad breath, irritations, gum redness, and tooth stains. Ginger Cayenne Paste Mix cayenne and ginger in equal amounts, add some water and prepare a paste. Then, apply it on the painful place using a cotton ball, and leave it to act in order to soothe the pain and swelling, fight off infection, and control bleeding. Myrrh According to RDH, “myrrh’s astringent properties help with inflammation, and a rinse can offer the added benefit of reducing bacteria”. To prepare a homemade myrrh rinse, simmer a teaspoon of myrrh in 2 cups of water, leave it to cool, and use it several times during the day. Essential Oils One 2014 study found that: “Essential oil rinses are found to be equally effective in inhibiting plaque. A study carried out by Pizzo et al. on plaque inhibitory effect of amine fluoride/stannous fluoride and essential oils showed no significant difference in efficacy of both. As chlorhexidine causes staining of teeth on long term use, essential oils can be used as an alternative to chlorhexidine rinse. Essential oils have shown to possess antimicrobial activity against subgingival pernio pathogens, too.” For best effects, use clove, tea tree oil, peppermint, myrrh, cinnamon, and spearmint. Acupressure Press the hand on the affected side, on the place where the base of the index finger and the thumb meet, and hold for several minutes. This will stimulate the release of endorphins, which will relieve the pain. Input by Sofia Nelly
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A lecture on electrocardiograms by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence. View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zX/
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A lecture on chronic coronary artery disease by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/videos/FXxnu5Eayfzl/info/chronic-coronary-artery-disease/
A lecture on acute coronary syndromes by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zZ/ Help us caption & translate this video! http://amara.org/v/B4zZ/
A lecture on evaluating a patient with chest pain by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zY/ Help us caption & translate this video! http://amara.org/v/B4zY/
Includes a display of instruments necessary for caries removal, a discussion of the steps and criteria involved and demonstration of a complete removal of a carious lesion. Orig. air date: JAN 8 74 This is part of the Open.Michigan collection at: http://open.umich.edu/education
Demonstrates on the skull and on a patient, various injection techniques. It also describes the basic dental chair position for injections. Orig. air date: NOV 8 74 This is part of the Open.Michigan collection at: http://open.umich.edu/education
Scaling and Root Planing: Part II Mandibular Teeth
Procedures for scaling and root planing the mandibular teeth. This is part of the Open.Michigan collection at: http://open.umich.edu/education
This is part of the Open.Michigan collection at: http://open.umich.edu/education
This sequence provides a comprehensive introduction to diseases of the cardiovascular system, how they present, how they are diagnosed, how they are prevented, and how they are treated. Students learn to identify the integral links between anatomy, physiology, pathology, and basic sciences with clinical medicine and other essential aspects of patient care for ambulatory and hospitalized patients who have cardiovascular disorders.
Physiology/ Pathophysiology of Coronary Blood Flow
Myocardial Ischemia Supply Demand Coronary Flow Reserve Determinants of Coronary Blood Flow Neural (autonomic) Mechanisms Endothelial Factors (Mechanisms) NOS, NO and ADMA
In this book we have set out to provide a practical guide to bone marrow diagnosis, based on an integrated assessment of peripheral blood and bone marrow aspirate films, trephine biopsy sections and various supplementary investigations. We believe that a trephine biopsy specimen should not be examined and interpreted in isolation. We have therefore discussed the clinical context of bone marrow diagnosis and have given equal weight to cytological and histological features. Since bone marrow diagnosis is no longer based on morphological features alone we have also, in this edition, discussed in considerable detail the role of immunophenotypic, cytogenetic and molecular genetic analysis.
A lecture on Hemoglobinopathies by Dr. David Ginsburg, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Patients and Populations Sequence. View the course materials: http://open.umich.edu/education/med/m1/patientspop-genetics/fall2008/materials. Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zS/
A lecture on Hemoglobinopathies by Dr. David Ginsburg, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Patients and Populations Sequence. View the course materials: http://open.umich.edu/education/med/m1/patientspop-genetics/fall2008/materials. Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/videos/LhfjxDzh1zha/info/hemoglobinopathies-part-2/
Surgical Excision of a Multi-Lobular, Recurrent, Bartholin Duct Cyst
Warning: Viewer discretion is advised, this medical content is graphic and may not be suitable for all viewers. This surgical video describes the etiology, diagnosis, and management of uncomplicated Bartholin duct cysts. The video provides specific attention to the pre-operative approach to recurrent and/or complicated Bartholin duct cysts, and demonstrates the surgical approach to a complicated, recurrent Bartholin duct cyst. Suggestions for surgical techniques are provided. Copyright 2011 Caren M Stalburg, Sarah Wallet, and Hope K. Haefner. Terms of Use: Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B5CA/ Help us caption & translate this video! http://amara.org/v/B5CA/
A lecture on Circulatory Derangements by Dr. Gerald Abrams, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Cardiovascular and Respiratory Sequence. View the course materials: http://open.umich.edu/education/med/m1/cardioresp/fall2008/materials Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Bs/ Help us caption & translate this video! http://amara.org/v/B5Bs/
A lecture on Circulatory Derangements by Dr. Gerald Abrams, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Cardiovascular and Respiratory Sequence. View the course materials: http://open.umich.edu/education/med/m1/cardioresp/fall2008/materials Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Bt/
The earth's biogeochemical systems involve complex, dynamic processes that depend upon many factors. The three main factors upon which life on the earth depends.
Welcome to Human Anatomy and Physiology, an OpenStax College resource. We created this textbook with several goals in mind: accessibility, customization, and student engagement—helping students reach high levels of academic scholarship. Instructors and students alike will find that this textbook offers a thorough introduction to the content in an accessible format.
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/basics-of-egg-development?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/spermatogenesis?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/meet-the-placenta?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/basics-of-egg-development?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/anatomy-of-the-male-reproductive-system?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson?https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
www.EmpoweRN.com Hi Guys! Thank you so much for watching this channel :) Here is just a quick & simple nursing skill, that I really hope you enjoy! I appreciate all of your comments, likes & shares so much!! Really looking forward to growing with you!! Winners from Last weeks Giveaway!! Please email me at: Empower.RN@gmail.com :) 1. Stephanie Cianciolo 2. journeytoRN 3. Sabrina Botelho 4. John Navarro 5. LizRN Thank you: Life Medical Equipment for making this video possible! www.LifeMedicalEquipment.com Thank you: Johanna Pialisa Asis for editing this video! Disclaimer: These videos are intended for entertainment purposes only. Please follow the policy and procedures that your institution requires. Please note that the views, ideas & opinions expressed on this channel and in the videos on this channel are not necessarily of those of my employer or institution. The views expressed on this channel and in the videos channel do not represent medical advice. If you have specific medical concerns, please contact your physician. In order to protect patient privacy, all patient identifiers in all videos have been deleted or altered. The views expressed on this channel and in the videos on this channel are personal opinions. I am not an expert nor do I dispense medical advice or procedural specifications. The information I present is for general knowledge and entertainment purposes only. You need to refer to your own medical director, teachers and protocols for specific treatment information. It is your responsibility to know how best to treat your patient in your jurisdiction.
G Protein Coupled Receptors Nervous system physiology
Video ini menjelaskan tentang G-protein coupled receptor (reseptor G-protein bergandengan) yang juga biasa dikenal dengan GPCRs. G-protein coupled receptors hanya bisa ditemukan pada eukariot dan GPCRs adalah kelas yang terbesar dari semua reseptor membran.
OER-Unsyiah Lib published via YouTube.com
Pain Temperature BY : UPT Perpustakaan Universitas Syiah Kuala UKM Literasi Unsyiah
oerlib unsyiah1234 published via YouTube.com
What is Clinical Pharmacy Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Clinical pharmacy is the branch of pharmacy in which pharmacists provide patient care that optimizes the use of medication and promotes health, wellness, and disease prevention. Clinical pharmacists care for patients in all health care settings but the clinical pharmacy movement initially began inside hospitals and clinics. Clinical pharmacists often work in collaboration with physicians, nurse practitioners, and other healthcare professionals. Clinical pharmacists have extensive education in the biomedical, pharmaceutical, socio-behavioural and clinical sciences. Most clinical pharmacists have a Doctor of Pharmacy (Pharm.D.) degree and many have completed one or more years of post-graduate training (for example, a general and/or specialty pharmacy residency). In the United States, clinical pharmacists can choose to become Board-certified through the Board of Pharmacy Specialties (BPS), which was organized in 1976 as an independent certification agency of the American Pharmacists Association. The BPS certifies pharmacists in the following specialities: ambulatory care pharmacy, critical care pharmacy, nuclear pharmacy, nutrition support pharmacy, oncology pharmacy, paediatric pharmacy, pharmacotherapy, and psychiatric pharmacy. Within the system of health care, clinical pharmacists are experts in the therapeutic use of medications. They routinely provide medication therapy evaluations and recommendations to patients and other health care professionals. Clinical pharmacists are a primary source of scientifically valid information and advice regarding the safe, appropriate, and cost-effective use of medications. Clinical pharmacists are also making themselves more readily available to the public. In the past, access to a clinical pharmacist was limited to hospitals, clinics, or educational institutions. However, clinical pharmacists are making themselves available through a medication information hotline, and reviewing medication lists, all in an effort to prevent medication errors in the foreseeable future. In the United Kingdom, clinical pharmacists are routinely involved in the direct care of patients within hospitals, and increasingly, in doctors surgeries. They also develop post registration professional education, professional curricula for workforce development, provide expertise on the use of medicines to national organizations such as NICE, the Department of Health, and the MHRA, and develop medicines guidelines for use in therapeutic areas. Clinical pharmacists interact directly with patients in several different ways. They use their knowledge of medication (including dosage, drug interactions, side effects, expense, effectiveness, etc.) to determine if a medication plan is appropriate for their patient. If it is not, the pharmacist will consult the primary physician to ensure that the patient is on the proper medication plan. The pharmacist also works to educate their patients on the importance of taking and finishing their medications. Studies conducted into Pharmacist-led Chronic Disease Management show that it was associated with effects similar to usual care and might improve physiological goal attainment. In some states, clinical pharmacists are given prescriptive authority under protocol with a medical provider, and their scope of practice is constantly evolving. In the United Kingdom clinical pharmacists are given independent prescriptive authority. Basic components of clinical pharmacy practice include: Prescribing drugs, administering drugs, monitoring prescriptions, managing drug use, and counselling patients.
Physical anthropologists study human biological variation in the past and present. They are not only interested in the physical aspect of the body but also how biology, culture and environment interact to produce variation. Part of this variation is found in the bones and teeth. Since these are the hardest parts of the body, they have the greatest chance of being found in the archaeological record. Thus they form the bulk of direct information about the biological course of human evolution.
Care in Healthcare: Reflections on Theory and Practice
This book examines the concept of care and care practices in healthcare from the interdisciplinary perspectives of continental philosophy, care ethics, the social sciences, and anthropology. Areas addressed include dementia care, midwifery, diabetes care, psychiatry, and reproductive medicine. Special attention is paid to ambivalences and tensions within both the concept of care and care practices. Contributions in the first section of the book explore phenomenological and hermeneutic approaches to care and reveal historical precursors to care ethics. Empirical case studies and reflections on care in institutionalised and standardised settings form the second section of the book. The concluding chapter, jointly written by many of the contributors, points at recurring challenges of understanding and practicing care that open up the field for further research and discussion. This collection will be of great value to scholars and practitioners of medicine, ethics, philosophy, social science and history.
Diseases of Children in the Subtropics and Tropics
Paediatrics is often thought of as following two main routes. One is that of ultra-technology and ever-narrower specialization. The other is recognition of child health in a community context, related to family circumstances (especially the health and welfare of mothers) and influenced by the environment, social stresses, economic limitations, cultural attitudes and practices, and policy decisions and priorities based on the political system. Neither is right, but rather a balance is needed. Thus, preventive programmes, such as immunization, depend on refined technology to produce appropriate vaccines and devise workable equipment for effective 'cold-chains'. Curative paediatrics, especially simplified methods in appropriate technology, has to be underpinned by science - both by necessity and to achieve acceptance by orthodox members of the Establishment. Examples include the work of gastroenterologists on the intestinal 'sodium pump' and how this can be 'primed' and made more effective by glucose. In this way, essential scientific credence has been given to the seemingly simple methods of oral rehydration, using prepared ORS packets or home-made mixtures of sugar and salt or dilute rice (or other staple) gruels. However, as always, it can be difficult to persuade physicians, including paediatricians, to acquire a community perspective, understanding and, still more, a truly active role. This is often in part because of their training which frequently remains predominantly clinical - 'we teach what we have been taught'. However, things are changing in some more enlightened training establishments, and the trend is certainly indicated in this Fourth Edition. Sound clinical work, as in a hospital environment, is vital and will always remain a major need. This approach alone cannot begin to touch the major issues of child health. Some of these may be beyond the scope of the paediatrician or of medical science. Nevertheless, an awareness of the need for an advocacy role has to be cultivated. In this way, advice and guidance may begin to move those in power towards policies which can improve community child health. The 'complete' paediatrician anywhere, but especially in less technically developed countries, often in tropical regions, needs to be much more than a blinkered 'vertical' /'horizontal' expert. Rather, there is a need for 'lateral' thinking, training and action. This implies realization of the wide range of factors needing consideration in child health work and also recognition of the value of a dove-tailed curative-preventive approach, as part of a team including paediatricians, nurses, community health workers and (importantly) parents, particularly mothers, in the community itself. The present edition of Diseases of Children in the Subtropics and Tropics moves in this direction and will most certainly be valuable not only as a clinical reference text. My hope is that it will also persuade its readers that a paediatrician should not only be clinically sound, but also able to recognize the wider community issues involved in the causation of problems and the need for imaginative interdisciplinary programes to improve the outlook for life and health of mothers and children in the Third World.
Field Trials of Health Interventions: A Toolbox
Abstract Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in `field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this open-access online guide, practical issues in trial design and conduct are discussed fully and in sufficient detail. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience
Health Case Studies is composed of eight separate health case studies. Each case study includes the patient narrative or story that models the best practice (at the time of publishing) in healthcare settings. Associated with each case is a set of specific learning objectives to support learning and facilitate educational strategies and evaluation. The case studies can be used online in a learning management system, in a classroom discussion, in a printed course pack or as part of a textbook created by the instructor. This flexibility is intentional and allows the educator to choose how best to convey the concepts presented in each case to the learner. Because these case studies were primarily developed for an electronic healthcare system, they are based predominantly in an acute healthcare setting. Educators can augment each case study to include primary healthcare settings, outpatient clinics, assisted living environments, and other contexts as relevant.
Interface Oral Health Science 2016: Innovative Research on Biosis–Abiosis Intelligent Interface
This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis–Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted “Interface Oral Health Science” several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014. This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines.
Public Health Ethics: Cases Spanning the Globe
This Open Access book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively new and emerging area. There are few practical training resources for public health practitioners, especially resources which include discussion of realistic cases which are likely to arise in the practice of public health. This work discusses these issues on a case to case basis and helps create awareness and understanding of the ethics of public health care. The main audience for the casebook is public health practitioners, including front-line workers, field epidemiology trainers and trainees, managers, planners, and decision makers who have an interest in learning about how to integrate ethical analysis into their day to day public health practice. The casebook is also useful to schools of public health and public health students as well as to academic ethicists who can use the book to teach public health ethics and distinguish it from clinical and research ethics.
Malaria was considered one of the most widespread disease-causing entities in the nineteenth century. It was associated with a variety of frailties far beyond fevers, ranging from idiocy to impotence. And yet, it was not a self-contained category. The reconsolidation of malaria as a diagnostic category during this period happened within a wider context in which cinchona plants and their most valuable extract, quinine, were reinforced as objects of natural knowledge and social control. In India, the exigencies and apparatuses of British imperial rule occasioned the close interactions between these histories. In the process, British imperial rule became entangled with a network of nonhumans that included, apart from cinchona plants and the drug quinine, a range of objects described as malarial, as well as mosquitoes. Malarial Subjects explores this history of the co-constitution of a cure and disease, of British colonial rule and nonhumans, and of science, medicine and empire. This title is also available as Open Access.
Nursing Care at the End of Life: What Every Clinician Should Know
Nursing Care at the End of Life: What Every Clinician Should Know should be an essential component of basic educational preparation for the professional registered nurse student. Recent studies show that only one in four nurses feel confident in caring for dying patients and their families and less than 2% of overall content in nursing textbooks is related to end-of-life care, despite the tremendous growth in palliative and end-of-life care programs across the country. The purpose of this textbook is to provide an indepth look at death and dying in this country, including the vital role of the nurse in assisting patients and families along the journey towards the end of life. There is an emphasis throughout the book on the simple, yet understated value of effective interpersonal communication between the patient and clinician. The text provides a basic foundation of understanding death and dying, including a brief historical examination of some main conceptual models associated with how patients cope with impending loss. An overview of illness trajectories and models of care, such as hospice and palliative care are discussed. Lastly, the latest evidence-based approaches for pain and symptom management, ethical concerns, cultural considerations, care at the time of death, and grief/bereavement are examined. The goal of this text is to foster the necessary skills for nurses to provide compassionate care to individuals who are nearing the end of life and their families. Every chapter contains a “What You Should Know” section which highlights and reinforces foundational concepts.
The manual contains the following labs: Introduction Tissues Integument Introduction to the Skeleton Axial Skeleton: Skull Axial Skeleton: Vertebral Appendicular Skeleton: Introduction and Pectoral Girdle Appendicular Skeleton: Upper Limbs Appendicular Skeleton: Pelvis Appendicular Skeleton: Lower Limbs Articulations/Joints Body Movements Muscles: Head, Neck, and Back Muscles: Abdomen and Thorax Muscles: Upper Limbs Muscles: Lower Limbs Spinal Cord Brain Cranial Nerves Special Senses: Ear Special Senses: Eye
The manual contains the following labs: Blood Composition Blood Typing Heart Anatomy Cardiovascular Physiology Systemic Blood Vessels Anatomy of the Respiratory System Physiology of the Respiratory System Renal Anatomy Urinalysis Digestive System Anatomy Digestive Physiology Male Reproductive System Female Reproductive System
Medical virology is always an interest to all healthcare disciplines, undergraduate and postgraduate students. These “Notes on Medical virology”, includes “what you really need to know”. The book comes in a new format, which places cases, keywords, facts and other considerations in colored tables and boxes only. As a result, extra spaces have been provided so that without expanding the length of the book the readers can enjoy a personal and practical learning experience.
The job of the respiratory system is to take oxygen from the air we breathe and get it to different parts of the body. Our bodies and the cells in them need oxygen (written with the chemical symbol O2) to live. Our cells give off carbon dioxide (written with the chemical symbol CO2) as a waste product or something they don’t need any more. The respiratory system takes this carbon dioxide out of the body. The main organ of the respiratory system is the lungs. The respiratory system starts when you take a breath. There is a muscle called the diaphragm that is at the bottom of the rib cage. It helps draw air into the lungs. Once a breath is taken, the air travels through the mouth or nose and travels through the windpipe into the lungs. Once the air is down the windpipe, it splits one of two directions into tubes called bronchi and then into the lungs. The bronchi branch off into more and more smaller tubes. At the very end of these are small sacs called alveoli. In the alveoli, the respiratory system works with the circulatory system. Small blood vessels take oxygen from the alveoli to the heart for distribution to the rest of the body. Blood also brings carbon dioxide to be exhaled back out. When we breathe in or inhale, the air coming into the body has a lot of oxygen. When we breathe out or exhale, the air has more carbon dioxide.
The circulatory system includes the heart, blood, and a huge network of blood vessels that carry blood all over the body. The job of the circulatory system is to deliver oxygen to cells all over the body and then to carry out waste product like carbon dioxide. The heart is an organ made out of muscle. It’s job is to pump blood through the body. The heart has four main sections or chambers: Right atrium Right ventricle Left atrium Left ventricle Blood flows into the right atrium through two large blood vessels called the superior vena cava (from the upper body) and the inferior vena cava (from the lower body). From there blood moves to the right ventricle. It then travels to the lungs to get oxygen. Blood coming back from the lungs enters the left atrium and then into the left ventricle. From there it leaves the heart through the aortic valve and goes into the aorta. This is the largest artery in the body, and it leads to all parts of the body. There are many kinds blood vessels that carry blood around the body. Arteries carry blood away from the heart. (You can remember arteries and away.) Veins carry blood back to the heart. Blood that is coming from the lungs has lots of fresh oxygen in it and is bright red. After the oxygen is delivered to cells and carbon dioxide is picked up, the blood is darker colored. Blood is made up of a liquid called plasma and three kinds of cells. Red blood cells carry oxygen to the various parts of the body. White blood cells help fight disease. Platelets help blood clot.
Our bodies need food to live and grow. The digestive system takes food and carries it to all the parts of the body. The beginning of the digestive system is the mouth and teeth. Food that we eat has to be broken down into nutrients that cells in our bodies can use. This starts with the teeth and tongue grinding food into smaller pieces. Saliva also helps break down food. Then the food is swallowed and goes down the esophagus, a tube that goes from the mouth to the stomach. The stomach breaks down the food further. Gastric juices that have acids and enzymes in them that help the process. Then the food goes to the small intestine. This is a long twisting tube that fills up much of your lower abdomen area. It is where most of the digestion occurs. The liver produces bile, and the pancreas produces juices that help break food down. Small blood vessels line the walls of the small intestine. Once the food is broken down, the nutrients are absorbed by these blood vessels. The blood then carries the nutrients to cells all over the body. The part of the food that is left moves on to the large intestine.
After food goes through the digestive system, the parts that are not digested need to be gotten rid of. That is the job of the excretory system. Unabsorbed food goes to the large intestine. The liver also filters out solid particles of waste from the blood. These solid wastes are removed from the body through the rectum, which is at the end of the large intestine. Liquid wastes are filtered by the kidneys, a part of the excretory system. The kidneys have long tubes coming out of them called ureters that drain liquid into the bladder. The bladder stores liquid waste called urine until it is passed out of the body through the urethra.
The human skeleton provides shape and form to the human body Our vital organs in our body are protected by our skeleton. More specifically our brain which is protected by what is called the skull and our heart and lungs are protected by our rib cage. Bones are connected by our ligaments and where the bones meet eachother is called a joint. Muscles are connected to the bones by tendons Bones are sonnected to each other by ligaments Blood cells are produced by the marrow located in some bones How your bones move! Muscles pull on the bones, making them move and when muscles contract the bones attached act as levers which makes the body move.
Cardio Exercises Below 1) Jog. You can do this outside on a treadmill or however you like. 2) Jump Rope routine 1 3) 10 Minute Jump Rope routine 4) Exercise Bikes 5) Sports Playing
Chambers and Circulation through the Heart
Dual System of the Human Blood Circulation. Blood flows from the right atrium to the right ventricle, where it is pumped into the pulmonary circuit. The blood in the pulmonary artery branches is low in oxygen but relatively high in carbon dioxide. Gas exchange occurs in the pulmonary capillaries (oxygen into the blood, carbon dioxide out), and blood high in oxygen and low in carbon dioxide is returned to the left atrium. From here, blood enters the left ventricle, which pumps it into the systemic circuit. Following exchange in the systemic capillaries (oxygen and nutrients out of the capillaries and carbon dioxide and wastes in), blood returns to the right atrium and the cycle is repeated.
The shoulder joint is called the glenohumeral joint. This is a ball-and-socket joint formed by the articulation between the head of the humerus and the glenoid cavity of the scapula ([link]). This joint has the largest range of motion of any joint in the body. However, this freedom of movement is due to the lack of structural support and thus the enhanced mobility is offset by a loss of stability. The large range of motions at the shoulder joint is provided by the articulation of the large, rounded humeral head with the small and shallow glenoid cavity, which is only about one third of the size of the humeral head. The socket formed by the glenoid cavity is deepened slightly by a small lip of fibrocartilage called the glenoid labrum, which extends around the outer margin of the cavity. The articular capsule that surrounds the glenohumeral joint is relatively thin and loose to allow for large motions of the upper limb. Some structural support for the joint is provided by thickenings of the articular capsule wall that form weak intrinsic ligaments. These include the coracohumeral ligament, running from the coracoid process of the scapula to the anterior humerus, and three ligaments, each called a glenohumeral ligament, located on the anterior side of the articular capsule. These ligaments help to strengthen the superior and anterior capsule walls. However, the primary support for the shoulder joint is provided by muscles crossing the joint, particularly the four rotator cuff muscles. These muscles (supraspinatus, infraspinatus, teres minor, and subscapularis) arise from the scapula and attach to the greater or lesser tubercles of the humerus. As these muscles cross the shoulder joint, their tendons encircle the head of the humerus and become fused to the anterior, superior, and posterior walls of the articular capsule. The thickening of the capsule formed by the fusion of these four muscle tendons is called the rotator cuff. Two bursae, the subacromial bursa and the subscapular bursa, help to prevent friction between the rotator cuff muscle tendons and the scapula as these tendons cross the glenohumeral joint. In addition to their individual actions of moving the upper limb, the rotator cuff muscles also serve to hold the head of the humerus in position within the glenoid cavity. By constantly adjusting their strength of contraction to resist forces acting on the shoulder, these muscles serve as “dynamic ligaments” and thus provide the primary structural support for the glenohumeral joint.
Levels of Structural Organization of the Human Body
Before you begin to study the different structures and functions of the human body, it is helpful to consider its basic architecture; that is, how its smallest parts are assembled into larger structures. It is convenient to consider the structures of the body in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, organisms and biosphere. To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of which are hydrogen, oxygen, carbon, nitrogen, calcium, and iron. The smallest unit of any of these pure substances (elements) is an atom. Atoms are made up of subatomic particles such as the proton, electron and neutron. Two or more atoms combine to form a molecule, such as the water molecules, proteins, and sugars found in living things. Molecules are the chemical building blocks of all body structures. A cell is the smallest independently functioning unit of a living organism. Even bacteria, which are extremely small, independently-living organisms, have a cellular structure. Each bacterium is a single cell. All living structures of human anatomy contain cells, and almost all functions of human physiology are performed in cells or are initiated by cells. A human cell typically consists of flexible membranes that enclose cytoplasm, a water-based cellular fluid together with a variety of tiny functioning units called organelles. In humans, as in all organisms, cells perform all functions of life. A tissue is a group of many similar cells (though sometimes composed of a few related types) that work together to perform a specific function. An organ is an anatomically distinct structure of the body composed of two or more tissue types. Each organ performs one or more specific physiological functions. An organ system is a group of organs that work together to perform major functions or meet physiological needs of the body.
Normal childbirth is driven by a positive feedback loop. A positive feedback loop results in a change in the body’s status, rather than a return to homeostasis.
The posterior (dorsal) and anterior (ventral) cavities are each subdivided into smaller cavities. In the posterior (dorsal) cavity, the cranial cavity houses the brain, and the spinal cavity (or vertebral cavity) encloses the spinal cord. Just as the brain and spinal cord make up a continuous, uninterrupted structure, the cranial and spinal cavities that house them are also continuous. The brain and spinal cord are protected by the bones of the skull and vertebral column and by cerebrospinal fluid, a colorless fluid produced by the brain, which cushions the brain and spinal cord within the posterior (dorsal) cavity. The anterior (ventral) cavity has two main subdivisions: the thoracic cavity and the abdominopelvic cavity (see [link]). The thoracic cavity is the more superior subdivision of the anterior cavity, and it is enclosed by the rib cage. The thoracic cavity contains the lungs and the heart, which is located in the mediastinum. The diaphragm forms the floor of the thoracic cavity and separates it from the more inferior abdominopelvic cavity. The abdominopelvic cavity is the largest cavity in the body. Although no membrane physically divides the abdominopelvic cavity, it can be useful to distinguish between the abdominal cavity, the division that houses the digestive organs, and the pelvic cavity, the division that houses the organs of reproduction.
Regions and Quadrants of the Peritoneal Cavity
The more detailed regional approach subdivides the cavity with one horizontal line immediately inferior to the ribs and one immediately superior to the pelvis, and two vertical lines drawn as if dropped from the midpoint of each clavicle (collarbone). There are nine resulting regions. The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersect at the patient’s umbilicus (navel)
A serous membrane (also referred to a serosa) is one of the thin membranes that cover the walls and organs in the thoracic and abdominopelvic cavities. The parietal layers of the membranes line the walls of the body cavity (pariet- refers to a cavity wall). The visceral layer of the membrane covers the organs (the viscera). Between the parietal and visceral layers is a very thin, fluid-filled serous space, or cavity There are three serous cavities and their associated membranes. The pleura is the serous membrane that surrounds the lungs in the pleural cavity; the pericardium is the serous membrane that surrounds the heart in the pericardial cavity; and the peritoneum is the serous membrane that surrounds several organs in the abdominopelvic cavity.The serous membranes form fluid-filled sacs, or cavities, that are meant to cushion and reduce friction on internal organs when they move, such as when the lungs inflate or the heart beats. Both the parietal and visceral serosa secrete the thin, slippery serous fluid located within the serous cavities. The pleural cavity reduces friction between the lungs and the body wall. Likewise, the pericardial cavity reduces friction between the heart and the wall of the pericardium. The peritoneal cavity reduces friction between the abdominal and pelvic organs and the body wall. Therefore, serous membranes provide additional protection to the viscera they enclose by reducing friction that could lead to inflammation of the organs.
Creative Clinical Teaching In The Health Professions
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The overall purpose of this preparatory course textbook is to help students familiarize with some terms and some basic concepts they will find later in the Human Anatomy and Physiology I course. The organization and functioning of the human organism generally is discussed in terms of different levels of increasing complexity, from the smallest building blocks to the entire body. This Anatomy and Physiology preparatory course covers the foundations on the chemical level, and a basic introduction to cellular level, organ level, and organ system levels. There is also an introduction to homeostasis at the beginning.
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High energy electromagnetic radiation allows the internal structures of the body, such as bones, to be seen in X-rays like these
(a) The results of a CT scan of the head are shown as successive transverse sections. (b) An MRI machine generates a magnetic field around a patient. (c) PET scans use radiopharmaceuticals to create images of active blood flow and physiologic activity of the organ or organs being targeted. (d) Ultrasound technology is used to monitor pregnancies because it is the least invasive of imaging techniques and uses no electromagnetic radiation.
The main elements that compose the human body are shown from most abundant to least abundant.
The nucleotide adenosine triphosphate (ATP), is composed of a ribose sugar, an adenine base, and three phosphate groups ([link]). ATP is classified as a high energy compound because the two covalent bonds linking its three phosphates store a significant amount of potential energy. In the body, the energy released from these high energy bonds helps fuel the body’s activities, from muscle contraction to the transport of substances in and out of cells to anabolic chemical reactions. When a phosphate group is cleaved from ATP, the products are adenosine diphosphate (ADP) and inorganic phosphate (Pi). This hydrolysis reaction can be written: ATP + H2O → ADP + Pi + energy Removal of a second phosphate leaves adenosine monophosphate (AMP) and two phosphate groups. Again, these reactions also liberate the energy that had been stored in the phosphate-phosphate bonds. They are reversible, too, as when ADP undergoes phosphorylation. Phosphorylation is the addition of a phosphate group to an organic compound, in this case, resulting in ATP. In such cases, the same level of energy that had been released during hydrolysis must be reinvested to power dehydration synthesis. Cells can also transfer a phosphate group from ATP to another organic compound. For example, when glucose first enters a cell, a phosphate group is transferred from ATP, forming glucose phosphate (C6H12O6—P) and ADP. Once glucose is phosphorylated in this way, it can be stored as glycogen or metabolized for immediate energy.
