Symptoms Of Type 2 Diabetes Creative Commons https://youtu.be/d8fBlTgn1_U This is always a surprising situation for most people around, who just go for regular check up to the doctor and end up knowing that they are suffering from one of the most common disease “diabetes “or “pre diabetes” condition. Even your doctor keep on warning you for the diabetes before or give you the idea that all such symptoms may lead to such terrible non ending disease. This thing is also so common that even if you are paying a lot of your attention on your body still it wouldn’t be an astonishing outcome that you are one of the victims of diabetes. Here are listed some highly observed warning signs for diabetes. 1. Need of Water Your body remains dehydrated and you always feel a need of water. Your mouth and lips dry out and you feel like drinking a huge amount of water all the time. Dehydration is linked with linked with your brain instead of your mouth. It is that even your mouth is dry and you don’t get any message from your brain you will never want the water. The brain cells always need a regular transfer of glucose beside the other part of your bodies. So; the system is followed as if your brain is overly concentrated with sugar water, it will order the supply of fluid from any other form to get diluted unease fluid surrounding each cell. In this way, your brain gets the water supply from other cells and leads towards the dehydration. This is the reason your body want to acquire more and more water. Most of the people have this misunderstanding that if you take soda you will remain hydrated. While soda is one of dangerous intake. So, if you feel the dehydrated most of the time, it means you need to get a checkup for diabetes. 2. Trips to the bathroom When you are taking a large amount of water supply in your body, then this is so sure that you need to urine. This also one of the alarming situations, which you need to take seriously because there is too much sugar in the blood vessel. All the water you take in will fill up your bladder and give you the feeling to pee. After which you feel thirsty and dehydrated again. This process of dehydration and hydration continue. Kidneys in this way release the excess amount of glucose from your body. And if the kidney can’t filter the waste properly, it means it is collecting toxins in your blood vessels. This condition can also damage the kidney on major level. 3. Weakness and Fatigue Sometimes you didn’t work out much and still your body is tired and exhausted, and you will never realize that this is cause of your diabetes which you are carrying inside. The actual problem lies here is that you can’t consume the glucose from your meals, the glucose is not readily enter into your cells. From all this less consumption of glucose and energy turn you weak and lazy. As you don’t gain energy from your meal, you still feel hungry after a while again. Here goes one more vital sign of diabetes. You should focus on each and every little aspect of your healthy and its related issues. 4. Lose Weight When you are suffering from diabetes, you start losing the weight in a specific pattern without any efforts of losing weight. If you are losing the weight, which even you are taking proper meals and food then it is one of the alarming condition. This kind of weight loss causes you to lose muscle mass. It happens in the part of the body which is looking for some energy and it breaks down the muscles of the cells. This is one of the clear symptoms of fatal diabetes. 5. Vision Disorder In the case, if the blood levels increase high ,it will drain all the fluid from all over body tissues .This also include you’re fluid fro Well come to our Channel: ''HEALTH & FITNESS'' Our channel ''HEALTH & FITNESS'' give us a lot of information about health and fitness. HEALTH & FITNESS is a most important for Healthy life. So keep watching to our channel for more videos HEALTH & FITNESS. Thanks For Subscribe ,Like and Share to our channel: https://goo.gl/UDorwZ Follow us on social media: Facebook https://goo.gl/vsGuJG Instagram https://goo.gl/F16iqI Youtube https://goo.gl/UDorwZ Google Plus https://goo.gl/pkrpC6 Disclaimer: The materials and the information contained on Natural Cures channel are provided for general and educational purposes only and do not constitute any legal, medical or other professional advice on any subject matter.None of the information on our videos is a substitute for a diagnosis and treatment by your health professional. Always seek the advice of your physician or other qualified health provider prior to starting any new diet or treatment and with any questions you may have regarding a medical condition. If you have or suspect that you have a medical problem, promptly contact your health care provider.
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This video was created for the contest " anatomy by students, international contest" Category 5. ENT, ophthalmology, General Practice This video by Hershko Sarah is licensed under the Creative Commons Attribution ShareAlike 4.0 International license, or later version, see: https://creativecommons.org/licenses/by-sa/4.0/
Brain action published via YouTube.com
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Introduction to The Anatomy of The Heart
Introduction to the anatomy of the heart, with explanation of the pericardium, myocardium, and endocardium.
Andrew Wolf published via YouTube.com
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Psych9B. Psychology Fundamentals. Lecture 1:
UCI Psych 9B: Psych Fundamentals (Fall 2015) Lec 01. Psych Fundamentals View the complete course: http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html Instructor: Mark Steyvers, Ph.D. License: Creative Commons CC-BY-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This one of the three courses that are a part of a three-quarter series, cross-listed as "Social Ecology Psy Beh P11 A, B, C" or "Social Sciences Psych 9 A, B, C." All three courses are offered every quarter and can be taken in any oder. The series is designed to give students a strong foundation in the major research areas of psychology, including such areas as human cognitive and social development, memory, language, emotional and social behavior, psychopathology, and neuroscience. This course sequence is required for students majoring in Psychology and Social Behavior in the School of Social Ecology and for students majoring in Psychology in the School of Social Sciences. These courses can also be taken by non-majors. In this course specifically, referred to as "Psy Beh P11B" or "Psych 9B," topics to be covered include memory, thinking, language, learning, and cognitive development Recorded on September 24, 2015. Required attribution: Steyvers, Mark. Psych Fundamentals 9B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/deed.en_US).
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Psych9B. Psychology Fundamentals. Lecture 2:
UCI Psych 9B: Psych Fundamentals (Fall 2015) Lec 02. Psych Fundamentals View the complete course: http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html Instructor: Mark Steyvers, Ph.D. License: Creative Commons CC-BY-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This one of the three courses that are a part of a three-quarter series, cross-listed as "Social Ecology Psy Beh P11 A, B, C" or "Social Sciences Psych 9 A, B, C." All three courses are offered every quarter and can be taken in any oder. The series is designed to give students a strong foundation in the major research areas of psychology, including such areas as human cognitive and social development, memory, language, emotional and social behavior, psychopathology, and neuroscience. This course sequence is required for students majoring in Psychology and Social Behavior in the School of Social Ecology and for students majoring in Psychology in the School of Social Sciences. These courses can also be taken by non-majors. In this course specifically, referred to as "Psy Beh P11B" or "Psych 9B," topics to be covered include memory, thinking, language, learning, and cognitive development Recorded on September 29, 2015. Required attribution: Steyvers, Mark. Psych Fundamentals 9B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/deed.en_US).
MIT 5.07SC Biological Chemistry, Fall 2013 View the complete course: http://ocw.mit.edu/5-07SCF13 Instructor: John Essigmann In this video, Professor Essigmann explores ketone bodies – what they are, how they are made, and how they are used in the body. He describes in detail the role ketone bodies play in diabetes and starvation scenarios. License: Creative Commons BY-NC-SA More information at http://ocw.mit.edu/terms More courses at http://ocw.mit.edu
MIT OpenCourseWare published via YouTube.com
Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Nauroz Syed. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/preterm-labor?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/uterine-inversion?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Lifestyle approaches aren’t just safer and cheaper. They can work better, because you’re treating the actual cause of the disease. Input by Sofia Nelly Subscribe to Dr. Greger’s free nutrition newsletter at http://www.nutritionfacts.org/subscribe and get a free excerpt from his latest NYT Bestseller HOW NOT TO DIE. (All proceeds Dr. Greger receives from the sales of his books, DVDs, and speaking engagements go to support the 501c3 nonprofit that runs NutritionFacts.org.) You can imagine how overwhelming NutritionFacts.org might be for someone new to the site. With videos on more than 2,000 health topics, where do you even begin? Imagine someone stumbling onto the site when the new video-of-the-day is about how some spice can be effective in treating a particular form of arthritis. It would be easy to miss the forest for the trees. That’s why I created this new series of overview videos, which are basically taken straight from my hour-long live 2016 presentation How Not to Die: Preventing, Arresting, and Reversing Our Top 15 Killers (http://nutritionfacts.org/video/how-not-to-die). Stay tuned for: • How Not to Die from Cancer (http://nutritionfacts.org/video/how-not-to-die-from-cancer/) • How Not to Die from Diabetes (http://nutritionfacts.org/video/how-not-to-die-from-diabetes/) • How Not to Die from Kidney Disease (http://nutritionfacts.org/video/how-not-to-die-from-kidney-disease/) • How Not to Die from High Blood Pressure (http://nutritionfacts.org/video/how-not-to-die-from-high-blood-pressure) If this video inspired you to learn more about the role diet may play in preventing and treating heart disease, check out some of these other popular videos on the topic: • Heart Disease Starts in Childhood (http://nutritionfacts.org/video/heart-disease-starts-in-childhood) • Lifestyle Medicine: Treating the Causes of Disease (http://nutritionfacts.org/video/lifestyle-medicine-treating-the-causes-of-disease) • The Actual Benefit of Diet vs. Drugs (http://nutritionfacts.org/video/the-actual-benefit-of-diet-vs-drugs) • Optimal Cholesterol Level (http://nutritionfacts.org/video/optimal-cholesterol-level) • Physicians May Be Missing Their Most Important Tool (http://nutritionfacts.org/video/physicians-may-be-missing-their-most-important-tool) • Oxygenating Blood with Nitrate Rich Vegetables (http://nutritionfacts.org/video/oxygenating-blood-with-nitrate-rich-vegetables) • Is Fish Oil Just Snake Oil? (http://nutritionfacts.org/video/is-fish-oil-just-snake-oil) • Does Cholesterol Size Matter? (http://nutritionfacts.org/video/does-cholesterol-size-matter) • When Low Risk Means High Risk (http://nutritionfacts.org/video/when-low-risk-means-high-risk) • Low Carb Diets and Coronary Blood Flow (http://nutritionfacts.org/video/low-carb-diets-and-coronary-blood-flow) • Fully Consensual Heart Disease Treatment (http://nutritionfacts.org/video/fully-consensual-heart-disease-treatment) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-not-to-die-from-heart-disease and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-not-to-die-from-heart-disease. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Google+: https://plus.google.com/+NutritionfactsOrgMD • Podcast: http://nutritionfacts.org/audio/
NutritionFacts.org published via YouTube.com
Hypotension is low blood pressure, especially in the arteries of the systemic circulation. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Hypotension is generally considered if systolic blood pressure less than 90 millimeters of mercury (mm Hg) or diastolic less than 60 mm Hg. However, in practice, blood pressure is considered too low only if noticeable symptoms are present. Hypotension is the opposite of hypertension, which is high blood pressure. It is best understood as a physiological state, rather than a disease. It is often associated with shock, though not necessarily indicative of it. For some people who exercise and are in top physical condition, low blood pressure is a sign of good health and fitness. For many people, excessively low blood pressure can cause dizziness and fainting or indicate serious heart, endocrine or neurological disorders. Severely low blood pressure can deprive the brain and other vital organs of oxygen and nutrients, leading to a life-threatening condition called shock. Input by Sofia Nelly
The Audiopedia published via YouTube.com