Fluorescence-stained Cell Undergoing Mitosis
A lung cell from a newt, commonly studied for its similarity to human lung cells, is stained with fluorescent dyes. The green stain reveals mitotic spindles, red is the cell membrane and part of the cytoplasm, and the structures that appear light blue are chromosomes. This cell is in anaphase of mitosis.
The cell membrane of the cell is a phospholipid bilayer containing many different molecular components, including proteins and cholesterol, some with carbohydrate groups attached.
Simple Diffusion across the Cell (Plasma) Membrane
The structure of the lipid bilayer allows small, uncharged substances such as oxygen and carbon dioxide, and hydrophobic molecules such as lipids, to pass through the cell membrane, down their concentration gradient, by simple diffusion.
(a) Facilitated diffusion of substances crossing the cell (plasma) membrane takes place with the help of proteins such as channel proteins and carrier proteins. Channel proteins are less selective than carrier proteins, and usually mildly discriminate between their cargo based on size and charge. (b) Carrier proteins are more selective, often only allowing one particular type of molecule to cross.
The sodium-potassium pump is found in many cell (plasma) membranes. Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell.
Endocytosis is a form of active transport in which a cell envelopes extracellular materials using its cell membrane. (a) In phagocytosis, which is relatively nonselective, the cell takes in a large particle. (b) In pinocytosis, the cell takes in small particles in fluid. (c) In contrast, receptor-mediated endocytosis is quite selective. When external receptors bind a specific ligand, the cell responds by endocytosing the ligand.
Exocytosis is much like endocytosis in reverse. Material destined for export is packaged into a vesicle inside the cell. The membrane of the vesicle fuses with the cell membrane, and the contents are released into the extracellular space.
The level of saturation of a fatty acid affects its shape. (a) Saturated fatty acid chains are straight. (b) Unsaturated fatty acid chains are kinked.
While this image is not indicative of any one particular human cell, it is a prototypical example of a cell containing the primary organelles and internal structures.
(a) The ER is a winding network of thin membranous sacs found in close association with the cell nucleus. The smooth and rough endoplasmic reticula are very different in appearance and function (source: mouse tissue). (b) Rough ER is studded with numerous ribosomes, which are sites of protein synthesis (source: mouse tissue). EM × 110,000. (c) Smooth ER synthesizes phospholipids, steroid hormones, regulates the concentration of cellular Ca++, metabolizes some carbohydrates, and breaks down certain toxins (source: mouse tissue)
(a) The Golgi apparatus manipulates products from the rough ER, and also produces new organelles called lysosomes. Proteins and other products of the ER are sent to the Golgi apparatus, which organizes, modifies, packages, and tags them. Some of these products are transported to other areas of the cell and some are exported from the cell through exocytosis. Enzymatic proteins are packaged as new lysosomes (or packaged and sent for fusion with existing lysosomes). (b) An electron micrograph of the Golgi apparatus.
The mitochondria are the energy-conversion factories of the cell. (a) A mitochondrion is composed of two separate lipid bilayer membranes. Along the inner membrane are various molecules that work together to produce ATP, the cell’s major energy currency. (b) An electron micrograph of mitochondri
The Three Components of the Cytoskeleton
The cytoskeleton consists of (a) microtubules, (b) microfilaments, and (c) intermediate filaments. The cytoskeleton plays an important role in maintaining cell shape and structure, promoting cellular movement, and aiding cell division.
The nucleus is the control center of the cell. The nucleus of living cells contains the genetic material that determines the entire structure and function of that cell.
Unlike cardiac muscle cells and smooth muscle cells, which have a single nucleus, a skeletal muscle cell contains many nuclei, and is referred to as “multinucleated.” These muscle cells are long and fibrous (often referred to as muscle fibers). During development, many smaller cells fuse to form a mature muscle fiber. The nuclei of the fused cells are conserved in the mature cell, thus imparting a multinucleate characteristic to mature muscle cells.
Strands of DNA are wrapped around supporting histones. These proteins are increasingly bundled and condensed into chromatin, which is packed tightly into chromosomes when the cell is ready to divide.
The DNA double helix is composed of two complementary strands. The strands are bonded together via their nitrogenous base pairs using hydrogen bonds.
DNA replication faithfully duplicates the entire genome of the cell. During DNA replication, a number of different enzymes work together to pull apart the two strands so each strand can be used as a template to synthesize new complementary strands. The two new daughter DNA molecules each contain one pre-existing strand and one newly synthesized strand. Thus, DNA replication is said to be “semiconservative
DNA holds all of the genetic information necessary to build a cell’s proteins. The nucleotide sequence of a gene is ultimately translated into an amino acid sequence of the gene’s corresponding protein.
In the first of the two stages of making protein from DNA, a gene on the DNA molecule is transcribed into a complementary mRNA molecule.
In the nucleus, a structure called a spliceosome cuts out introns (noncoding regions) within a pre-mRNA transcript and reconnects the exons.
During translation, the mRNA transcript is “read” by a functional complex consisting of the ribosome and tRNA molecules. tRNAs bring the appropriate amino acids in sequence to the growing polypeptide chain by matching their anti-codons with codons on the mRNA strand.
From DNA to Protein: Transcription through Translation
Transcription within the cell nucleus produces an mRNA molecule, which is modified and then sent into the cytoplasm for translation. The transcript is decoded into a protein with the help of a ribosome and tRNA molecules.
A Homologous Pair of Chromosomes with their Attached Sister Chromatids
The red and blue colors correspond to a homologous pair of chromosomes. Each member of the pair was separately inherited from one parent. Each chromosome in the homologous pair is also bound to an identical sister chromatid, which is produced by DNA replication, and results in the familiar “X” shape.
The stages of cell division oversee the separation of identical genetic material into two new nuclei, followed by the division of the cytoplasm.
The process of hematopoiesis involves the differentiation of multipotent cells into blood and immune cells. The multipotent hematopoietic stem cells give rise to many different cell types, including the cells of the immune system and red blood cells.
The capacity of stem cells to differentiate into specialized cells make them potentially valuable in therapeutic applications designed to replace damaged cells of different body tissues.
This figure is a view of the regular architecture of normal tissue contrasted with the irregular arrangement of cancerous cells.
The four types of tissues are exemplified in nervous tissue, stratified squamous epithelial tissue, cardiac muscle tissue, and connective tissue in small intestine. Clockwise from nervous tissue
The zygote, or fertilized egg, is a single cell formed by the fusion of an egg and sperm. After fertilization the zygote gives rise to rapid mitotic cycles, generating many cells to form the embryo. The first embryonic cells generated have the ability to differentiate into any type of cell in the body and, as such, are called totipotent, meaning each has the capacity to divide, differentiate, and develop into a new organism. As cell proliferation progresses, three major cell lineages are established within the embryo. As explained in a later chapter, each of these lineages of embryonic cells forms the distinct germ layers from which all the tissues and organs of the human body eventually form. Each germ layer is identified by its relative position: ectoderm (ecto- = “outer”), mesoderm (meso- = “middle”), and endoderm (endo- = “inner”). The types of tissues and organs associated with the each of the three germ layers. Note that epithelial tissue originates in all three layers, whereas nervous tissue derives primarily from the ectoderm and muscle tissue from mesoderm.
The two broad categories of tissue membranes in the body are (1) connective tissue membranes, which include synovial membranes, and (2) epithelial membranes, which include mucous membranes, serous membranes, and the cutaneous membrane, in other words, the skin.
The three basic types of cell-to-cell junctions are tight junctions, gap junctions, and anchoring junctions.
Simple epithelial tissue is organized as a single layer of cells and stratified epithelial tissue is formed by several layers of cells.
(a) In the lining of the small intestine, columnar epithelium cells are interspersed with goblet cells. (b) The arrows in this micrograph point to the mucous-secreting goblet cells.
A stratified epithelium consists of several stacked layers of cells. This epithelium protects against physical and chemical wear and tear. The stratified epithelium is named by the shape of the most apical layer of cells, closest to the free space. Stratified squamous epithelium is the most common type of stratified epithelium in the human body. The apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The top layer may be covered with dead cells filled with keratin. Mammalian skin is an example of this dry, keratinized, stratified squamous epithelium. The lining of the mouth cavity is an example of an unkeratinized, stratified squamous epithelium. Stratified cuboidal epithelium and stratified columnar epithelium can also be found in certain glands and ducts, but are uncommon in the human body. Another kind of stratified epithelium is transitional epithelium, so-called because of the gradual changes in the shapes of the apical cells as the bladder fills with urine. It is found only in the urinary system, specifically the ureters and urinary bladder. When the bladder is empty, this epithelium is convoluted and has cuboidal apical cells with convex, umbrella shaped, apical surfaces. As the bladder fills with urine, this epithelium loses its convolutions and the apical cells transition from cuboidal to squamous. It appears thicker and more multi-layered when the bladder is empty, and more stretched out and less stratified when the bladder is full and distended. summarizes the different categories of epithelial cell tissue cells.
Exocrine glands are classified by their structure.
(a) In merocrine secretion, the cell remains intact. (b) In apocrine secretion, the apical portion of the cell is released, as well. (c) In holocrine secretion, the cell is destroyed as it releases its product and the cell itself becomes part of the secretion.
These glands secrete oils that lubricate and protect the skin. They are holocrine glands and they are destroyed after releasing their contents. New glandular cells form to replace the cells that are lost
Fibroblasts produce this fibrous tissue. Connective tissue proper includes the fixed cells fibrocytes, adipocytes, and mesenchymal cells.
This is a loose connective tissue that consists of fat cells with little extracellular matrix. It stores fat for energy and provides insulation.
This is a loose connective tissue made up of a network of reticular fibers that provides a supportive framework for soft organs.
(a) Dense regular connective tissue consists of collagenous fibers packed into parallel bundles. (b) Dense irregular connective tissue consists of collagenous fibers interwoven into a mesh-like network. From top,
Cartilage is a connective tissue consisting of collagenous fibers embedded in a firm matrix of chondroitin sulfates. (a) Hyaline cartilage provides support with some flexibility. The example is from dog tissue. (b) Fibrocartilage provides some compressibility and can absorb pressure. (c) Elastic cartilage provides firm but elastic support. From top,
The cell body of a neuron, also called the soma, contains the nucleus and mitochondria. The dendrites transfer the nerve impulse to the soma. The axon carries the action potential away to another excitable cell.
Nervous tissue is made up of neurons and neuroglia. The cells of nervous tissue are specialized to transmit and receive impulses
The skin is composed of two main layers: the epidermis, made of closely packed epithelial cells, and the dermis, made of dense, irregular connective tissue that houses blood vessels, hair follicles, sweat glands, and other structures. Beneath the dermis lies the hypodermis, which is composed mainly of loose connective and fatty tissues.
The epidermis of thick skin has five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in the different layers of the epidermis originate from basal cells located in the stratum basale, yet the cells of each layer are distinctively different.
This stained slide shows the two components of the dermis—the papillary layer and the reticular layer. Both are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
The relative coloration of the skin depends of the amount of melanin produced by melanocytes in the stratum basale and taken up by keratinocytes.
Moles range from benign accumulations of melanocytes to melanomas. These structures populate the landscape of our skin.
Individuals with vitiligo experience depigmentation that results in lighter colored patches of skin. The condition is especially noticeable on darker skin.
Hair follicles originate in the epidermis and have many different parts.
The nail is an accessory structure of the integumentary system.
Eccrine glands are coiled glands in the dermis that release sweat that is mostly water.
During strenuous physical activities, such as skiing (a) or running (c), the dermal blood vessels dilate and sweat secretion increases (b). These mechanisms prevent the body from overheating. In contrast, the dermal blood vessels constrict to minimize heat loss in response to low temperatures (b)
Acne is a result of over-productive sebaceous glands, which leads to formation of blackheads and inflammation of the skin.
The cranium completely surrounds and protects the brain from non-traumatic injury.
Bones are classified according to their shape.
A typical long bone shows the gross anatomical characteristics of bone.
The periosteum forms the outer surface of bone, and the endosteum lines the medullary cavity.
This cross-section of a flat bone shows the spongy bone (diploë) lined on either side by a layer of compact bone.
The surface features of bones depend on their function, location, attachment of ligaments and tendons, or the penetration of blood vessels and nerves.
Four types of cells are found within bone tissue. Osteogenic cells are undifferentiated and develop into osteoblasts. When osteoblasts get trapped within the calcified matrix, their structure and function changes, and they become osteocytes. Osteoclasts develop from monocytes and macrophages and differ in appearance from other bone cells.
(a) This cross-sectional view of compact bone shows the basic structural unit, the osteon. (b) In this micrograph of the osteon, you can clearly see the concentric lamellae and central canals.
Spongy bone is composed of trabeculae that contain the osteocytes. Red marrow fills the spaces in some bones.
Normal leg bones are relatively straight, but those affected by Paget’s disease are porous and curved.
Diagram of Blood and Nerve Supply to Bone
Blood vessels and nerves enter the bone through the nutrient foramen.
Intramembranous ossification follows four steps. (a) Mesenchymal cells group into clusters, and ossification centers form. (b) Secreted osteoid traps osteoblasts, which then become osteocytes. (c) Trabecular matrix and periosteum form. (d) Compact bone develops superficial to the trabecular bone, and crowded blood vessels condense into red marrow.
Endochondral ossification follows five steps. (a) Mesenchymal cells differentiate into chondrocytes. (b) The cartilage model of the future bony skeleton and the perichondrium form. (c) Capillaries penetrate cartilage. Perichondrium transforms into periosteum. Periosteal collar develops. Primary ossification center develops. (d) Cartilage and chondrocytes continue to grow at ends of the bone. (e) Secondary ossification centers develop. (f) Cartilage remains at epiphyseal (growth) plate and at joint surface as articular cartilage.
The epiphyseal plate is responsible for longitudinal bone growth.
Progression from Epiphyseal Plate to Epiphyseal Line
As a bone matures, the epiphyseal plate progresses to an epiphyseal line. (a) Epiphyseal plates are visible in a growing bone. (b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone.
Compare healthy bone with different types of fractures: (a) closed fracture, (b) open fracture, (c) transverse fracture, (d) spiral fracture, (e) comminuted fracture, (f) impacted fracture, (g) greenstick fracture, and (h) oblique fracture.
The healing of a bone fracture follows a series of progressive steps: (a) A fracture hematoma forms. (b) Internal and external calli form. (c) Cartilage of the calli is replaced by trabecular bone. (d) Remodeling occurs.
Graph Showing Relationship Between Age and Bone Mass
Bone density peaks at about 30 years of age. Women lose bone mass more rapidly than men.
The body regulates calcium homeostasis with two pathways; one is signaled to turn on when blood calcium levels drop below normal and one is the pathway that is signaled to turn on when blood calcium levels are elevated.
The axial skeleton supports the head, neck, back, and chest and thus forms the vertical axis of the body. It consists of the skull, vertebral column (including the sacrum and coccyx), and the thoracic cage, formed by the ribs and sternum. The appendicular skeleton is made up of all bones of the upper and lower limbs.
The skull consists of the rounded brain case that houses the brain and the facial bones that form the upper and lower jaws, nose, orbits, and other facial structures.
An anterior view of the skull shows the bones that form the forehead, orbits (eye sockets), nasal cavity, nasal septum, and upper and lower jaws.
The lateral skull shows the large rounded brain case, zygomatic arch, and the upper and lower jaws. The zygomatic arch is formed jointly by the zygomatic process of the temporal bone and the temporal process of the zygomatic bone. The shallow space above the zygomatic arch is the temporal fossa. The space inferior to the zygomatic arch and deep to the posterior mandible is the infratemporal fossa.
The bones of the brain case surround and protect the brain, which occupies the cranial cavity. The base of the brain case, which forms the floor of cranial cavity, is subdivided into the shallow anterior cranial fossa, the middle cranial fossa, and the deep posterior cranial fossa.
A lateral view of the isolated temporal bone shows the squamous, mastoid, and zygomatic portions of the temporal bone.
External and Internal Views of Base of Skull
(a) The hard palate is formed anteriorly by the palatine processes of the maxilla bones and posteriorly by the horizontal plate of the palatine bones. (b) The complex floor of the cranial cavity is formed by the frontal, ethmoid, sphenoid, temporal, and occipital bones. The lesser wing of the sphenoid bone separates the anterior and middle cranial fossae. The petrous ridge (petrous portion of temporal bone) separates the middle and posterior cranial fossae.
This view of the posterior skull shows attachment sites for muscles and joints that support the skull.
Shown in isolation in (a) superior and (b) posterior views, the sphenoid bone is a single midline bone that forms the anterior walls and floor of the middle cranial fossa. It has a pair of lesser wings and a pair of greater wings. The sella turcica surrounds the hypophyseal fossa. Projecting downward are the medial and lateral pterygoid plates. The sphenoid has multiple openings for the passage of nerves and blood vessels, including the optic canal, superior orbital fissure, foramen rotundum, foramen ovale, and foramen spinosum.
This midline view of the sagittally sectioned skull shows the nasal septum.
The unpaired ethmoid bone is located at the midline within the central skull. It has an upward projection, the crista galli, and a downward projection, the perpendicular plate, which forms the upper nasal septum. The cribriform plates form both the roof of the nasal cavity and a portion of the anterior cranial fossa floor. The lateral sides of the ethmoid bone form the lateral walls of the upper nasal cavity, part of the medial orbit wall, and give rise to the superior and middle nasal conchae. The ethmoid bone also contains the ethmoid air cells.
The three nasal conchae are curved bones that project from the lateral walls of the nasal cavity. The superior nasal concha and middle nasal concha are parts of the ethmoid bone. The inferior nasal concha is an independent bone of the sku
The maxillary bone forms the upper jaw and supports the upper teeth. Each maxilla also forms the lateral floor of each orbit and the majority of the hard palate.
The mandible is the only moveable bone of the skull.
Seven skull bones contribute to the walls of the orbit. Opening into the posterior orbit from the cranial cavity are the optic canal and superior orbital fissure.
The nasal septum is formed by the perpendicular plate of the ethmoid bone and the vomer bone. The septal cartilage fills the gap between these bones and extends into the nose.
The paranasal sinuses are hollow, air-filled spaces named for the skull bone that each occupies. The most anterior is the frontal sinus, located in the frontal bone above the eyebrows. The largest are the maxillary sinuses, located in the right and left maxillary bones below the orbits. The most posterior is the sphenoid sinus, located in the body of the sphenoid bone, under the sella turcica. The ethmoid air cells are multiple small spaces located in the right and left sides of the ethmoid bone, between the medial wall of the orbit and lateral wall of the upper nasal cavity.
The hyoid bone is located in the upper neck and does not join with any other bone. It provides attachments for muscles that act on the tongue, larynx, and pharynx.
The adult vertebral column consists of 24 vertebrae, plus the sacrum and coccyx. The vertebrae are divided into three regions: cervical C1–C7 vertebrae, thoracic T1–T12 vertebrae, and lumbar L1–L5 vertebrae. The vertebral column is curved, with two primary curvatures (thoracic and sacrococcygeal curves) and two secondary curvatures (cervical and lumbar curves).
Abnormal Curvatures of the Vertebral Column
(a) Scoliosis is an abnormal lateral bending of the vertebral column. (b) An excessive curvature of the upper thoracic vertebral column is called kyphosis. (c) Lordosis is an excessive curvature in the lumbar region of the vertebral column.
Osteoporosis is an age-related disorder that causes the gradual loss of bone density and strength. When the thoracic vertebrae are affected, there can be a gradual collapse of the vertebrae. This results in kyphosis, an excessive curvature of the thoracic region.
A typical vertebra consists of a body and a vertebral arch. The arch is formed by the paired pedicles and paired laminae. Arising from the vertebral arch are the transverse, spinous, superior articular, and inferior articular processes. The vertebral foramen provides for passage of the spinal cord. Each spinal nerve exits through an intervertebral foramen, located between adjacent vertebrae. Intervertebral discs unite the bodies of adjacent vertebrae.
The bodies of adjacent vertebrae are separated and united by an intervertebral disc, which provides padding and allows for movements between adjacent vertebrae. The disc consists of a fibrous outer layer called the anulus fibrosus and a gel-like center called the nucleus pulposus. The intervertebral foramen is the opening formed between adjacent vertebrae for the exit of a spinal nerve.
A typical cervical vertebra has a small body, a bifid spinous process, transverse processes that have a transverse foramen and are curved for spinal nerve passage. The atlas (C1 vertebra) does not have a body or spinous process. It consists of an anterior and a posterior arch and elongated transverse processes. The axis (C2 vertebra) has the upward projecting dens, which articulates with the anterior arch of the atlas.
A typical thoracic vertebra is distinguished by the spinous process, which is long and projects downward to overlap the next inferior vertebra. It also has articulation sites (facets) on the vertebral body and a transverse process for rib attachment.
Lumbar vertebrae are characterized by having a large, thick body and a short, rounded spinous process.
The sacrum is formed from the fusion of five sacral vertebrae, whose lines of fusion are indicated by the transverse ridges. The fused spinous processes form the median sacral crest, while the lateral sacral crest arises from the fused transverse processes. The coccyx is formed by the fusion of four small coccygeal vertebrae.
Weakening of the anulus fibrosus can result in herniation (protrusion) of the nucleus pulposus and compression of a spinal nerve, resulting in pain and/or muscle weakness in the body regions supplied by that nerve.
The anterior longitudinal ligament runs the length of the vertebral column, uniting the anterior sides of the vertebral bodies. The supraspinous ligament connects the spinous processes of the thoracic and lumbar vertebrae. In the posterior neck, the supraspinous ligament enlarges to form the nuchal ligament, which attaches to the cervical spinous processes and to the base of the skull.
Thoracic vertebrae have superior and inferior articular facets on the vertebral body for articulation with the head of a rib, and a transverse process facet for articulation with the rib tubercle.
The thoracic cage is formed by the (a) sternum and (b) 12 pairs of ribs with their costal cartilages. The ribs are anchored posteriorly to the 12 thoracic vertebrae. The sternum consists of the manubrium, body, and xiphoid process. The ribs are classified as true ribs (1–7) and false ribs (8–12). The last two pairs of false ribs are also known as floating ribs (11–12).
The bones of the newborn skull are not fully ossified and are separated by large areas called fontanelles, which are filled with fibrous connective tissue. The fontanelles allow for continued growth of the skull after birth. At the time of birth, the facial bones are small and underdeveloped, and the mastoid process has not yet formed.
The pectoral girdle consists of the clavicle and the scapula, which serve to attach the upper limb to the sternum of the axial skeleton.
The isolated scapula is shown here from its anterior (deep) side and its posterior (superficial) side.
The humerus is the single bone of the upper arm region. It articulates with the radius and ulna bones of the forearm to form the elbow joint.
The ulna is located on the medial side of the forearm, and the radius is on the lateral side. These bones are attached to each other by an interosseous membrane.
The eight carpal bones form the base of the hand. These are arranged into proximal and distal rows of four bones each. The metacarpal bones form the palm of the hand. The thumb and fingers consist of the phalanx bones.
This radiograph shows the position of the bones within the hand. Note the carpal bones that form the base of the hand
The carpal tunnel is the passageway by which nine muscle tendons and a major nerve enter the hand from the anterior forearm. The walls and floor of the carpal tunnel are formed by the U-shaped grouping of the carpal bones, and the roof is formed by the flexor retinaculum, a strong ligament that anteriorly unites the bones.
During tight gripping—compare (b) to (a)—the fourth and, particularly, the fifth metatarsal bones are pulled anteriorly. This increases the contact between the object and the medial side of the hand, thus improving the firmness of the grip.
Falls or direct blows can result in fractures of the surgical neck or shaft of the humerus. Falls onto the elbow can fracture the distal humerus. A Colles fracture of the distal radius is the most common forearm fracture.
The pelvic girdle is formed by a single hip bone. The hip bone attaches the lower limb to the axial skeleton through its articulation with the sacrum. The right and left hip bones, plus the sacrum and the coccyx, together form the pelvis.
The adult hip bone consists of three regions. The ilium forms the large, fan-shaped superior portion, the ischium forms the posteroinferior portion, and the pubis forms the anteromedial portion.
The posterior sacroiliac ligament supports the sacroiliac joint. The sacrospinous ligament spans the sacrum to the ischial spine, and the sacrotuberous ligament spans the sacrum to the ischial tuberosity. The sacrospinous and sacrotuberous ligaments contribute to the formation of the greater and lesser sciatic foramens.
The female pelvis is adapted for childbirth and is broader, with a larger subpubic angle, a rounder pelvic brim, and a wider and more shallow lesser pelvic cavity than the male pelvis.
The femur is the single bone of the thigh region. It articulates superiorly with the hip bone at the hip joint, and inferiorly with the tibia at the knee joint. The patella only articulates with the distal end of the femur.
The Q-angle is a measure of the amount of lateral deviation of the femur from the vertical line of the tibia. Adult females have a larger Q-angle due to their wider pelvis than adult males.
The tibia is the larger, weight-bearing bone located on the medial side of the leg. The fibula is the slender bone of the lateral side of the leg and does not bear weight.
The bones of the foot are divided into three groups. The posterior foot is formed by the seven tarsal bones. The mid-foot has the five metatarsal bones. The toes contain the phalanges.
Limb buds are visible in an embryo at the end of the seventh week of development (embryo derived from an ectopic pregnancy)
Clubfoot This photograph shows a baby with a clubfoot.Clubfoot is a common deformity of the ankle and foot that is present at birth. Most cases are corrected without surgery, and affected individuals will grow up to lead normal, active lives. (credit: James W. Hanson)
The suture joints of the skull are an example of a synarthrosis, an immobile or essentially immobile joint.
A multiaxial joint, such as the hip joint, allows for three types of movement: anterior-posterior, medial-lateral, and rotational.
Fibrous joints form strong connections between bones. (a) Sutures join most bones of the skull. (b) An interosseous membrane forms a syndesmosis between the radius and ulna bones of the forearm. (c) A gomphosis is a specialized fibrous joint that anchors a tooth to its socket in the jaw.
The fontanelles of a newborn’s skull are broad areas of fibrous connective tissue that form fibrous joints between the bones of the skull.
Synovial joints allow for smooth movements between the adjacent bones. The joint is surrounded by an articular capsule that defines a joint cavity filled with synovial fluid. The articulating surfaces of the bones are covered by a thin layer of articular cartilage. Ligaments support the joint by holding the bones together and resisting excess or abnormal joint motions.
Bursae are fluid-filled sacs that serve to prevent friction between skin, muscle, or tendon and an underlying bone. Three major bursae and a fat pad are part of the complex joint that unites the femur and tibia of the leg.
The six types of synovial joints allow the body to move in a variety of ways. (a) Pivot joints allow for rotation around an axis, such as between the first and second cervical vertebrae, which allows for side-to-side rotation of the head. (b) The hinge joint of the elbow works like a door hinge. (c) The articulation between the trapezium carpal bone and the first metacarpal bone at the base of the thumb is a saddle joint. (d) Plane joints, such as those between the tarsal bones of the foot, allow for limited gliding movements between bones. (e) The radiocarpal joint of the wrist is a condyloid joint. (f) The hip and shoulder joints are the only ball-and-socket joints of the body.
Osteoarthritis of a synovial joint results from aging or prolonged joint wear and tear. These cause erosion and loss of the articular cartilage covering the surfaces of the bones, resulting in inflammation that causes joint stiffness and pain.
Synovial joints give the body many ways in which to move. (a)–(b) Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist, metacarpophalangeal, metatarsophalangeal, and interphalangeal joints. (c)–(d) Anterior bending of the head or vertebral column is flexion, while any posterior-going movement is extension. (e) Abduction and adduction are motions of the limbs, hand, fingers, or toes in the coronal (medial–lateral) plane of movement. Moving the limb or hand laterally away from the body, or spreading the fingers or toes, is abduction. Adduction brings the limb or hand toward or across the midline of the body, or brings the fingers or toes together. Circumduction is the movement of the limb, hand, or fingers in a circular pattern, using the sequential combination of flexion, adduction, extension, and abduction motions. Adduction/abduction and circumduction take place at the shoulder, hip, wrist, metacarpophalangeal, and metatarsophalangeal joints. (f) Turning of the head side to side or twisting of the body is rotation. Medial and lateral rotation of the upper limb at the shoulder or lower limb at the hip involves turning the anterior surface of the limb toward the midline of the body (medial or internal rotation) or away from the midline (lateral or external rotation).
(g) Supination of the forearm turns the hand to the palm forward position in which the radius and ulna are parallel, while forearm pronation turns the hand to the palm backward position in which the radius crosses over the ulna to form an "X." (h) Dorsiflexion of the foot at the ankle joint moves the top of the foot toward the leg, while plantar flexion lifts the heel and points the toes. (i) Eversion of the foot moves the bottom (sole) of the foot away from the midline of the body, while foot inversion faces the sole toward the midline. (j) Protraction of the mandible pushes the chin forward, and retraction pulls the chin back. (k) Depression of the mandible opens the mouth, while elevation closes it. (l) Opposition of the thumb brings the tip of the thumb into contact with the tip of the fingers of the same hand and reposition brings the thumb back next to the index finger.
The atlantoaxial joint is a pivot type of joint between the dens portion of the axis (C2 vertebra) and the anterior arch of the atlas (C1 vertebra), with the dens held in place by a ligament.
The temporomandibular joint is the articulation between the temporal bone of the skull and the condyle of the mandible, with an articular disc located between these bones. During depression of the mandible (opening of the mouth), the mandibular condyle moves both forward and hinges downward as it travels from the mandibular fossa onto the articular tubercle.
The glenohumeral (shoulder) joint is a ball-and-socket joint that provides the widest range of motions. It has a loose articular capsule and is supported by ligaments and the rotator cuff muscles.
(a) The elbow is a hinge joint that allows only for flexion and extension of the forearm. (b) It is supported by the ulnar and radial collateral ligaments. (c) The annular ligament supports the head of the radius at the proximal radioulnar joint, the pivot joint that allows for rotation of the radius.
(a) The ball-and-socket joint of the hip is a multiaxial joint that provides both stability and a wide range of motion. (b–c) When standing, the supporting ligaments are tight, pulling the head of the femur into the acetabulum.
(a) The knee joint is the largest joint of the body. (b)–(c) It is supported by the tibial and fibular collateral ligaments located on the sides of the knee outside of the articular capsule, and the anterior and posterior cruciate ligaments found inside the capsule. The medial and lateral menisci provide padding and support between the femoral condyles and tibial condyles.
A strong blow to the lateral side of the extended knee will cause three injuries, in sequence: tearing of the tibial collateral ligament, damage to the medial meniscus, and rupture of the anterior cruciate ligament.
The talocrural (ankle) joint is a uniaxial hinge joint that only allows for dorsiflexion or plantar flexion of the foot. Movements at the subtalar joint, between the talus and calcaneus bones, combined with motions at other intertarsal joints, enables eversion/inversion movements of the foot. Ligaments that unite the medial or lateral malleolus with the talus and calcaneus bones serve to support the talocrural joint and to resist excess eversion or inversion of the foot.
The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle.
Bundles of muscle fibers, called fascicles, are covered by the perimysium. Muscle fibers are covered by the endomysium.
A skeletal muscle fiber is surrounded by a plasma membrane called the sarcolemma, which contains sarcoplasm, the cytoplasm of muscle cells. A muscle fiber is composed of many fibrils, which give the cell its striated appearance.
The sarcomere, the region from one Z-line to the next Z-line, is the functional unit of a skeletal muscle fiber.
At the NMJ, the axon terminal releases ACh. The motor end-plate is the location of the ACh-receptors in the muscle fiber sarcolemma. When ACh molecules are released, they diffuse across a minute space called the synaptic cleft and bind to the receptors.
Narrow T-tubules permit the conduction of electrical impulses. The SR functions to regulate intracellular levels of calcium. Two terminal cisternae (where enlarged SR connects to the T-tubule) and one T-tubule comprise a triad—a “threesome” of membranes, with those of SR on two sides and the T-tubule sandwiched between them.
A cross-bridge forms between actin and the myosin heads triggering contraction. As long as Ca++ ions remain in the sarcoplasm to bind to troponin, and as long as ATP is available, the muscle fiber will continue to shorten.
Ca++ ions are pumped back into the SR, which causes the tropomyosin to reshield the binding sites on the actin strands. A muscle may also stop contracting when it runs out of ATP and becomes fatigued.
The Sliding Filament Model of Muscle Contraction
When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap completely.
(a) The active site on actin is exposed as calcium binds to troponin. (b) The myosin head is attracted to actin, and myosin binds actin at its actin-binding site, forming the cross-bridge. (c) During the power stroke, the phosphate generated in the previous contraction cycle is released. This results in the myosin head pivoting toward the center of the sarcomere, after which the attached ADP and phosphate group are released. (d) A new molecule of ATP attaches to the myosin head, causing the cross-bridge to detach. (e) The myosin head hydrolyzes ATP to ADP and phosphate, which returns the myosin to the cocked position.
(a) Some ATP is stored in a resting muscle. As contraction starts, it is used up in seconds. More ATP is generated from creatine phosphate for about 15 seconds. (b) Each glucose molecule produces two ATP and two molecules of pyruvic acid, which can be used in aerobic respiration or converted to lactic acid. If oxygen is not available, pyruvic acid is converted to lactic acid, which may contribute to muscle fatigue. This occurs during strenuous exercise when high amounts of energy are needed but oxygen cannot be sufficiently delivered to muscle. (c) Aerobic respiration is the breakdown of glucose in the presence of oxygen (O2) to produce carbon dioxide, water, and ATP. Approximately 95 percent of the ATP required for resting or moderately active muscles is provided by aerobic respiration, which takes place in mitochondria.
During isotonic contractions, muscle length changes to move a load. During isometric contractions, muscle length does not change because the load exceeds the tension the muscle can generate.
Muscle mass is reduced as muscles atrophy with disuse.
Intercalated discs are part of the cardiac muscle sarcolemma and they contain gap junctions and desmosomes.
Smooth muscle tissue is found around organs in the digestive, respiratory, reproductive tracts and the iris of the eye.
The dense bodies and intermediate filaments are networked through the sarcoplasm, which cause the muscle fiber to contract.
A series of axon-like swelling, called varicosities or “boutons,” from autonomic neurons form motor units through the smooth muscle.
The biceps brachii flex the lower arm. The brachoradialis, in the forearm, and brachialis, located deep to the biceps in the upper arm, are both synergists that aid in this motion.
The skeletal muscles of the body typically come in seven different general shapes.
On the anterior and posterior views of the muscular system above, superficial muscles (those at the surface) are shown on the right side of the body while deep muscles (those underneath the superficial muscles) are shown on the left half of the body. For the legs, superficial muscles are shown in the anterior view while the posterior view shows both superficial and deep muscles.
Many of the muscles of facial expression insert into the skin surrounding the eyelids, nose and mouth, producing facial expressions by moving the skin rather than bones.
(a) The extrinsic eye muscles originate outside of the eye on the skull. (b) Each muscle inserts onto the eyeball.
The muscles that move the lower jaw are typically located within the cheek and originate from processes in the skull. This provides the jaw muscles with the large amount of leverage needed for chewing.
Tongue muscles can be extrinsic or intrinsic. Extrinsic tongue muscles insert into the tongue from outside origins, and the intrinsic tongue muscles insert into the tongue from origins within it. The extrinsic muscles move the whole tongue in different directions, whereas the intrinsic muscles allow the tongue to change its shape (such as, curling the tongue in a loop or flattening it).
The anterior muscles of the neck facilitate swallowing and speech. The suprahyoid muscles originate from above the hyoid bone in the chin region. The infrahyoid muscles originate below the hyoid bone in the lower neck.
The superficial and deep muscles of the neck are responsible for moving the head, cervical vertebrae, and scapulas.
The large, complex muscles of the neck and back move the head, shoulders, and vertebral column.
(a) The anterior abdominal muscles include the medially located rectus abdominis, which is covered by a sheet of connective tissue called the rectus sheath. On the flanks of the body, medial to the rectus abdominis, the abdominal wall is composed of three layers. The external oblique muscles form the superficial layer, while the internal oblique muscles form the middle layer, and the transverses abdominus forms the deepest layer. (b) The muscles of the lower back move the lumbar spine but also assist in femur movements.
The diaphragm separates the thoracic and abdominal cavities.
The external intercostals are located laterally on the sides of the body. The internal intercostals are located medially near the sternum. The innermost intercostals are located deep to both the internal and external intercostals.
The pelvic floor muscles support the pelvic organs, resist intra-abdominal pressure, and work as sphincters for the urethra, rectum, and vagina.
Muscles That Position the Pectoral Girdle
The muscles that stabilize the pectoral girdle make it a steady base on which other muscles can move the arm. Note that the pectoralis major and deltoid, which move the humerus, are cut here to show the deeper positioning muscles.
(a, c) The muscles that move the humerus anteriorly are generally located on the anterior side of the body and originate from the sternum (e.g., pectoralis major) or the anterior side of the scapula (e.g., subscapularis). (b) The muscles that move the humerus superiorly generally originate from the superior surfaces of the scapula and/or the clavicle (e.g., deltoids). The muscles that move the humerus inferiorly generally originate from middle or lower back (e.g., latissiumus dorsi). (d) The muscles that move the humerus posteriorly are generally located on the posterior side of the body and insert into the scapula (e.g., infraspinatus).
The muscles originating in the upper arm flex, extend, pronate, and supinate the forearm. The muscles originating in the forearm move the wrists, hands, and fingers.
The intrinsic muscles of the hand both originate and insert within the hand. These muscles provide the fine motor control of the fingers by flexing, extending, abducting, and adducting the more distal finger and thumb segments.
The large and powerful muscles of the hip that move the femur generally originate on the pelvic girdle and insert into the femur. The muscles that move the lower leg typically originate on the femur and insert into the bones of the knee joint. The anterior muscles of the femur extend the lower leg but also aid in flexing the thigh. The posterior muscles of the femur flex the lower leg but also aid in extending the thigh. A combination of gluteal and thigh muscles also adduct, abduct, and rotate the thigh and lower leg.
The muscles along the dorsal side of the foot (a) generally extend the toes while the muscles of the plantar side of the foot (b, c, d) generally flex the toes. The plantar muscles exist in three layers, providing the foot the strength to counterbalance the weight of the body. In this diagram, these three layers are shown from a plantar view beginning with the bottom-most layer just under the plantar skin of the foot (b) and ending with the top-most layer (d) located just inferior to the foot and toe bones.
The muscles of the anterior compartment of the lower leg are generally responsible for dorsiflexion, and the muscles of the posterior compartment of the lower leg are generally responsible for plantar flexion. The lateral and medial muscles in both compartments invert, evert, and rotate the foot.
The structures of the PNS are referred to as ganglia and nerves, which can be seen as distinct structures. The equivalent structures in the CNS are not obvious from this overall perspective and are best examined in prepared tissue under the microscope.
(a) The nucleus of an atom contains its protons and neutrons. (b) The nucleus of a cell is the organelle that contains DNA. (c) A nucleus in the CNS is a localized center of function with the cell bodies of several neurons, shown here circled in red
This drawing of the connections of the eye to the brain shows the optic nerve extending from the eye to the chiasm, where the structure continues as the optic tract. The same axons extend from the eye to the brain through these two bundles of fibers, but the chiasm represents the border between peripheral and central.
Somatic, Autonomic, and Enteric Structures of the Nervous System
Somatic structures include the spinal nerves, both motor and sensory fibers, as well as the sensory ganglia (posterior root ganglia and cranial nerve ganglia). Autonomic structures are found in the nerves also, but include the sympathetic and parasympathetic ganglia. The enteric nervous system includes the nervous tissue within the organs of the digestive tract.
The major parts of the neuron are labeled on a multipolar neuron from the CNS.
Unipolar cells have one process that includes both the axon and dendrite. Bipolar cells have two processes, the axon and a dendrite. Multipolar cells have more than two processes, the axon and two or more dendrites.
Three examples of neurons that are classified on the basis of other criteria. (a) The pyramidal cell is a multipolar cell with a cell body that is shaped something like a pyramid. (b) The Purkinje cell in the cerebellum was named after the scientist who originally described it. (c) Olfactory neurons are named for the functional group with which they belong.
The CNS has astrocytes, oligodendrocytes, microglia, and ependymal cells that support the neurons of the CNS in several ways.
The PNS has satellite cells and Schwann cells.
Myelinating glia wrap several layers of cell membrane around the cell membrane of an axon segment. A single Schwann cell insulates a segment of a peripheral nerve, whereas in the CNS, an oligodendrocyte may provide insulation for a few separate axon segments
(1) The sensory neuron has endings in the skin that sense a stimulus such as water temperature. The strength of the signal that starts here is dependent on the strength of the stimulus. (2) The graded potential from the sensory endings, if strong enough, will initiate an action potential at the initial segment of the axon (which is immediately adjacent to the sensory endings in the skin). (3) The axon of the peripheral sensory neuron enters the spinal cord and contacts another neuron in the gray matter. The contact is a synapse where another graded potential is caused by the release of a chemical signal from the axon terminals. (4) An action potential is initiated at the initial segment of this neuron and travels up the sensory pathway to a region of the brain called the thalamus. Another synapse passes the information along to the next neuron. (5) The sensory pathway ends when the signal reaches the cerebral cortex. (6) After integration with neurons in other parts of the cerebral cortex, a motor command is sent from the precentral gyrus of the frontal cortex. (7) The upper motor neuron sends an action potential down to the spinal cord. The target of the upper motor neuron is the dendrites of the lower motor neuron in the gray matter of the spinal cord. (8) The axon of the lower motor neuron emerges from the spinal cord in a nerve and connects to a muscle through a neuromuscular junction to cause contraction of the target muscle.
Receptors in the skin sense the temperature of the water.
On the basis of the sensory input and the integration in the CNS, a motor response is formulated and executed.
Cell Membrane and Transmembrane Proteins
The cell membrane is composed of a phospholipid bilayer and has many transmembrane proteins, including different types of channel proteins that serve as ion channels.
When the ligand, in this case the neurotransmitter acetylcholine, binds to a specific location on the extracellular surface of the channel protein, the pore opens to allow select ions through. The ions, in this case, are cations of sodium, calcium, and potassium.
Voltage-gated channels open when the transmembrane voltage changes around them. Amino acids in the structure of the protein are sensitive to charge and cause the pore to open to the selected ion.
In certain situations, ions need to move across the membrane randomly. The particular electrical properties of certain cells are modified by the presence of this type of channel.
Graded potentials are temporary changes in the membrane voltage, the characteristics of which depend on the size of the stimulus. Some types of stimuli cause depolarization of the membrane, whereas others cause hyperpolarization. It depends on the specific ion channels that are activated in the cell membrane.
The synapse is a connection between a neuron and its target cell (which is not necessarily a neuron). The presynaptic element is the synaptic end bulb of the axon where Ca2+ enters the bulb to cause vesicle fusion and neurotransmitter release. The neurotransmitter diffuses across the synaptic cleft to bind to its receptor. The neurotransmitter is cleared from the synapse either by enzymatic degradation, neuronal reuptake, or glial reuptake.
(a) An ionotropic receptor is a channel that opens when the neurotransmitter binds to it. (b) A metabotropic receptor is a complex that causes metabolic changes in the cell when the neurotransmitter binds to it (1). After binding, the G protein hydrolyzes GTP and moves to the effector protein (2). When the G protein contacts the effector protein, a second messenger is generated, such as cAMP (3). The second messenger can then go on to cause changes in the neuron, such as opening or closing ion channels, metabolic changes, and changes in gene transcription.
Early Embryonic Development of Nervous System
The neuroectoderm begins to fold inward to form the neural groove. As the two sides of the neural groove converge, they form the neural tube, which lies beneath the ectoderm. The anterior end of the neural tube will develop into the brain, and the posterior portion will become the spinal cord. The neural crest develops into peripheral structures.
Primary and Secondary Vesicle Stages of Development
The embryonic brain develops complexity through enlargements of the neural tube called vesicles; (a) The primary vesicle stage has three regions, and (b) the secondary vesicle stage has five regions.
(a) Spina bifida is a birth defect of the spinal cord caused when the neural tube does not completely close, but the rest of development continues. The result is the emergence of meninges and neural tissue through the vertebral column. (b) Fetal myelomeningocele is evident in this ultrasound taken at 21 weeks.
The cerebrum is a large component of the CNS in humans, and the most obvious aspect of it is the folded surface called the cerebral cortex.
The cerebral cortex is divided into four lobes. Extensive folding increases the surface area available for cerebral functions.
Brodmann mapping of functionally distinct regions of the cortex was based on its cytoarchitecture at a microscopic level.
Frontal Section of Cerebral Cortex and Basal Nuclei
The major components of the basal nuclei, shown in a frontal section of the brain, are the caudate (just lateral to the lateral ventricle), the putamen (inferior to the caudate and separated by the large white-matter structure called the internal capsule), and the globus pallidus (medial to the putamen).
The diencephalon is composed primarily of the thalamus and hypothalamus, which together define the walls of the third ventricle. The thalami are two elongated, ovoid structures on either side of the midline that make contact in the middle. The hypothalamus is inferior and anterior to the thalamus, culminating in a sharp angle to which the pituitary gland is attached.
The brain stem comprises three regions: the midbrain, the pons, and the medulla.
The cerebellum is situated on the posterior surface of the brain stem. Descending input from the cerebellum enters through the large white matter structure of the pons. Ascending input from the periphery and spinal cord enters through the fibers of the inferior olive. Output goes to the midbrain, which sends a descending signal to the spinal cord.
The cross-section of a thoracic spinal cord segment shows the posterior, anterior, and lateral horns of gray matter, as well as the posterior, anterior, and lateral columns of white matter
The blood supply to the brain enters through the internal carotid arteries and the vertebral arteries, eventually giving rise to the circle of Willis.
Blood drains from the brain through a series of sinuses that connect to the jugular veins.
The choroid plexus in the four ventricles produce CSF, which is circulated through the ventricular system and then enters the subarachnoid space through the median and lateral apertures. The CSF is then reabsorbed into the blood at the arachnoid granulations, where the arachnoid membrane emerges into the dural sinuses.
The cell bodies of sensory neurons, which are unipolar neurons by shape, are seen in this photomicrograph. Also, the fibrous region is composed of the axons of these neurons that are passing through the ganglion to be part of the dorsal nerve root (tissue source: canine)
The slide includes both a cross-section of the lumbar spinal cord and a section of the dorsal root ganglion (see also [link]) (tissue source: canine).
The structure of a nerve is organized by the layers of connective tissue on the outside, around each fascicle, and surrounding the individual nerve fibers (tissue source: simian).
Zoom in on this slide of a nerve trunk to examine the endoneurium, perineurium, and epineurium in greater detail (tissue source: simian).
The anatomical arrangement of the roots of the cranial nerves observed from an inferior view of the brain.
There are four main nerve plexuses in the human body. The cervical plexus supplies nerves to the posterior head and neck, as well as to the diaphragm. The brachial plexus supplies nerves to the arm. The lumbar plexus supplies nerves to the anterior leg. The sacral plexus supplies nerves to the posterior leg.
Receptor cell types can be classified on the basis of their structure. Sensory neurons can have either (a) free nerve endings or (b) encapsulated endings. Photoreceptors in the eyes, such as rod cells, are examples of (c) specialized receptor cells. These cells release neurotransmitters onto a bipolar cell, which then synapses with the optic nerve neurons.
The tongue is covered with small bumps, called papillae, which contain taste buds that are sensitive to chemicals in ingested food or drink. Different types of papillae are found in different regions of the tongue. The taste buds contain specialized gustatory receptor cells that respond to chemical stimuli dissolved in the saliva. These receptor cells activate sensory neurons that are part of the facial and glossopharyngeal nerves.
(a) The olfactory system begins in the peripheral structures of the nasal cavity. (b) The olfactory receptor neurons are within the olfactory epithelium. (c) Axons of the olfactory receptor neurons project through the cribriform plate of the ethmoid bone and synapse with the neurons of the olfactory bulb (tissue source: simian).
The external ear contains the auricle, ear canal, and tympanic membrane. The middle ear contains the ossicles and is connected to the pharynx by the Eustachian tube. The inner ear contains the cochlea and vestibule, which are responsible for audition and equilibrium, respectively.
A sound wave causes the tympanic membrane to vibrate. This vibration is amplified as it moves across the malleus, incus, and stapes. The amplified vibration is picked up by the oval window causing pressure waves in the fluid of the scala vestibuli and scala tympani. The complexity of the pressure waves is determined by the changes in amplitude and frequency of the sound waves entering the ear.
The three major spaces within the cochlea are highlighted. The scala tympani and scala vestibuli lie on either side of the cochlear duct. The organ of Corti, containing the mechanoreceptor hair cells, is adjacent to the scala tympani, where it sits atop the basilar membrane.
The hair cell is a mechanoreceptor with an array of stereocilia emerging from its apical surface. The stereocilia are tethered together by proteins that open ion channels when the array is bent toward the tallest member of their array, and closed when the array is bent toward the shortest member of their array.
a given region of the basilar membrane will only move if the incoming sound is at a specific frequency. Because the tectorial membrane only moves where the basilar membrane moves, the hair cells in this region will also only respond to sounds of this specific frequency. Therefore, as the frequency of a sound changes, different hair cells are activated all along the basilar membrane. The cochlea encodes auditory stimuli for frequencies between 20 and 20,000 Hz, which is the range of sound that human ears can detect. The unit of Hertz measures the frequency of sound waves in terms of cycles produced per second. Frequencies as low as 20 Hz are detected by hair cells at the apex, or tip, of the cochlea. Frequencies in the higher ranges of 20 KHz are encoded by hair cells at the base of the cochlea, close to the round and oval windows ([link]). Most auditory stimuli contain a mixture of sounds at a variety of frequencies and intensities (represented by the amplitude of the sound wave). The hair cells along the length of the cochlear duct, which are each sensitive to a particular frequency, allow the cochlea to separate auditory stimuli by frequency, just as a prism separates visible light into its component colors.
The standing sound wave generated in the cochlea by the movement of the oval window deflects the basilar membrane on the basis of the frequency of sound. Therefore, hair cells at the base of the cochlea are activated only by high frequencies, whereas those at the apex of the cochlea are activated only by low frequencies.
The maculae are specialized for sensing linear acceleration, such as when gravity acts on the tilting head, or if the head starts moving in a straight line. The difference in inertia between the hair cell stereocilia and the otolithic membrane in which they are embedded leads to a shearing force that causes the stereocilia to bend in the direction of that linear acceleration.
Rotational Coding by Semicircular Canals
Rotational movement of the head is encoded by the hair cells in the base of the semicircular canals. As one of the canals moves in an arc with the head, the internal fluid moves in the opposite direction, causing the cupula and stereocilia to bend. The movement of two canals within a plane results in information about the direction in which the head is moving, and activation of all six canals can give a very precise indication of head movement in three dimensions.
The eye is located within the orbit and surrounded by soft tissues that protect and support its function. The orbit is surrounded by cranial bones of the skull.
The extraocular muscles move the eye within the orbit.
The sphere of the eye can be divided into anterior and posterior chambers. The wall of the eye is composed of three layers: the fibrous tunic, vascular tunic, and neural tunic. Within the neural tunic is the retina, with three layers of cells and two synaptic layers in between. The center of the retina has a small indentation known as the fovea.
(a) All photoreceptors have inner segments containing the nucleus and other important organelles and outer segments with membrane arrays containing the photosensitive opsin molecules. Rod outer segments are long columnar shapes with stacks of membrane-bound discs that contain the rhodopsin pigment. Cone outer segments are short, tapered shapes with folds of membrane in place of the discs in the rods. (b) Tissue of the retina shows a dense layer of nuclei of the rods and cones.
The retinal molecule has two isomers, (a) one before a photon interacts with it and (b) one that is altered through photoisomerization.
Comparison of Color Sensitivity of Photopigments
Comparing the peak sensitivity and absorbance spectra of the four photopigments suggests that they are most sensitive to particular wavelengths.
Ascending Sensory Pathways of the Spinal Cord
The dorsal column system and spinothalamic tract are the major ascending pathways that connect the periphery with the brain.
Auditory Brain Stem Mechanisms of Sound Localization
Localizing sound in the horizontal plane is achieved by processing in the medullary nuclei of the auditory system. Connections between neurons on either side are able to compare very slight differences in sound stimuli that arrive at either ear and represent interaural time and intensity differences.
Connections between the vestibular system and the cranial nerves controlling eye movement keep the eyes centered on a visual stimulus, even though the head is moving. During head movement, the eye muscles move the eyes in the opposite direction as the head movement, keeping the visual stimulus centered in the field of view.
Segregation of Visual Field Information at the Optic Chiasm
Contralateral visual field information from the lateral retina projects to the ipsilateral brain, whereas ipsilateral visual field information has to decussate at the optic chiasm to reach the opposite side of the brain.
A cartoon representation of the sensory homunculus arranged adjacent to the cortical region in which the processing takes place.
Topographic Mapping of the Retina onto the Visual Cortex
The visual field projects onto the retina through the lenses and falls on the retinae as an inverted, reversed image. The topography of this image is maintained as the visual information travels through the visual pathway to the cortex.
Because of the interocular distance, which results in objects of different distances falling on different spots of the two retinae, the brain can extract depth perception from the two-dimensional information of the visual field.
From the primary visual cortex in the occipital lobe, visual processing continues in two streams—one into the temporal lobe and one into the parietal lobe.
The major descending tract that controls skeletal muscle movements is the corticospinal tract. It is composed of two neurons, the upper motor neuron and the lower motor neuron. The upper motor neuron has its cell body in the primary motor cortex of the frontal lobe and synapses on the lower motor neuron, which is in the ventral horn of the spinal cord and projects to the skeletal muscle in the periphery.
Connections of Parasympathetic Division of the Autonomic Nervous System
Neurons from brain-stem nuclei, or from the lateral horn of the sacral spinal cord, project to terminal ganglia near or within the various organs of the body. Axons from these ganglionic neurons then project the short distance to those target effectors.
The connection between autonomic fibers and target effectors is not the same as the typical synapse, such as the neuromuscular junction. Instead of a synaptic end bulb, a neurotransmitter is released from swellings along the length of a fiber that makes an extended network of connections in the target effector.
Comparison of Somatic and Visceral Reflexes
The afferent inputs to somatic and visceral reflexes are essentially the same, whereas the efferent branches are different. Somatic reflexes, for instance, involve a direct connection from the ventral horn of the spinal cord to the skeletal muscle. Visceral reflexes involve a projection from the central neuron to a ganglion, followed by a second projection from the ganglion to the target effector.
Stigmatization, discrimination and illness
“She was given her own plate, her own cup, everything of her own, even when she just touched a cloth then nobody wanted to touch it again.” (Halima, HIV-seropositive) The book sheds light on the profound influence of an HIV-seropositive diagnosis on the lives of women and their social environment in the United Republic of Tanzania. The author, a medical doctor and social anthropologist, tells the story of six Tanzanian HIV-seropositive women, focusing on their negotiation and perception of illness and disease. Furthermore, the high levels of discrimination and stigmatization in the context of HIV-seropositivity that they experience are presented in detail, weaving together the impacts of an HIV-seropositive diagnosis with results analyzed both from a Medical Anthropology and Public Health perspective. Despite a new era of antiretroviral treatment, available in Tanzania free of cost, that has given cause for hope in a change in how the disease is perceived, the book impressively underlines that being HIV-seropositive remains a great challenge and heavy burden for women in Tanzania.
Several bones that help form the walls of the nasal cavity have air-containing spaces called the paranasal sinuses, which serve to warm and humidify incoming air. Sinuses are lined with a mucosa. Each paranasal sinus is named for its associated bone: frontal sinus, maxillary sinus, sphenoidal sinus, and ethmoidal sinus. The sinuses produce mucus and lighten the weight of the skull.
Kansas State University Human Nutrition Flexbook
The CK-12 foundation defines a flexbook as a “free and open source textbook platform where one can build and edit collaborative textbooks1 .” The FNDH 400 (formerly HN 400, department changed its name from Human Nutrition to Food, Nutrition, Dietetics and Health) Flexbook fits this definition, but I felt the name was particularly accurate due to the flexibility of Google Docs that it was built on. The flexbook is divided into 13 chapters with sections and subsections. These are numbered in such a way that the first number represents the chapter. A period separates the chapter from the section number, and another period is followed by the subsection number. The figures are non-copyrighted figures or I have made them myself in PowerPoint. The flexbook also contains links to articles, videos, and animations in Web Link boxes. These can be clicked to open the link, and urls for these resources are also provided at the end of the section or subsection.
The field of Urogynaecology has expanded dramatically over the past decade with the advent of a number of new medical and surgical treatment modalities. The evidence base on pelvic floor dysfunction has also grown extensively. This multi-contributor text will prove invaluable to gynecology, urology and surgery registrars and specialists. Physiotherapists and nurses working in the field of Urogynaecology will also find it extremely useful.
Home health services are those which are provided within the comforts of the home setting to help people avoid hospitalization or skilled nursing facility placement while they recover from illness, injury, or disability. Home health care may also be provided to people who suffer from chronic illnesses, those who have cognitive or physical disabilities or those who have been diagnosed with a terminal illness. Home Health Aide and Personal Care Aide are two of the fastest growing occupations. This text will provide you with the background necessary to begin working toward a career in the home care field.
Middle Mediastinum and Heart - Anatomy and Dissection Guide
The anatomy shown in this video is based off of the UBC MEDD 411 gross anatomy checklist.
Hypothalamus and Limbic System - UBC Neuroanatomy - Season 1 - Ep 4
Dr. Claudia Krebs, Tamara Bodnar, Parker Holman, Dr. Joanne Weinberg
UBC Medicine - Educational Media published via YouTube.com
In this video, I demonstrate the surgeon's knot and the square knot and give some general beginner tips on how to suture.
Lifelong Nursing published via YouTube.com
This video shows the first stage of the production of a cast gold crown for a damaged tooth. The crown is made on the model (See Videos 2 and 3) using wax, which will be replaced by molten gold in the lost wax casting process. The technique of making the wax template and adjusting it to fit the model accurately is shown. Courtesy of Dr Christopher Stokes and Dr Duncan Wood
Dr Christopher Stokes and Dr Duncan Wood
School of Clinical Dentistry, The University of Sheffield.
Creative Commons
This video shows the second stage of the production of a cast gold crown for a damaged tooth. The wax template of the tooth is sprued using wax wire, then invested in a refractory investment material. The video shows the mould being heated to both expand it and prevent against thermal shock. A centrifugal casting process is shown, using an electrical furnace for melting the gold.
This video shows the final stage of the production of a cast gold crown for a damaged tooth. The gold casting is cooled and removed from the mould. Sand blasting, an acid bath and then a series of abrasive burs are used to trim and finish the casting before a final polish is applied.
MCQs in Oral and Maxillofacial Surgery - Local and General Anesthetics
Oral and Maxillofacial Surgery MCQs - Local and General Anesthetics Practice these MCQs for MDS entrance preparation in AIIMS, COMEDK, AIPG, PGI, BHU, etc. Also useful for ADA, NBDE, NDEB and other dental board exams. Please Share and Subscribe to Support us.
Dentosphere : World of Dentistry published via YouTube.com
Creative Commons License .
This is the first lecture in the Bioinformatics for Cancer Genomics 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Trevor Pugh from the Princess Margaret Cancer Centre. For tutorials and lecture slides for this workshop, please visit bioinformaticsdotca.github.io.
http://incompetech.com/music/royalty-...
Breast Cancer Eliminated Using Keshe Technologies - Demo by Dr.Rodrigo Vildosola
Dr. Rodrigo Vildosola explains his method for treating breast cancer using Keshe Plasma Technologies. He gives an example of how he used this with one of his patients with stunning results. Warning: The video contains graphic images of a medical nature.
This is a tutorial/lecture on Drug Formulations. We cover some topics important for classes such as Biochemistry and Pharmacology.
TheSalmonellaPlace published via YouTube.com
Coming Off Psychiatric Drugs: A Harm Reduction Approach to Medication Withdrawal | Will Hall
Psychiatric medications can sometimes be very useful, but there is often little information or guidance when the risks and harm start to outweigh the benefits. Will Hall provides an introductory overview of how to come off psychiatric medication. Will Hall is a survivor of a schizophrenia diagnosis who today works as a therapist and teaches internationally on mental diversity, including psychiatric medication. This video provides some basic guidance for anyone considering reducing or coming off psychiatric medications and their supporters, and is discussed in greater detail in the Harm Reduction Guideto Coming Off Psychiatric Drugs.
Will Hall published via YouTube.com
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of esophageal cancer, including etiology, epidemiology, screening, pathology, staging, and treatment.
University of Massachusetts Medical School
As we get started on our journey into the world of health and nutrition, our first focus will be to demonstrate that nutritional science is an evolving field of study, continually being updated and supported by research, studies, and trials.
Pharmacokinetics/ADME Of Drugs | Pharmacology Online Lecture-1 | For Upcoming D.Pharm & B.Pharm Exam
In this video , we have discussed about PHARMACOKINETICS OF DRUGS - ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION (ADME) IN BRIEF. Watch the video till the end to get complete information regarding pharmacokinetics of drugs. Topic discussed in the video :- Pharmacokinetics - the branch of pharmacology concerned with the movement of drugs within the body, the time course of its absorption, bioavailability, distribution, metabolism, and excretion or sometimes described as what the body does to a drug. It include four steps:- Absorption, Distribution, Metabolism, Excretion.
LEARNINGPHARMACY.IN published via YouTube.com
Food as Medicine: Preventing and Treating the Most Common Diseases with Diet
This is Dr. Greger's 2015 live presentation. Dr. Greger has scoured the world's scholarly literature on clinical nutrition and developed this new presentation based on the latest in cutting-edge research exploring the role diet may play in preventing, arresting, and even reversing some of our leading causes of death and disability. Subscribe to Dr. Greger’s free nutrition newsletter and get the Evidence-Based Eating Guide: A Healthy Living Resource from Dr. Greger and NutritionFacts.org.
Nutrition Facts.org published via YouTube.com
This is the first lecture in the Bioinformatics of Genomic Medicine 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Michael Brudno from the Hospital for Sick Children. For tutorials and lecture slides for this workshop, please visit bioinformaticsdotca.github.io.
Bioinformatics Dot Ca published via YouTube.com
1. A variety of different malignancies fall into the category of “Head and. Neck Cancers”. This chapter focuses on upper aerodigestive tract cancer. 2. Tobacco and alcohol use and human papillomavirus infection are common causes of head and neck cancers. 3. Most head and neck cancers are squamous cell carcinomas. 4. Treatment of head and neck cancers commonly requires some combination of surgery, radiation, and chemotherapy. Close cooperation between otolaryngologists, radiation oncologists, and medical oncologists is mandatory for successful treatment of these cancers. 5. Preservation of organ function in addition to cure of cancer, is an important goal of treatment. 6. Any patient with persistent symptoms of sore throat, hoarseness, difficulty swallowing or an enlarged cervical lymph node should be evaluated for possible head and neck cancer.
James Liebmann, MD, Ali Akalin MD, PhD., Liana Puscas, MD, MHS., Andrew Chen MD., Richard S. Pieters, MD
Metastatic Extramammary Paget's Disease: Pathogenesis and Novel Therapeutic Approach
Metastatic Extramammary Paget's Disease, Pathogenesis and Novel Therapeutic Approach
Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.