Creative accounting is a euphemism referring to accounting practices that may follow the letter of the rules of standard accounting practices, but deviate from the spirit of those rules. They are characterized by excessive complication and the use of novel ways of characterizing income, assets, or liabilities and the intent to influence readers towards the interpretations desired by the authors. The terms "innovative" or "aggressive" are also sometimes used. Other synonyms include Cooking the books and Enronomics. The term as generally understood refers to systematic misrepresentation of the true income and assets of corporations or other organizations. "Creative accounting" has been at the root of a number of accounting scandals, and many proposals for accounting reform – usually centering on an updated analysis of capital and factors of production that would correctly reflect how value is added. Newspaper and television journalists have hypothesized that the stock market downturn of 2002 was precipitated by reports of "accounting irregularities" at Enron, Worldcom, and other firms in the United States. One commonly accepted incentive for the systemic over-reporting of corporate income which came to light in 2002 was the granting of stock options as part of executive compensation packages. Since stock prices reflect earning reports, stock options could be most profitably exercised when income is exaggerated, and the stock can be sold at an inflated profit. The most notable activist is Abraham Briloff (professor emeritus of CUNY Baruch) who for years wrote a column for Barron's that constantly analyzed breaches of ethics and audit professionalism among CPA firms. His book is called Unaccountable Accounting. The profession, in turn, was not kind to Dr. Briloff but much of what he advocated has been forced on the industry in the wake of the Enron scandal (See Sarbanes-Oxley). According to critic David Ehrenstein, the term "creative accounting" was first used in 1968 in the film The Producers by Mel Brooks. Input by : Elvira Nadya Saleh
In the past, before modern dentistry, people use to treat a tooth pain naturally because they had no other option. Nowadays, modern medicine has its own solutions, but there still several natural toothache remedies that people use just to avoid the visit to the dentist. There a few well-known causes of tooth pain, like Infected gums/ Gum Disease, Tooth Decay, Tooth eruption, An abnormal bite, Abscessed Tooth, Tooth Fracture or a damaged filling and all of them can cause pain, fever, headache, and swelling around the teeth. In this video, we represent 12 effective Home Toothache Remedies that will help you to get rid of the pain! Raw Garlic Garlic effectively fights fungi, bacteria, and viruses. You should crush the clove, leave it for a couple of minutes to activate its compounds, add some salt, and apply it on the painful tooth. You can also chew clove several times daily using the affected tooth. Ice To soothe the swelling and pain before going to the dentist, Apply an ice or a cold compress on the cheek. Salt Water Gargle Add a teaspoon of salt to a cup of boiling water, and as soon as it cools, gargle it for half a minute. This will alleviate pain and infections, remove debris, and ease the swelling. Chewing Gum The area around a broken tooth, or around a tooth which lacks the filling is irritated and painful. To relieve this pain, chew a gum on the opposite side of the mouth and apply it onto the painful tooth. Peppermint Tea A 2013 study found that peppermint oil has potent antiseptic properties which are useful against oral pathogens. You should drink peppermint tea with a teaspoon of peppermint leaves steeped for 15-20 minutes, to treat bad breath and toothaches. Clove Oil Clove oil is high in eugenol, which has powerful antiseptic and anesthetic properties that destroy germs and relieve gum pain. Studies have found that it is as effective as benzocaine in numbing pain. You should combine a few drops of this oil with a teaspoon of coconut oil, and use a cotton ball, apply the mixture on the painful area. When the place is numb, remove it, and wash the mouth. You can also chew a few cloves using the painful side of the mouth. Vanilla Extract The scent of vanilla soothes the anxiety linked to a toothache, and its alcohol content numbs the pain. Therefore, dab vanilla extracts on the finger and rub it onto the painful tooth twice daily to relieve the pain. Turmeric Paste Mix a teaspoon of turmeric powder, several drops of peppermint oil, and a tablespoon of coconut oil, and prepare a paste. Then, brush the teeth and leave it to act for a few minutes. And rinse. It has strong antiviral and antibacterial properties and will help you fight bad breath, irritations, gum redness, and tooth stains. Ginger Cayenne Paste Mix cayenne and ginger in equal amounts, add some water and prepare a paste. Then, apply it on the painful place using a cotton ball, and leave it to act in order to soothe the pain and swelling, fight off infection, and control bleeding. Myrrh According to RDH, “myrrh’s astringent properties help with inflammation, and a rinse can offer the added benefit of reducing bacteria”. To prepare a homemade myrrh rinse, simmer a teaspoon of myrrh in 2 cups of water, leave it to cool, and use it several times during the day. Essential Oils One 2014 study found that: “Essential oil rinses are found to be equally effective in inhibiting plaque. A study carried out by Pizzo et al. on plaque inhibitory effect of amine fluoride/stannous fluoride and essential oils showed no significant difference in efficacy of both. As chlorhexidine causes staining of teeth on long term use, essential oils can be used as an alternative to chlorhexidine rinse. Essential oils have shown to possess antimicrobial activity against subgingival pernio pathogens, too.” For best effects, use clove, tea tree oil, peppermint, myrrh, cinnamon, and spearmint. Acupressure Press the hand on the affected side, on the place where the base of the index finger and the thumb meet, and hold for several minutes. This will stimulate the release of endorphins, which will relieve the pain. Input by Sofia Nelly
Natural Remedies published via YouTube.com
A lecture on electrocardiograms by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence. View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zX/
openmichigan published via YouTube.com
A lecture on chronic coronary artery disease by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/videos/FXxnu5Eayfzl/info/chronic-coronary-artery-disease/
A lecture on acute coronary syndromes by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zZ/ Help us caption & translate this video! http://amara.org/v/B4zZ/
A lecture on evaluating a patient with chest pain by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zY/ Help us caption & translate this video! http://amara.org/v/B4zY/
Includes a display of instruments necessary for caries removal, a discussion of the steps and criteria involved and demonstration of a complete removal of a carious lesion. Orig. air date: JAN 8 74 This is part of the Open.Michigan collection at: http://open.umich.edu/education
Demonstrates on the skull and on a patient, various injection techniques. It also describes the basic dental chair position for injections. Orig. air date: NOV 8 74 This is part of the Open.Michigan collection at: http://open.umich.edu/education
Scaling and Root Planing: Part II Mandibular Teeth
Procedures for scaling and root planing the mandibular teeth. This is part of the Open.Michigan collection at: http://open.umich.edu/education
This is part of the Open.Michigan collection at: http://open.umich.edu/education
After viewing previous lectures on seismicity you have basic understanding of earthquakes. Let’s have a further look at what this means for buildings and its foundations. This introduction lecture on geotechnical engineering by Carlos Merino discusses the behaviour of foundations under seismic loading and some more advanced topics, such as soil structure interaction.
UPT. Perpustakaan Universitas Syiah Kuala published via YouTube.com
This sequence provides a comprehensive introduction to diseases of the cardiovascular system, how they present, how they are diagnosed, how they are prevented, and how they are treated. Students learn to identify the integral links between anatomy, physiology, pathology, and basic sciences with clinical medicine and other essential aspects of patient care for ambulatory and hospitalized patients who have cardiovascular disorders.
Physiology/ Pathophysiology of Coronary Blood Flow
Myocardial Ischemia Supply Demand Coronary Flow Reserve Determinants of Coronary Blood Flow Neural (autonomic) Mechanisms Endothelial Factors (Mechanisms) NOS, NO and ADMA
In this book we have set out to provide a practical guide to bone marrow diagnosis, based on an integrated assessment of peripheral blood and bone marrow aspirate films, trephine biopsy sections and various supplementary investigations. We believe that a trephine biopsy specimen should not be examined and interpreted in isolation. We have therefore discussed the clinical context of bone marrow diagnosis and have given equal weight to cytological and histological features. Since bone marrow diagnosis is no longer based on morphological features alone we have also, in this edition, discussed in considerable detail the role of immunophenotypic, cytogenetic and molecular genetic analysis.
A lecture on Hemoglobinopathies by Dr. David Ginsburg, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Patients and Populations Sequence. View the course materials: http://open.umich.edu/education/med/m1/patientspop-genetics/fall2008/materials. Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zS/
A lecture on Hemoglobinopathies by Dr. David Ginsburg, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Patients and Populations Sequence. View the course materials: http://open.umich.edu/education/med/m1/patientspop-genetics/fall2008/materials. Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/videos/LhfjxDzh1zha/info/hemoglobinopathies-part-2/
Surgical Excision of a Multi-Lobular, Recurrent, Bartholin Duct Cyst
Warning: Viewer discretion is advised, this medical content is graphic and may not be suitable for all viewers. This surgical video describes the etiology, diagnosis, and management of uncomplicated Bartholin duct cysts. The video provides specific attention to the pre-operative approach to recurrent and/or complicated Bartholin duct cysts, and demonstrates the surgical approach to a complicated, recurrent Bartholin duct cyst. Suggestions for surgical techniques are provided. Copyright 2011 Caren M Stalburg, Sarah Wallet, and Hope K. Haefner. Terms of Use: Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B5CA/ Help us caption & translate this video! http://amara.org/v/B5CA/
A lecture on Circulatory Derangements by Dr. Gerald Abrams, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Cardiovascular and Respiratory Sequence. View the course materials: http://open.umich.edu/education/med/m1/cardioresp/fall2008/materials Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Bs/ Help us caption & translate this video! http://amara.org/v/B5Bs/
A lecture on Circulatory Derangements by Dr. Gerald Abrams, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Cardiovascular and Respiratory Sequence. View the course materials: http://open.umich.edu/education/med/m1/cardioresp/fall2008/materials Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Bt/
The earth's biogeochemical systems involve complex, dynamic processes that depend upon many factors. The three main factors upon which life on the earth depends.
Welcome to Human Anatomy and Physiology, an OpenStax College resource. We created this textbook with several goals in mind: accessibility, customization, and student engagement—helping students reach high levels of academic scholarship. Instructors and students alike will find that this textbook offers a thorough introduction to the content in an accessible format.
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/basics-of-egg-development?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/spermatogenesis?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/meet-the-placenta?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/basics-of-egg-development?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/anatomy-of-the-male-reproductive-system?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson?https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
www.EmpoweRN.com Hi Guys! Thank you so much for watching this channel :) Here is just a quick & simple nursing skill, that I really hope you enjoy! I appreciate all of your comments, likes & shares so much!! Really looking forward to growing with you!! Winners from Last weeks Giveaway!! Please email me at: Empower.RN@gmail.com :) 1. Stephanie Cianciolo 2. journeytoRN 3. Sabrina Botelho 4. John Navarro 5. LizRN Thank you: Life Medical Equipment for making this video possible! www.LifeMedicalEquipment.com Thank you: Johanna Pialisa Asis for editing this video! Disclaimer: These videos are intended for entertainment purposes only. Please follow the policy and procedures that your institution requires. Please note that the views, ideas & opinions expressed on this channel and in the videos on this channel are not necessarily of those of my employer or institution. The views expressed on this channel and in the videos channel do not represent medical advice. If you have specific medical concerns, please contact your physician. In order to protect patient privacy, all patient identifiers in all videos have been deleted or altered. The views expressed on this channel and in the videos on this channel are personal opinions. I am not an expert nor do I dispense medical advice or procedural specifications. The information I present is for general knowledge and entertainment purposes only. You need to refer to your own medical director, teachers and protocols for specific treatment information. It is your responsibility to know how best to treat your patient in your jurisdiction.
G Protein Coupled Receptors Nervous system physiology
Video ini menjelaskan tentang G-protein coupled receptor (reseptor G-protein bergandengan) yang juga biasa dikenal dengan GPCRs. G-protein coupled receptors hanya bisa ditemukan pada eukariot dan GPCRs adalah kelas yang terbesar dari semua reseptor membran.
OER-Unsyiah Lib published via YouTube.com
Pain Temperature BY : UPT Perpustakaan Universitas Syiah Kuala UKM Literasi Unsyiah
oerlib unsyiah1234 published via YouTube.com
Fundamentals of Electrical Engineering I
The text focuses on the creation, manipulation, transmission, and reception of information by electronic means. Contents: 1) Introduction. 2) Signals and Systems. 3) Analog Signal Processing. 4) Frequency Domain. 5) Digital Signal Processing. 6) Information Communication. 7) Appendices: Decibels; Permutations and Combinations, Frequency Allocations.
A First Course in Electrical and Computer Engineering
Louis Scharf, Daniel Williamson, C. Sidney Burrus, Richard Baraniuk
An introduction to solid state device including field effect and bipolar transistors. Properties of transmission lines and propagating E&M waves.
Accounting Principles: A Business Perspective, Financial Accounting (Chapters 1 – 8)
Preface from the eight edition: Philosophy and purpose Imagine that you have graduated from college without taking an accounting course. You are employed by a company as a sales person, and you eventually become the sales manager of a territory. While attending a sales managers' meeting, financial results are reviewed by the Vice President of Sales and terms such as gross margin percentage, cash flows from operating activities, and LIFO inventory methods are being discussed. The Vice President eventually asks you to discuss these topics as they relate to your territory. You try to do so, but it is obvious to everyone in the meeting that you do not know what you are talking about.
Accounting Principles: Managerial Accounting
Process: Cost systems Learning objectives After studying this chapter, you should be able to: • Describe the types of operations that require a process cost system. • Distinguish between process and job costing systems. • Discuss the concept of equivalent units in a process cost system. • Compute equivalent units of production and unit costs under the average cost procedure. • Prepare a production cost report for a process cost system and discuss its relationship to the Work in Process Inventory account. • Distinguish between normal and abnormal spoilage. • Compute equivalent units of production and unit costs under the first-in first-out (FIFO) system (Appendix 19-A). • Discuss how joint costs are allocated to joint products (Appendix 19-B). This chapter continues the discussion of cost accumulation systems. In Chapter 18, we explained and illustrated job costing. The job cost system (job costing) accumulates costs incurred to produce a product according to individual jobs. For example, construction companies use job costing to keep track of the costs of each construction job.
Principles of Management is adapted from a work produced by a publisher who has requested that they and the original author not receive attribution. This adapted edition is produced by the University of Minnesota Libraries Publishing through the eLearning Support Initiative. Principles of Management teaches management principles to tomorrow’s business leaders by weaving three threads through every chapter: strategy, entrepreneurship and active leadership. Strategic — All business school teachings have some orientation toward performance and strategy and are concerned with making choices that lead to high performance. Principles of Management will frame performance using the notion of the triple bottom-line — the idea that economic performance allows individuals and organizations to perform positively in social and environmental ways as well. The triple bottom line is financial, social, and environmental performance. It is important for all students to understand the interdependence of these three facets of organizational performance.
Authors Removed At Requeest of Original Publisher
University of Minnesota Libraries Publishing edition, 2015. This edition adapted from a work originally produced in 2010 by a publisher who has requested that it not receive attribution.
Approaches of Antiviral Production in Tissue Culture of Medicinal Plants
Medicinal and Aromatic Plants (MAPs): Diversity and Vegetative Propagation-I
Recent Advances in Microalgal Biotechnology
Dr. Jin Liu, Dr. Zheng Sun and Dr. Henri Gerken
What is Clinical Pharmacy Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Clinical pharmacy is the branch of pharmacy in which pharmacists provide patient care that optimizes the use of medication and promotes health, wellness, and disease prevention. Clinical pharmacists care for patients in all health care settings but the clinical pharmacy movement initially began inside hospitals and clinics. Clinical pharmacists often work in collaboration with physicians, nurse practitioners, and other healthcare professionals. Clinical pharmacists have extensive education in the biomedical, pharmaceutical, socio-behavioural and clinical sciences. Most clinical pharmacists have a Doctor of Pharmacy (Pharm.D.) degree and many have completed one or more years of post-graduate training (for example, a general and/or specialty pharmacy residency). In the United States, clinical pharmacists can choose to become Board-certified through the Board of Pharmacy Specialties (BPS), which was organized in 1976 as an independent certification agency of the American Pharmacists Association. The BPS certifies pharmacists in the following specialities: ambulatory care pharmacy, critical care pharmacy, nuclear pharmacy, nutrition support pharmacy, oncology pharmacy, paediatric pharmacy, pharmacotherapy, and psychiatric pharmacy. Within the system of health care, clinical pharmacists are experts in the therapeutic use of medications. They routinely provide medication therapy evaluations and recommendations to patients and other health care professionals. Clinical pharmacists are a primary source of scientifically valid information and advice regarding the safe, appropriate, and cost-effective use of medications. Clinical pharmacists are also making themselves more readily available to the public. In the past, access to a clinical pharmacist was limited to hospitals, clinics, or educational institutions. However, clinical pharmacists are making themselves available through a medication information hotline, and reviewing medication lists, all in an effort to prevent medication errors in the foreseeable future. In the United Kingdom, clinical pharmacists are routinely involved in the direct care of patients within hospitals, and increasingly, in doctors surgeries. They also develop post registration professional education, professional curricula for workforce development, provide expertise on the use of medicines to national organizations such as NICE, the Department of Health, and the MHRA, and develop medicines guidelines for use in therapeutic areas. Clinical pharmacists interact directly with patients in several different ways. They use their knowledge of medication (including dosage, drug interactions, side effects, expense, effectiveness, etc.) to determine if a medication plan is appropriate for their patient. If it is not, the pharmacist will consult the primary physician to ensure that the patient is on the proper medication plan. The pharmacist also works to educate their patients on the importance of taking and finishing their medications. Studies conducted into Pharmacist-led Chronic Disease Management show that it was associated with effects similar to usual care and might improve physiological goal attainment. In some states, clinical pharmacists are given prescriptive authority under protocol with a medical provider, and their scope of practice is constantly evolving. In the United Kingdom clinical pharmacists are given independent prescriptive authority. Basic components of clinical pharmacy practice include: Prescribing drugs, administering drugs, monitoring prescriptions, managing drug use, and counselling patients.
Implementing a Discrete System (Moving Averager) in Matlab
David Dorran published via YouTube.com
Physical anthropologists study human biological variation in the past and present. They are not only interested in the physical aspect of the body but also how biology, culture and environment interact to produce variation. Part of this variation is found in the bones and teeth. Since these are the hardest parts of the body, they have the greatest chance of being found in the archaeological record. Thus they form the bulk of direct information about the biological course of human evolution.
Introduction To Linear, Time-Invariant, Dynamic Systems For Students Of Engineering
Permission of the author is granted for reproduction in any form of this book or any part of this book, provided that there is appropriate attribution, for example, by a citation in the References section of a technical article, and provided that the reproduction is not made for the purpose of charging a fee to users (e.g., students in a class) beyond the cost of reproduction. However, plagiarism from this book is prohibited, and any use of the material in this book to produce profit or income beyond the cost of reproduction is prohibited.
Department of Aerospace and Ocean Engineering (AOE)
Project Management For Instructional Designers
Project Management for Instructional Designers (PM4ID) is – as the name suggests – a book about project management tailored specifically for instructional designers. This book is a revise / remix of a pre-existing, openly licensed project management textbook which was donated to the commons by a benefactor that desires to be attributed as Anonymous
In the modern world of ever-advancing technologies, actual tests of products and processes are more and more often preceded, if not replaced, by computer modeling. This saves the time and resources required for actual tests, and enables a better understanding of processes that occur in the course of tests. Preliminary computer modeling favors prudent planning of experiments. Calculations in thermal analysis are used everywhere, for example, in estimating the efficiency of thermal insulation of pipelines and in estimating the critical overheating conditions for some chemical substances under which their decomposition, self-heating, explosion, and so forth, occurs. This methodical manual focuses on a small aspect of calculations in thermal analysis dealing with constructing kinetic models from thermogravimetry and differential scanning calorimetry experimental data.
eGirls, eCitizens is a landmark work that explores the many forces that shape girls’ and young women’s experiences of privacy, identity, and equality in our digitally networked society. Drawing on the multi-disciplinary expertise of a remarkable team of leading Canadian and international scholars, as well as Canada’s foremost digital literacy organization, MediaSmarts, this collection presents the complex realities of digitized communications for girls and young women as revealed through the findings of The eGirls Project (www.egirlsproject.ca) and other important research initiatives. Aimed at moving dialogues on scholarship and policy around girls and technology away from established binaries of good vs bad, or risk vs opportunity, these seminal contributions explore the interplay of factors that shape online environments characterized by a gendered gaze and too often punctuated by sexualized violence. Perhaps most importantly, this collection offers first-hand perspectives collected from girls and young women themselves, providing a unique window on what it is to be a girl in today’s digitized society.
University of Ottawa Press / Les Presses de l’Université d’Ottawa
A Guide to Veterinary Clinical Skills Laboratories
Clinical and practical skills are an essential part of the competences required of veterinary graduates (European Association of Establishments for Veterinary Education (EAEVE) 2014, Royal College of Veterinary Surgeons (RCVS) 2014 American Veterinary Medical Association (AVMA) 2014, North American Veterinary Medical Educators Consortium (NAVMEC) 2011) and clinical skills laboratories (CSLs) are playing an increasingly important role in veterinary curricula around the world. Clinical training used to rely entirely on an apprenticeship model, as described in medical education over 100 years ago (Halsted, 1904), where the trainee shadows a clinician, initially watching and then performing the procedure under the expert’s supervision. Although such teaching is still central to medical and veterinary training, recent changes in veterinary education, including increasing student numbers and an expectation that where possible, the use of animals in teaching should be reduced, mean that there is a need to find additional ways to support learning.
The results of our investigation on the microbial community of the high-temperature Dagang oilfield (P.R. China) are summarized. Detailed experimental data are provided on syntrophic acetate degradation by thermophilic associations, on the isolation of pure cultures from these associations, their physiological characteristics, and reconstruction of microbial interactions during acetate degradation to methane. The microbial community of the high-temperature Dagang oilfield was investigated by culture-based, radioisotope, and 16S rRNA gene techniques. Cultivable microorganisms (aerobic oil-oxidizing, anaerobic fermentative, sulfate-reducing, and methanogenic) were found in formation water. Methanogenic enrichments were obtained in media both with Н2+CO2 and acetate.