Clinical Procedures for Safer Patient Care
British Columbia Institute of Technology (BCIT)
Essentials of Nutrition: A Functional Approach! This book is written for students who are not majoring in nutrition, but want to learn about the fundamental aspects of nutrition and how it applies to their own lives. We have written this book with the assumption that you have little or no prior knowledge of college level chemistry, biology, or physiology. But that does not mean it’s not scientific! Nutrition is a science-based discipline, so all the material included is backed up by rigorous scientific research, but it is presented in a clear, easy-to-understand fashion without requiring a background in science.
Brehe’s Grammar Anatomy makes grammar accessible to general and specialist readers alike. This book provides an in-depth look at beginner grammar terms and concepts, providing clear examples with limited technical jargon. Whether for academic or personal use, Brehe’s Grammar Anatomy is the perfect addition to any resource library.
Intimate Communities . Wartime Healthcare and the Birth of Modern China, 1937–1945
When China’s War of Resistance against Japan began in July 1937, it sparked an immediate health crisis throughout China. In the end, China not only survived the war but emerged from the trauma with a more cohesive population. Intimate Communities argues that women who worked as military and civilian nurses, doctors, and midwives during this turbulent period built the national community, one relationship at a time. In a country with a majority illiterate, agricultural population that could not relate to urban elites’ conceptualization of nationalism, these women used their work of healing to create emotional bonds with soldiers and civilians from across the country. These bonds transcended the divides of social class, region, gender, and language. “Nicole Elizabeth Barnes demonstrates remarkable insights into some of the most well-known figures in healthcare in wartime China—and introduces many previously unknown—providing pointed character analyses while also connecting individual experiences to larger sociopolitical trends across the tumultuous wartime landscape.” SONYA GRYPMA, PhD, RN, author of China Interrupted: Japanese Internment and the Reshaping of a Canadian Missionary Community “Not only a major contribution to the histories of medicine, gender, emotion, and nationalism, but even more importantly, it opens up exciting horizons by making visible and exploring the surprising entanglements between them all.” SEAN HSIANG-LIN LEI, author of Neither Donkey nor Horse: Medicine in the Struggle over China’s Modernity
Undergraduate Diagnostic Imaging Fundamentals
Diagnostic Imaging principles and concepts are augmented by the presentation of images for common clinical conditions. Guiding principles related to minimizing radiation exposure and requesting the most appropriate imaging examination are addressed.Static images are enhanced by the ability to access images stored and displayed on an Html-5 compatible, Dicom image viewer that simulates a simple Picture Archive and Communication system (PACS). Users can also access other imaging from the Dicom viewer (ODIN), beyond the basic curriculum provided, to further advance their experience with viewing diagnostic imaging pathologies.
The Precision Medicine Initiative, which was instituted by President Barack Obama on January 20, 2015, highlighted the importance that advances in genomics and related “-omic” approaches have made to science and medicine, and it set the stage for their federally funded and mandated integration into the delivery of health care. Whether these advances comprise large-scale approaches, such as The Cancer Genome Atlas, which provides a modern classification of cancers based on molecular profiles, or genealogy initiatives, which seek to trace the movement of our early ancestors out of Africa, genomic technology has taken us closer to developing targeted therapies and a refined understanding of our evolutionary journey.
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
t Quantitative four-dimensional (4D) image reconstruction methods with respiratory and cardiac motion compensation are an active area of research in ECT imaging, including SPECT and PET. They are the extensions of three-dimensional (3D) statistical image reconstruction methods with iterative algorithms that incorporate accurate models of the imaging process and provide significant improvement in the quality and quantitative accuracy of the reconstructed images as compared to that obtained from conventional analytical image reconstruction methods. The new 4D image reconstruction methods incorporate additional models of the respiratory and cardiac motion of the patient to reduce image blurring due to respiratory motion and image noise of the cardiac-gated frames of the 4D cardiac-gated images.
The core of the present study is an investigation on eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in reference works such as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice1 , as well as a growing awareness of health issues (Pirohakul-Wallis 2014: 3-4), favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole.
Innovative Medicine : Basic Research and Development
Reactive oxygen species (ROS) are an intricate part of normal cellular physiology. In excess, however, ROS can damage all three major classes of acromolecules and compromise cell via bility. We briefl y discuss the physiology of ROS but focus on the mechanisms cells use to preserve redox homeostasis upon oxidative stress, with particular emphasis on glycolysis. ROS inhibits multiple glycolytic enzymes, including glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase M2, and phosphofructokinase-1. Consistently, glycolytic inhibition promotes fl ux into the oxidative arm of the pentose phosphate pathway to generate NADPH. NADPH is critically important, as it provides the reducing power that fuels the protein-based antioxidant systems and recycles oxidized glutathione. The unique ability of pyruvate kinase M2 inhibition to promote serine synthesis in the context of oxidative stress is also discussed.
Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto
Our species has always used plants as medicines, during our 200,000 year existence. This is made obvious by the plant medicines found in mummy burials, around the world, dating back thousands of years. Human beings evolved using plant medicines to stay alive. This has resulted in a genetic selection in which those who were healed by plant medicines and survived were able to pass on their genes. Modern humans must continue to use plant medicines. When a Traditional Healer is asked how her people learned how to use a specific plant medicine, the answer is usually that God taught them. Each of us has a spiritual sense that can be used to seek answers [1]. Finding a new plant medicine involves fasting, praying, and spending as much as four days with the plant that will become a new medicine [2]. Traditional Healers are still the major or only source of healthcare for many regions of the world. The loss of Traditional Healers in some areas has resulted in major changes in healthcare, sometimes to the detriment of the people [3,4]. Since Traditional Healers may be religious leaders also, they provide moral direction for the community. The displacement of traditional religious beliefs has been detrimental in some regions
Drug-Diagnostics Co-Development in Oncology
The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen-receptor modulator tamoxifen was developed in the 1970s for the treatment of breast cancer, data on estrogen-receptor status were correlated with the treatment outcome. Based on a phase II study performed in patients with advanced breast cancer, published in 1976, the investigators concluded:“a high degree of correlation between response and positive estrogen-receptor assay suggests the value of the diagnostic test as a means to select patients for tamoxifen treatment” (1). Despite the fact that this conclusion was drawn nearly 40 years ago, the adaptation of the drug-diagnostic co-development model has been relatively slowand it is only within the last decade that it has gained widespread acceptance.
Machine Learning with Radiation Oncology Big Data
Half of all cancer patients may receive radiotherapy as part of their treatment. With the wealth of diverse data generated every day in the clinic, the radiation oncology community possesses a unique advantage in harnessing these massive data with the predictive power of machine learning methods for the beneﬁt of millions of cancer patients undergoing radiotherapy worldwide. In this Research Topic “Machine Learning with Radiation Oncology Big Data,” a wide range of clinical applications involving various machine learning algorithms have been described and demonstrated, with the hope of ushering in more widespread applications of artiﬁcial intelligence in medicine, particularly in cancer radiotherapy in order to achieve a truly individualized radiation oncology and an evidence-based learning healthcare system.
The Impact of Systems Medicine on Human Health and Disease
Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties.
Homeostasis and Allostasis of Thyroid Function
Alterations of thyroid function, especially hypothyroidism, are exceptionally common conditions. Studies from several developed countries revealed the prevalence of subclinical and overt hypothyroidism to be between 5 and 15 % and between 1 and 10%, respectively. Diagnosis and treatment of (overt or subclinical) hypothyroidism are considered to be easy tasks, since thyrotropin (TSH) concentration mirrors the supply with thyroid hormones and is therefore accepted as a biomarker for both diagnosis and dose calibration for substitution therapy.
Johannes W. Dietrich, John E. M. Midgley, Rudolf Hoermann
Mind-Body Medicine in Children and Adolescents
The field of mind-body medicine holds significant promise for children and adolescents. Growing recognition of the intricate connections between thought, emotion, and physiology highlights the need for new therapies that leverage inner resources and offer non-invasive treatment options. Modern imaging techniques such as functional magnetic resonance imaging (fMRI) have advanced our understanding and appreciation of how the mind-body therapies can benefit health, increasing confidence in their use and propelling them into the mainstream of medicine. Mind-body therapies have special value in addressing pain, fear, and stress that accompanies many pediatric medical encounters. Some of the mind-body therapies such as mindfulness, have their roots in ancient traditions and are now being used routinely in the practice of pediatric integrative medicine, an emerging field focused on preventive health that blends conventional and evidence-based complementary therapies
MDPI - Multidisciplinary Digital Publishing Institute
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease
The Research Defence Society (RDS) was founded in 1908 by Dr Stephen Paget, son of the eminent Victorian surgeon, Sir James Paget. Its role was to defend scientists conducting medical research using animals and to inform the public about the importance of animal experimentation. In its first year it attracted a membership of 2000 which included scientists in the pharmaceutical industry, in academia and in research institutes. Past presidents of the Society include such distinguished figures as Lord Perry of Walton and Sir William Paton.
Secondary Analysis of Electronic Health Records
While wonderful new medical discoveries and innovations are in the news every day, healthcare providers continue to struggle with using information. Uncertainties and unanswered clinical questions are a daily reality for the decision makers who provide care. Perhaps the biggest limitation in making the best possible decisions for patients is that the information available is usually not focused on the specific individual or situation at hand. For example, there are general clinical guidelines that outline the ideal target blood pressure for a patient with a severe infection. However, the truly best blood pressure levels likely differ from patient to patient, and perhaps even change for an individual patient over the course of treatment. The ongoing computerization of health records presents an opportunity to overcome this limitation.
Innovative Radiopharmaceuticals in Oncology and Neurology
Personalized medicine is presented as the future of patient care. Nuclear Medicine will play a major role in the selection of patients for targeted therapies and in early therapy assessment with the investigation of phenotypes and functions using sensitive and specific SPECT and PET imaging techniques and theranostic approaches. Nuclear Medicine is already a key in the development of new therapies and targeted radionuclide therapy provides efficacious treatment modalities against cancer. An incredible amount of innovation is related to the use of a variety of radionuclides, new or improved multimodality imaging devices, and numbers of recently marketed radiopharmaceuticals in all medical domains and particularly cardiology, neurology, and oncology.
Rabies Symptoms, Diagnosis, Prophylaxis and Treatment
Rabies is an acute, progressive, incurable viral encephalitis found throughout the world. Despite being one of the oldest recognized pathogens, its impact remains substantial in public health, veterinary medicine, and conservation biology. Thus, it is Essential to apply existing tools and to seek new methods to improve upon prevention, control, selective variant elimination, and treatment efforts. Advances in diagnosis, vaccinology, pathobiology, and related research techniques continue to afford enhanced insights on rabies. Although rabies is not a candidate for eradication, the results of these innovative communications provide further knowledge to deﬁne a more optimal approach to understanding and managing this complex infectious disease of nature on a global basis in a One Health context.
Charles Rupprecht (Ed.), Bernhard Dietzschold (Ed.)
Appropriate mathematical tools and methodologies are critical for ensuring robust and reliable computational model predictions based on medical and healthcare data in the era of the digital health revolution (Duggal et al., 2018). Patient-speciﬁc approaches are being increasingly pursued, with simulations benchmarked by clinical data (e.g., brain activity recordings; Breakspear, 2017) obtained in non-invasive manner on individual level (e.g., resting state; Spetsieris et al., 2015). Precision Medicine, although not a new concept, is gaining momentum (Hodson, 2016) powered by the ever increasing volume of patients data (Colijn et al.). Quantifying patient similarity is an important challenge that is critical in predicting patients’ disease trajectories (Sharafoddini et al., 2017). In an opinion article (Brown) patient similarity concept has been introduced as a paradigm shift in optimizing personalisation of patient care.
Krasimira Tsaneva-Atanasova, Vanessa Diaz-Zuccarini
Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation
In recent years, there has been vast improvement in the survival of solid organ grafts. Improved immunosuppression has resulted in efficient control of cell-mediated immune responses and has also mitigated the effects of HLA mismatching between the recipient and the grafted organ. ntibodymediated rejection (AMR) however still remains a clinical challenge and the identification of donorspecific HLA antibodies pretransplant are a mandatory requirement for successful grafting. Accurate and sensitive HLA antibody identification has been made possible by the introduction of solid phase assays such as the Luminex bead based platform for antibody testing. Despite this advancement in detecting and understanding the role of HLA antibodies in rejection, many questions still require answers in order to maximize the outcome in solid organ transplantation. Many of these aspects are dealt with efficiently in this excellent series of papers addressing the role of antibodies in solid organ rejection. This collection of reviews, some including new findings, by world leaders in their particular
Narinder K. Mehra --- Ajay Kumar Baranwal --- Brian D. Tait
Natural Antibodies in Health and Disease
Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition,
Ana Maria Hernandez , Nichol E. Holodick
Ontogeny and Phylogeny of Brain Barrier Mechanisms
Norman R. Saunders , Helen B. Stolp, Shane A. Liddelow
Sensory Hair Cell Death and Regeneration
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as agin g, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of hese hair cells lead to deficits in hearing and balance, and in ammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells.
Michael E. Smith , Andrew K. Groves, Allison B. Coffin
Breaking the cycle: Attacking the malaria parasite in the liver
Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular eﬀector mechanisms capable of eliminating Plasmodium from the liver. However, malaria liver stage immunity is complex. The anatomic site of priming of naive Plasmodium-speciﬁc CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may in fact determine the speciﬁcity of the eﬀector CD8 T cells. The participation of particular antigenpresenting cells (Corradin and Levitskaya, 2014) and tissue signatures that inﬂuence the activation of intrahepatic CD8 T cells against malaria sporozoites (Morrot and Rodrigues, 2014) are still incompletely understood. Similarly, how eﬀector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.
Ute Frevert, Urszula Krzych , Thomas L. Richie
Lyme Disease: Recent Advances and Perspectives
he interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging.
Tanja Petnicki Ocwieja, - Catherine A Brissette
NK Cell Subsets in Health and Disease: New Developments
Under physiological conditions, the distribution /intensity of the surface markers CD56 and CD16 (FcγRIII) defines two subsets of NK lymphocytes: the CD56bright/CD16neg-dim (generally referred to as CD56bright) population that make up about 10% of blood NK cells in adults and the CD56dim/CD16bright (generally referred to as CD56dim) cells that comprise for about 90% of circulating NK cells. CD56bright NK cells exert only marginal cytotoxic capacity but are higly proficient in production of cytokines such as interferon IFN-γ, TNF-α and GM-CSF. Because of this property, CD56bright NK cells have been generally referred to as regulatory NK cells.
Emanuela Marcenaro, - Luigi D. Notarangelo ,- Jordan S. Orange --- Eric Vivier
Applications of STEM (Science, Technology, Engineering and Mathematics) tools in microbiology of infectious diseases
Science, technology, engineering, and mathematical (STEM) tools and approaches are expected to become a critical component for the prevention, control, and eradication of animal diseases at a global scale in the near future. In the last decades the amount of information that is being generated in all scientific disciplines, including microbiological studies applied to infectious diseases, has increased exponentially, becoming a problem in itself due to the lack of tools and expertise to analyze data. The formulation and parameterization of such a body of empirical knowledge combined with theoretical knowledge into mathematical models
Drug-induced hypersensitivity reactions play a prominent role among adverse drug effects, and constitute a major health problem. It has been suggested that up to 6% of all hospital admissions are related to these reactions. Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions.
The first human tumor virus was discovered in the middle of the last century by Anthony Epstein, Bert Achong and Yvonne Barr in African pediatric patients with Burkitt’s lymphoma. To date, seven viruses -EBV, KSHV, high-risk HPV, MCPV, HBV, HCV and HTLV1- have been consistently linked to different types of human cancer, and infections are estimated to account for up to 20% of all cancer cases worldwide. Viral oncogenic mechanisms generally include: generation of genomic instability, increase in the rate of cell proliferation, resistance to apoptosis, alterations in DNA repair mechanisms and cell polarity changes, which often coexist with evasion mechanisms of the antiviral immune response. Viral agents also indirectly contribute to the development of cancer mainly through immunosuppression or chronic inflammation, but also through chronic antigenic stimulation
The Transcriptional Regulation of Memory
The formation of human memories involves a series of complicated biochemical processes many of which are not fully understood. However, recent data implicate several families of transcription factors that appear critically important in the regulation of memory. For example, CREB, NF-kB, AP-1, Egr, and C/EBP ...The formation of human memories involves a series of complicated biochemical processes many of which are not fully understood. However, recent data implicate several families of transcription factors that appear critically important in the regulation of memory. For example, CREB, NF-kB, AP-1, Egr, and C/EBP families are emerging as key transcriptional regulators of synaptic plasticity and long term memory.
Benedict C. Albensi , Jelena Djordjevic
Dynamics of decision making: from evidence to preference and belief
At the core of the many debates throughout cognitive science concerning how decisions are made are the processes governing the time course of preference formation and decision. From perceptual choices, such as whether the signal on a radar screen indicates an enemy missile or a spot on a CT scan indicates a tumor, to cognitive value-based decisions, such as selecting an agreeable flatmate or deciding the guilt of a defendant, significant and everyday decisions are dynamic over time. Phenomena such as decoy effects, preference reversals and order effects are still puzzling researchers
Marius Usher -, Konstantinos Tsetsos -, Erica Yu -, David A. Lagnado
Danger Signals Triggering Immune Response and Inflammation
The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial or mesenchymal) and injured tissue. Some endogenous danger signals are heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular-matrix breakdown products such as hyaluronan fragments, neuromediators and cytokines like the interferons (IFNs).
Abdulraouf Ramadan --- Walter G. Land --- Sophie Paczesny
So-called altered states of consciousness (ASC) are an intriguing, still under-researched topic, with profound neuropsychological and epistemological implications. In the last few decades there has been increasing multidisciplinary interest in consciousness and ASC, a term encompassing a wide range of pathological and non-pathological conditions, including dreaming, near-death experiences (NDEs), hypnagogic states, hallucinogenic experiences, epileptic seizures, psychotic symptoms, coma, and minimally conscious states
Platelets as immune cells in physiology and immunopathology
Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells—which all specialists consider at the time being—are they immune cells? The issue that platelets participate in immunity is no longer debated; however, the issue that they are key cells in immunity is challenged. It has even been proposed a couple of years ago that platelets can present antigen to T-lymphocytes by using their HLA class I molecules. No one has the same functional definition of platelets. The ‘Frontiers Research Topic’- coordinators’ own view is that platelets are primarily repairing cells, what they do in deploying tools of physiological inflammation.
Drug Development for Parasite-Induced Diarrheal Diseases
One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease
Computers and Games for Mental Health and Well-Being
Recent years have seen important developments in the computer and game industry, including the emergence of the concept of serious games. It is hypothesized that tools such as games, virtual reality, or applications for smartphones may foster learning, enhance motivation, promote behavioral change, support psychotherapy, favor empowerment, and improve some cognitive functions. Computers and games may create supports for training or help people with cognitive, emotional, or behavioral change.
Medical Geology: Impacts of the Natural Environment on Public Health
B. anthracis infections in wildlife and livestock have been recognized as a critically important disease in the United States for over 200 years. Historical data on environmental, weather/climate and geographical factors that influence the occurrence of these infections are well known and include; (1) warm seasons during dry periods that follow moderate to heavy precipitation events (weather/climate); (2) regions containing post-flood organic detritus and/or short dry grazing grasses (environmental); and (3) topological lows, such as waterholes or riverbanks, calcareous and alluvial soils with elevated nutrient content and pH values greater than 6.0 (geology). Other geological factors that may influence B. anthracis outbreak occurrence, as noted through in vivo or in vitro observations, are elevated phosphate (which results in higher protective antigen production), magnesium, sodium, copper, zinc (needed for lethal factor production) and manganese (typically found in very low concentrations in calcareous soils and needed for gene regulation of exotoxins and antibiotics) [1–5].
Handbook of Life Course Health Development
A critical mass of research linking early life events, experiences, and exposures with adult health conditions is delineating the developmental origins of many common chronic diseases. This emerging body of life course health development (LCHD) research specifies the complex adaptive processes by which both adversity and opportunity are integrated into developing biobehavioral systems. It is also challenging long-held views about origins and etiology of health and disease. There is a growing momentum among practitioners and policymakers to “connect the dots” between this rapidly expanding evidence base and the related practices and policies that are implemented within the fields of medicine, public health, nursing, mental health, education, urban planning, community development, social welfare, and others.
Development and Application of Herbal Medicine from Marine Origin
Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research.
Cloud-Based Benchmarking of Medical Image Analysis
This book presents the VISCERAL project benchmarks for analysis and retrieval of 3D medical images (CT and MRI) on a large scale, which used an innovative cloud-based evaluation approach where the image data were stored centrally on a cloud infrastructure and participants placed their programs in virtual machines on the cloud. The book presents the points of view of both the organizers of the VISCERAL benchmarks and the participants.The book is divided into five parts. Part I presents the cloud-based benchmarking and Evaluation-as-a-Service paradigm that the VISCERAL benchmarks used. Part II focuses on the datasets of medical images annotated with ground truth created in VISCERAL that continue to be available for research.
Allan Hanbury , - Henning Müller , - Georg Langs
Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book
his open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
Role of health economic data in policy making and reimbursement of new medical technologies
An accelerated growth of health spending began in the 1960s exceeding the historical 4% GDP threshold. This phenomenon was noticed early on in mature market economies led by the US and during the following decades spread to many global regions. Health policy makers became increasingly exposed to new harsh challenges in the uneasy task to provide universal health coverage and decent equity of access to the medical services. Among the most prominent demand-side issues are population aging, rise of non-communicable diseases and growing patient expectations.
Mihajlo (Michael) Jakovljevic -, Tetsuji Yamada
Drugs quality control (Theoretical foundation and practical application): The Coursebook
The Course book presents the basics of drugs quality control in accordance with regulatory documents (pharmacopoeia of Europe, USA, Japan, Russia) and new data from current scientific periodicals, monographs The features of the physical, spectral and chemical quality control of medicines according to the indicators «identification», «tests» and «assay» are described in detail. Part II presents a workbook, which includes questions for the self-control of the material studied and tasks for a laboratory workshop. The Course book contains reference material and samples of pharmacopoeial articles. The Course book is designed for students of the specialty «Pharmacy».
A Laboratory Guide to Clinical Hematology
This is eBook will be constantly updated, edited, and reviewed as new emerging information arises.
Calcium Signaling in Human Health and Diseases
Intracellular Ca2+ signals regulate a myriad of cellular functions, ranging from short-term responses, such as excitation-contraction coupling and stimulus-secretion coupling, to long-term processes, such as proliferation, gene expression, differentiation, motility, synaptic plasticity, programmed cell death (or apoptosis), and metabolism. It is, therefore, not surprising that any derangement of the multifaceted Ca2+ toolkit that shapes the elevation in intracellular Ca2+ concentration ([Ca2+]i) may lead to severe pathological disorders, including cancer, chronic heart failure, epileptic and neurodegenerative disorders, immunodeficiency, and developmental defects. An increase in [Ca2+]i is shaped by the concerted interaction among the components of an extremely versatile network of channels, transporters, pumps, and buffers that can be uniquely assembled by each cell type to generate intracellular Ca2+ signals with spatio-temporal properties precisely tailored to regulate specific functions.
Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because women’s health care has its own unique challenges, the intersection between cancer care delivery and women’s health is to be examined in this Frontiers in Oncology issue.
Cancer Metabolism: Molecular Targeting and Implications for Therapy
“Metabolic reprogramming” is one of the hallmarks of cancer, and is exemplified by distinctive biochemical alterations which include enhanced glucose uptake, aerobic glycolysis and glutamine-metabolism. Clinically, the prominent feature of altered metabolism, (i.e.) rapid glucose utilization, has already been exploited to diagnose majority of solid malignancies using PET/CT imaging. In the light of recent research it has become evident that cancer-specific metabolic shift complements pro-survival and anti-apoptotic events during unfavorable conditions such as nutrient-deprivation and therapeutic challenges.
Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-3 FA-enriched oral nutritional supplement (ONS) providing 2.0 g of eicosapentaenoic acid (EPA) and 1.0 g of docosahexaenoic acid (DHA) per day or a standard ONS for seven days before surgery. On the day of operation, there was a significant increase in the production of leukotriene B5 (LTB5) (p < 0.01) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p < 0.01), a significant decrease in the production of leukotriene B4 (LTB4) (p < 0.01) and a trend for a decrease in the production of 5-hydroxyeicosatetraenoic acid (5-HETE) (p < 0.1) from stimulated neutrophils in the active group compared with controls. There was no association between LTB4 values and postoperative complications. In conclusion, oral n-3 FA exerts anti-inflammatory effects in surgical patients, without reducing the risk of postoperative complications.
Advances in Virtual Agents and Affective Computing for the Understanding and Remediation of Social Cognitive Disorders
Recent advances in computer technologies and research now enable to simulate realistic social interaction thanks to the use of increasingly complex computer models. Virtual agents reproducing both human appearance and expressive behaviors are now available for supporting affective interactions with users. Two deeply intertwined fields of knowledge already benefit from such innovations concerning virtual agents and affective computing: psychiatry and social neurosciences
Anatomy and Plasticity in Large-Scale Brain Models
Supercomputing facilities are becoming increasingly available in neuroscience, predominantly for simulating the dynamics of electrical activity propagating through neuronal circuits. On today's most advanced supercomputers, large-scale models can be simulated with up to a billion of neurons. However, merely further increasing the number of neurons and synapses will not be sufficient to create biologically realistic full-scale brain models.
This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types.
Nano/Micro-Assisted Regenerative Medicine
Regenerative medicine is an emerging multidisciplinary field that aims to repair and restore the normal functions of tissues and organs damaged by aging, disease, injury, or congenital disorders. The basic concept of "Nano/Micro-Assisted Regenerative Medicine" is to use advanced nano/micro-technologies, either alone or in combination with specific cells, such as stem cells, to replace, enhance, or regenerate damaged or diseased human tissues or organs.
The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets.
The Poetics and Politics of Alzheimer’s Disease Life-Writing
The introduction gives an overview on sociopolitical and research-related developments regarding dementia, and attempts explanations for why the interest in dementia of critical scholarship continues to be very limited and particularly focused on caregiver accounts. It illustrates that an understanding of the obvious neglect of dementia patient narratives sheds some light onto the ethical implications and challenges of critically reading such narratives: these narratives seem least of all fit to match classical survivor illness literature, and serious impairment in the ability to tell or understand stories has been taken as motivation to neglect patient narratives.
This collection of papers describes the recent development of travel health and vaccination services delivered by pharmacists. It is the first dedicated collection of its type and provides a template for the continued growth of pharmacy practice in this area. The articles examine and report on aspects of such services in the UK, US, Canada, Australia, Switzerland, and South Africa, which will provide useful insight for those in other countries developing such pharmacy-based services.
Galectins in Cancer and Translational Medicine
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell “glycome” in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well.Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs.
Anatomy Quizbook: for students studying or intending to study medicine
Anatomy Quizbook is an interactive learning book that will help students and tutors – indeed anyone interested in anatomy – learn, test and improve their knowledge of the human body.Readers are presented with carefully selected questions and diagrams addressing core learning in clinically-relevant anatomy. This selective rather than exhaustive approach will especially suit time-poor scholars. Regular self-testing will also ensure a robust and strategic understanding of the subject matter.In this first Volume, you can develop your knowledge of fundamental anatomy, including clinically-relevant terminology and the significant parts and operation of thethorax focusing on the heart, lungs, and associated bones, muscles, nerves, blood and lymphatic vessels.abdomen exploring the stomach, intestines, pancreas, liver, gallbladder, kidneys, spleen and their supporting structures (muscles, nerves, blood and lymphatic vessels).pelvis examining the bones, ligaments, vessels and nerves of the pelvic region, the features of male and female pelves, and the major digestive and excretory organs (colon, rectum, bladder and urethra).Whilst developed primarily for students who are studying, or intend to study, medicine, the Anatomy Quizbook will reward all readers who seek to explore and learn about the workings of the human body
Principles and Practice of Case-based Clinical Reasoning Education
Practice of Case-based Clinical Reasoning
This volume describes and explains the educational method of Case-Based Clinical Reasoning (CBCR) used successfully in medical schools to prepare students to think like doctors before they enter the clinical arena and become engaged in patient care. Although this approach poses the paradoxical problem of a lack of clinical experience that is so essential for building proficiency in clinical reasoning, CBCR is built on the premise that solving clinical problems involves the ability to reason about disease processes. This requires knowledge of anatomy and the working and pathology of organ systems, as well as the ability to regard patient problems as patterns and compare them with instances of illness scripts of patients the clinician has seen in the past and stored in memory
White Paper on Joint Replacement: Status of Hip and Knee Arthroplasty Care in Germany
This White Paper details the status of hip and knee arthroplasty care in Germany. Hip and knee replacements are amongst the most frequently performed procedures and usually become necessarily due to age-related wear of the joint, osteoarthritis and fractures of the femoral neck. In light of demographic change, demands with regard to standards of care and the procedures are likely to rise.This book addresses people involved in shaping and representing the healthcare system from a variety of fields including medical professions, health insurances and health sciences as well as journalists and patient representatives.
Compartment syndrome is a complex physiologic process with significant potential harm, and though an important clinical problem, the basic science and research surrounding this entity remains poorly understood. This unique open access book fills the gap in the knowledge of compartment syndrome, re-evaluating the current state of the art on this condition. The current clinical diagnostic criteria are presented, as well as the multiple dilemmas facing the surgeon. Pathophysiology, ischemic thresholds and pressure management techniques and limitations are discussed in detail.
X-Ray Contrast Media: Overview, Use and Pharmaceutical Aspects
This open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspects of X-ray contrast media. The overall goal of this book is to provide a comprehensive overview relevant for the optimal use of x-ray contrast media covering next to the historic development, their structure and properties also practical information for handling of contrast media, and explanation of the relevant risks during use and measures for prevention and treatment of potential side effects
Designed as an easy-to-use, practical guide to tumors of the eye, lids, and orbit, this open access book comprehensively addresses surgical treatment and management of diseases related to ophthalmic oncology. Surgical Ophthalmic Oncology: A Collaborative Open Access Reference is an ideal reference for general ophthalmologists, surgeons, fellows and trainees around the world who encounter these diseases in the care of their patients. Notably, this book includes considerations for those ophthalmologists offering subspecialty care in environments with limited access to advanced technology and instrumentation.
Clinical Text Mining: Secondary Use of Electronic Patient Records
This open access book describes the results of natural language processing and machine learning methods applied to clinical text from electronic patient records.It is divided into twelve chapters. Chapters 1-4 discuss the history and background of the original paper-based patient records, their purpose, and how they are written and structured. These initial chapters do not require any technical or medical background knowledge.
The Emerging Discipline of Quantitative Systems Pharmacology
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research.
Allergy and Immunology --- Medicine (General)
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation.
Epigenetics of B Cells and Antibody Responses
Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states.
Optical Methods in Sensing and Imaging for Medical and Biological Applications
General and Civil Engineering --- Medicine (General) --- Therapeutics
The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject.
Dragan Indjin (Ed.) --- Željka Cvejić (Ed.) --- Małgorzata Jędrzejewska-Szczerska (Ed.)
The Tohoku University Graduate School of Dentistry first introduced the concept of “Interface Oral Health Science”, designed to establish and maintain healthy oral cavities, which are home to a number of mixed systems. Included in those systems are: (1) host tissues such as teeth, mucosa, muscle and bone, (2) parasites and microorganisms cohabiting the surfaces of the oral cavity and (3) biomaterials that are used for the rehabilitation of oral functions. In addition, (4) these systems are subject to severe and complex mechanical forces.