Agile Processes in Software Engineering and Extreme Programming
A retrospective is a standard agile meeting practice designed for agile software teams to reﬂect and tune their process. Despite its integral importance, we know little about what aspects are focused upon during retrospectives and how reﬂection occurs in this practice. We conducted Case Study research involving data collected from interviews of sixteen software practitioners from four agile teams and observations of their retrospective meetings. We found that the important aspects focused on during the retrospective meeting include identifying and discussing obstacles, discussing feelings, analyzing previous action points, identifying background reasons, identifying future action points and generating a plan. Reﬂection occurs when the agile teams embody these aspects within three levels of reﬂection: reporting and responding, relating and reasoning, and recon structing. Critically, we show that agile teams may not achieve all levels of reﬂection simply by performing retrospective meetings. One of the key contributions of our work is to present a reﬂection framework for agile retrospective meetings that explains and embeds three levels of reﬂection within the ﬁve steps of a standard agile retrospective. Agile teams can use this framework to achievebetter focus and higher levels of reﬂection in their retrospective meetings
This book has been created to help you make decisions about practical conservation management by providing an assessment, from the available scientific evidence, of what works and what does not work in conservation. It also tells you if no evidence has been found about whether or not a conservation intervention is effective. This is the 2017 edition of What Works in Conservation, which was first published in 2015 and will be updated annually.
The Busy Coder's Guide to Android Development
Thanks for your interest in developing applications for Android! Increasingly, people will access Internet-based services using so-called "non-traditional" means, such as mobile devices. The more we do in that space now, the more that people will help invest in that space to make it easier to build more powerful mobile applications in the future. Android is new – Android-powered devices appeared on the scene first in late 2008 – but it likely will rapidly grow in importance due to the size and scope of the Open Handset Alliance. And, most of all, thanks for your interest in this book! I sincerely hope you find it useful and at least occasionally entertaining.
The Economics of Food and Agricultural Markets
The Economics of agriculture is important and interesting! Food and agricultural markets are in the news and on social media every day. Numerous fascinating and complex issues are the subject of this course: food prices, food safety, diet and nutrition, agricultural policy, globalization, obesity, use of antibiotics and hormones in meat production, hog confinement, and many more. As we work through the course material this semester, please find examples of the economics of food and agriculture in the news. You can earn extra credit by writing a report on a topic that is related to our course material!
The Art of Insight in Science and Engineering
Science and engineering, our modern ways of understanding and altering the world, are said to be about accuracy and precision. Yet we best master the complexity of our world by cultivating insight rather than precision. We need insight because our minds are but a small part of the world. An insight uniﬁes fragments of knowledge into a compact picture that ﬁts in our minds. But precision can overﬂow our mental registers, washing away the understanding brought by insight. This book shows you how to build insight and understanding ﬁrst, so that you do not drown in complexity.
System Innovations, Knowledge Regimes, and Design Practices towards Transitions for Sustainable Agriculture
This book places itself within the traditions and the ongoing activity of UCL’s Bartlett Development Planning Unit, and within its research cluster, Environmental Justice, Urbanisation & Resilience. It draws heavily upon my teaching for the Environment and Sustainable Development Masters. I owe an immense debt to all my fellow Development Planning Unit (DPU) staff, as well as past and present students, from whom I have learned much. In particular I am happy to acknowledge the contribution of Yves Cabannes: together we created a Masters module on Urban Agriculture, and explored the framework for a radical redefinition of the topic. My colleagues Zeremariam Fre and Michel Pimbert also played important roles in the module’s subsequent development and influenced my thinking in several ways. At the same time, I approach this topic as a food- growing practitioner and allotmentholder: the allotment movement and its working-class traditions of self- organisation continue to inspire me. This is a book about how people can feed themselves into the future, and also about major aspects of climate adaptation/ mitigation. I sought to approach these extremely serious topics in a spirit of responsibility. The United Nations Food and Agriculture Organisation (FAO) has proposed the need for a ‘new paradigm’ premised on ‘sustainable intensification’ andI felt it was essential to engage with this constructively rather than merely critiquing its ‘discourse’. A core concern of DPU is to address environmental crisis through the lens of the interests of working and oppressed peoples; on this basis, we always seek win- win solutions to ecological- social problems. While such solutions are concrete, and thus specific to each case, they also suggest more general conceptual insights, which can in turn serve to guide new projects.
Socioeconomics may be under greater pressure to deﬁne itself than the “classical” sciences. The latter have largely been deﬁned by the conceptualization of real-world phenomena: biology, for example, arose because of the willingness to better understand the phenomenon of life in its different speciﬁcities. Economics arose to study and resolve the issue of scarcity. And sociology was created to analyze the dynamics of societal groups. But socioeconomics? Its name pays tribute to the existence of sociology and economics, so one might either suspect that socioeconomics is merely is a combination of both sciences (S + E = SE), or that there is an intersection of sociology and economics which is best termed as socioeconomics (S ∩ E = SE). Most past attempts to deﬁne socioeconomics as a science in its own right may have been motivated to counter such a simplistic understanding of socioeconomics. In this chapter, we review past attempts to deﬁne socioeconomics before the approach is chosen that we applied in this book.
Small-signal stability, control and dynamic performance of power systems
The main purpose of this book is to introduce the graduate engineer to the concepts and applications of small-signal analysis and controller design for the enhancement of the dynamic performance of multi-machine power systems. To this end, the analyses of the control and dynamic performance are illustrated by examples based on an interconnected highvoltage system comprising fourteen generating stations and various types of FACTS devices. An emphasis in the book is on more recent theoretical developments and application to practical issues which are amenable to small-signal analysis using a comprehensive software package. In addition, the tools in - and features of - such a software package for analysis and controller design are illustrated.
Agricultural Implications of the Fukushima Nuclear Accident
This book reports the results from on-site research into radioactive cesium contamination in various agricultural systems affected by the Fukushima Daiichi Nuclear Power Plant accident that occurred in March 2011. This is the second volume from the research groups formed in the Graduate School of Agricultural and Life Sciences of The University of Tokyo who have published the initial data in their first volume. In this book, additional data collected in the subsequent years are presented to show how the radioactivity level in agricultural products and their growing environments have changed with time. The data clarify the route by which radioactive materials entered agricultural products and their movement among different components (e.g., soil, water, and trees) within an environmental system (e.g., forests). The book consists of various topics, including radioactivity inspection of food products; decontamination trials for rice and livestock production; the state of contamination in wild animals and birds, trees, mushrooms, and timber; the dynamics of radioactivity distribution in mountain and paddy fields; damage incurred by the forestry and fishery industries; and the change in consumers’ minds. The last chapter introduces a real-time radioisotope imaging system, the forefront technique to visualize actual movement of cesium in soil and in plants. This is the only book to provide systematic data about the actual change of radioactivity, and thus is of great value for all researchers who wish to understand the effect of radioactive fallout on agriculture. The project is ongoing; the research groups continue their work in the field for further evaluation of the long-term effects.
Up to date review of theory and experience of agricultural input subsidies in low income countries, with new theoretical and empirical insights Detailed and comprehensive analysis of the Malawi Agricultural Input Subsidy Programme Strong emphasis on political as well as technical issues in policy and programme development and implementation Considers economy wide issues in agricultural input subsidies in low income countries Detailed analysis of the history and context of agricultural development and rural livelihoods in Malawi
Animal (De)liberation: Should the Consumption of Animal Products Be Banned?
In this book, Jan Deckers addresses the most crucial question that people must deliberate in relation to how we should treat other animals: whether we should eat animal products. Many people object to the consumption of animal products from the conviction that it inflicts pain, suffering, and death upon animals. This book argues that a convincing ethical theory cannot be based on these important concerns: rather, it must focus on our interest in human health. Tending to this interest demands not only that we extend speciesism—the attribution of special significance to members of our own species merely because they belong to the same species as ourself—towards nonhuman animals, but also that we safeguard the integrity of nature. In this light, projects that aim to engineer the genetic material of animals to reduce their capacities to feel pain and to suffer are morally suspect. The same applies to projects that aim to develop in-vitro flesh, even if the production of such flesh should be welcomed on other grounds. The theory proposed in this book is accompanied by a political goal, the ‘vegan project’, which strives for a qualified ban on the consumption of animal products. Deckers also provides empirical evidence that some support for this goal exists already, and his analysis of the views of others—including those of slaughterhouse workers—reveals that the vegan project stands firm in spite of public opposition. Many charges have been pressed against vegan diets, including: that they alienate human beings from nature; that they increase human food security concerns; and that they are unsustainable. Deckers argues that these charges are legitimate in some cases, but that, in many situations, vegan diets are actually superior. For those who remain doubtful, the book also contains an appendix that considers whether vegan diets might actually be nutritionally adequate.
Animal Metropolis brings a Canadian perspective to the growing field of animal history, ranging across species and cities, from the beavers who engineered Stanley Park to the carthorses who shaped the city of Montreal. Some essays consider animals as spectacle: orca captivity in Vancouver, polar bear tourism in Churchill, Manitoba, fish on display in the Dominion Fisheries Museum, and the racialized memory of Jumbo the elephant in St. Thomas, Ontario. Others examine the bodily intimacies of shared urban spaces: the regulation of rabid dogs in Banff, the maternal politics of pure milk in Hamilton and the circulation of tetanus bacilli from horse to human in Toronto. Another considers the marginalization of women in Canada’s animal welfare movement. The authors collectively push forward from a historiography that features nonhuman animals as objects within human-centered inquiries to a historiography that considers the eclectic contacts, exchanges, and cohabitation of human and nonhuman animals.
Aquaculture Perspective of Multi-Use Sites in the Open Ocean: The Untapped Potential for Marine Resources in the Anthropocene
The first-of-its-kind compilation that comprehensively explores the scientific, engineering, economic and policy aspects of marine aquaculture multi-use of offshore platforms A timely analysis of the rapid development of offshore energy production platforms and the massive projected global seafood deficit Individual chapters written contemporaneously with EU “Oceans of Tomorrow” developments as well as proposals by the Food and Agriculture Organization (FAO), authored by highly-respected, international experts in the field
Care in Healthcare: Reflections on Theory and Practice
This book examines the concept of care and care practices in healthcare from the interdisciplinary perspectives of continental philosophy, care ethics, the social sciences, and anthropology. Areas addressed include dementia care, midwifery, diabetes care, psychiatry, and reproductive medicine. Special attention is paid to ambivalences and tensions within both the concept of care and care practices. Contributions in the first section of the book explore phenomenological and hermeneutic approaches to care and reveal historical precursors to care ethics. Empirical case studies and reflections on care in institutionalised and standardised settings form the second section of the book. The concluding chapter, jointly written by many of the contributors, points at recurring challenges of understanding and practicing care that open up the field for further research and discussion. This collection will be of great value to scholars and practitioners of medicine, ethics, philosophy, social science and history.
Climate Smart Agriculture: Building Resilience to Climate Change
The book uses an economic lens to identify the main features of climate-smart agriculture (CSA), its likely impact, and the challenges associated with its implementation. Drawing upon theory and concepts from agricultural development, institutional, and resource economics, this book expands and formalizes the conceptual foundations of CSA. Focusing on the adaptation/resilience dimension of CSA, the text embraces a mixture of conceptual analyses, including theory, empirical and policy analysis, and case studies, to look at adaptation and resilience through three possible avenues: ex-ante reduction of vulnerability, increasing adaptive capacity, and ex-post risk coping. The book is divided into three sections. The first section provides conceptual framing, giving an overview of the CSA concept and grounding it in core economic principles. The second section is devoted to a set of case studies illustrating the economic basis of CSA in terms of reducing vulnerability, increasing adaptive capacity and ex-post risk coping. The final section addresses policy issues related to climate change. Providing information on this new and important field in an approachable way, this book helps make sense of CSA and fills intellectual and policy gaps by defining the concept and placing it within an economic decision-making framework. This book will be of interest to agricultural, environmental, and natural resource economists, development economists, and scholars of development studies, climate change, and agriculture. It will also appeal to policy-makers, development practitioners, and members of governmental and non-governmental organizations interested in agriculture, food security and climate change.