Keiichi Sasaki --- Osamu Suzuki --- Nobuhiro Takahashi
Safer Healthcare: Strategies for the Real World
Pharmacy and materia medica --- Medicine (General) --- Biotechnology -
The authors of this book set out a system of safety strategies and interventions for managing patient safety on a day-to-day basis and improving safety over the long term. These strategies are applicable at all levels of the healthcare system from the frontline to the regulation and governance of the system. There have been many advances in patient safety, but we now need a new and broader vision that encompasses care throughout the patient’s journey. The authors argue that we need to see safety through the patient’s eyes, to consider how safety is managed in different contexts and to develop a wider strategic and practical vision in which patient safety is recast as the management of risk over time.
Cyril Mauffrey --- David J. Hak --- Murphy P. Martin III
his open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspects of X-ray contrast media. The overall goal of this book is to provide a comprehensive overview relevant for the optimal use of x-ray contrast media covering next to the historic development, their structure and properties also practical information for handling of contrast media, and explanation of the relevant risks during use and measures for prevention and treatment of potential side effects
Medicine (General) --- Pharmacy and materia medica
his Open Access book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively new and emerging area. There are few practical training resources for public health practitioners, especially resources which include discussion of realistic cases which are likely to arise in the practice of public health.
Barrett, D.H --- Ortmann, L.H --- Dawson, A --- Saenz, C --- et al.
Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
his volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration
Toshio Nakanishi --- Roger R. Markwald --- H.Scott Baldwin --- Bradley B. Keller --- et al.
Contemporary Bioethics: Islamic Perspective
This book combines Islamic textual analysis with juridical methodology to engage dominant secular bioethics in the Muslim healthcare institutions. It integrates Islamic textual resources with medical information in order to provide careful analyses of the political, economic and cultural terrains that are necessary for bioethicists to effectively promote social justice
Mohammed Ali Al-Bar --- Hassan Chamsi-Pasha
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
Rudolf Jaenisch --- Feng Zhang --- Fred Gage
This is a lab manual for a college-level human anatomy course. Mastery of anatomy requires a fair amount of memorization and recall skills. The activities in this manual encourage students to engage with new vocabulary in many ways, including grouping key terms, matching terms to structures, recalling definitions, and written exercises. Most of the activities in this manual utilize anatomical models, and several dissections of animal tissues and histological examinations are also included. Each unit includes both pre- and post-lab questions and six lab exercises designed for a classroom where students move from station to station. The vocabulary terms used in each unit are listed at the end of the manual and serve as a checklist for practicals.
Non-Vitamin K Antagonist Oral Anticoagulants: A Concise Guide
Surgery --- Medicine (General) --- Biotechnology --- Therapeutics --- Cardiovascular
This book is an essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.
urgical infections are caused by the breakdown of the equilibrium existing between organisms and the host. This may occur after a breach in a protective surface, as occurs after surgical trauma, changes in host resistance, or particular characteristics of the organism. The possible outcomes are abscess formation, local spread with/without tissue death, distant spread or resolution. A surgical infection is an infection requiring operative treatment (excision or drainage), and occupies an unvascularized space in tissue, or may occur in an operated site. Common examples of the former group are furuncles and carbuncles, hollow viscus inflammations, such as appendicitis, cholecystitis, and most abscesses. The latter group comprises all surgical site infections.
Evangelos P. Misiakos --- Konstantinos George Tsalis
High Density Lipoproteins: From Biological Understanding to Clinical Exploitation
this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.
Arnold von Eckardstein --- Dimitris Kardassis
The Sustainability of Agro-Food and Natural Resource Systems in the Mediterranean Basin
Pharmacy and materia medica --- Nutrition and Food Sciences --
This book is focused on the challenges to implement sustainability in diverse contexts such as agribusiness, natural resource systems and new technologies. The experiences made by the researchers of the School of Agricultural, Forestry, Food and Environmental Science (SAFE) of the University of Basilicata offer a wide and multidisciplinary approach to the identification and testing of different solutions tailored to the economic, social and environmental characteristics of the region and the surrounding areas.
The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models
Pharmacy and materia medica --- Physiology
Infogest' (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (including food scientists, gut physiologists and nutritionists)
Kitty Verhoeckx --- Paul Cotter --- Iván López-Expósito --- Charlotte
Innovative Medicine: Basic Research and Development
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”.
Kazuwa Nakao --- Nagahiro Minato --- Shinji Uemoto
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers
This in-depth survey of salutogenesis shows the breadth and strengths of this innovative perspective on health promotion, health care, and wellness. Background and historical chapters trace the development of the salutogenic model of health, and flesh out the central concepts, most notably generalized resistance resources and the sense of coherence, that differentiate it from pathogenesis. From there, experts describe a range of real-world applications within and outside health contexts, from positive psychology to geriatrics, from small towns to corrections facilities, and from school and workplace to professional training.
Maurice B. Mittelmark --- Shifra Sagy --- Monica Eriksson --- Georg F. Bauer --- et al.
Hormones, Metabolism and the Benefits of Exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism.
Self-Reported Population Health: An International Perspective based on EQ-5D
The EQ-5D instrument, as a standardized, cross-culturally validated measure of self-assessed health has a hugely important role in understanding population health within and across countries. Over the past two decades a wealth of international population health survey data have been accumulated by the EuroQol Group from research conducted in many countries across four continents. One of the success factors of the EQ-5D instruments has been the easy availability of national or international sets of EQ-5D data, as well as clear explanations and guidance for users.
Agota Szende --- Bas Janssen --- Juan Cabases
This open access book describes the results of natural language processing and machine learning methods applied to clinical text from electronic patient records. It is divided into twelve chapters. Chapters 1-4 discuss the history and background of the original paper-based patient records, their purpose, and how they are written and structured. These initial chapters do not require any technical or medical background knowledge. The remaining eight chapters are more technical in nature and describe various medical classifications and terminologies such as ICD diagnosis codes, SNOMED CT, MeSH, UMLS, and ATC.
Cognitive Supervision for Robot-Assisted Minimally Invasive Laser Surgery
This thesis lays the groundwork for the automatic supervision of the laser incision process, which aims to complement surgeons’ perception of the state of tissues and enhance their control over laser incisions. The research problem is formulated as the estimation of variables that are representative of the state of tissues during laser cutting. Prior research in this area leveraged numerical computation methods that bear a high computational cost and are not straightforward to use in a surgical setting.
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field.
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book.
Akinori Akaike --- Shun Shimohama --- Yoshimi Misu
This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Caws, Maxine --- Marais, Ben --- Heemskerk, Dorothee --- Farrar, Jeremy
This publication addresses the global challenges of food and water security in a rapidly changing and complex world. The essays highlight the links between bio-physical and socio-cultural processes, making connections between local and global scales, and focusing on the everyday practices of eating and drinking, essential for human survival. Written by international experts, each contribution is research-based but accessible to the general public.
Peter Jackson --- Walter E.L. Spiess --- Farhana Sultana
Acupuncture – Basic Research and Clinical Application
This book focuses on the investigation, development, and modernization of acupuncture in basic research settings as well as in clinical applications. The book contains 13 chapters reporting the latest evidence-based results of acupuncture research and exploring acupuncture in general. Altogether, 44 authors from all over the world contributed to this book.
Advances in Micro-Bioreactor Design for Organ Cell Studies
Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or using bioreactors for the production of biologics. This book highlights these issues with a strong focus on new engineering design.
Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes
Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake.
Lluis Serra-Majem (Ed.) --- Mariela Nissensohn (Ed.)
The Biology and Treatment of Myeloid Leukaemias
There has been an observed decrease in the global mortality from cancer, mostly atributable to improved, particularly early, detection and prevention. For many carcinomas and leukaemias in adults, once the disease has reached a certain stage there are no therapies that are able to erradicate the cancer cells and cure patients. There has been progress in the treatment of acute myeloid leukaemia (AML) and remissions are achievable; however, the presence of chemoresistent blast cells leads to most patients relapsing, and relapse is difficult to treat and thus patients die due to their disease
Geoffrey Brown (Ed.) --- Ewa Marcinkowska (Ed.)
Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent.
Cancer Biomarkers and Targets in Digestive Organs
Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets.
Chemical and Molecular Approach to Tumor Metastases
Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies.
Gianni Sava (Ed.) --- Alberta Bergamo (Ed.)
This reprint book ‘Communication in Pharmacy Practice’ is launched to help improve communication practices by increasing knowledge of different aspects of communication in pharmacy practice. The book consists of recently published research articles and illustrates that pharmacy communication is a research subject that is investigated globally and from many perspectives. The overall pharmacy communicational themes investigated and discussed in this book are as follows: Communication between health care professionals; communication between pharmacists and patients in the context of both prescription and over-the-counter (OTC) medicines; and factors impacting communication
Sofia Kälvemark Sporrong (Ed.) --- Susanne Kaae (Ed.)
The educational system leading up to the pharmacy degree, student training, and the continuing personal development of pharmacists are being more and more mapped to the competences pharmacists require to provide the relevant safe and efficient pharmaceutical services to meet the health needs of patients. This book draws on the experience of experts involved in the develoment of competence training for pharmacy education and training in Europe, North America, and Australia. It discusses the philosophy and implications of such an approach, as well as the production and development of models, and their application to existing courses.
Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease
Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features.
Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade.
Hwang, Tsong-Long --- Sung, Ping-Jyun --- Liaw, Chih-Chuang
his Special Issue of Nutrients, entitled "DHA for Optimal Health", consists of evidence-based original research or reviews of the scientific literature. Manuscripts focus on the evidence that underpins dietary requirements throughout the lifespan (from in-utero to the elderly) for optimal brain function and/or prevention (or treatment) of disease.
Diagnosis and Management of Pediatric Diseases
A screenshot of some the most rapidly evolving fields in Neonatology and Pediatrics with articles reviewing some metabolic dysregulations as well as non-oncologic diseases that may occur in infancy, childhood, youth. The illustrative material with original photographs and drawings highlighting some pathogenetic concepts are keystones of this book.
Diagnosis and Treatment of Thoracic Outlet Syndrome
Thoracic outlet syndrome (TOS) is a spectrum of disorders resulting from the compression of the neurovascular structures within the thoracic outlet. The three main subtypes of TOS are defined by the anatomic structure affected by the extrinsic compression. In the most common subtype—neurogenic TOS—the brachial plexus is compressed and symptoms include pain, arm paresthesias, and sometimes weakness. Venous TOS is characterized by the compression of the subclavian vein and its resultant thrombosis. Arterial TOS is the least common and is distinguished by the compression of the subclavian artery and the development of aneurysms or stenoses with distal embolization.
Julie Ann Freischlag (Ed.) --- Natalia O. Glebova (Ed.)
Diagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain.
The purpose of these books is to have an updated systematic overview examining, in detail, the functional role of different diets and dietary components in maintaining glucose homeostasis and preventing long-term complications. The first book includes experimental evidence from preclinical research, whereas the second book provides studies in the clinical scenario.
Dietary intake in children is not only associated with current and future health, but also with behavior and learning. Especially during early childhood and throughout the school-age years, adequate food and nutrient intake to support brain development and function are critical. Data on the effect of sugar intake on children’s activity levels, or their ability to focus on cognitive tasks, are mixed. Overall, more research into nutrition and children’s behavior is needed to address the questions: How does behavior affect children’s nutrition and how does nutrition affect children’s behavior?
Gluten Related Disorders: People Shall not Live on Bread Alone
Once upon a time, gluten was not part of the human diet, and therefore, there were no gluten-related disorders. With the advent of agriculture 10,000 years ago, the introduction of gluten-containing grains in the human diet created conditions for human diseases related to gluten exposure. These diseases, including celiac disease, non-celiac gluten sensitivity, and wheat allergy, have distinct pathophysiological mechanisms, serological markers, and long-term treatments, but similar, often overlapping clinical presentations.
In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD.
Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential
Antimicrobial peptides are key defense molecules adopted by all life forms to prevent infection. They also have other beneficial effects such as boosting immune response, anticancer, and wound healing. The antiviral effects of antimicrobial peptides have laid the foundations for developing new agents to combat seasonal Flu, HIV-1, RSV, Zika, and Ebola. This eBook is constructed to systematically deal with antimicrobial peptides from a variety of natural sources, including fungi, plants, and animals (insects, fish, amphibians, birds, and reptiles).
Magnesium is universally recognized as an essential nutrient for human life and health. Indeed, magnesium plays an important physiologic role in every organ of the human body. Disturbances of Mg homeostasis have been implicated in the pathophysiology of several diseases, and Mg supplementation has been evaluated in numerous large-scale clinical trials. The World Health Organization has listed magnesium as among those essential nutrients that are consumed in suboptimal amounts by the general population.
Federica Wolf (Ed.) --- Valentina Trapani (Ed.)
[Selective and quantitative detection of different kinds of biocomponents plays an important role in biomedical applications, clinical diagnostics, environmental monitoring, toxicology, regenerative medicine and drug delivery. Therefore, multidisciplinary area of magnetic biosensing have been extensively developed in recent years, aiming to create compact analytical devices for non-expensive and low time consuming analysis provided at the point of care by non-skilled personnel.
In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity.
Friedemann Honecker (Ed.) --- Sergey A. Dyshlovoy (Ed.)
Mitochondrial Dysfunction in Ageing and Diseases
The past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors. Impairment of the mitochondria may be caused by mutations or deletions in nuclear or mitochondrial DNA. Hallmarks of mitochondrial dysfunction include decreased ATP production, decreased mitochondrial membrane potential, swollen mitochondria, damaged cristae, increased oxidative stress, and decreased mitochondrial DNA copy number.
The Molecular and Cellular Basis for Parkinson's Disease
The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.
Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs.
Molecular Pharmacology and Pathology of Strokes
Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke.
Joen-Rong Sheu (Ed.) --- Howard Prentice (Ed.)
Molecular Science for Drug Development and Biomedicine
With the avalanche of biological sequences generated in the postgenomic age, molecular science is facing an unprecedented challenge, i.e., how to timely utilize the huge amount of data to benefit human beings. Stimulated by such a challenge, a rapid development has taken place in molecular science, particularly in the areas associated with drug development and biomedicine, both experimental and theoretical. The current thematic issue was launched with the focus on the topic of “Molecular Science for Drug Development and Biomedicine”, in hopes to further stimulate more useful techniques and findings from various approaches of molecular science for drug development and biomedicine.
Natural Compounds as New Cancer Treatments
Cancer remains one of the main causes of morbidity and mortality worldwide. Although many pharmacological and clinical advances have been made, there is a constant need for new molecules to improve the overall options for treatment. Natural compounds from animal, microbial, vegetal, or fungal origin represent countless sources of new compounds that can be used as anticancer drugs, provided their activity, bioavailability, and toxicity are adequate. This book aims to compile both original articles and reviews that cover the most recent advances in the use of natural compounds for cancer treatment, and provide new objectives and advice for future research in the field of biological activity of natural compounds.
Natural Products for Cancer Prevention and Therapy
This Special Issue book, “Natural Products for Cancer Prevention and Therapy”, is based on recent advances in natural products for cancer prevention and therapy. For this purpose, the authors of this book have been organizing a biennial international conference series. The first meeting (First International Conference on Natural Products for Cancer Prevention and Therapy) was held in Istanbul between 31 August and 2 September 2015, with the support and contribution of many valuable researchers in this field
Anupam Bishayee (Ed.) --- Mukerrem Betul Yerer-Aycan (Ed.)
Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia
This Special Issue focuses on recent research on the important emerging and neglected tropical diseases (NTDs) in South and South East Asia and Northern Australia. This region stretches from Afghanistan in the west to Papua New Guinea in the east, and includes the Indian subcontinent, mainland South-East Asia (Indo China), maritime South East Asia, and the tropical regions of Australia. Many of these areas are highly endemic for important NTDs and emerging infectious diseases including lymphatic filariasis, leprosy, soil-transmitted helminthiases (hookworm, Trichuris, Ascaris, and Strongyloides), food-borne trematodiases, schistosomiasis, dengue/chikungunya/zika, leptospirosis, meloidosis, scabies, trachoma, and yaws. Several of these diseases are targeted for elimination or enhanced control by the World Health Organization in the next 5 to 10 years, although some have chronic lasting sequelae needing lifelong management.
Patricia Graves (Ed.) --- Thewarach Laha (Ed.) --- Peter A. Leggat (Ed.) --- Khin Saw Aye (Ed.)
New Lipid Lowering Therapies for Cardiovascular and Metabolic Diseases: Lessons from the Past and Future Challenges
This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.
Novel Pharmacological Inhibitors for Bacterial Protein Toxins
Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present.
Nutraceuticals and the Skin: Roles in Health and Disease
he skin is the largest organ of the body and serves as a barrier between the inner and external environments. As such, any problems in the skin can have serious effects on systemic health and well-being. Several studies have established that both nutritional and dietary factors play an important role in the maintenance of normal skin integrity, and can execute a causative, preventative and/or treatment role in a number of skin related conditions.
Jean Christopher Chamcheu (Ed.) --- Deeba Nadeem Syed (Ed.) --- G. Kerr Whitfield (Ed.)
Infants are not just small adults; they have a complex set of nutrient requirements and interactions to account for the high metabolic rate, growth, immunological and cognitive development, etc. Each year there are 138 million births, including 30 million from the least developed countries, where health is most at risk. Nutrition during infancy establishes growth patterns and development which moderate short term and long term health and life expectancy. There is continuing progress in understanding the nutrient composition of breastmilk and the importance nutritious and timely complementary foods.
Colin Binns (Ed.) --- Mi Kyung Lee (Ed.) --- Masaharu Kagawa (Ed.)
Nutrients, Infectious and Inflammatory Diseases
Foodborne disease like salmonellosis and toxoplasmosis are amongst the most significant causes of hospitalization in the U.S. and globally. Gastrointestinal infections alter gut microbiomes and increase permeability to toxins. Various invasions by microbial, fungal, viral and parasitic agents stimulate inflammation, a defensive mechanism of the body’s immune system. Other stimuli include environmental stimuli, oxidative stress, aging and the physiological process. A long-lasting, persistent and excessive inflammatory response is a significant risk factor for developing various chronic inflammatory and infectious diseases.
The purpose of this Special Issue, “Nutrition and Allergic Diseases”, is to provide an overview of the role of nutrition in allergy. The prevalence of asthma, rhinitis, and food allergy has increased tremendously over the last few decades. Is there a role for nutrition to help managing this global challenge? This Special Issue touches upon the many aspects that relate to nutrition and allergy and focuses on two fundamental questions: 1) Can nutrition play a role in allergy prevention and induction? 2) Can nutrition play a role in managing allergies?
Joost van Neerven (Ed.) --- Huub Savelkoul (Ed.)
The development and treatment of cancer presents a complex interaction between tumor and host. Provision of nutrients not only enables the maintenance of nutritional status, but also provides substrates and signals for immunity, tumor metabolism and protection of the host from treatment toxicities. Fat is one dietary element that has been explored for its role in cancer development. While the bulk of these studies have been observational or experimental, the evidence assembled suggests that dietary lipids behave uniquely to prevent or promote cancers
Malnutrition in people with liver disease is a challenging issue due to its multifactorial nature, which includes hypermetabolism, increased energy needs, malabsorption, and anorexia. Despite advances in both assessment and management, correct nutritional support is still an often-unanswered need in the care of these patients to avoid poor outcomes. One of the central issues remains how to improve muscolar mass of sarcopenic chronically malnourished individuals with end stage liver diseases and cirrhosis, as only a correct nutritional assessment and subsequent nutritional handling may enhance quality of life and disease outcome.
Pietro Vajro (Ed.) --- Claudia Mandato (Ed.)
Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients. Added to this complexity is the distinction between maternal and fetal nutrition and the impact the placenta plays in nutrient metabolism and overall nutrient supply to the fetus.
Janna L. Morrison --- Timothy R.H. Regnault
Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients.
The One Health concept recognizes that the health of humans, animals, and their ecosystems are interconnected, and that a coordinated, collaborative, multidisciplinary, and cross-sectoral approach is necessary to fully understand and respond to potential or existing risks that originate at the animal–human–ecosystems interfaces. Thus, the One Health concept represents a holistic vision for addressing some of the complex challenges that threaten human and animal health, food safety, and the environments in which diseases flourish.
Plant medicines are the original medicines that humans have always used. Many people continue to use plant medicines today including teas, coffee, chocolate, ginger, and other medicines. Traditional medicine is based on plant medicines and is the primary form of medicine for many people throughout the world. The current volume discusses traditional medicines and presents various plant medicines that could be tested in clinical trials. Modern medicine continues to use many drugs that are derived from plants. The current work has much to teach modern medicine about the treatment of several diseases.
Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin.
Polyamine Metabolism in Disease and Polyamine-Targeted Therapies
Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis
Roles of NF-κB in Cancer and Their Therapeutic Approaches
Although mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity.
Teenage Reproductive Health: Pregnancy, Contraception, Unsafe Abortion, Fertility
Maternal mortality is still globally high and reducing it is a top priority. Teenage pregnancies have more complications and are also unwanted in many cases. This contributes to the high maternal mortality with both obstetric complications and burden of unsafe abortion. Additionally, many teenagers live in areas with heavy pollution that affects the mother and the unborn child. Global public health is a very important issue that aims to prevent disease, prolong life, and promote physical, mental and social well-being.
Toxins in Drug Discovery and Pharmacology
Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology for their own biological purposes by producing venoms that contain a structural and functional diversity of neurotoxins.
Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed.
Arpad Szallasi (Ed.) --- Susan M. Huang (Ed.)
Transmucosal Absorption Enhancers in the Drug Delivery Field
Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption.
Casettari, Luca --- Maher, Sam --- Illum, Lisbeth
Tribological Performance of Artificial Joints
Joint replacement is a very successful medical treatment. However, the survivorship of the implants could be adversely affected due to the loss of materials in the form of particles or ions as the bearing surfaces articulate against earch other. The consequent tissue and immune response to the wear products, remain one of the key factors of their failure. Tribology has been defined as the science and technology of interacting surfaces in relative motion and all related wear products (e.g., particles, ions, etc.).
Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment.
The Tumor Microenvironment of High Grade Serous Ovarian Cancer
The Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distinct components in particular, and the role of the TME in the context of disease recurrence and development of chemoresistance.
M. Sharon Stack (Ed.) --- Kenneth P. Nephew (Ed.) --- Joanna E. Burdette (Ed.) --- Anirban K. Mitra (Ed.)
This open access Nursing Pharmacology textbook is designed for entry-level undergraduate nursing students. It explains basic concepts of pharmacology and describes common medication classes. This book is not intended to be used as a drug reference book, but direct links are provided to DailyMed, which provides trustworthy information about marketed drugs in the United States.
Chippewa Valley Technical College, Eau Claire, WI
Advances in Pharma Business Management and Research
This open access book presents a unique collection of practical examples from the field of pharma business management and research. It covers a wide range of topics such as: 'Brexit and its Impact on pharmaceutical Law - Implications for Global Pharma Companies', 'Implementation of Measures and Sustainable Actions to Improve Employee's Engagement', 'Global Medical Clinical and Regulatory Affairs (GMCRA)', and 'A Quality Management System for R&D Project and Portfolio Management in a Pharmaceutical Company'. The chapters are summaries of master’s theses by "high potential" Pharma MBA students from the Goethe Business School, Frankfurt/Main, Germany, with 8-10 years of work experience and are based on scientific know-how and real-world experience.
Schweizer, Lars --- Dingermann, Theodor --- Russe, Otto Quintus --- Jansen, Christian
Advancing the Science of Cancer in Latinos
This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos – the largest, youngest, and fastest-growing minority group in the United States – are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress.
Ramirez, Amelie G. --- Trapido, Edward J.
Animals and the Shaping of Modern Medicine
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological. Each chapter analyses an important episode in which animals changed and were changed by medicine.
Woods, Abigail --- Bresalier, Michael --- Cassidy, Angela --- Mason Dentinger, Rachel
Belly-Rippers, Surgical Innovation and the Ovariotomy Controversy
This open access book looks at the dramatic history of ovariotomy, an operation to remove ovarian tumours first practiced in the early nineteenth century. Bold and daring, surgeons who performed it claimed to be initiating a new era of surgery by opening the abdomen. Ovariotomy soon occupied a complex position within medicine and society, as an operation which symbolised surgical progress, while also remaining at the boundaries of ethical acceptability. This book traces the operation’s innovation, from its roots in eighteenth-century pathology, through the denouncement of those who performed it as ‘belly-rippers’, to its rapid uptake in the 1880s, when ovariotomists were accused of over-operating.
This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows.
This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner.
Makarov, Sergey --- Horner, Marc --- Noetscher, Gregory
This open access book describes modern applications of computational human modeling in an effort to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields. Readers working on any application that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest models and techniques available to assess a given technology’s safety and efficacy in a timely and efficient manner.
Makarov, Sergey N. --- Noetscher, Gregory M. --- Nummenmaa, Aapo
A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans. ; Supports further investigation by summarizing state of the art in the field of Buruli ulcer research Enriches understanding of epidemiology of Buruli ulcer in different geographic regions Reviews exhaustively the characteristics of Mycobacterium ulcerans disease
This open access volume is the first academic book on the controversial issue of including spiritual care in integrated electronic medical records (EMR). Based on an international study group comprising researchers from Europe (The Netherlands, Belgium and Switzerland), the United States, Canada, and Australia, this edited collection provides an overview of different charting practices and experiences in various countries and healthcare contexts. Encompassing case studies and analyses of theological, ethical, legal, healthcare policy, and practical issues, the volume is a groundbreaking reference for future discussion, research, and strategic planning for inter- or multi-faith healthcare chaplains and other spiritual care providers involved in the new field of documenting spiritual care in EMR.
Foundations of Neuroscience is aimed at undergraduate students new to the field of neuroscience. The first edition specifically targets students enrolled in Neurobiology at Michigan State University and primarily contains topics covered in that course.
This open access Nursing Skills textbook includes physical assessments routinely performed by entry-level registered nurses and basic nursing skills performed by licensed practical nurses. It is based on the Wisconsin Technical College System (WTCS) statewide nursing curriculum for the Nursing Skills course (543-102), the 2019 NCLEX-RN Test Plan, the 2020 NCLEX-PN Test Plan, and the Wisconsin Nurse Practice Act. Learning activities are included to encourage the student to engage in critical thinking and apply the nursing process while analyzing assessment findings.
Kimberly Ernstmeyer, Elizabeth Christman
Fundamentals of Anatomy and Physiology - Australian Edition
ght in Australia, aiming to provide students with an increased access to free, high-quality learning materials. The material in this textbook is largely based on OpenStax’s Anatomy & Physiology textbook, however, has been modified for Australian course curriculum.
Medical Terminology for Healthcare Professions
Medical Terminology for Healthcare Professions is an Open Educational Resource (OER) that focuses on breaking down, pronouncing, and learning the meaning of medical terms within the context of anatomy and physiology. This resource is targeted for Healthcare Administration, Health Sciences, and Pre-Professional students.
Pulmonary Pathophysiology for Pre-Clinical Students
Pulmonary Pathophysiology for Pre-Clinical Students is an undergraduate medical-level resource for foundational knowledge of pulmonary pathophysiology. This text is designed for a course pre-clinical undergraduate medical curriculum and it is aligned to USMLE(r) (United States Medical Licensing Examination) content guidelines. The text is meant to provide the essential information in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience
Opening Eyes onto Inclusion and Diversity
Susan Carter; Professor Lindy-Anne Abawi; Professor Jill Lawrence; Associate Professor Charlotte Brownlow; Renee Desmarchelier; Melissa Fanshawe; Kathryn Gilbey; Michelle Turner; and Jillian Guy
Susan Carter, Lindy Abawi, Jill Lawrence
Most books about epidemiology are written for graduate students but this book is especially designed for undergraduates, who are taking an introductory course in epidemiology, and especially for those students who want to know more about epidemiology. But not because it is directed mainly to undergraduates and not to graduate students the course has less rigour and quality, it is because the concepts are introduced, and presented in an easier and simplified form, so, the study of epidemiology becomes less intimidating.
Minnesota State Colleges and Universities
This open access book is the outcome of a Global Forum on Innovation, Intellectual Property and Access to Medicines held in December 2019 at the Max Plank Instititute in Munich, organised by the South Centre and the Max Plank Institute. The academics and experts from international organisations participating have contributed chapters to this book. The book is for policy makers (in Ministries of Health, Ministries of Trade, Ministries of Foreign Affairs, patent offices), but also relevant for academics (law, trade, public health), on the flexibilities available in the Agreement on Trade Related Aspects of Intellectual Property Rights (TRIPS) of the World Trade Organization to promote access to medicines.
Correa, Carlos M. (editor) , Hilty, Reto M. (editor)
Health technology innovation in low- and middle-income countries (LMICs), including countries in Africa, falls far short of meeting the healthcare needs of these settings. The result is a heavy reliance on products and technologies imported from industrialised countries that are often not suited to, or sustainable for, LMICs. Appropriate healthcare products for LMICs are best developed in these countries, where local knowledge and understanding of needs, context and available resources may be incorporated into designs and implementation plans. The objectives for enabling health technology development in LMICs include: 1) expanding the base of expertise through research training programmes with a problem-solving focus; 2) stimulating new knowledge, approaches and solutions by enabling innovation; and 3) integrating research communities within and across institutions to build critical mass.
Introduction to Neuroscience is designed for undergraduate students enrolled in introductory neuroscience courses. This book specifically targets students enrolled in Introduction to Neuroscience 1 and Introduction to Neuroscience 2 at Michigan State University and primarily contains topics covered in those courses. This first edition will guide students through the structure and function of nervous system cells and nervous system structures, signaling within the nervous system, and introduce various sensory systems.
Mental Health is a Verb: A Pocket Guide to Mental Health for Nursing Students
MENTAL HEALTH IS A VERB is an Open Education Resource written by Jake Bush, Ph.D., RN, CNE and Jill Van Der Like, DNP, MSN, RNC through University of West Florida which addresses mental health nursing care. The book reviews the foundations of mental health, phsychopharmacology, and the most common mental health diagnoses.
This textbook is an open educational resource (OER) with CC-BY licensing aligned with Wisconsin Technical College System’s Nursing Assistant program (30-543-300). The Nursing Assistant program prepares students for employment as nursing assistants as well as for entry to other health-related programs. It is recognized by the Wisconsin Department of Health Services as a nurse aide training program. Upon successful completion of a Nursing Assistant program, the student is eligible to take the Wisconsin Nursing Assistant competency evaluation for inclusion on the Wisconsin Nurse Aide Registry and employment in nursing homes, hospitals, home health agencies, hospices, community based residential facilities, assisted living centers, and homes for the developmentally disabled.
21st Century Media and Female Mental Health
This open access book examines the conversations around gendered mental health in contemporary Western media culture. While early 21st century-media was marked by a distinct focus on happiness, productivity and success, during the 2010s negative feelings and discussions around mental health have become increasingly common in that same media landscape. This book traces this turn to sadness in women’s media culture and shows that it emerged indirectly as a result of a culture overtly focused on happiness. By tracing the coverage of mental health issues in magazines, among female celebrities, and on social media this book shows how an increasingly intimate media environment has made way for a profitable vulnerability, that takes the shape of marketable and brand-friendly mental illness awareness that strengthens the authenticity of those who embrace it.
A Practical Guide on Behaviour Change Support for Self-Managing Chronic Disease
This open access book is a valuable resource for students in health and other professions and practicing professionals interested in supporting effective change in self-management behaviors in chronic disease, such as medication taking, physical activity and healthy eating. Developed under the auspices of the Train4Health project, funded by the Erasmus+ program of the European Union, the book contains six chapters written by international contributors from different disciplines. Chapter one introduces the competencies necessary for delivering effective behavior change support, based on an established program of work, and related learning outcomes.