Diseases of Children in the Subtropics and Tropics
Paediatrics is often thought of as following two main routes. One is that of ultra-technology and ever-narrower specialization. The other is recognition of child health in a community context, related to family circumstances (especially the health and welfare of mothers) and influenced by the environment, social stresses, economic limitations, cultural attitudes and practices, and policy decisions and priorities based on the political system. Neither is right, but rather a balance is needed. Thus, preventive programmes, such as immunization, depend on refined technology to produce appropriate vaccines and devise workable equipment for effective 'cold-chains'. Curative paediatrics, especially simplified methods in appropriate technology, has to be underpinned by science - both by necessity and to achieve acceptance by orthodox members of the Establishment. Examples include the work of gastroenterologists on the intestinal 'sodium pump' and how this can be 'primed' and made more effective by glucose. In this way, essential scientific credence has been given to the seemingly simple methods of oral rehydration, using prepared ORS packets or home-made mixtures of sugar and salt or dilute rice (or other staple) gruels. However, as always, it can be difficult to persuade physicians, including paediatricians, to acquire a community perspective, understanding and, still more, a truly active role. This is often in part because of their training which frequently remains predominantly clinical - 'we teach what we have been taught'. However, things are changing in some more enlightened training establishments, and the trend is certainly indicated in this Fourth Edition. Sound clinical work, as in a hospital environment, is vital and will always remain a major need. This approach alone cannot begin to touch the major issues of child health. Some of these may be beyond the scope of the paediatrician or of medical science. Nevertheless, an awareness of the need for an advocacy role has to be cultivated. In this way, advice and guidance may begin to move those in power towards policies which can improve community child health. The 'complete' paediatrician anywhere, but especially in less technically developed countries, often in tropical regions, needs to be much more than a blinkered 'vertical' /'horizontal' expert. Rather, there is a need for 'lateral' thinking, training and action. This implies realization of the wide range of factors needing consideration in child health work and also recognition of the value of a dove-tailed curative-preventive approach, as part of a team including paediatricians, nurses, community health workers and (importantly) parents, particularly mothers, in the community itself. The present edition of Diseases of Children in the Subtropics and Tropics moves in this direction and will most certainly be valuable not only as a clinical reference text. My hope is that it will also persuade its readers that a paediatrician should not only be clinically sound, but also able to recognize the wider community issues involved in the causation of problems and the need for imaginative interdisciplinary programes to improve the outlook for life and health of mothers and children in the Third World.
Published in 1989 by Prentice-Hall, this book is a useful resource for educators and self-learners alike. The text is aimed at those who have seen Maxwell's equations in integral and differential form and who have been exposed to some integral theorems and differential operators. A hypertext version of this textbook can be found here. An accompanying set of video demonstrations is available below. These video demonstrations convey electromagnetism concepts. The demonstrations are related to topics covered in the textbook. They were prepared by Markus Zahn, James R. Melcher, and Manuel L. Silva and were produced by the Department of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology. The purpose of these demonstrations is to make mathematical analysis of electromagnetism take on physical meaning. Based on relatively simple configurations and arrangements of equipment, they make a direct connection between what has been analytically derived and what is observed. They permit the student to observe physically what has been described symbolically. Often presented with a plot of theoretical predictions that are compared to measured data, these demonstrations give the opportunity to test the range of validity of the theory and present a quantitative approach to dealing with the physical world. The short form of these videos contains the demonstrations only. The long form also presents theory, diagrams, and calculations in support of the demonstrations.
VT Publishing, Virginia Tech University Libraries
First published in 1968 by John Wiley and Sons, Inc., Electromechanical Dynamics discusses the interaction of electromagnetic fields with media in motion. The subject combines classical mechanics and electromagnetic theory and provides opportunities to develop physical intuition. The book uses examples that emphasize the connections between physical reality and analytical models. Types of electromechanical interactions covered include rotating machinery, plasma dynamics, the electromechanics of biological systems, and magnetoelasticity.
This book bridges the gap between playing with robots in school and studying robotics at the upper undergraduate and graduate levels to prepare for careers in industry and research. Robotic algorithms are presented formally, but using only mathematics known by high-school and first-year college students, such as calculus, matrices and probability. Concepts and algorithms are explained through detailed diagrams and calculations. Elements of Robotics presents an overview of different types of robots and the components used to build robots, but focuses on robotic algorithms: simple algorithms like odometry and feedback control, as well as algorithms for advanced topics like localization, mapping, image processing, machine learning and swarm robotics. These algorithms are demonstrated in simplified contexts that enable detailed computations to be performed and feasible activities to be posed. Students who study these simplified demonstrations will be well prepared for advanced study of robotics. The algorithms are presented at a relatively abstract level, not tied to any specific robot. Instead a generic robot is defined that uses elements common to most educational robots: differential drive with two motors, proximity sensors and some method of displaying output to the user. The theory is supplemented with over 100 activities, most of which can be successfully implemented using inexpensive educational robots. Activities that require more computation can be programmed on a computer. Archives are available with suggested implementations for the Thymio robot and standalone programs in Python.
This book is the direct result of nearly five years of work on the Energy Vulnerability and Urban Transitions in Europe project (www.urbanenergy.org), generously supported by a Starting Grant from the European Research Council—under the European Union’s Seventh Framework Programme (FP7/2007–2013/ERC grant agreement number 313478). The project, commonly known under the acronym EVALUATE (Energy Vulnerability and Urban Transitions in Europe project), has sought to transform scientific knowledge and policy action on energy poverty—a form of material deprivation that affects billions of people across the world. EVALUATE is a multi-sited study, involving extensive research across a variety of cities and countries. Focusing primarily on four Central and Eastern European cities (Budapest, Gdań sk, Prague and Skopje) the project has undertaken a customized survey with 2435 households, supplemented with insights from in-depth household interviews, ‘energy diaries’ and energy efficiency audits in the homes of approximately 160 households living in the four cities. EVALUATE has entailed 195 expert interviews in a much wider range of sites across the world, as well as an analysis of micro-data from national and European Union surveys of energy poverty. It has led to more than 200 dissemination activities, while laying the basis for the European Energy Poverty Observatory as well as a new European Co-operation for Science and Technology Action on ‘European Energy Poverty: Agenda Co-Creation and Knowledge Innovation’.
This open access book disseminates some of the results of the European H2020 AiRT Project (Technology transfer of RPAs for the creative industry). In particular, it presents findings related to mitigating safety and security concerns when civil drones are piloted by the service sector (mainly, the creative industry). European policies regarding drones generally focus on outdoor drones, but they are also used indoors. Moreover, a number of European countries have fragmented regulations on drone use, and as a result, European institutions are attempting address these issues. This work is based on a detailed study of the European policies, a comparative analysis of the regulation in various European countries, an analysis of the drone sector in Europe, and primary data from members of the creative industry. The authors created focus groups in Spain, the UK and Belgium in order to discuss with the creative industry the concerns on safety and security when using civil drones for their work. Based on these results, the book offers advice to the European industry, as well as new insights for academics and policymakers.
Field Trials of Health Interventions: A Toolbox
Abstract Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in `field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this open-access online guide, practical issues in trial design and conduct are discussed fully and in sufficient detail. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience
Forest Measurements: an Applied Approach
This is a forest measurements textbook written for field technicians. Silvicultural applications and illustrations are provided to demonstrate the relevance of the measurements. Special “technique tips” for each skill are intended to help increase data collection accuracy and confidence. These include how to avoid common pitfalls, effective short cuts and essentials for recording field data correctly. The emphasis is on elementary skills; it is not intended to be a timber cruising guide.
Fundamentals of Infrastructure Management
The authors believe this free of charge book, Fundamentals of Infrastructure Management, will expand the impact of the material and help improve the practice of infrastructure management. By ‘free of charge,’ we mean that the material can be freely obtained, but readers should devote time and effort to mastering the material. We have provided problem assignments for various chapters, and we strongly urge readers to undertake the problems as a learning experience. This book grew out of a decade of co-teaching a course entitled ‘Infrastructure Management’ at Carnegie Mellon University. Our teaching philosophy was to prepare students for work in the field of infrastructure management. We believe that infrastructure management is a professional endeavor and an attractive professional career. The book is co-authored by two accomplished engineers - each representing professional practice, academic research and theoretical evaluation. Their collective strengths are presented throughout the text and serve to support both the practice of infrastructure management and a role for infrastructure management inquiry and search. Importantly, both co-authors have academic research interests (and a number of research publications) on various topics of infrastructure management. That said, the primary audience for this book is expected to be professionals intending to practice infrastructure management, and only secondarily individuals who intend to pursue a career of research in the area. The text draws examples and discusses a wide variety of infrastructure systems, including roadways, telecommunications, power generation, buildings and systems of infrastructure. We have found that some common fundamentals of asset management, analysis tools and informed decision-making are useful for a variety of such systems. Certainly, many infrastructure managers encounter a variety of infrastructure types during their professional careers. Moreover, due to the functional inter-dependencies of different infrastructure systems, it is certainly advantageous for managers of one infrastructure type to understand other types of infrastructure. For example, roadway managers rely upon the power grid for traffic signal operation.
Health Case Studies is composed of eight separate health case studies. Each case study includes the patient narrative or story that models the best practice (at the time of publishing) in healthcare settings. Associated with each case is a set of specific learning objectives to support learning and facilitate educational strategies and evaluation. The case studies can be used online in a learning management system, in a classroom discussion, in a printed course pack or as part of a textbook created by the instructor. This flexibility is intentional and allows the educator to choose how best to convey the concepts presented in each case to the learner. Because these case studies were primarily developed for an electronic healthcare system, they are based predominantly in an acute healthcare setting. Educators can augment each case study to include primary healthcare settings, outpatient clinics, assisted living environments, and other contexts as relevant.
Interface Oral Health Science 2016: Innovative Research on Biosis–Abiosis Intelligent Interface
This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis–Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted “Interface Oral Health Science” several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014. This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines.
Leak Detection Technology and Implementation
Leak Detection: Technology and Implementation assists water utilities with the development and implementation of leak detection programs. Leak detection and repair is one of the components of controlling water loss. In addition, techniques are discussed within this book and relevant case studies are presented. The book provides useful and practical information on leakage issues.
Math, Numerics, & Programming (for Mechanical Engineers)
All readings are from the textbook: Masayuki Yano, et al. Math, Numerics, and Programming (for Mechanical Engineers). V2.1, August 2013. Files for each available unit are provided in the following table, courtesy of the authors. The entire textbook is available for download as a single file. Students should read all of the assignments for the unit before proceeding to the associated Problem Sets and the MATLAB® Tutorials. In general, students should skip the advanced material in the textbook. This advanced material is indicated either by blue shading or by blue "Advanced Material" bookends.