Guerreiro, Mara Pereira, Brito Félix, Isa . Moreira Marques, Marta
The introduction of permanent cardiac pacing in the late 1950s began the era of cardiac electrotherapy. In the 1980s, implantable cardioverter defibrillators (ICDs) were introduced. These advances created new challenges for cardiac implantable electronic devices (CIEDs). Right ventricular pacing was the primary breakthrough; however, over the years, it has become apparent that it can induce cardiac contraction dyssynchrony. Biventricular pacing allowed for the alleviation of dyssynchrony and improved the survival of patients with heart failure and bundle branch block. In recent decades, His bundle pacing has become a new strategy for physiological ventricular activation.
Lewicka, Ewa (editor) , Dąbrowska-Kugacka, Alicja (editor), Liżewska-Springer, Aleksandra
Leading Change in Health Systems: Strategies for RN-BSN Students
Leading Change in Health Systems: Strategies for RN-BSN Students is designed for practicing nurses pursuing a Bachelor of Science in Nursing. This book is focused on building upon previous knowledge, skills and attitudes Registered Nurses (RNs) related to leadership in healthcare systems. Readers will be able to apply the theoretical knowledge gained from this course in their clinical practice environment.
Anatomy and Physiology Laboratory Manual for Nursing and Allied Health
Authors’ Institution: Norfolk State University, Norfolk, VA, USA , Funding: Virtual Library of Virginia (VIVA) Course Redesign Grant, 2020 – 2023
Marz, Kamatchi, D'Silva, Prabhakaran, Chandra, and Isekeije
Nursing Management and Professional Concepts
This book introduces concepts related to nursing leadership and management, prioritization strategies, delegation and supervision, legal implications of nursing practice, ethical nursing practice, collaboration within the interprofessional team, health care economics, quality and evidencebased practice, advocacy, preparation for the RN role, and the avoidance of burnout with self-care. Several online, interactive learning activities are included in each chapter that encourage application of content to patientcare situations. Additionally, the Appendix includes a “suite of patients” with suggested prompts for classroom discussion to assist students in applying concepts from the book to real patient-care situations
This textbook is an open educational resource with CC-BY licensing developed specifically for prelicensure nursing students. The e-book and downloadable versions are free. Affordable print versions are published in collaboration with XanEdu and available on Amazon and in college bookstores. Content is based on the Wisconsin Technical College System (WTCS) statewide nursing curriculum for the Nursing Advanced Skills course (543-112) and the NCLEX-RN Test Plan.
This open access book examines the conversations around gendered mental health in contemporary Western media culture. While early 21st century-media was marked by a distinct focus on happiness, productivity and success, during the 2010s negative feelings and discussions around mental health have become increasingly common in that same media landscape. This book traces this turn to sadness in women’s media culture and shows that it emerged indirectly as a result of a culture overtly focused on happiness.
A History of Genomics across Species, Communities and Projects
This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation.
Thumbnail Advancing the Science of Cancer in Latinos
This open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos.
All-Optical Methods to Study Neuronal Function
This open access volume provides an overview of the latest methods used to study neuronal function with all-optical experimental approaches, where light is used for both stimulation and monitoring of neuronal activity. The chapters in this book cover topics over a broad range, from fundamental background information in both physiology and optics in the context of all-optical neurophysiology experiments, to the design principles and hardware implementation of optical methods used for photoactivation and imaging. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Medicine Creek (Faulk County-Spink County, S.D.)
This open access book describes the latest advances in the anal incontinence diagnostic and therapeutic processes. Anal incontinence is a devastating condition heavily impacting on the patients’ lives. Those suffering from this disorder are generally very embarrassed and reluctant to undergo an appropriate clinical evaluation, thus becoming more isolated and worsening the quality of their life.
Docimo, Ludovico (editor), Brusciano, Luigi (editor)
Faith Community Nursing ; An International Specialty Practice Changing the Understanding of Health
This book is the work of many. The contributors, each with their own rich experiences in the practice and ministry of faith community nursing, have generously taken the time to work with the editors in making this book a reality. The chapter authors have all practiced or continue to contribute to the specialty of faith community nursing.
P. Ann Solari-Twadell , Deborah Jean Ziebarth,. Editors
The population of the United Kingdom is projected to increase by 4.9 million from an estimated 62.3 million in 2010 to 67.2 million over the 10-year period to 2020. Projected natural increase (more births than deaths) will account for 56% of the projected increase over the next decade, resulting in an overall UK population increase to 73.2 million over the 25-year period to mid-2035. The population is also projected to continue ageing with the average (median) age rising from 39.7 years in 2010 to 39.9 years in 2020 and 42.2 by 2035 (Office for National Statistics 2011).
In A history of Population Health Johan P. Mackenbach offers a comparative study of trends in 40 specific diseases in Europe and their explanation, focusing on the causes of the spectacular improvements in people’s health since the early 18th century. ; Readership: Health care professionals with an interest in medical history, students and scientists in public health, economics, sociology, and related disciplines, and anyone interested in the history of health and disease.
Ramirez, Amelie G. (editor) Trapido, Edward J. (editor)
Ageing in Times of the COVID-19 Pandemic
This Open Access Book contains reports on the situation of people in the second half of life during the first year of the Covid-19 pandemic. The analyses are based on the German Ageing Survey (DEAS) and they provide insights on four main areas of life: income and work, subjective health and well-being, social support and loneliness as well as societal participation. This book is useful for scientists as well as political actors by directing attention to the risk groups that have been hard hit by the pandemic while also highlighting the resilience and adaptive capacities of many people in the second half of life.
Simonson, Julia (editor) Wünsche, Jenna (editor) Tesch-Römer, Clemens (editor)
Biomedical Engineering Lab Manual Volume 2
The lab manual was written as the second installment that coincides with two lab courses taught at the University of Oklahoma (BME3171, BME3181). These courses are designed to provide Biomedical Engineering students with lab skills and experience in biomedical engineering research and clinical techniques. This manual is used with BME3181 Biomedical Engineering Lab 2 and the following wet lab topics are covered in this lab manual; bioimaging, cell culture, tissue engineering, live-dead and DNA assays.
Biomedical Engineering Lab Manual Volume 1
The lab manual was written as the first installment that coincides with two lab courses taught at the University of Oklahoma (BME3171, BME3181). These courses are designed to provide Biomedical Engineering students with lab skills and experience in biomedical engineering research and clinical techniques. This manual is used with BME3171 Lab 1 and the following topics are covered in this lab manual; functional human models, musculoskeletal lever systems, bioimaging (ultrasound), bioelectricity (electromyography), & uni-axial testing
Precision Nutrition and Advanced Culinary Medicine
This electronic textbook (eBook) accompanies NS801, Precision Nutrition and Advanced Culinary Medicine, a 1-credit, 8-week online medical elective course for the University of Kentucky College of Medicine Office of Medical Education. The eBook provides module-based background information including text, tables, and figures to support each module of the online course
General Inpatient Management of Pediatric Diabetes Mellitus at University of Iowa Stead Family Children's Hospital
This eBook is a medical education resource intended to supplement the knowledge, skills, and attitudes of medical students and pediatric residents in furthering their own knowledge about the general inpatient management of pediatric diabetes mellitus. This book may be of further use to any physician, advanced practitioners, or nurses who may also encounter pediatric patients with diabetes mellitus in the inpatient hospital setting. This book is specific to protocols and preferences for pediatric diabetes management at the University of Iowa Stead Family Children's Hospital. However, it also contains overarching concepts that transcend location wherever pediatric diabetes may be managed.
Creating a circular healthcare economy: Sustainable strategies for a circular healthcare
Our world is the only planet, as far as we know, which harbors life. The number of humans on our planet has grown tremendously in recent centuries. In 1800 one billion humans occupied our earth; on 15 November 2022, this number reached 8 billion. A result of this growth, the emissions of carbon dioxide (CO2), the primary greenhouse gas emitted by human activities, drastically increased. The increased concentrations of greenhouse gases in our atmosphere foster the long-term increase of our earth’s temperatures, also referred to as global warming.
Bart van Straten, Letizia Alvino, Tim Horeman
Community interventions in obesity-related chronic diseases
The rate of obesity continues to climb in the United States in all age groups. National reports, including the Trust for America’s Health annual report State of Obesity: Better Policies for a Healthier America, highlight key findings and policy recommendations. The need to continue to work towards stabilization of the obesity epidemic could not be more important as consequences of this chronic disease can be dire, potentially affecting physical health with an increase in risk for chronic diseases including cardiovascular disease, type 2 diabetes and several types of cancer as well as potentially affecting behavioral health.
Sherri M. Cirignano, Sara A. Elnakib, Karen Ensle. et al
Case Studies for Health, Research and Practice in Australia and New Zealand
The OER includes case studies of 5 families from a variety of backgrounds in metropolitan and regional Queensland (QLD), New South Wales (NSW), and Victoria (VIC), Australia. Case studies have been popular in nursing to help students bring their learning to life and enhance their critical thinking. However, often case studies appear in one unit or one particular content area to aid students learning for a particular condition or point in time.
Council of Australian University Librarians
A Practical Guide for Pediatric Nuclear Medicine
This open access book will provide a foundation for the understanding of, and knowledge for a successful routine use of diagnostic Nuclear Medicine procedures in children through expertise and cases provided by representative busy pediatric nuclear medicine facilities. The book highlights important aspects of nuclear medicine in children and the differences between adult and pediatric practice where relevant. An introductory chapter provides general information detailing the advantages and limitations for performing nuclear medicine tests in children, as well as suggestions on how to approach and provide relevant data to the patients, their parents or next of kin. In the remaining 11 chapters, containing over 115 cases of children evaluated for various clinical indications, procedures are presented and subsequently detailed according to their clinical significance or prevalence based on the clinical experience of the contributors.
Bar-Sever, Zvi (editor) Giammarile, Francesco (editor) Israel, Ora (editor) Nadel, Helen (editor)
Epidemiology is an openly licensed text designed for medical degree–seeking clinical students without a prior background in public health. Using sports medicine and injury prevention examples and applications, it aims to provide students with the basics of epidemiology terms and concepts and is intended to guide medical school students as they prepare for the USMLE Step 1 Exam and to transition from student to clinician. It includes an introduction to general concepts and terminology of epidemiology, study designs and their relationship to clinical questions, and the use of epidemiology in clinical diagnosis and screening of disease. Concluding sections of the book present sources of errors in epidemiologic studies, including bias, confounding, and effect modification.
Stress is a feeling you get when faced with a challenge. In small doses, stress can be good for you because it makes you more alert and gives you a burst of energy. For instance, if you start to cross the street and see a car about to run you over, that jolt you feel helps you to jump out of the way before you get hit. But feeling stressed for a long time can take a toll on your mental and physical health. Even though it may seem hard to find ways to de-stress with all the things you have to do, it’s important to find those ways. Your health depends on it.
Social Determinants of Health in Nursing Education: Integrating Into Curriculum and Practice
This workbook was established with nurse educators and nursing students in mind to provide knowledge, guidance, and support for integrating SDOH across the nursing education spectrum. Contents from this workbook are applicable to pre-licensure baccalaureate nursing programs, RN-to-BSN programs, and graduate education. A strategic approach for this workbook was purposefully designed to meet the structure of the National Council of State Boards of Nursing (NCSBN) Clinical Judgment Measure Model® with a combined focus on the four spheres of care supported by the American Association of Colleges of Nursing (AACN®).
This open textbook is designed to provide a deep understanding of the biological and biomedical aspects of human reproduction, covering a wide range of topics from basic reproductive biology to clinical applications. The book starts with foundational knowledge and progresses to more advanced topics while also including real-world clinical orientation for practical contexts.
Drug Use and Misuse: A Community Health Perspective
Drug Use and Misuse: A Community Health Perspective provides students with an introduction to the biological, psychological, and legal aspects of drug use and misuse through the lens of community health and discusses the impact of drug use and misuse on community health. The book contains eight distinct chapters addressing the background of drug use and misuse, including key terms, as well as an introduction to different categories of drugs including gateway drugs, opioids, and prescription drugs, and a conclusion that describes evidence-based prevention and treatment models.
Inclusive Approach to Anthropometric Body Measurement Assessments
Inclusive Approach to Anthropometric Body Measurement Assessments” is an open educational resource (OER) created for undergraduate nursing students at the introductory level. The resource introduces students to body measurements, but does so in an inclusive manner. This resource is a unique contribution to nursing education as content is theoretically informed by an inclusive approach to assessment that incorporates culturallyresponsive techniques related to race/ethnicity, gender/sex/ sexual orientation, body sizes/types, and ability/disability.
Shelly Philip LaForest, Michelle Hughes, Lisa Seto Nielsen
This compilation gathers OER sources on body weight, nutrition, and movement, and it also problematizes the cultural meaning of these readings. Roughly, this anthology is divided into two parts--informational and theoretical--in depicting how medical research and journalism influence and are influenced by social stereotypes, constructed ideas about bodies, food, and individual choices within social systems.
The structure of the human body is usually considered in courses in gross anatomy. These courses typically consist of lectures by the faculty, readings in assigned textbooks and the study of photographs and illustrations in human anatomy atlases. However, as student’s progress through the curriculum and move into the more clinical or practice oriented phases, many discover that the anatomical knowledge they actually need is somewhat different from the kind they possess. What many encounter is difficulty in applying their knowledge to a clinical setting
The United States has been at the forefront of globalized health care for many years by influencing international healthcare policy and establishing international healthcare agencies to address global health threats such as HIV/AIDS, tuberculosis, and malaria. It has also been a leader in medical innovation and technology over the past two decades, a time of many changes in the world of healthcare. Due to these changes, the rules, regulations, and legislation are also constantly changing, making healthcare compliance a challenge. This chapter will discuss the rise of U.S. healthcare on the global stage, define healthcare compliance, and discuss penalties for noncompliance.
Healthcare in the United States: Navigating the Basics of a Complex System
This book is a collaborative effort among three faculty members from the Darton College of Health Professions, Nursing Department, at Albany State University, a Historically Black College and University (HBCU), and part of the UniversitySystem of Georgia. The book idea originated from a grant-funded program to create open education resources (OER) for students learning in UniversitySystem of Georgia’s eMajor courses. The cost of education in the United States is remarkably expensive, and the added burden of purchasing textbooks for each course can be prohibitive. The opportunity to create free educational materials has been a rewarding experience. A free pdf form of this text is available for download.
Deanna L. Howe, Andrea L. Dozier,Sheree O. Dickenson
Urban Health: A Practical Application for Clinical Based Learning
Urban Health: A Practical Application for Clinical Based Learning is an openly licensed, peer-reviewed textbook for clinical-based nursing educators covering barriers in urban health and their impact on patient health outcomes. The authors explore perspectives of urban communities, urban patients, and urban healthcare providers to offer insight into how healthcare providers can address disparities in urban healthcare, provide meaningful care with the lived experiences of urban patients in mind, and improve patient-provider communication by moving towards a more solution-driven, team-based care approach. Features include learning activities, exemplars, and case studies.
Cynthera McNeill, Umeika Stephens, Tara Walker
Foundations of Biomedical Science: Quantitative Literacy: Theory and Problems
Foundations of Biomedical Science: Quantitative Literacy Theory and Problems is designed to help students develop the fundamental mathematical and quantitative literacy required to navigate and interpret evidence-based Biomedical data. This will provide students with the skills and confidence to habitually question any quantitative data they come across and to use these skills to make informed judgements regarding their veracity
Introduction to Health (OER) - 2nd edition
The Introduction to Health OER Textbook provides a broad overview of information pertaining to human health and opportunities for improving health and wellness throughout life. The intended goal of the book is to equip the learners with important information needed to better understand their own health and how their daily choices may impact both their quantity and quality of life. Although this is a "health" textbook, it could actually be called a "life" textbook.
This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology.
Ultrasound Physics and its Application in Medicine
Ultrasound has a wide range of medical applications. Some of these include obstetrics (monitoring the progress of pregnancy), oncology (monitoring the growth of tumors), cardiology (visualizing the heart function and physiology), biopsy (guiding needles in various procedures), and physiotherapy. For example, today, an estimated 60-70% of pregnant women in the United States undergo ultrasound examination during pregnancy. An estimated 250 million fetal ultrasound examinations are performed every year in the USA. In the last few decades, ultrasound technology has expanded to medical imaging in various other specialties: Anesthesiology, Critical Care, Emergency Medicine, General Pediatrics, Internal Medicine, Obstetrics and Gynecology (OB-GYN), Pediatric Emergency Medicine, Physiatry, Sports Medicine, and Surgery.
Hybrid Organic-Inorganic Materials Used to Improve the Environment and Human Health
The Special Issue of Crystals entitled “Hybrid Organic–Inorganic Materials Used to Improve the Environment and Human Health” resulted in the publication of 11 articles. This reprint focuses on theoretical and experimental research works providing new insights and practical findings on topics of real interest, such as catalytic processes, solar cells, and sensors. The interconnection between the two fields, environment and health, has led to original monographs on new ways and methods of reducing or monitoring pollution, which directly influences people's health. At the same time, organic–inorganic hybrid materials with luminescent properties with uses in various fields such as optical, medical, and food industry applications, which directly influence human health and condition, were addressed.
Fierascu, Radu Claudiu (editor), Raduly, Florentina Monica (editor)
Health Security Intelligence : Managing Emerging Threats and Risks in a Post-Covid World
The book takes a multi-disciplinary approach to explore the role national security intelligence agencies played in supporting national governments’ response to COVID-19. Spanning the ‘Five Eyes’ intelligence countries (UK, USA, Canada, Australia and New Zealand), this book offers the first cross-comparative analysis of what intelligence agencies need to focus on in responding more effectively to future emerging health and biological security threats risks and hazards post-COVID-19. The volume addresses three principal issues. First, it investigates what roles the Five Eyes intelligence communities played (along with other key stakeholders, such as public health agencies) in managing the COVID-19 pandemic. Second, it assesses the challenges of and lessons learnt from these intelligence communities’ engagement in managing aspects of the pandemic.
Fundamentals of Human Anatomy Laboratory Manual
This laboratory manual is meant to be used in a lab course that accompanies a college-level introductory human anatomy course. It covers the language of anatomy, cells and tissues, and the organ systems that comprise the human body. Multiple open textbooks were adapted to create this lab manual. Attribution for these sources are provided at the end of each chapter.
This manual is a guide for anatomy and physiology laboratory exercises. It includes dissection guidance with detailed images; instructions for physiology experiments including foundational content; and gross anatomy study guides for six body systems. Videos and tutorial links provide additional support.
Effective airway management is a cornerstone of emergency medicine, and timely intervention can be lifesaving. Healthcare providers must be prepared to assess, intervene, and manage the airway efficiently in a variety of emergency situations to optimize patient outcomes. This book provides valuable information about emergency airway management.
Aslanidis, Theodoros (editor), Darcy Alves Bersot, Carlos (editor)
This book highlights heat-related illness, and its better management and prevention. Medicine is a continuously advancing and progressive science, and healthcare providers constantly enhance their knowledge and develop their clinical management skills. Written by leading and experienced authors, the book addresses the need for a ready reference for emergency and acute care physicians, surgeons, and anesthesiologists, as well as intensive care teams. This book is written in a simplified, understandable language and hence is an equally useful resource for medical and paramedical healthcare providers.
According to the American Cancer Society, more than 1.6 million people will be diagnosed with cancer during this year. Outcomes have steadily risen over the last several decades with the advent of newer therapies. As outcomes have improved, more and more cancer patients are developing critical illness. In the not-too-distant past, patients with active malignancy were thought not appropriate for critical care services as decreased longevity related to the cancer suggested poor prognosis for intensive care utilization. More recently, evidence supports rapid activation of critical care services leading to improved outcomes in cancer patients. Moreover, just as sub-subspecialty critical care experience in trauma and neurosciences has proved beneficial, the emerging field of oncology critical care warrants specific attention.
Optimizing Population Health: Strategies for Advanced Level Nurses
This resource provides an overview of population health concepts along with health promotion strategies utilized by advanced practice nurses. Resources are intended to be exemplary, but not exhaustive and introduce the reader to strategies that can be practiced while in graduate school as well as in healthcare settings.
Over the past many years, new and novel antibiotics have been developed against resistant bacterial species, but their increased clinical usage has led to reduced bacterial susceptibility and increased bacterial resistance to these novel agents. When a new antibiotic is developed, bacterial species initially show susceptibility to the agent, but with the passage of time, as the use of the antibiotic increases, the bacterial species acquire resistance against the drug or even the drug class.
Ensuring the delivery of quality, accessible, affordable, and safe healthcare presents an ongoing complex challenge crucial to the progression and advancement of modern healthcare systems. In addition to providing the highest quality health care to patients, healthcare leadership and systems must also provide for the safety and security of healthcare providers throughout the entire, complex healthcare conglomerate, including pre-hospital providers, pharmacists, patient care technicians, radiological technicians, nurses, physical therapists, physician extenders, and physicians.
Philip N. Salen (editor) Stanislaw P. Stawicki (editor)
The current book, Global Health Security - Contemporary Considerations and Developments, represents a collective work of multiple authors from around the world, with an ultimate goal of providing the reader with a comprehensive exploration of critical issues shaping modern global health security, especially in the post-COVID-19 reality of today.
Allincia Michaud (editor) Stanislaw P. Stawicki (editor)
Despite enormous technical and scientific advances in medicine, neglected tropical diseases continue to be a major challenge in many regions of the world. As a result, the health systems of developing countries are overwhelmed by a double burden of disease, one represented by common health problems and another represented by these diseases.
Women’s Health Problems - A Global Perspective demonstrates the outcome of a considerable evolutionary search for the improved human condition. This edited volume thoroughly examines fundamental aspects of women`s health focusing on environmental, social, and age factors. Esteemed contributors from various disciplines present critical analyses and evidence-based insights on topics such as reproductive and sexual health, menstruation, women’s and maternal diseases, healthcare access, gender-based violence, and systemic inequalities.
Nursing - Trends and Developments brings together different, innovative, and challenging perspectives on the future of nursing. It includes eleven chapters that discuss innovation and technology, teaching and learning, and trends and development in nursing.
COVID-19 Pandemic as a Catalyst for Change – Consumer's Perspective
The COVID-19 pandemic has radically altered the functioning of modern societies and economies, causing a global crisis on an unprecedented scale. This book considers whether the end of the pandemic has marked a new beginning or a return to the pre-pandemic reality. It identifies diverse changes in consumer and organizational behavior during the pandemic, discussing both the negative and positive influences of the pandemic on consumers.
Barbara Kucharska Grzegorz Maciejewski et.al
Antimicrobial Use across Different Healthcare Settings, Countries and Specific Populations
Antimicrobial use is one of the main drivers of antimicrobial resistance (AMR), a crisis threatening modern medicine. To combat and reverse AMR, finding determinants of resistance development/antibiotic use, identifying the target points of interventions, and implementing antibiotic stewardship measures are crucial. This Special Issue disseminates a wide variety of research conducted by various study designs and diverse settings and populations.
Gyöngyvér Soós (editor) Ria Benkő (editor)
This book includes eight chapters that focus on various important aspects of dental prosthetics and implantology, such as modern materials choices, prosthetic management of teeth malposition, and novel approaches to restoration design.
Lavinia Cosmina Ardelean (editor) Laura Cristina Rusu (editor)
Burnout is a relatively common yet poorly understood phenomenon that often results from relentlessly giving of oneself in the service of others. It has also been known to occur in non-human service work. When this giving of oneself becomes excessive, dysfunctional consequences can develop, such as emotional exhaustion, cynicism, depression, and withdrawal. A range of physical consequences can also develop, including high blood pressure, immune system depletion, and a wide range of physical ailments. This book details our evolving knowledge of burnout syndrome and addresses a variety of proposed interventions.
The book Advances in Hematologic Malignancies presents new knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic, and genomic changes that have influenced the current outlook toward hematological malignancies.
This book highlights heat-related illness, and its better management and prevention. Medicine is a continuously advancing and progressive science, and healthcare providers constantly enhance their knowledge and develop their clinical management skills.
Rational Use of Intravenous Fluids in Critically Ill Patients
This open access book, published by Springer under the Open Access CC BY 4.0 Licence in collaboration with the International Fluid Academy (IFA, www.fluidacademy.org), explores rationalized intravenous fluid therapy for critically ill patients. Despite being commonly prescribed in inpatient settings, intravenous fluids are often administered without evidence-based guidelines, neglecting essential considerations such as the fact they are drugs, that need proper dosing, duration, indications, contraindications, side effects, and de-escalation.
Manu L.N.G Malbrain. (editor) Adrian Wong (editor)
This book has three sections that discuss selected topics on foreign bodies in the ear, nose, and aerodigestive tract in children and adults, which may be organic or inorganic, highlighting recent updates in diagnosis, complications, and management. Organic foreign bodies, unlike inorganic or inert ones, present early due to the more inflammatory response at the site of impaction. For the aerodigestive foreign bodies, the cricopharyngeus is the narrowest part of the airway among the pediatric group with high risks of airway foreign body impaction.
Human Anatomy and Physiology Laboratory Manual: Understanding How Structure Determines Function
This lab manual introduces students to Human Anatomy and Physiology concepts. The laboratory exercises contain applied activities and experiments to help students visualize anatomical structures and relate them to specific functions and the complex physiological events that allow us to maintain homeostasis.
eep is undoubtedly one of the most intricate and abstruse issues in humans. Disturbances of sleep are widespread and can have a great impact on involved individuals as well as an economic influence on society. The COVID-19 pandemic forced predominant changes in recent years, such as the development of wearable devices and the Internet of Things (IoT) in telehealth. These are helpful for disease evaluation and treatment, however, they may not be adequate for dealing with the complexity of sleep medicine.
Community and Public Health Nursing: A Call to Action
Community and Public Health Nursing: A Call to Action is a primer exploring the diverse roles of community and public health nurses through a social justice lens. Students will gain the fundamental knowledge and skills to work with community members and other stakeholders to promote health and well-being and to prevent disease. This textbook examines key issues such as health disparities, access to care, cultural competence, and the impact of social determinants on public health outcomes. Students will gain knowledge, practical skills, and insight into how nurses can improve community health, advocate for health-related policies, and promote health equity at the individual through systemic levels. The textbook also maps the content to the AACN New Essentials for Baccalaureate Nursing Education.
Felisa Smith, Gretchen Wiersma, Jamela M. Martin, Judith Rogers Fruiterman, Roy Brown,
A Pragmatic Approach to Conceptualization of Health and Disease
Schermer, Maartje (editor), Binney, Nicholas (editor)
A Literary History of Medicine by the Syrian physician Ibn Abī Uṣaybiʿah (d. 1270) is the earliest comprehensive history of medicine. It contains biographies of over 432 physicians, ranging from the ancient Greeks to the author’s contemporaries, describing their training and practice, often as court physicians, and listing their medical works; all this interlaced with poems and anecdotes.
Geert Jan Gelder (editor) Emilie Savage-Smith(editor)
Evolving Therapies and Technologies in Extracorporeal Membrane Oxygenation
Over the past 20 years, coinciding with the global H1H1 influenza and COVID-19 pandemics, there has been an exponential increase in the application of Extracorporeal Membrane Oxygenation (ECMO) therapies for acute cardiac and/or respiratory failure. Not only has the number of patients supported with ECMO increased substantially but so has the number of centers offering such technologies and the types of clinical problems successfully managed with ECMO.
Pearls in Biological and Molecular Tissue Repair Pathways
The field of biological and molecular tissue repair, regeneration, and wound healing techniques and treatment strategies is a promising and continually developing area of advanced healthcare activities. There is an unmet need to treat complex pathological tissue conditions, like chronic wounds and traumatized and degenerative tissue structures, in a multidisciplinary fashion at the point of care.
Peter A. Everts (editor) Robert W. Alexander (editor)
Printable study companion aligned with Medical Terminology, an open educational resource that focuses on breaking down medical terms into their word parts, pronouncing medical terms, and learning the meaning of medical terms. This resource is targeted for health services students in the first year of their college programs.
Tertiary care requires highly specialized doctors, medical experts, and equipment to care for serious or life-threatening illnesses in tertiary-level hospitals or similar specific centers. This book provides a comprehensive overview of tertiary health care, including case examples. Chapters address such topics as tertiary care in India, psychosocial care, treatment services in tertiary care, and much more.
Enabling and Optimising Recovery from COVID-19
This textbook provides readers with up to date knowledge about the assessment, management and support of people experiencing Long COVID. Learning activities draw upon personas co-authored with people with Long COVID.
Danielle Hitch, Genevieve Pepin, Kelli Nicola-Richmond, Valerie Watchorn,
Health and development require one another: there can be no development without a critical mass of people who are sufficiently healthy, and people cannot be healthy without societal developments. 11 case studies from 9 countries on 3 continents since the late 19th century show how different actors have struggled to reconcile the nature of health and development policies, and the subordination of these policies to a range of political objectives.
Iris Borowy (editor), Bernard Harris (editor)
Disparities in Health-Risk Behaviors and Health
As they have become inherently ingrained in our society and societies worldwide, the noxious disparities in health-risk behaviors and health require far-reaching investigation, supporting greater uniformity across groups. The deep-seated nature of discrimination, stigmatization, and marginalization in our social structure means that the human rights and health of too many individuals suffer, while social injustice and inequity persist.
Celia C. Lo (editor), William Ash-Houchen (editor)
Improving Health Literacy for People with Low Literacy
Health literacy and low health literacy have received increased attention due to their association with poor understanding of health information, and consequently negative health outcomes. Although much research discusses health literacy and its role; there are gaps in explaining the relationship between health literacy and low literacy; as well as various determinants of health (i.e., social, cultural, political, etc.).
Nutritional Status and Interventions for Patients with Cancer
Cancer is one of the leading causes of morbidity and mortality worldwide. The World Cancer Research Fund determined that the diet and nutrition conditions of the individuals are modifiable risk factors in the development of several cancers and a predominant component in the recovery and effectiveness of the treatments. Nutritional intervention is critical, but nutritional support is not widely accessible to all individuals, leading to potential nutritional risk and nutrition wasting.
Annisa Triyanti (editor) Mochamad Indrawan (editor)
Nutritional Value of Meat and Meat Products and Their Role in Human Health
Meat and meat products are among the most nutrient-dense food sources in the human diet. They fulfill most of our bodily requirements, acting as important sources of energy and a variety of essential nutrients needed for metabolic functions. Meat and meat products may also contain non-nutritive components, such as sodium, saturated fat, nitrites, heterocyclic aromatic amines, and polycyclic aromatic hydrocarbons, which are associated with negative health-related outcomes.
Food Environment and Its Effects on Human Nutrition and Health
In addition to the proportions of foods we include in our diet, there are other conditioning factors that can affect the effects of these foods on human health. Thus, food contributions of bacteria, viruses, fungi, food additives, residues of chemical substances, or exoxomes can have an important effect on human health.
Mal-Nutrition documents how maternal health interventions in Guatemala are complicit in reproducing poverty. Policy makers speak about how a critical window of biological growth around the time of pregnancy—called the ""first 1,000 days of life""—determines health and wealth across the life course. They argue that fetal development is the key to global development.
Health Inequality - A Comprehensive Exploration is an insightful and significant work delving into the complex realm of health disparities and their multifaceted impact on society. This book skillfully bridges the gap between theoretical understanding and practical realities, presenting a holistic view of health inequality from various global perspectives.