Public Health Ethics: Cases Spanning the Globe
This Open Access book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively new and emerging area. There are few practical training resources for public health practitioners, especially resources which include discussion of realistic cases which are likely to arise in the practice of public health. This work discusses these issues on a case to case basis and helps create awareness and understanding of the ethics of public health care. The main audience for the casebook is public health practitioners, including front-line workers, field epidemiology trainers and trainees, managers, planners, and decision makers who have an interest in learning about how to integrate ethical analysis into their day to day public health practice. The casebook is also useful to schools of public health and public health students as well as to academic ethicists who can use the book to teach public health ethics and distinguish it from clinical and research ethics.
Sago Palm: Multiple Contributions to Food Security and Sustainable Livelihoods
This book addresses a wide variety of events and technologies concerning the sago palm, ranging from its botanical characteristics, culture and use to social conditions in the places where it is grown, in order to provide a record of research findings and to benefit society. It discusses various subjects, including the sago palm and related species; differentiation of species of starch-producing palm; habitat, morphological, physiological and growth characteristics; culture and management; productivity of carbon dioxide; starch extraction and manufacture; characteristics and utilization of starch; and cultural anthropological and folkloristic aspects. Problems such as food shortages due to increasing populations, global warming and climate change, and decreasing reserves of oil and other underground resources, have become more pressing in recent years. In the context of these problems, the book examines the role of the sago palm in sustainable food production, in the manufacture of other foodstuffs, as a raw material for ethanol and in the manufacture of biodegradable plastics. In addition to academics, this book will be useful to researchers and government officials working for international agencies, national governments, municipalities, and other research organizations; technicians, researchers, managers, entrepreneurs, and others working in industries such as agriculture, plant production, food production, manufacturing, chemical engineering, energy production, and distribution.
Animals and the Shaping of Modern Medicine: One Health and its Histories
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological. Each chapter analyses an important episode in which animals changed and were changed by medicine. Ranging across the animal inhabitants of Britain’s zoos, sick sheep on Scottish farms, unproductive livestock in developing countries, and the tapeworms of California and Beirut, they illuminate the multi-species dimensions of modern medicine and its rich historical connections with biology, zoology, ag riculture and veterinary medicine. The modern movement for One Health – whose history is also analyzed – is therefore revealed as just the latest attempt to improve health by working across species and disciplines. This book will appeal to historians of animals, science and medicine, to those involved in the promotion and practice of One Health today.
This book covers Direct Current (DC) circuit theory and is broken up into three modules. Module 1 covers the basics for circuits that include DC sources (voltage or current) and resistors. Even though Module 1 is not very difficult, it forms the foundation for more complicated topics in Module 2 and 3 so it is important to have a firm grasp of all Module 1 topics before moving on. Module 2 covers more difficult problem solving techniques for circuits that include only DC sources and resistors. Module 3 introduces capacitors and inductors. These non-linear reactive components are analyzed in the transient and steady state regions in circuits with DC sources in Module 3. There are two follow-on eBooks in this 3-part series. They are AC Circuits (published in 2017) and Electromechanical Systems (Coming in 2018).
Information Technology and the Networked Economy
The beginning of the 21st century has seen a rapid change from the industrial economy to a networked economy built on computers, connectivity, and human knowledge. The networked economy is characterized by rapidly changing market conditions and methods of commerce. Instead of leveraging human strength with machines as was done in the industr ial economy, the networked economy leverages human knowledge with computers and connectivity to produce goods and services. The networked economy requires that organizations concentrate on improving their organizational productivity rather than worrying about personal productivity. To meet the needs of tomorrow's organizations, colleges and universities must immediately begin to prepare students to work in the networked economy. The sec­ond edition of Information Tech nology and the Ne tworked Economy is aimed at provid­ ing today's business students with the knowledge of the networked economy necessary to be successful employees and managers in the 21st century.
ICT in Agriculture: Connecting Smallholders to Knowledge, Networks, and Institutions
Malaria was considered one of the most widespread disease-causing entities in the nineteenth century. It was associated with a variety of frailties far beyond fevers, ranging from idiocy to impotence. And yet, it was not a self-contained category. The reconsolidation of malaria as a diagnostic category during this period happened within a wider context in which cinchona plants and their most valuable extract, quinine, were reinforced as objects of natural knowledge and social control. In India, the exigencies and apparatuses of British imperial rule occasioned the close interactions between these histories. In the process, British imperial rule became entangled with a network of nonhumans that included, apart from cinchona plants and the drug quinine, a range of objects described as malarial, as well as mosquitoes. Malarial Subjects explores this history of the co-constitution of a cure and disease, of British colonial rule and nonhumans, and of science, medicine and empire. This title is also available as Open Access.
Medicinal Plants and Its Therapeutic Uses
Nursing Care at the End of Life: What Every Clinician Should Know
Nursing Care at the End of Life: What Every Clinician Should Know should be an essential component of basic educational preparation for the professional registered nurse student. Recent studies show that only one in four nurses feel confident in caring for dying patients and their families and less than 2% of overall content in nursing textbooks is related to end-of-life care, despite the tremendous growth in palliative and end-of-life care programs across the country. The purpose of this textbook is to provide an indepth look at death and dying in this country, including the vital role of the nurse in assisting patients and families along the journey towards the end of life. There is an emphasis throughout the book on the simple, yet understated value of effective interpersonal communication between the patient and clinician. The text provides a basic foundation of understanding death and dying, including a brief historical examination of some main conceptual models associated with how patients cope with impending loss. An overview of illness trajectories and models of care, such as hospice and palliative care are discussed. Lastly, the latest evidence-based approaches for pain and symptom management, ethical concerns, cultural considerations, care at the time of death, and grief/bereavement are examined. The goal of this text is to foster the necessary skills for nurses to provide compassionate care to individuals who are nearing the end of life and their families. Every chapter contains a “What You Should Know” section which highlights and reinforces foundational concepts.
Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Report
The manual contains the following labs: Introduction Tissues Integument Introduction to the Skeleton Axial Skeleton: Skull Axial Skeleton: Vertebral Appendicular Skeleton: Introduction and Pectoral Girdle Appendicular Skeleton: Upper Limbs Appendicular Skeleton: Pelvis Appendicular Skeleton: Lower Limbs Articulations/Joints Body Movements Muscles: Head, Neck, and Back Muscles: Abdomen and Thorax Muscles: Upper Limbs Muscles: Lower Limbs Spinal Cord Brain Cranial Nerves Special Senses: Ear Special Senses: Eye
The manual contains the following labs: Blood Composition Blood Typing Heart Anatomy Cardiovascular Physiology Systemic Blood Vessels Anatomy of the Respiratory System Physiology of the Respiratory System Renal Anatomy Urinalysis Digestive System Anatomy Digestive Physiology Male Reproductive System Female Reproductive System
Energy Poverty : (Dis)Assembling Europe’s Infrastructural Divide
EVALUATE is a multi-sited study, involving extensive research across a variety of cities and countries. Focusing primarily on four Central and Eastern European cities (Budapest, Gdańsk, Prague and Skopje) the project has undertaken a customized survey with 2435 households, supplemented with insights from in-depth household interviews, ‘energy diaries’ and energy efficiency audits in the homes of approximately 160 households living in the four cities. EVALUATE has entailed 195 expert interviews in a much wider range of sites across the world, as well as an analysis of micro-data from national and European Union surveys of energy poverty. It has led to more than 200 dissemination activities, while laying the basis for the European Energy Poverty Observatory as well as a new European Co-operation for Science and Technology Action on ‘European Energy Poverty: Agenda Co-Creation and Knowledge Innovation’
Meat Cutting and Processing for Food Service
This book is intended to give students a basic understanding of the various types of meat and poultry used in the food service industry, and how the terminology used by retail, wholesale, and food service customers varies. Meat cutting for restaurants and hotels differs slightly from meat cutting for retail. Restaurants and hotels sometimes use names of cuts on menus that are common in the kitchen vernacular or in other jurisdictions like Europe or the United States, while retail meat cutters are bound by Canadian regulations regarding labelling and marketing of meat products to consumers for retail. Meat Cutting and Processing for Food Service is one of a series of Culinary Arts books developed to support the training of students and apprentices in British Columbia’s food service and hospitality industry. Although created with the Professional Cook and Baker programs in mind, these have been designed as a modular series, and therefore can be used to support a wide variety of programs that offer training in food service skills.
Medical virology is always an interest to all healthcare disciplines, undergraduate and postgraduate students. These “Notes on Medical virology”, includes “what you really need to know”. The book comes in a new format, which places cases, keywords, facts and other considerations in colored tables and boxes only. As a result, extra spaces have been provided so that without expanding the length of the book the readers can enjoy a personal and practical learning experience.
Digital Scholarly Editing : Theories and Practices
"This volume presents the state of the art in digital scholarly editing. Drawing together the work of established and emerging researchers, it gives pause at a crucial moment in the history of technology in order to offer a sustained reflection on the practices involved in producing, editing and reading digital scholarly editions—and the theories that underpin them. The unrelenting progress of computer technology has changed the nature of textual scholarship at the most fundamental level: the way editors and scholars work, the tools they use to do such work and the research questions they attempt to answer have all been affected. Each of the essays in Digital Scholarly Editing approaches these changes with a different methodological consideration in mind. Together, they make a compelling case for re-evaluating the foundation of the discipline—one that tests its assertions against manuscripts and printed works from across literary history, and the globe. The sheer breadth of Digital Scholarly Editing, along with its successful integration of theory and practice, help redefine a rapidly-changing field, as its firm grounding and future-looking ambit ensure the work will be an indispensable starting point for further scholarship. This collection is essential reading for editors, scholars, students and readers who are invested in the future of textual scholarship and the digital humanities. "
Beyond Lean: Simulation in Practice, Second Edition
Lean thinking, as well as associated processes and tools, have involved into a ubiquitous perspective for improving systems particularly in the manufacturing arena. With application experience has come an understanding of the boundaries of lean capabilities and the benefits of getting beyond these boundaries to further improve performance. Discrete event simulation is recognized as one beyond-the-boundaries of lean technique. Thus, the fundamental goal of this text is to show how discrete event simulation can be used in addition to lean thinking to achieve greater benefits in system improvement than with lean alone. Realizing this goal requires learning the problems that simulation solves as well as the methods required to solve them. The problems that simulation solves are captured in a collection of case studies. These studies serve as metaphors for industrial problems that are commonly addressed using lean and simulation.
Despite all advances in computing technologies, the human-computer interface and the interactions that it provides are the most fundamental. Some of the most anticipated advancements in computer technology lie in the area of interfaces – not least because the unlimited computing power and innovative Internet applications must have an outward face and the ability to communicate effectively with users. Consumers of these resources have an expectation that the interfaces should be just as compelling and useful as the resources themselves. The interfaces should be adaptable to the consumers' lives and useful in all applicable environments – home, office and, most certainly, mobile. But there remain many unanswered questions in the study of human-computer interfaces. How much more interactive or rich is it realistic to expect device interfaces to become? What interfaces now in the laboratory might be able to address the mobile and distributed computing demands of the future? What interactions will replace the familiar graphical user interface (GUI)? This module begins to explore these questions. We'll start with a quick tour of the evolution of the graphical user interface, then consider some more advanced interaction models.