Environmental Health Environmental factors
Authored by contributors from diverse backgrounds, this book compiles new evidence, methodologies, and perspectives to redefine the environmental health literacy paradigm, aiming to enhance the well-being of current and future generations. Explore critical topics, from the impact of plastics on child health to the significance of environmental studies on microplastic pollution.
Antimicrobial Resistance and Environmental Health
Environmental Health Environmental economics
This reprint comprises 11 articles addressing diverse aspects of the environmental dimension of AMR. It provides a comprehensive update on antimicrobial resistance and environmental health. One article reviewed the impact of tetracycline pollution on AMR in the environment and its ripple effect on ecological and human health.
Environmental Toxicology and Human Health
Humans and animals may be exposed on a continuous daily basis to a mixture of environmental contaminants that may cause adverse consequences. This Topic focuses on environmental pollutants including heavy metals, pesticides, nanoparticles, micro-nanoplastics, indoor air pollutants, pharmaceuticals, and industrial toxicants with effects on human health, risk assessment, and the relationship between various diseases and environmental pollutants.
Artificial Intelligence Advances for Medical Computer-Aided Diagnosis
This Special Issue, "Artificial Intelligence Advances for Medical Computer-Aided Diagnosis," explores the transformative role of AI and ML in modern diagnostics. Featuring contributions from leading researchers, this collection highlights innovative algorithms, models, and applications that enhance diagnostic accuracy, speed, and predictive power across various medical fields, including radiology, pathology, genomics, and personalized medicine.
Reconstructive Microsurgery: Challenges and New Perspectives
The subspecialty of reconstructive microsurgery utilizes microsurgical techniques to allow surgeons to operate on the smallest of structures, including vessels, lymphatics, and nerves. Traditionally, these procedures have been used by microsurgeons to reconstruct complex tissue defects through the use of free tissue transfer, which involves the transfer of tissue (free flaps) between distant anatomic sites on the body.
Implementation of Chemometrics and Other Techniques as Means of Authenticity and Traceability to Detect Adulteration in Foods for the Protection of Human Health
Authenticity and traceability are crucial in order to overcome frauds in the international food trade. Control measures are perceived as the greatest vulnerability in the food supply chain. In order to decrease contribution to the overall perceived fraud vulnerability, analytical approaches and chemometrics are usually employed.
Recent Clinical and Basic Research on Endocrine Surgery
Endocrine surgery pertains to surgery for thyroid, parathyroid, and adrenal diseases, and the role of surgical treatment is the most important aspect of patients’ care.
Current Status and Future Directions of Bone Trauma Surgery
The field of bone trauma surgery and bone regeneration is constantly evolving, driven by ongoing advancements in medical technology, surgical techniques, and a deeper understanding of the biological processes involved in bone healing and regeneration.
In order to be able to analyze and give proper advice on sport techniques, it is important to understand the biomechanical and physiological demands of different sports. In a coaching situation, feedback to the athlete should be given without too much delay.
Advances in Cardiac Electrophysiology and Pacing
Medicine and Nursing Cardiovascular medicine
Today, interventional treatment and clinical management of cardiac arrhythmias represent a continuous challenge. This is mainly due to the widening of indications for implantable electronic devices and for catheter ablation procedures as well as the continuous improvement of technologies and medical therapies.
Deep Learning for Pathology Detection and Diagnosis in Medical Imaging
Severe pathologies, such as the diffuse liver diseases or tumors, can lead to the significant degradation of the human health and sometimes to lethal stages. The most reliable methods for the diagnosis of these affections, such as the classical biopsy or surgery, are invasive and dangerous. Advanced computerized methods are urgently needed to reduce invasiveness and enhance the information derived from medical images as much as possible by unveiling their subtle aspects, conducting to a virtual biopsy.
Sergiu Nedevschi Delia-Alexandrina Mitrea
Clinical Diagnosis and Management of Pregnancy Complications
This reprint focuses on emerging trials related to pregnancy complications, including new diagnostic approaches for hypertensive disorders, gestational diabetes thresholds, and innovative management strategies for preterm birth and fetal growth restrictions.
Towards Sustainable Good Health and Well-being
The purpose of this open access book is threefold. The first is to shed light on patient participation and health literacy for Good Health and Well-being, which is one of the UN's Sustainable Development Goals. Health literacy is considered a prerequisite for patients to be able to participate in shared decisions on their own treatment (WHO,1998).
This innovative, open access volume explores the core characteristics of the halal industry through case studies of five East and Southeast Asian countries—Brunei Darussalam, Malaysia, Japan, Indonesia and China—representing both Muslim-majority and Muslim-minority societies. The contributors focus on some of the leading sectors of the Islamic economy, comprising food, finance, pharmaceuticals, and travel and tourism, in order to diagnose the challenges they face and the opportunities that present themselves.
This Special Issue focuses on feeding and feed technology advances and challenges in aquaculture. These are of particular interest since aquaculture and fisheries are considered crucial sources of animal protein in human diets, providing around 17% of global edible animal protein.
Bayesian Filter Design for Computational Medicine
This book serves as a tutorial that explains how different state estimators (Bayesian filters) can be built when all or part of the observations are binary. The book begins by briefly motivating the need for point process state estimation followed by an introduction to the overall approach, as well as some basic background material in statistics that are necessary for the equation derivations that are utilized in subsequent chapters.
Dilranjan S. Wickramasuriya Rose T. Faghih
Since the concept of evidence-based medicine was introduced into medical practice, a paradigm shift from conventional empirical-based physical therapy to evidence-based physical therapy has been promoted. In order to practice evidence-based physical therapy, the elements of "using evidence," "creating evidence," and "communicating evidence" are essential.
Effects of Physical Activity on Chronic Disease
This Special Issue focuses on the recent research on the effect of physical activity on chronic diseases, including COPD, other lung diseases, cognitive impairment, irritable bowel syndrome, and atherosclerosis . The associated factors, the evaluation methods, and the effective interventions were evaluated. Two review papers and eight original articles are included.
Healthcare Strategies for Patients with Chronic Diseases in an Ageing Society
The ageing of society has become a significant global issue, with over 30% of the population aged 65 and above in some developed countries. In this context, the required forms of healthcare and medical services are also evolving.
Psycho-Educational Assessments: Theory and Practice
Psycho-educational assessments, such as intelligence tests, cognitive test batteries and behavioral measures, serve as invaluable tools for school psychologists and educators. They provide profound insights into children's learning and behavioral profiles, enhancing our understanding of their academic and cognitive capacities.
The 2024 Special Issue of Inequality in Immunization collates 14 global research and review contributions that spotlight differences in the attainment of immunization coverage across population groups, capturing findings pertaining to various types of immunization (including COVID-19 and childhood immunization).
Ahmad Reza Hosseinpoor, Devaki Nambiar, et. al
This book focuses on health risks, a domain in which risk expansion has been particularly prolific. As a result of massive gains in scientific knowledge, made possible by statistical developments, data accumulation and computerisation over the last decades, more and more attention has been geared towards risks in the fields of public health and medicine.
Multidisciplinary Perspectives on Immigrant Health
This open access book analyses the ever-complex relationship between immigration and health in contemporary societies using the Spanish society as a case study. It addresses some of the main dimensions of migrant health in Spain, including migrant-specific vulnerability factors, health changes associated with time spent at the migratory destination, and differentiated problems of certain subpopulations of migrants.
The development of health and social care policy is crucial for ensuring the welfare of individuals and communities. It involves a complex interplay of political, economic, social, and ethical factors. It addresses the social determinants that impact health outcomes and seeks to promote equity in healthcare delivery. Health and social care policy aims to address inequalities and improve access to quality care for all individuals.
Public Health Palliative Care and Public Palliative Care Education
The collection on “Public Health Palliative Care (PHPC) and Public Palliative Care Education (PPCE)” highlights recent advances and challenges in PHPC and PPCE. The articles demonstrate the breadth and diversity of local responses from across the globe, including Europe, Asia, Australia and South America. The COVID-19 pandemic clearly shows how collaboration between healthcare services and communities is an essential component of public health.
In the age of Apple Watches and Fitbits, the concept of “health” emerges through an embodied experience of a digital health device or platform, not simply through the biomedical data it provides. Sensing Health: Bodies, Data, and Digital Health Technologies analyzes popular digital health technologies as aesthetic experiences to understand how these devices and platforms have impacted the way individuals perceive their bodies, behaviors, health, and well-being.
Physical Activity, Exercise Testing and Clinical Assessment in Sports Medicine
Physical activity and exercise testing are two key points in sports medicine. Sports medicine is a field of medicine concerned with the prevention and treatment of injuries and disorders that are related to participation in sports. Clinical assessment in sports medicine can solve many questions about diagnosis, treatment, and prognosis related to health in sports.
Sport Modalities, Performance and Health
Sport modalities are highly practiced in order to improve many aspects of human beings, including performance and health. The increasing interest in the quantitative and qualitative aspects of sport training is ascribable to the fact that several training systems and new methodologies are appearing in all sport modalities.
Diego Muñoz Marín José Alberto Frade Martins Parraca
Auditory and Phonetic Processes in Speech Perception
In the past two decades, great advancements have been made in phonetic, auditory, and psycholinguistic research on speech perception. As the fields have advanced, there has been increasing interdisciplinary collaboration between them, which has, in turn, revealed their interdependence.
The continuous demand for electronic devices operating at increasing current and power levels has driven research into wide-bandgap (WBG) semiconductors in recent decades. In particular, the 4H hexagonal polytype of silicon carbide (4H-SiC) is the most promising for use in power electronic applications in the medium- to high-voltage range.
Functional Biomaterials and Digital Technologies in Dentistry
The publication "Functional Biomaterials and Digital Technologies in Dentistry: From Bench to Bedside," featured in the Journal of Functional Biomaterials, signifies a pivotal advancement in dental and maxillofacial healthcare. It underscores groundbreaking innovations in the field of biomaterials, including the use of metals, polymers, and composites, alongside the revolutionary role of digital technologies such as computer-aided imaging (CAI), design (CAD), and manufacturing (CAM) in dentistry.
Influence of Domestic Violence on Mental Health
Domestic violence (also referred to as family or intimate partner violence) is a public health problem that continues to affect the lives of individuals of all backgrounds, with women and children being the most common victims of acts of physical, psychological, and sexual violence. Longstanding research has recognized the mental health sequelae of domestic violence and the potential role of social, economic, and environmental factors.
New Perspectives in Oral Health for Patients with Special Needs and Compromised Older Adults
This Special Issue was designed to provide a multifaceted look at the latest clinical and research findings in the field of geriatric dentistry, which has rapidly gained importance since the beginning of the 21st century. It covers oral frailty, rapid oral health deterioration (ROHD), and oral hypofunction syndrome as comprehensive disease concepts related to the oral health of older people, explains their causes, and introduces the latest technology for diagnosing the deterioration of the oral environment and of oral function.
Takahiro Ono, Leonardo Marchini, Anastassia E. Kossioni
Protection and Prevention Approaches in Occupational Health and Safety
Developments in working life have also brought about occupational health and safety (OHS) problems. While the development of technology and protective equipment has created a safer working environment over time, new risks that pose a danger have also emerged. OHS aims to prevent the deterioration of employees' health in all occupational groups, protect employees from the hazards and risks in the environment, and provide environments that will allow individuals to continue to work at the highest level physiologically and spiritually.
The aim of this Special Issue is to provide a broad view on the studies that focus on the anatomical field, and to stimulate a holistic and humanistic perspective, taking into account the innumerous connections between the history of anatomy and the recent advances of this discipline. Multidisciplinary approaches related to anatomy include historical aspects, morphological techniques, anatomical education, and comparative and veterinary anatomy.
Medicine and Nursing Public health - Medicine
Digital pathology workflow implementation remains challenging. In laboratories worldwide, there are growing examples of successful implementation and pathologists acknowledging the advantages of this new model of practicing pathology. This Special Issue of Diagnostics is a collection of records of successful digital pathology implementation for primary diagnosis or secondary applications, that serve as an inspiration to those readers who are still skeptical about it.
This heavily revised open access edition provides a thorough overview of the technologies available to assemble, manage and assess the quality of health information systems. It details a variety of scenarios in the context of both health and heath care, including where prevention and wellness are related, such as the treatment of both acute and chronic diseases.
Alfred Winter, Elske Ammenwerth, Medical equipment and techniques
Leadership and Governance in Primary Healthcare
Good leadership and governance at all levels of the healthcare system is necessary for better performance of the system and health outcomes. Lack of good leadership and governance practices can lead to misuse of health system inputs such as human resources, health commodities and financial resources hence lowering the quality of services delivered. Thus, this guide was developed through collaborative efforts envisioned to respond to the needs of improving good governance practices at the primary healthcare level in resource-limited healthcare systems.
Mackfallen G. Anasel, Ntuli A. Kapologwe, Albino Kalolo
Food quality, including dietary quality and diversity, is as essential to human health as air is to human life. In addition, other healthy lifestyle factors, including a healthy body mass index, regular exercise, no smoking, and sufficient sleep duration, are associated with a lower incidence of chronic non-communicable diseases and longer life expectancy. More importantly, maternal healthy lifestyle factors are also associated with a substantially reduced risk of chronic diseases in their offspring.
Public Health and International Economic Law
Public Health - Medicine Public International law
Available open access digitally under CC-BY-NC-ND licence. Although non-communicable diseases (NCDs) such as cancers, diabetes, and heart diseases are preventable, they have risen dramatically over the last 30 years. This is in part due to increased international trade and foreign direct investment in the tobacco, alcohol and food industries. As governments attempt to regulate these industries, this book raises important and timely questions about the relationship between public health and international trade and investment law.
Focusing on the provision of gender-affirming care, Health Care Civil Rights analyzes the difficulties and potential of discrimination law in health care settings. The application of civil rights law could be a powerful response to health inequalities in the US, but conservative challenges and the complex and fragmented nature of our health care system have limited the real-world success of this strategy.
Artificial Intelligence in Healthcare: Current State and Future Perspectives
Public health and preventive medicine Artificial Intelligence
Artificial intelligence (AI), which is the simulation of human intelligence processes by machines, is having a growing impact on healthcare. Via AI, researchers can provide new approaches to merge, analyze, and process complex “big data” and gain more actionable insights, understanding, and knowledge at an individual and population level. Medical staff can be helped by AI-assisted clinical decision support (CDS), i.e., machine learning (ML) and deep learning (DL) models that analyze large medical datasets. They do this by summarizing radiology and pathology reports by means of natural language processing (NLP), automating repetitive but time-consuming tasks, and much more. Patients can talk to chatbots who have access to all medical knowledge in the world, including the patient’s medical history, and provide personalized advice. This Special Issue intends to show some examples of how AI impacts healthcare, with some discussion on potential future developments as well as challenges.
Diabetic Foot Complications: Current Challenges and Future Prospects—Part II
Diabetic foot is a growing complication due to the global increase in diabetes mellitus prevalence; this disease affects 9.1 to 26.1 million people annually, and between 19% and 34% of people develop diabetes at least once in their life. Diabetic foot is sometimes associated with lower limb amputations and higher rates of mortality than certain types of cancer, such as breast or prostate cancer. In recent years, research has focused on managing the main complications that lead to limb loss, such as diabetic foot infections or peripheral vascular disease.
José Luis Lázaro-Martínez, Luigi Uccioli
Dermatology: Advances on Pathophysiology and Therapies
This reprint presents a meticulous compilation of 11 cutting-edge articles from leading authors in the field of dermatology, originally featured in our previous manuscript. This collection illustrates the significant advancements and innovations that have shaped dermatological science and practice in recent years. Each article within this compendium delves into various aspects of dermatological advancements, ranging from the development of novel therapeutic approaches and understanding the genetic underpinnings of skin diseases to the exploration of new diagnostic tools and the integration of technology in dermatological care.
Montserrat Fernández-Guarino, Asunción Ballester-Martinez
Insights into Antibiotics in Human, Animal, and Agriculture: Resistance, Determinant, and Treatment
Mathematics and Science Biology Microbiology
This Special Issue assembles a set of fifteen articles, consisting of one review and fourteen research articles. The review by Liang S. and colleagues covers the application of bacteriophage therapy. The 14 research articles included (1) methodologies and techniques to detect AMR organisms, such as VRE by Saenhom N et al. and carbapenemase-producing Eterobacterales by Hatrongjit R. et al.; (2) characterization of AMR from patients, foods, and the environment, such as by Yinsai et al., Li R. et al., Kamal Hossain M., et al., Kansaen R., et al., Tabut et al., Lopes E.S. et al., and Kumar Rout A. et al., respectively; (3) antibiotics residue management approached, such as by Chokejaroenrat et al. and Sakulthaew et al., and (4) medical care of AMR patients and carriage, such as by Ngamprasertchai T et al.
Genetic, Epigenetic, Environmental, and Pharmacological Models for Neuroscience, Neurologic Diseases, and Psychiatric Disorders: Advancement in Bench-to-Bedside Translational Research
The Special Issue, "Genetic, Epigenetic, Environmental, and Pharmacological Models for Neuroscience, Neurologic Diseases, and Psychiatric Disorders: Advancement in Bench-to-Bedside Translational Research," delves into the complexities of neurological and psychiatric disorders, which affect millions worldwide. Despite advances, the etiology and pathogenesis of these disorders remain largely unknown, and current treatments often fall short or have adverse effects.
The field of infant nutrition and feeding has been a long-standing and permanent concern within the field of child health, given the crucial role it plays in the current and future health and development of individuals. Although optimal feeding practices are recognized to achieve greater well-being, growth, and child health, differences and gaps still persist. This book covers a variety of crucial topics related to infant nutrition and feeding, which have been grouped into four sections.
Dietary Patterns and Nutritional Value in Non-communicable Diseases
It is well known that the quality of human nutrition is fundamental to human health and affects the risk of non-communicable diseases (NCDs). The global food system has been dramatically changing in recent years, which results in negative consequences concerning the nutritional quality of foods, and consequently, the risk of NCDs. Therefore, the need for diagnostic tools to use in the evaluation of nutritional value and the improvement of nutrition counseling and disease prevention is more important than ever before.
Andriana Kaliora, Chara Tzavara, Charalampia Amerikanou
Medicine and Nursing Medical toxicology Drug Abuse
Over the last decades, interest in forensic toxicology has continually increased. Consequently, the discipline assumed a leading role, becoming one of the reference sciences for elucidating events of judicial importance. The need to reconcile analytical problems (e.g., relating to the qualitative/quantitative analysis of substances of abuse in complex biological matrices) with judicial requirements (i.e., providing data that can be used as documentary evidence in proceedings) makes the discipline unique among all "analytical" sciences.
Interactions between animals and plants exist on a spectrum that ranges from completely antagonistic relationships to those of obligatory mutualism, as seen in the pollination of certain tropical orchid species. In fact, these relationships are highly conditional and can change radically depending on variations in environmental conditions such as temperature, rainfall, and fluctuations in the populations of other interacting species.
Recent Advances in the Health Benefits of Tea
Alternative medicine - Therapetics Tea - Food
Tea is one of the most popular beverages in the world, and the second most consumed after water. Based on evidence from cellular, animal, epidemiological, and clinical studies, tea consumption has been linked to several health benefits, including cancer chemoprevention, chronic inflammation, heart and liver diseases, diabetes, and neurodegenerative disorders. This book provides an up-to-date critical view of the health benefits of tea, including its phytochemistry, traditional usage, current applications, and future directions for the development of tea compounds as effective medicinal agents.
This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies.
Young pediatric surgeons usually look for a comprehensive textbook updating their surgical knowledge and skills in a simple way. This is the idea behind the project of this series regarding pediatric surgical procedures. We try to update theoretical information, clinical decision-making, and surgical steps via chapters with many illustrations and figures that could guide the surgeon’s decisions and pave the way for competent training and skills improvement. In this Volume I, six chapters are included, starting with a general section covering general anaesthesia background for pediatric laparoscopic surgery.
Infections in surgery, commonly known as surgical site infections (SSIs), are complications that may occur after a surgical procedure. SSIs represent a serious problem leading to increased morbidity, mortality, and healthcare costs, highlighting the need for continued efforts to improve surgical practices and reduce their incidence.
Stefano Bartoli, Francesco Cortese, et. all
This book provides a comprehensive and up-to-date examination of appendicitis, a condition that continues to present challenges to medical professionals worldwide. It explores the latest developments in minimally invasive surgical techniques, non-surgical treatment options, and the emerging role of artificial intelligence in diagnosis and treatment. Readers are offered global insights into disparities in healthcare access, particularly in rural areas of developing countries, with personal accounts that illustrate the real-life experiences of patients. The book also takes a holistic approach to the diagnosis and management of appendicitis in both children and adults, offering a complete overview of this common surgical condition.
The caesarean section is a widely accepted surgical procedure, that is mainly used in complex cases. However, the significant increase in caesarean section rates especially in developed countries, causes several medical and socio-economic problems. The main role of this book project is the presentation of recent advances in caesarean section surgical technique, most common perioperative complications and appropriate measures in order to reduce unnecessary caesarean section procedures.
Antimicrobial Biomaterials: Recent Progress
Biomaterials can be used as implantable devices or drug delivery platforms with a significant influence on a patients’ quality of life. Indeed, every year a substantial number of new biomaterials and scaffolding systems are engineered and introduced in the biomedical field with increased potential for biomedical uses. However, their long-term use can be threatened by the adhesion and proliferation of microorganisms, which can interact and form biofilms, or the formation of fibrosis, with cytotoxic responses being very common.
Computational and Mathematical Methods for Neuroscience
This reprint immerses readers in the latest advancements in the computational and mathematical modeling of neural systems, with a focus on brain functionality. It explores foundational principles, established models, and emerging technologies that are shaping the future of computational neuroscience. By integrating theoretical foundations with empirical data, the approaches presented not only enhance our understanding of neural dynamics but also pave the way for transformative applications in clinical practice and therapeutic innovation.
The Future Health Workforce: Integrated Solutions and Models of Care
This edited collection brings together a diverse set of original research and review articles that contribute towards a unified objective of redesigning the future health workforce. Our fundamental premise is that the future health workforce needs to be more closely aligned to population needs and be able to address emerging challenges of the 21st century. • The collection includes 13 articles (11 original research; 2 review) from nine countries.
This reprint provides a rich and varied collection of articles reflecting the landscape of contemporary research and scholarship on chronic pain and its management. The collection includes reviews and primary research that challenge established beliefs and open new avenues for exploration. The collection has been edited by Mark I. Johnson, PhD, Professor of Pain and Analgesia, and Director of the Centre for Pain Research at Leeds Beckett University.
Food Pesticide Residues Monitoring and Health Risk Assessment
Pesticide residue and food safety problems have become concerns that need to be addressed all over the world. This reprint presents recent developments in pesticide residue monitoring and risk assessment in food and contains studies and reviews involving the pre-treatment of pesticide residues in food and detection methods for and the risk assessment of these residues.
Chromatographic Analysis of Pesticide in Environmental and Food
Humans are constantly engaged in struggles against competitors and diseases. One way to gain an advantage in many of those ecological interactions is through the use of pesticides. These substances are used to protect crop plants, livestock, domestic animals and people from damage and diseases caused by microorganisms, fungi, insects, rodents and other "pests,'' and to defend crops from competition with unwanted but abundant "weeds".
Pesticides - Agronomic Application and Environmental Impact is a seminal work that navigates the delicate balance between the indispensable role of pesticides in modern agriculture and the critical need for environmental preservation. In an era where food security and ecological sustainability are paramount, this book emerges as a beacon of knowledge and understanding. This volume encapsulates a comprehensive exploration of the world of pesticides, shedding light on their vital function in ensuring crop health and abundance.
Impact of Environmental Factors and Management Practices on Bee Health
This compilation of twenty-three original articles and a communication underscores the urgency of using interdisciplinary approaches to safeguard bee health and ecosystem sustainability. The published articles explore complex factors affecting health, emphasizing the global honeybee and pollinator populations crisis.
This book examines the importance of DNA molecules as fundamental genomic elements in different types of organisms. In recent years, a wide range of tools and techniques have become available to investigate the versatility of genomic variabilities, exchanges, and differentiations. This book presents data and information from population genetics and evolutionary biology, making it a useful resource for scientists worldwide.
Breeding Strategies for Healthy and Sustainable Development of Animal Husbandry
Healthy and sustainable animal husbandry is the goal of animal breeding. This book provides a detailed overview of applications of post-genome era techniques for livestock genetics and breeding. It also describes techniques for genetically selecting highly productive animals without producing large amounts of greenhouse gas emissions, community-based breeding programs for breeding rams and bucks, the response of bovine species to in vitro thermal stress stimulation, and the semen characteristics of wool-breed ram lamb-raised in conditions of high altitude. The book not only presents advanced animal genetic and breeding methods but also highlights useful, practical technology for animal breeding under specific climate, geographic, and environmental conditions.
Accounting for Social and Environmental Sustainability
Business strategy Development studies Environmental economics
For a company, managing its social and environmental performance is no longer just a matter of reducing its impact; it must also be able to assess its contribution to resolving or aggravating social and environmental problems. This book argues that the current work on accounting for sustainability has not yet given organisations a tool to integrate their performance within the planetary and social framework that conveys actual "planetary and social budgets", and that business organisations lack the possibility to go beyond incremental performance measurement.
The Role of Religion in Marriage and Family Life
The creation of this reprint was prompted by the creation of a section in the journal Religions, entitled "The Role of Religion in the Life of Marriage and Family". It contains several peer reviewed articles. The authors are specialists in various fields and denominations. All of them, in different ways, show the value of religion for individuals and the relationships they establish. Religion accompanies people of different ages and in different life situations. It is support for engaged couples, spouses, and parents in preparing for marriage, in raising children, as well as in experiencing difficult moments, such as mourning the death of a loved one and preparing for one's own death.
Basic Health Care in Family Medicine and Public Health
Although shaped primarily according to the economic and social structures of countries, basic health services aim to provide equal and accessible health services to everyone. While the public health discipline is involved in the planning and supervising of basic health services, the family medicine discipline is directly responsible for ensuring the implementation of these services. These disciplines must cooperate and coordinate to provide organized and effective basic health services.
Gender, Work and Family in Turbulent Times
This is an open access book. This book provides a distinctive perspective on the daily utilization and consumption of medicines and drugs. It seamlessly integrates the research traditions of the medical and pharmaceutical realms with the approach of fostering the relationship between users and products, a characteristic of design and user studies. By applying a diverse range of expertise, the authors endeavor to reestablish the interconnectedness of issues that place the drug and the indispensable information for its use directly into the hands of the patient.
Global Challenges in Cardiovascular Prevention in Populations with Low Socioeconomic Status
Cardiovascular Systems - Medicine Family medicine
Cardiovascular Prevention (CVP) has included important technological advances and determined improvements in morbidity and mortality since the last 70 and 60 years. However, in populations with socioeconomic limited resources even basic health preserving tools such as access to a primary care provider and basic drug therapy for diabetes mellitus, high blood pressure, and high cholesterol are not within the reach of many. This book, in contrast, will go precisely in the opposite direction, defining the most basic and known effective CVP tools applied in the largest segment of the world’s population.
Tomás Romero, Carolina Nazzal Nazal, Fernando Lanas
Surgery Gastroenterology Family medicine
This open access book offers a comprehensive review of hepatocellular carcinoma (HCC) with a particular focus on the pathobiology and clinical aspects of the disease, including diagnosis and treatment. HCC is becoming one of the most common causes of cancer-related death worldwide. It is the fifth most common malignancy in men and the ninth in women, with an estimated 500,000 to 1 million new cases annually around the world. Independent of its cause, cirrhosis is considered a major clinical and histopathological risk factor for HCC development.
This book presents the new advances and new perspectives of personalized medicine, emphasizing personalized, predictive medicine, personalized preventive medicine, personalized therapy, and personalized diagnosis/prognostic assessment. The research and practice of multiomics-based pattern biomarkers will significantly contribute to personalized medicine, including deeply addressing the accurate molecular mechanism, stratifying the patients, discovering effective biomarkers, and determining the effective therapeutic targets/drugs for patients to significantly benefit the patients and their families to reduce the medical cost and improve the life quality of patients.
Sexuality, Family Planning, and Reproduction
The history of sexuality, family planning, and reproduction in Central and Eastern Europe sounds out the historical dimensions across a broad field where human biology, medicine, policy, and government social programmes intersect with fundamental conceptions of desired or feared social developments. From contraception to representations of motherhood, and controversies over reproductive rights, using the example of the historically changing political, social, cultural and scientific interconnections in Central and Eastern Europe, the contributors to this volume invite reflections on historical developments that open new perspectives for the 21st century.
Fritz Dross, Birgit Nemec, Igor Kąkolewski
Dyslipidemia is an important risk factor for atherosclerotic cardiovascular disease (ASCVD). However, despite current traditional therapies (e.g., statins), significant residual risks for the onset of ASCVD remain, warranting the need to better understand newer therapeutic options for diminishing this prospect. This Special Issue will discuss state-of-the-art clinical trials and other research developments regarding newer and emerging therapies for the management of dyslipidemia to reduce the residual risks of ASCVD.
In this book, leading experts in the field of exercise medicine reveal the transformative impact of exercise/physical activity on health and well-being. From historical perspectives to the latest research, this comprehensive guide covers: • The evolution of exercise medicine: from ancient practices to modern therapies • The science behind exercise: understanding its physiological and psychological benefits • Lifestyle intervention strategies: promoting physical activity for health and disease prevention
Wellness, Fitness, Body Composition, Training and Performance Monitoring to Improve Athletes Life Quality
The present reprint presents information to update the state of the art in professional and recreational, male and female athletes of different sports (e.g., soccer, speed skating, triathlon, strength training, and pole dancing). Moreover, it addresses some gaps in the literature, such as immunological and hormonal responses, body composition effects, and well-being/wellness. Notwithstanding, this reprint contributes information to improve load monitoring practices (of training and competition) and quality of life through direct or indirect research.
Biomechanical Analysis in Physical Activity and Sports
This reprint, published by the Journal of Functional Morphology and Kinesiology, presents a comprehensive collection of research focused on the role of biomechanics in athletic performance. Featuring contributions from leading experts in the field, this reprint explores advanced biomechanical analysis techniques and their practical applications in sports and physical activity.
Meeting Challenges in the Diagnosis and Treatment of Glaucoma
Glaucoma is a progressive, multifactorial optic neurodegenerative disease that affects over 80 million patients worldwide. The disease’s insidious onset, combined with our reliance on subjective diagnostic tools, hinders early detection and timely intervention. Current treatments, while beneficial, often fail to provide consistent intraocular pressure control, and management is further complicated by variability in disease progression, non-adherence to therapy, socioeconomic challenges, complications from surgical interventions, and new risk factors.
Clinical Updates on the Aortic Aneurysm and Aortic Dissection
Aortic aneurysms and aortic dissections are potentially life-threatening conditions that require urgent attention. In recent years, a substantial amount of research has been conducted. Despite advances in diagnosis and treatment, there are significant treatment gaps that need to be addressed to save lives. One major gap is the early detection and diagnosis of aortic aneurysms, as they often present no symptoms until a catastrophic event occurs. Increased awareness and effective screening programs are crucial to identify at-risk individuals.
Healthy Eating in Relation to National Dietary Guidelines
National dietary guidelines provide a set of principles to guide decisions about healthy diet and lifestyle. They should be informed by scientific evidence and country-specific public health and nutrition priorities, as well as sociocultural and contextual factors. Dietary guidelines commonly propose a set of recommendations related to the consumption of individual foods and/or food groups in sufficient quantities to meet nutrient intake requirements based on life stage and sex, for both health promotion and chronic disease prevention.