Manufacturing and Inspection Technologies
In this module, we will look at how manufacturing systems have developed over the years, comparing and contrasting the various systems that have sprung up in different countries. We will then move into the present as we study four modern manufacturing systems that are commonly used: mass production, just-in-time manufacturing, lean manufacturing and flexible manufacturing.
The job of the respiratory system is to take oxygen from the air we breathe and get it to different parts of the body. Our bodies and the cells in them need oxygen (written with the chemical symbol O2) to live. Our cells give off carbon dioxide (written with the chemical symbol CO2) as a waste product or something they don’t need any more. The respiratory system takes this carbon dioxide out of the body. The main organ of the respiratory system is the lungs. The respiratory system starts when you take a breath. There is a muscle called the diaphragm that is at the bottom of the rib cage. It helps draw air into the lungs. Once a breath is taken, the air travels through the mouth or nose and travels through the windpipe into the lungs. Once the air is down the windpipe, it splits one of two directions into tubes called bronchi and then into the lungs. The bronchi branch off into more and more smaller tubes. At the very end of these are small sacs called alveoli. In the alveoli, the respiratory system works with the circulatory system. Small blood vessels take oxygen from the alveoli to the heart for distribution to the rest of the body. Blood also brings carbon dioxide to be exhaled back out. When we breathe in or inhale, the air coming into the body has a lot of oxygen. When we breathe out or exhale, the air has more carbon dioxide.
The circulatory system includes the heart, blood, and a huge network of blood vessels that carry blood all over the body. The job of the circulatory system is to deliver oxygen to cells all over the body and then to carry out waste product like carbon dioxide. The heart is an organ made out of muscle. It’s job is to pump blood through the body. The heart has four main sections or chambers: Right atrium Right ventricle Left atrium Left ventricle Blood flows into the right atrium through two large blood vessels called the superior vena cava (from the upper body) and the inferior vena cava (from the lower body). From there blood moves to the right ventricle. It then travels to the lungs to get oxygen. Blood coming back from the lungs enters the left atrium and then into the left ventricle. From there it leaves the heart through the aortic valve and goes into the aorta. This is the largest artery in the body, and it leads to all parts of the body. There are many kinds blood vessels that carry blood around the body. Arteries carry blood away from the heart. (You can remember arteries and away.) Veins carry blood back to the heart. Blood that is coming from the lungs has lots of fresh oxygen in it and is bright red. After the oxygen is delivered to cells and carbon dioxide is picked up, the blood is darker colored. Blood is made up of a liquid called plasma and three kinds of cells. Red blood cells carry oxygen to the various parts of the body. White blood cells help fight disease. Platelets help blood clot.
Our bodies need food to live and grow. The digestive system takes food and carries it to all the parts of the body. The beginning of the digestive system is the mouth and teeth. Food that we eat has to be broken down into nutrients that cells in our bodies can use. This starts with the teeth and tongue grinding food into smaller pieces. Saliva also helps break down food. Then the food is swallowed and goes down the esophagus, a tube that goes from the mouth to the stomach. The stomach breaks down the food further. Gastric juices that have acids and enzymes in them that help the process. Then the food goes to the small intestine. This is a long twisting tube that fills up much of your lower abdomen area. It is where most of the digestion occurs. The liver produces bile, and the pancreas produces juices that help break food down. Small blood vessels line the walls of the small intestine. Once the food is broken down, the nutrients are absorbed by these blood vessels. The blood then carries the nutrients to cells all over the body. The part of the food that is left moves on to the large intestine.
After food goes through the digestive system, the parts that are not digested need to be gotten rid of. That is the job of the excretory system. Unabsorbed food goes to the large intestine. The liver also filters out solid particles of waste from the blood. These solid wastes are removed from the body through the rectum, which is at the end of the large intestine. Liquid wastes are filtered by the kidneys, a part of the excretory system. The kidneys have long tubes coming out of them called ureters that drain liquid into the bladder. The bladder stores liquid waste called urine until it is passed out of the body through the urethra.
The human skeleton provides shape and form to the human body Our vital organs in our body are protected by our skeleton. More specifically our brain which is protected by what is called the skull and our heart and lungs are protected by our rib cage. Bones are connected by our ligaments and where the bones meet eachother is called a joint. Muscles are connected to the bones by tendons Bones are sonnected to each other by ligaments Blood cells are produced by the marrow located in some bones How your bones move! Muscles pull on the bones, making them move and when muscles contract the bones attached act as levers which makes the body move.
Cardio Exercises Below 1) Jog. You can do this outside on a treadmill or however you like. 2) Jump Rope routine 1 3) 10 Minute Jump Rope routine 4) Exercise Bikes 5) Sports Playing
Chambers and Circulation through the Heart
Dual System of the Human Blood Circulation. Blood flows from the right atrium to the right ventricle, where it is pumped into the pulmonary circuit. The blood in the pulmonary artery branches is low in oxygen but relatively high in carbon dioxide. Gas exchange occurs in the pulmonary capillaries (oxygen into the blood, carbon dioxide out), and blood high in oxygen and low in carbon dioxide is returned to the left atrium. From here, blood enters the left ventricle, which pumps it into the systemic circuit. Following exchange in the systemic capillaries (oxygen and nutrients out of the capillaries and carbon dioxide and wastes in), blood returns to the right atrium and the cycle is repeated.
The shoulder joint is called the glenohumeral joint. This is a ball-and-socket joint formed by the articulation between the head of the humerus and the glenoid cavity of the scapula ([link]). This joint has the largest range of motion of any joint in the body. However, this freedom of movement is due to the lack of structural support and thus the enhanced mobility is offset by a loss of stability. The large range of motions at the shoulder joint is provided by the articulation of the large, rounded humeral head with the small and shallow glenoid cavity, which is only about one third of the size of the humeral head. The socket formed by the glenoid cavity is deepened slightly by a small lip of fibrocartilage called the glenoid labrum, which extends around the outer margin of the cavity. The articular capsule that surrounds the glenohumeral joint is relatively thin and loose to allow for large motions of the upper limb. Some structural support for the joint is provided by thickenings of the articular capsule wall that form weak intrinsic ligaments. These include the coracohumeral ligament, running from the coracoid process of the scapula to the anterior humerus, and three ligaments, each called a glenohumeral ligament, located on the anterior side of the articular capsule. These ligaments help to strengthen the superior and anterior capsule walls. However, the primary support for the shoulder joint is provided by muscles crossing the joint, particularly the four rotator cuff muscles. These muscles (supraspinatus, infraspinatus, teres minor, and subscapularis) arise from the scapula and attach to the greater or lesser tubercles of the humerus. As these muscles cross the shoulder joint, their tendons encircle the head of the humerus and become fused to the anterior, superior, and posterior walls of the articular capsule. The thickening of the capsule formed by the fusion of these four muscle tendons is called the rotator cuff. Two bursae, the subacromial bursa and the subscapular bursa, help to prevent friction between the rotator cuff muscle tendons and the scapula as these tendons cross the glenohumeral joint. In addition to their individual actions of moving the upper limb, the rotator cuff muscles also serve to hold the head of the humerus in position within the glenoid cavity. By constantly adjusting their strength of contraction to resist forces acting on the shoulder, these muscles serve as “dynamic ligaments” and thus provide the primary structural support for the glenohumeral joint.
Levels of Structural Organization of the Human Body
Before you begin to study the different structures and functions of the human body, it is helpful to consider its basic architecture; that is, how its smallest parts are assembled into larger structures. It is convenient to consider the structures of the body in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, organisms and biosphere. To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of which are hydrogen, oxygen, carbon, nitrogen, calcium, and iron. The smallest unit of any of these pure substances (elements) is an atom. Atoms are made up of subatomic particles such as the proton, electron and neutron. Two or more atoms combine to form a molecule, such as the water molecules, proteins, and sugars found in living things. Molecules are the chemical building blocks of all body structures. A cell is the smallest independently functioning unit of a living organism. Even bacteria, which are extremely small, independently-living organisms, have a cellular structure. Each bacterium is a single cell. All living structures of human anatomy contain cells, and almost all functions of human physiology are performed in cells or are initiated by cells. A human cell typically consists of flexible membranes that enclose cytoplasm, a water-based cellular fluid together with a variety of tiny functioning units called organelles. In humans, as in all organisms, cells perform all functions of life. A tissue is a group of many similar cells (though sometimes composed of a few related types) that work together to perform a specific function. An organ is an anatomically distinct structure of the body composed of two or more tissue types. Each organ performs one or more specific physiological functions. An organ system is a group of organs that work together to perform major functions or meet physiological needs of the body.
Normal childbirth is driven by a positive feedback loop. A positive feedback loop results in a change in the body’s status, rather than a return to homeostasis.
The posterior (dorsal) and anterior (ventral) cavities are each subdivided into smaller cavities. In the posterior (dorsal) cavity, the cranial cavity houses the brain, and the spinal cavity (or vertebral cavity) encloses the spinal cord. Just as the brain and spinal cord make up a continuous, uninterrupted structure, the cranial and spinal cavities that house them are also continuous. The brain and spinal cord are protected by the bones of the skull and vertebral column and by cerebrospinal fluid, a colorless fluid produced by the brain, which cushions the brain and spinal cord within the posterior (dorsal) cavity. The anterior (ventral) cavity has two main subdivisions: the thoracic cavity and the abdominopelvic cavity (see [link]). The thoracic cavity is the more superior subdivision of the anterior cavity, and it is enclosed by the rib cage. The thoracic cavity contains the lungs and the heart, which is located in the mediastinum. The diaphragm forms the floor of the thoracic cavity and separates it from the more inferior abdominopelvic cavity. The abdominopelvic cavity is the largest cavity in the body. Although no membrane physically divides the abdominopelvic cavity, it can be useful to distinguish between the abdominal cavity, the division that houses the digestive organs, and the pelvic cavity, the division that houses the organs of reproduction.
Regions and Quadrants of the Peritoneal Cavity
The more detailed regional approach subdivides the cavity with one horizontal line immediately inferior to the ribs and one immediately superior to the pelvis, and two vertical lines drawn as if dropped from the midpoint of each clavicle (collarbone). There are nine resulting regions. The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersect at the patient’s umbilicus (navel)
A serous membrane (also referred to a serosa) is one of the thin membranes that cover the walls and organs in the thoracic and abdominopelvic cavities. The parietal layers of the membranes line the walls of the body cavity (pariet- refers to a cavity wall). The visceral layer of the membrane covers the organs (the viscera). Between the parietal and visceral layers is a very thin, fluid-filled serous space, or cavity There are three serous cavities and their associated membranes. The pleura is the serous membrane that surrounds the lungs in the pleural cavity; the pericardium is the serous membrane that surrounds the heart in the pericardial cavity; and the peritoneum is the serous membrane that surrounds several organs in the abdominopelvic cavity.The serous membranes form fluid-filled sacs, or cavities, that are meant to cushion and reduce friction on internal organs when they move, such as when the lungs inflate or the heart beats. Both the parietal and visceral serosa secrete the thin, slippery serous fluid located within the serous cavities. The pleural cavity reduces friction between the lungs and the body wall. Likewise, the pericardial cavity reduces friction between the heart and the wall of the pericardium. The peritoneal cavity reduces friction between the abdominal and pelvic organs and the body wall. Therefore, serous membranes provide additional protection to the viscera they enclose by reducing friction that could lead to inflammation of the organs.