Biology of T Cells in Health and Disease
More than half a century of groundbreaking discoveries in the field of immunology have been made, and no cells have shown more potential than the lymphocytes known as T cells.This book aims to foster collaboration between world-class bench scientists and clinicians in the fields of immunology, pathology, and oncology as they come together to highlight the complexity and diversity of T cells as well as their contributions to our immune homeostasis and overall health and to discuss the revolutionary therapeutic applications of T cells in fighting infectious diseases, autoimmunity, and malignant neoplasms.
This book offers remarkable coverage of innate immunity from its molecular basis to its crucial role in controlling infectious diseases, inflammation and cancer. It provides an updated and novel approach to innate immunity and how it controls infection, inflammation and cancer. To ensure the high quality of this book, important insights are included, and the book is rigorously and authentically discussed. This book discusses relevant immunological processes for establishing antibiotic resistance, inflammation, and cancer.
Ankylosing Spondylitis - Recent Concepts provides a comprehensive overview of ankylosing spondylitis (AS). It includes five chapters organized into two sections. The first section is dedicated to the history of AS, the chronology of diagnostic/classification criteria across the years, and imaging in AS. The second section examines the molecular genetics, immunology, enteric microbiome, and pharmacologic and nonpharmacologic treatment of AS.
Systemic lupus erythematosus (SLE) is a complex autoimmune condition characterized by various interacting susceptibility factors. Significant progress has been made in understanding the mechanisms that underlie its pathogenesis, as well as in identifying diagnostic markers. This advancement has led to the development of targeted therapies and alternative treatment options. The future management of SLE lies in molecular and personalized medicine, aiming to create high-quality treatments tailored to individual patients. This book on lupus offers a comprehensive analysis of the current status and future prospects of SLE diagnostics, along with recent developments in the field.
New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications
Diabetes mellitus is a major health problem globally, with an ascendant trend, and is expected to reach up to 700 million cases by 2045. The microvascular triad includes diabetic retinopathy, nephropathy, and neuropathy, unique in diabetes. Despite significant achievements in early diagnosis and therapy, diabetic retinopathy remains the leading cause of blindness in the working-age population, with a severe impact on patients' quality of life.
Diabetes is a leading global health problem. Long-term diabetes-associated complications include nephropathy, neuropathy, and retinopathy. Diabetic retinopathy (DR) is a disease that damages the tiny blood vessels in the retina and is a leading cause of blindness among diabetic adults worldwide. Despite extensive laboratory and clinical investigations, the fundamental root cause of vision loss due to diabetes remains uncertain.
Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights, Mechanisms, and Pharmacotherapies
Cardiovascular diseases (CVD) are the leading causes of mortality in patients with diabetes, and many factors, including hypertension, contribute to this high prevalence of CVD. The current evidence regarding these diseases is quickly expanding, especially in the vascular mechanisms that predispose someone to both conditions. Furthermore, several novel therapies, such as sodium glucose co-transporter 2 inhibitors, have recently beenshown to have benefits against CVD in patients with type 2 diabetes.
Sex and gender can affect the incidence, prevalence, symptoms, course and response to drug therapy in many illnesses, with sex (the biological side) and gender (the social‒cultural one) being variously interconnected. During the two days of the meeting "Gender Differences in Diabetic Disease" held in Olbia, Italy, on 4 and 5 December 2020, we discussed the various medical, social, ethnic, psychological and anthropological aspects of gender differences to build as broad a picture as possible of how these differences are present and evident in diabetic disease.
Advances in Clinical Diabetes, Obesity, and Metabolic Diseases
This reprint is a collection of peer-reviewed articles originally published in the Special Issue "Advances in Clinical Diabetes, Obesity, and Metabolic Diseases" in Medicina. It explores recent developments in the diagnosis, treatment, and management of metabolic disorders, highlighting the role of novel pharmacological agents, real-world data, and clinical strategies. This reprint serves as a valuable reference for endocrinologists, internists, clinical researchers, and healthcare professionals engaged in metabolic disease management.
Yuzuru Ohshiro, Kunimasa Yagi, Yasuhiro Maeno.
The Role of Natural Products on Diabetes Mellitus Treatment
The utilization of medicinal plants in the treatment of diabetes mellitus (DM) holds significant promise due to their diverse bioactive compounds. These plants have been historically acknowledged for their potential in managing DM and its complications. They often contain secondary metabolites with inherent hypoglycemic properties, aiding in regulating blood glucose levels. Several plants and secondary metabolites have shown effectiveness in improving insulin sensitivity, enhancing glucose uptake, and mitigating the adverse effects associated with DM. For instance, bitter melon (Momordica charantia) contains charantin and polypeptide-p, both known for their hypoglycemic effects.
Diana Marcela Aragon Novoa, Fátima Regina Mena Barreto Silva
Dear Colleagues, this Special Issue presents a comprehensive collection of studies showcasing the latest innovations in dentistry, emphasizing the integration of multidisciplinary approaches and technological advancements. With a focus on improving patient outcomes and advancing oral health care, the contributions explore a range of topics, including the development of new biomaterials, minimally invasive techniques, and novel treatment protocols.
This reprint compiles thirty-two peer-reviewed articles that capture the broad landscape of COVID-19 research three years after the pandemic. Organized into six thematic sections—Epidemiology and Public Health Perspectives (7 papers: 1–7), Pathophysiology and Mechanistic Insights (9 papers: 8–16), Diagnostics and Detection Methods (7 papers: 17–23), Therapeutics and Clinical Management (5 papers: 24–28), Vaccines and Immunization Studies (2 papers: 29–30), and Long COVID and Future Directions (2 papers: 31–32)—these works address key scientific and clinical developments in viral evolution, host–pathogen interactions, and public health policies.
Advances in Endodontics and Periodontics
This Special Issue of Applied Sciences, titled "Advances in Endodontics and Periodontics", aims to improve the state of the art in relation to the most relevant advances in Endodontics and Periodontics. Topics addressed in this Special Issue include alternative treatment strategies such as “green” antimicrobials, the relationship with systemic diseases, new devices and materials which enable a reduction in therapy failures, as well as updating evidence-based knowledge pertaining to endodontics and periodontics.
Iron deficiency (ID) and iron deficiency anemia (IDA) are global problems that affect more than 2 billion people, accounting for significant mortality annually worldwide. Children, girls, and women of reproductive age are particularly vulnerable to ID and IDA due to their high physiological iron demands. The consequences of IDA include deleterious effects on cognition, mental function, work performance, and pregnancy outcomes.
Chronic obstructive pulmonary disease is a (currently) incurable and irreversible lung condition with worldwide mortality rates similar to stroke, diabetes, and Alzheimer’s disease. Treatments are limited to the removal of the underlying causes (e.g., exposure to smoke), easing some of the symptoms, and slowing the rate at which the disease worsens. As a consequence of smoking, it is less well known than lung cancer even though it has an equal or higher mortality rate.
Acute Trauma and Trauma Care in Orthopedics
Orthopedics and trauma surgery are clinically challenging areas involving the treatment of injuries and related diseases of the musculoskeletal system, which can be caused by trauma, accidents, sports injuries, degenerative and congenital diseases, infections, and tumors. We have witnessed developments in all aspects of orthopedic surgery, such as the use of both invasive procedures and non-invasive and non-surgical methods to correct and treat disease. Common orthopedic problems include knee osteoarthritis, spinal deformities, and a variety of different sports injuries.
Effect of Long-Term Insomnia on Mental Health
The purpose of this reprint is to explain the health-related factors, mechanisms, and consequences of mental health problems associated with chronic sleep disorders. The reprint presents how insomnia and sleep disorders affect mental health across genders and high-risk groups, including populations such as university students, healthcare workers, firefighters, people with ADHD symptoms, people with chronic spinal pain, and patients of forensic hospitals suffering from chronic neuropsychiatric disorders.
This Special Issue addresses the problem of treating neurodegenerative diseases from a variety of perspectives, from basic research into the molecular mechanisms responsible for a disease to reviews of the most advanced therapies available. This topic can provide exciting insights into new therapeutic approaches for various neurodegenerative disorders, expanding our knowledge on the biological basis and clinical research, as well as new challenges and future perspectives in neurodegeneration.
Musculoskeletal disorders (MSDs) are associated with various degrees of disability affecting participation in activities of daily living (ADL) and the overall quality of life (QoL) of affected individuals. MSDs pose a significant burden to health systems, social care systems and caregivers. Such disorders encompass a diverse group of conditions affecting bones, muscles and joints, including degenerative conditions, inflammatory rheumatic diseases, fragility conditions and several types of bodily pain.
Advances in Scoliosis, Spinal Deformity and Other Spinal Disorders
The present Special Issue focuses on the management of spinal deformity, including contributions from international experts. Points of discussion include nonoperative management, instrumentation level determination, and complication prediction (e.g., infection and durotomy). Though far from being all-encompassing, this Special Issue aims to highlight ongoing areas of investigation in the management of spine deformity and should be of interest to those practicing within this field.
Zach Pennington, Daniel M. Sciubba, Benjamin D. Elder
Written by renowned neurosurgeons and orthopedic spine surgeons, Adult and Pediatric Spinal Deformities - Recent Advances and Evolution of Technologies provides insights into the latest development of technologies and their application in managing both adult and pediatric spinal deformities. The primary goal of this book is to help the spine surgeons navigate a daunting number of available devices and modern techniques and leverage the latest technologies to achieve optimal patient outcomes.
In the orthopedic surgical field, knee surgeries, including articular cartilage repair procedures, meniscus surgery, ligament reconstruction surgery, osteotomy surgery, and partial/total knee arthroplasty surgery, have made great advances over the last few decades. This Special Issue highlights and focuses on the surgical concepts and techniques, decision-making processes, perioperative management protocols, and clinical outcomes of the recent various advanced knee surgery procedures. URI
In the evolving field of orthopedics, the shift towards personalized medicine heralds a new era of patient care—promising enhanced treatment accuracy and improved outcomes. This collection, derived from the Special Issue in the Journal of Personalized Medicine, showcases cutting-edge research and reviews focusing on tailoring orthopedic treatments to individual patient needs. Emphasizing innovation in surgical technologies, implant designs, and non-operative approaches, this SI critically addresses the challenges of standardization and the necessity for patient-specific treatment strategies.
This Special Issue (SI) focuses on a rare disease by the name of solitary fibrous tumor. This SI includes review articles and original reports. The original reports range from translational to cinical science and focus on gaining new treatment and management approaches for this rare disease. I want to thank all contributing authors for their efforts and hard work that made this SI possible.
Medicine Information technology industries
Neuroimaging is a rapidly evolving field that involves the use of non-invasive imaging techniques to visualize and study the structure and function of the human brain. With the advent of artificial intelligence (AI), the field of neuroimaging has seen significant breakthroughs in terms of accuracy, speed, and efficiency in identifying various brain disorders. AI models have been widely applied in the analysis and interpretation of neuroimaging data, aiding researchers and clinicians to diagnose, treat, and monitor patients with neurological and psychiatric disorders.
Iman Beheshti, Daichi Sone, Carson K. Leung
Infrared Thermography as a Tool for Assessing Animal Welfare and Its Usefulness in Veterinary Research
This Special Issue, Infrared Thermography as a Tool for Assessing Animal Welfare and its Usefulness in Veterinary Research, presents leading research on the application of infrared thermography (IRT) and thermal imaging to analyze temperature variations in domestic and wild animals, encompassing both poikilothermic and homeothermic species. These variations reflect physiological responses to environmental stressors, including cold, heat, pain, fear, hunger, anxiety, and boredom, as well as natural processes such as illness, growth, aging, weight fluctuations, exercise, courtship, mating, imprinting, and stages like estrus, pregnancy, parturition, and lactation.
Bovine Viral Diarrhea Virus and Related Pestiviruses
The pestiviruses encompass some of the most economically important viral infections in the cattle, swine, and sheep industries worldwide. Discovered more than 70 years ago, bovine viral diarrhea virus (BVDV) and classical swine fever virus (CSFV) were long the main concern, but many new pestiviruses have emerged in recent years, which may also present additional threats to biosecurity and food safety.
Multidisciplinary Teamwork in Healthcare
Effective healthcare is vital to prevent illnesses and injuries, to provide treatments and rehabilitation from illnesses and injuries, and to enhance physical, psychological, and social health and well-being. Twenty-first-century healthcare has become a “team sport” that requires multidisciplinary teams with diverse knowledge, skills, abilities, perspectives, and wisdom. Multidisciplinary healthcare teams include physicians, nurses, dentists, psychologists, physical and occupational therapists, and other healthcare practitioners; healthcare researchers, scholars, and educators; healthcare administrators and policymakers; as well as patients and patients’ significant others.
Discover fresh insights and confront emerging challenges in the world of midwifery with Midwifery - New Perspectives and Challenges. This edited volume delves into the evolving landscape of midwifery, offering a comprehensive exploration of contemporary issues, practices, and perspectives shaping this vital field. From the latest advancements in maternal care to the evolving role of midwives in today’s healthcare system, this book brings together a diverse range of voices and expertise to illuminate the transformative potential of midwifery.
Reproductive injustice is an urgent global problem. We are faced with the increased criminalization of abortion, higher maternal and neonatal mortality rates for people of color, and more and more research addressing the structural nature of obstetric violence. In this collection of essays, the cause of reproductive injustice is understood as the institutionalized isolation of (potentially) pregnant people, making them vulnerable for bio- and necropolitical disciplination and control.
Successful breastfeeding has benefits for both mother and infant that extend the lifespan. Unfortunately, the health disparities in breastfeeding are striking, and the variable rate of breastfeeding across racial or ethnic groups and among individuals with different socioeconomic statuses is an under-appreciated public health crisis. Overall parity in breastfeeding rates through 6 months could substantially reduce the incidence of childhood infection and the devastation of sudden infant death syndrome.
Policies and Strategies in Sexual and Reproductive Health
The topics covered in the book cover different aspects of sexual and reproductive health. This book provides novel research results that may be essential as a basis for the development of health policies and strategies in sexual and reproductive health. These policies are necessary to achieve greater health protection. Among others, issues as important as the increase in STIs, their risk factors, vulnerable situations and populations, as well as the issue of priority in reproductive health, such as the care that must be provided during pregnancy and childbirth in order to guarantee healthy women and children, are developed in the book.
Juan Miguel Martínez Galiano, Miguel Delgado-Rodríguez
The year 2020 is considered by the World Health Organization to be the International Year of the Nurse and Midwife. This book supports the visibility of the contribution of nurses to society. We have included 30 articles on high-quality original research or reviews that provide solid new discoveries that expand current knowledge.
Elena Fernández-Martínez, Lisa Alves Gomes, Cristina Liébana-Presa
Comparative Vertebrate and Human Anatomy: Ecology, Evolution, and Function
This book provides an ecology- and function-oriented approach to understanding the evolution of vertebrate structure. The text has a modular format, such that each module can be used as a stand-alone instructional tool, or grouped together as a comprehensive textbook, making the text versatile for use in courses with diverse structures. The text also includes human-specific modules for each anatomical system, as many small, liberal arts colleges teach comparative and human anatomy in a single course. Detailed, human-specific modules may be added or removed, as needed for individual courses, depending on the scope and learning objectives of the class.
Vanessa K Hilliard, Lisa Whitenack, Bill Ryerson, Amy Cheu
This Open Access textbook, endorsed by UK Oncology Nursing Society (UKONS), covers the effects impact of the COVID-19 pandemic on Cancer care and how health care professionals and people with a cancer diagnosis have been affected. It discusses current research covering COVID and Cancer and considers the different impacts on patients with solid tumours and those with a haematological malignancy. The authors critically appraise how technology has been used to combat the pandemic as well as impacts on patient management and their well-being, education of health care professionals as well as the delivery of oncology cancer treatments.
Mark Foulkes, Helen Roe, Andreas Charalambous
Innovative Technologies and Translational Therapies for Deafness
This reprint focuses on the diagnosis, treatment, and technological innovations related to inner ear diseases. It encompasses cutting-edge areas, such as virtual reality training, to enhance hearing adaptation, gene therapy, microneedle drug delivery, and more.
Olivier Sterkers, Ghizlène Lahlou, Huan Jia
Current Trends, Innovations and Issues in Nursing Practice and Education
The development of health sciences in recent years has made it necessary to implement changes in the training of health professionals from the undergraduate level. This training must include the acquisition of knowledge, skills, and attitudes that ultimately improve patient safety and quality of care. Concurrently, the use of different tools to assess the level of knowledge in certain areas of the training of nurses and analysis of the different study plans allow training to be oriented to the specific needs of each reality.Nowadays, it is necessary to develop, plan, and utilize new teaching methodologies and tools that allow us to assess and measure the level of knowledge of professionals and students and evaluate the quality of training at the different levels of care.
Antonio Martinez-Sabater, Elena Chover-Sierra, Carles Saus-Ortega
Venous thromboembolism (VTE), which includes deep venous thrombosis (DVT) and pulmonary embolism (PE), is a common but complicated condition that is often associated with significant morbidity and mortality. This book is an essential resource for healthcare professionals, combining expert knowledge with practical strategies for managing the challenges of VTE in various clinical contexts.
This Special Issue focuses on novel and scarcely investigated topics in relation to atrial fibrillation (AF), from the role of f-wave harmonic spectral structures in improving the preoperative prediction of catheter ablation outcomes in AF to the design of a study to investigate the effectiveness of a hand-held device in screening for AF when embedded into the handles of supermarket trolleys.
Cardiovascular Risk Factors and Intervention Strategies for the Prevention of Cardiovascular Disease
This reprint provides insights into the cardiovascular risk landscape, emphasizing the impact of major risk factors and their interaction with the cardiovascular system. In this Special Issue, the role of other less established risk factors such as uric acid, sleep disorders, or blood pressure variability has been taken into consideration. Evidence-based strategies to prevent the detrimental consequences of these risk factors have been focused on in this Special Issue, with particular emphasis on glycemic control, lipid management, hypertension diagnosis, blood pressure regulation, and implementation of lifestyle modifications. By implementing the most modern strategies and fostering collaboration across disciplines, we can reduce the cardiovascular risk, thereby avoiding adverse outcomes.
Nonlinear Dynamics in Cardiovascular Signals
The cardiovascular system involves many regulatory mechanisms that maintain the stability of blood pressure by interacting strongly with other vital systems (including the respiratory, endocrine, and autonomous nervous systems). Non-invasive measurements of cardiovascular signals have enhanced the study of the cardiovascular system, providing deeper insights into its physiological modulation, the pathophysiology of cardiovascular and other chronic diseases, and new methods to improve their diagnosis and prognosis.
Advances in Cardiovascular Magnetic Resonance
Medicine and Nursing Cardiovascular System - Medicine
Cardiovascular disease remains the leading cause of death worldwide. Cardiovascular magnetic resonance (CMR) imaging is a versatile and non-invasive imaging modality that accurately diagnoses and characterizes cardiovascular disease. CMR is widely accepted as the gold standard for the evaluation of cardiac function. CMR can also characterize various conditions affecting myocardial tissue such as inflammation, edema, necrosis, and fibrosis. Recently, new techniques including T1 mapping, extracellular volume fraction, myocardial strain, 4D flow, DWI/DTI, and chemical exchange saturation transfer (CEST) have further expanded the role of CMR in the diagnosis, risk stratification, and management of cardiovascular diseases.
Modern Pharmaceutics for Cardiovascular Diseases
Although various non-pharmaceutical strategies addressed to the primary prevention of cardiovascular diseases such as tobacco control policies, reducing the consumption of harmful food, and increasing physical activity still represent a key strategy, often they are not sufficient. Moreover, despite the availability of a plethora of pharmaceutic approaches specifically targeting mechanisms involved in cardiovascular diseases over recent years, the burden of these pathologies has only been marginally alleviated.
New Insights into Cardiovascular and Exercise Physiology
This reprint aims to provide insights into recent knowledge on the cardiovascular system and its adaptation to different diseases and exogenous conditions. Considering the increasing incidence of cardiovascular diseases, a major cause of death worldwide, and the need to attain treatment strategies, knowledge of the physiological processes behind them remains the basis for future research and is a prerequisite for improved clinical studies. Physical exercise is increasingly being regarded as one of the potentially beneficial measures to improve cardiovascular health, interfering with numerous elements of the cardiovascular system and affecting a multitude of potential mechanisms.
This book provides a comprehensive review of inflammatory myocardial diseases. It is organized into three sections: (1) Pathobiology of Myocardial Inflammatory Diseases; (2) Imaging for Inflammatory Myocardial Diseases; and (3) Interventions for Inflammatory Myocardial Diseases. Chapters address topics including inflammatory diseases in rheumatological patients; acute and recurrent pediatric pericarditis; clinical detection methods; imaging methods, including cardiac magnetic resonance in scleroderma; extracorporeal membrane oxygenation for fulminant myocarditis complicated with cardiogenic shock and surgical interventions.
Renin-Angiotensin System in Cardiovascular Biology
Medicine and Nursing Cardiovascular Biology
The renin–angiotensin system (RAS) plays an important role in maintaining the salt and water balance of very diverse animal species under very diverse conditions. Angiotensin II (Ang II) is a hormone with much more complex actions than is typical for other agonists with heterotrimeric G protein-coupled receptors (GPCRs). Its principal receptor, angiotensin type 1 receptor (AT1R), is distributed in many cells of the body in diverse organs, controlling the water and salt balance, vascular contractility, and blood pressure.
Mária Szekeres, György L. Nádasy, András Balla
C-Reactive Protein and Cardiovascular Disease : Clinical Aspects
This Special Issue focuses on the clinical relevance of the C-reactive protein. Most physicians are familiar with it as a diagnostic biomarker. Only a few have realized that it can be a pathomolecule. After all, the biomarker is, of course, not a physiological function. The main task of CRP is to mark cells to be disposed of, which has been shown for decades in various animal models and has been broken down into molecular detail. The articles presented in this Special Issue reveal a broad spectrum of indications with CRP involvement.
Advancements in Cardiovascular and Antidiabetic Drug Therapy
The aim of this reprint is to immerse the reader in the transformative advancements in drug-based therapies for cardiovascular diseases and diabetes, two major contributors to global morbidity and mortality. From the groundbreaking use of sodium–glucose cotransporter 2 inhibitors in heart failure and diabetes management to the development of novel incretin therapies and innovative insulin delivery systems, this collection examines the potential and promise of these cutting-edge pharmacological strategies.
The Special Issue “Risk of Type 2 Diabetes Mellitus: Cardiorenometabolic Syndrome and Its Components”, guest-edited by Dr. Andrej Belančić, Prof. Bojan Jelaković, and Dr. Martina Matovinović, explored the complex interrelationship between metabolic syndrome (MetS) and the global burden of type 2 diabetes mellitus (T2DM). This interdisciplinary collection examined how insulin resistance, dyslipidemia, central obesity, and hypertension—core components of MetS—converge to elevate the risk of T2DM and cardiovascular disease, the leading causes of morbidity and mortality worldwide.
Andrej Belancic, Bojan Jelakovic, Martina Matovinović
Periodontitis: Current Status and the Future
Periodontitis is a common inflammatory disease, in which the composition of the oral biofilm and the individual immune response have significant impacts. Severe periodontitis is one of the most prevalent conditions in the world, leading to periodontitis being a public health concern. It is widely accepted that periodontitis may be a modifiable risk factor/modulator for several systemic diseases, including diabetes, cardiovascular disease, adverse pregnancy outcomes, rheumatoid arthritis, chronic obstructive pulmonary disease and chronic kidney disease.
Oxidative stress (OS) is recognized as a pivotal contributor to the pathogenesis of various, chronic human ailments, including cardiovascular and renal diseases, diabetes, neurodegenerative disorders, cancer, inflammatory conditions, and the aging process. It manifests as an imbalance between the generation and accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) within cells and tissues. OS occurs when the production of these species surpasses the detoxification capacity of the biological system.
Calcified aortic valve disease (CAVD) affects over six million Americans and is associated with changes in the mechanical properties of valve leaflets, resulting in impaired valvular blood flow. CAVD is a fibrocalcific disease with multifactorial risk factors that are related to the complex environment where the aortic valve (AV) resides. This special issue focuses on the field of heart disease, exploring the relationship between heart valve disease, arrhythmia, kidney disease, and cardiovascular disease, as well as research progress on new treatment strategies and risk prediction.
Medicinal Plants Alternative Medicine - Therapuetics
For centuries, plants have been humanity's most reliable and accessible source of healing. From ancient civilizations to modern herbal medicine, medicinal plants have provided remedies for countless ailments, both physical and mental. They hold within them the power to treat, prevent, and promote health naturally, making them an integral part of human survival and wellness. Medicinal Plants - Harnessing the Healing Power of Plants is a comprehensive exploration of the rich heritage of plant-based medicine.
Emerging Strategies in Drug Development and Clinical Care in the Era of Personalized and Precision Medicine
In the dynamic realm of modern medicine, we stand at a pivotal juncture where the convergence of disease, drugs, and patient individuality is shaping a new paradigm. The field is transitioning from traditional drug development towards personalized therapeutic strategies tailored to the unique physiology of each person. Over past decades, significant progress in preventive measures, diagnostic techniques, and treatment approaches has greatly improved patient care.
Cristina Manuela Dragoi, Alina Crenguța Nicolae, Lon-Bogdan Dumitrescu
Coagulation is a crucial and essential defense mechanism that is typically well-balanced and effective under normal circumstances. However, since Virchow’s Triad was published in the mid-19th century, its elements have inspired an overwhelming amount of innovative and cutting-edge research, much of which was initiated at the bedside and later unraveled in the laboratory. These approaches have been multidisciplinary, driven by out-of-the-box thinking, keen observation, and problem-solving.
Osteoporosis is defined as a systemic bone loss disease exemplified by the deterioration of bone tissues and low bone mineral density (BMD), subsequently leading to an enhanced risk of developing fragility-related fractures. It’s a chronic inflammatory condition and is the 4th most burdensome chronic disease after ischemic heart disease, dementia, and lung cancer, with a huge economic burden on the world economy. This skeletal disorder affects predominantly women compared to men, and the risk increases with age.
Aflatoxins are among the most dangerous natural contaminants affecting global food and feed systems. This book offers a concise yet comprehensive overview of recent scientific and technological advances in detecting, controlling, and mitigating aflatoxin contamination. Addressing a wide range of multidisciplinary perspectives, from food safety and toxicology to biotechnology and regulatory science, this book explores innovative strategies for minimizing risks associated with aflatoxins in agriculture and food processing.
Evaluation and Prevention of Mycotoxin Contamination and Toxicological Effects
Over the last few decades, mycotoxins, toxic fungal secondary metabolites that frequently contaminate foods and feeds, have attracted great interest at both scientific and industrial levels. The toxicity of these compounds has led to several regulations in many countries to control and quantify these contaminants for their subsequent risk assessment.
Advances in Medical Image Processing, Segmentation and Classification
Medical data typically include physiological signals, diagnostic images, and treatment histories, offering essential insights into patient conditions and outcomes. Computer-aided diagnosis (CAD) systems—used for detection, segmentation, and classification—are now key components of clinical workflows. These systems apply image processing techniques to ensure accurate analysis across CT, MRI, X-ray, and ultrasound scans. Artificial intelligence (AI), especially machine learning and deep learning, has further advanced CAD by enabling automated, accurate disease detection.
The management of hydrocephalus is a complex and significant challenge in neurosurgical practice, with varied clinical presentations and multiple treatment options. The book Hydrocephalus - Surgical Treatment covers hydrocephalus secondary to subarachnoid and intraventricular hemorrhage, Normal Pressure Hydrocephalus, Idiopathic Intracranial Hypertension, and post-traumatic hydrocephalus. The book presents the personal experiences of experts, as well as current evidence-based approaches for the diagnosis and surgical management of hydrocephalus.
Hot Topics in Reproductive Medicine Research
This Special Issue titled "Hot Topics in Reproductive Medicine Research" tries to cover some of the most debated topics in this field from a scientific and clinical point of view. In particular, the quality of embryos using compared tools such as incubator time-lapse and aneuploidy detection, the endometrioma impact on embryo quality, the influence of paternal age on obstetrical and perinatal outcome in IVF, and the possibility of performing assisted reproductive technology (ART) without discarding or freezing embryos.
The Nursing Process as a Strategy for a (De-)Professionalization in Nursing
The nursing process generally is understood as key element of professional nursing care in Germany. This study follows this argument back to the introduction of the nursing process in the 1970s and 1980s. At that time, the German healthcare system underwent dramatic changes and economic reorganization, which can be understood as the emergence of the neoliberal rationale in Germany. The argument of cost explosion was used to restructure hospitals into enterprises that were to operate based on the logic of the market. Its cybernetic logic made the nursing process an ideal instrument to restructure nursing care.
This is one of the few books nurses wrote on their own professional and educational challenges. Therefore, the book is of great importance to nurses and nursing teachers. It covers various topics from standardized education to the professional pathology of nurses and the nurses' approach to different chapters of human pathology. We are proud to present you a true example of inclusivity, because our book benefits from a global perspective, including chapters written by specialists from four continents, each reflecting and sharing their own experience.
New Advances in the Management of Voice Disorders
Despite recurring symptoms in voice disorder patterns, experience and know-how of clinicians—the practical knowledge acquired over the years on various medical or therapeutic methods of providers—the extent of the voice disorder, prognosis, and effective as well as efficient treatments for the individual patient remain unaffected. In order to optimize medical–therapeutic action, it is necessary to be regularly informed about the selection of appropriate treatment options for voice disorders based on new research evidence from, for example, clinical trials, systematic reviews, and meta-analyses, in order to pursue better clinical reasoning and treatment success.
Clinical Advances in Allergy and Asthma: Issues, Strategies, and Future Directions
This reprint aims to provide the reader with the latest clinical strategies and therapeutic innovations employed in managing asthma and allergies. This Special Issue seeks to unveil the potential and prospects of a multidisciplinary approach from traditional diagnostic methods to advanced functional monitoring techniques and the innovation of conventional and emerging therapies, including revolutionary monoclonal antibody-based biologic therapies. In this reprint, leading experts share their insights and cutting-edge visions for redefining the treatment of complex diseases, highlighting the path to increasingly personalized and effective management.
This book discusses the state of the art of the human lymphatic system and its involvement in health and disease conditions. The modulation of lymphatic organs and their interplay could be valid strategies to prevent and treat different diseases, promoting a global healthy state. The authors emphasize the strict correlation between anatomic-morphological and functional changes and different pathophysiological states. This book is designed to encourage researchers to investigate the anatomic morphology of the lymphatic system and its correlation to different disease states.
Skin Sensitization Testing Using New Approach Methodologies
Skin sensitization, representing one of the regulatory toxicity endpoints, is seeing significant progress in the uptake of new approach methodologies, comprising non-animal evaluations, to provide regulatory and product development information on chemical and product hazard and potency.
Morphological Design and Synthesis of Nanoparticles
The aim of this reprint is to capture some of the current trends in nanoparticle research focused on the correlation between nanoparticle morphology and function. For instance, the asymmetry of Janus nanoparticles gives them amphiphilic properties and the ability to partition at interfaces, self-assemble into superstructures, emulsify, or act as unidirectional nanomotors, among other things. However, there are countless other examples of functionality that stem from the morphological design of the nanoparticles, such as in nanoparticle catalysis, in drug delivery systems, or for nanoparticles used as technology facilitators for designing nanostructured materials, interfaces, and composites.
This reprint captures how functional connectivity research is revolutionizing brain science. The featured papers bridge fundamental discovery with tangible applications, uncovering the neural architecture of decision-making, social cognition, and clinical disorders. Integrating methods from electrophysiology to artificial intelligence, the contributions advance beyond correlation toward predictive modeling and mechanistic insight. This collection affirms that mapping brain networks is a foundational tool for progress in healthcare, neurotechnology, and our core understanding of the human mind.