Animals & Ethics 101: Thinking Critically About Animal Rights
This book provides an overview of the current debates about the nature and extent of our moral obligations to animals. Which, if any, uses of animals are morally wrong, which are morally permissible (i.e., not wrong) and why? What, if any, moral obligations do we, individually and as a society (and a global community), have towards animals and why? How should animals be treated? Why? We will explore the most influential and most developed answers to these questions – given by philosophers, scientists, and animal advocates and their critics – to try to determine which positions are supported by the best moral reasons.
Creative Clinical Teaching In The Health Professions
This peer reviewed e-book is a must-read for nurses and other health professionals who strive to teach with creativity and excellence in clinical settings. Each chapter presents current evidence informed educational practice knowledge. Each topic is also presented with text boxes describing ‘Creative Strategies’ that clinical teachers from across Canada have successfully implemented. For those who are interested in background knowledge, the authors provided a comprehensive literature base. And, for those interested mainly in 'what to do,' the text box summaries offer step-by-step directions for creative, challenging activities that both new and experienced instructors can begin using immediately.
Health and Safety in Canadian Workplaces
Workplace injuries happen every day and can profoundly affect workers, their families, and the communities they live in. This textbook provides workers with an introduction to effective injury prevention. The book pays particular attention to how issues of precarious employment, gender, and ill health can be better handled in Canadian occupational health and safety (OHS). This introduction to OHS differs from others because it contends that the practice of occupational health and safety can only be properly understood if we acknowledge that workers and employers have conflicting interests. Specifically, we investigate which workplace hazards are recognized and controlled, the manner in which these hazards are controlled, and who makes these decisions. These are all factors that reflect the broader political economy of employment and suggest that OHS is contested terrain.
Human Anatomy and Physiology Preparatory Course
The overall purpose of this preparatory course textbook is to help students familiarize with some terms and some basic concepts they will find later in the Human Anatomy and Physiology I course. The organization and functioning of the human organism generally is discussed in terms of different levels of increasing complexity, from the smallest building blocks to the entire body. This Anatomy and Physiology preparatory course covers the foundations on the chemical level, and a basic introduction to cellular level, organ level, and organ system levels. There is also an introduction to homeostasis at the beginning.
Literature Reviews for Education and Nursing Graduate Students
Literature Reviews for Education and Nursing Graduate Students is an open textbook designed for students in graduate-level nursing and education programs. Its intent is to recognize the significant role the literature review plays in the research process and to prepare students for the work that goes into writing one. Developed for new graduate students and novice researchers just entering into the work of a chosen discipline, each of the eight chapters covers a component of the literature review process. Students will learn how to form a research question, search existing literature, synthesize results and write the review. The book contains examples, checklists, supplementary materials, and additional resources. Literature Reviews for Education and Nursing Graduate Students is written by two librarians with expertise guiding students through research and writing assignments, and is openly licensed.
High energy electromagnetic radiation allows the internal structures of the body, such as bones, to be seen in X-rays like these
(a) The results of a CT scan of the head are shown as successive transverse sections. (b) An MRI machine generates a magnetic field around a patient. (c) PET scans use radiopharmaceuticals to create images of active blood flow and physiologic activity of the organ or organs being targeted. (d) Ultrasound technology is used to monitor pregnancies because it is the least invasive of imaging techniques and uses no electromagnetic radiation.
The main elements that compose the human body are shown from most abundant to least abundant.
The nucleotide adenosine triphosphate (ATP), is composed of a ribose sugar, an adenine base, and three phosphate groups ([link]). ATP is classified as a high energy compound because the two covalent bonds linking its three phosphates store a significant amount of potential energy. In the body, the energy released from these high energy bonds helps fuel the body’s activities, from muscle contraction to the transport of substances in and out of cells to anabolic chemical reactions. When a phosphate group is cleaved from ATP, the products are adenosine diphosphate (ADP) and inorganic phosphate (Pi). This hydrolysis reaction can be written: ATP + H2O → ADP + Pi + energy Removal of a second phosphate leaves adenosine monophosphate (AMP) and two phosphate groups. Again, these reactions also liberate the energy that had been stored in the phosphate-phosphate bonds. They are reversible, too, as when ADP undergoes phosphorylation. Phosphorylation is the addition of a phosphate group to an organic compound, in this case, resulting in ATP. In such cases, the same level of energy that had been released during hydrolysis must be reinvested to power dehydration synthesis. Cells can also transfer a phosphate group from ATP to another organic compound. For example, when glucose first enters a cell, a phosphate group is transferred from ATP, forming glucose phosphate (C6H12O6—P) and ADP. Once glucose is phosphorylated in this way, it can be stored as glycogen or metabolized for immediate energy.
Fluorescence-stained Cell Undergoing Mitosis
A lung cell from a newt, commonly studied for its similarity to human lung cells, is stained with fluorescent dyes. The green stain reveals mitotic spindles, red is the cell membrane and part of the cytoplasm, and the structures that appear light blue are chromosomes. This cell is in anaphase of mitosis.
The cell membrane of the cell is a phospholipid bilayer containing many different molecular components, including proteins and cholesterol, some with carbohydrate groups attached.
Simple Diffusion across the Cell (Plasma) Membrane
The structure of the lipid bilayer allows small, uncharged substances such as oxygen and carbon dioxide, and hydrophobic molecules such as lipids, to pass through the cell membrane, down their concentration gradient, by simple diffusion.
(a) Facilitated diffusion of substances crossing the cell (plasma) membrane takes place with the help of proteins such as channel proteins and carrier proteins. Channel proteins are less selective than carrier proteins, and usually mildly discriminate between their cargo based on size and charge. (b) Carrier proteins are more selective, often only allowing one particular type of molecule to cross.
The sodium-potassium pump is found in many cell (plasma) membranes. Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell.
Endocytosis is a form of active transport in which a cell envelopes extracellular materials using its cell membrane. (a) In phagocytosis, which is relatively nonselective, the cell takes in a large particle. (b) In pinocytosis, the cell takes in small particles in fluid. (c) In contrast, receptor-mediated endocytosis is quite selective. When external receptors bind a specific ligand, the cell responds by endocytosing the ligand.
Exocytosis is much like endocytosis in reverse. Material destined for export is packaged into a vesicle inside the cell. The membrane of the vesicle fuses with the cell membrane, and the contents are released into the extracellular space.
The level of saturation of a fatty acid affects its shape. (a) Saturated fatty acid chains are straight. (b) Unsaturated fatty acid chains are kinked.
While this image is not indicative of any one particular human cell, it is a prototypical example of a cell containing the primary organelles and internal structures.
(a) The ER is a winding network of thin membranous sacs found in close association with the cell nucleus. The smooth and rough endoplasmic reticula are very different in appearance and function (source: mouse tissue). (b) Rough ER is studded with numerous ribosomes, which are sites of protein synthesis (source: mouse tissue). EM × 110,000. (c) Smooth ER synthesizes phospholipids, steroid hormones, regulates the concentration of cellular Ca++, metabolizes some carbohydrates, and breaks down certain toxins (source: mouse tissue)
(a) The Golgi apparatus manipulates products from the rough ER, and also produces new organelles called lysosomes. Proteins and other products of the ER are sent to the Golgi apparatus, which organizes, modifies, packages, and tags them. Some of these products are transported to other areas of the cell and some are exported from the cell through exocytosis. Enzymatic proteins are packaged as new lysosomes (or packaged and sent for fusion with existing lysosomes). (b) An electron micrograph of the Golgi apparatus.
The mitochondria are the energy-conversion factories of the cell. (a) A mitochondrion is composed of two separate lipid bilayer membranes. Along the inner membrane are various molecules that work together to produce ATP, the cell’s major energy currency. (b) An electron micrograph of mitochondri
The Three Components of the Cytoskeleton
The cytoskeleton consists of (a) microtubules, (b) microfilaments, and (c) intermediate filaments. The cytoskeleton plays an important role in maintaining cell shape and structure, promoting cellular movement, and aiding cell division.
The nucleus is the control center of the cell. The nucleus of living cells contains the genetic material that determines the entire structure and function of that cell.
Unlike cardiac muscle cells and smooth muscle cells, which have a single nucleus, a skeletal muscle cell contains many nuclei, and is referred to as “multinucleated.” These muscle cells are long and fibrous (often referred to as muscle fibers). During development, many smaller cells fuse to form a mature muscle fiber. The nuclei of the fused cells are conserved in the mature cell, thus imparting a multinucleate characteristic to mature muscle cells.
Strands of DNA are wrapped around supporting histones. These proteins are increasingly bundled and condensed into chromatin, which is packed tightly into chromosomes when the cell is ready to divide.
The DNA double helix is composed of two complementary strands. The strands are bonded together via their nitrogenous base pairs using hydrogen bonds.
DNA replication faithfully duplicates the entire genome of the cell. During DNA replication, a number of different enzymes work together to pull apart the two strands so each strand can be used as a template to synthesize new complementary strands. The two new daughter DNA molecules each contain one pre-existing strand and one newly synthesized strand. Thus, DNA replication is said to be “semiconservative
DNA holds all of the genetic information necessary to build a cell’s proteins. The nucleotide sequence of a gene is ultimately translated into an amino acid sequence of the gene’s corresponding protein.
In the first of the two stages of making protein from DNA, a gene on the DNA molecule is transcribed into a complementary mRNA molecule.
In the nucleus, a structure called a spliceosome cuts out introns (noncoding regions) within a pre-mRNA transcript and reconnects the exons.
During translation, the mRNA transcript is “read” by a functional complex consisting of the ribosome and tRNA molecules. tRNAs bring the appropriate amino acids in sequence to the growing polypeptide chain by matching their anti-codons with codons on the mRNA strand.
From DNA to Protein: Transcription through Translation
Transcription within the cell nucleus produces an mRNA molecule, which is modified and then sent into the cytoplasm for translation. The transcript is decoded into a protein with the help of a ribosome and tRNA molecules.
A Homologous Pair of Chromosomes with their Attached Sister Chromatids
The red and blue colors correspond to a homologous pair of chromosomes. Each member of the pair was separately inherited from one parent. Each chromosome in the homologous pair is also bound to an identical sister chromatid, which is produced by DNA replication, and results in the familiar “X” shape.
The stages of cell division oversee the separation of identical genetic material into two new nuclei, followed by the division of the cytoplasm.
The process of hematopoiesis involves the differentiation of multipotent cells into blood and immune cells. The multipotent hematopoietic stem cells give rise to many different cell types, including the cells of the immune system and red blood cells.
The capacity of stem cells to differentiate into specialized cells make them potentially valuable in therapeutic applications designed to replace damaged cells of different body tissues.
This figure is a view of the regular architecture of normal tissue contrasted with the irregular arrangement of cancerous cells.
The four types of tissues are exemplified in nervous tissue, stratified squamous epithelial tissue, cardiac muscle tissue, and connective tissue in small intestine. Clockwise from nervous tissue
The zygote, or fertilized egg, is a single cell formed by the fusion of an egg and sperm. After fertilization the zygote gives rise to rapid mitotic cycles, generating many cells to form the embryo. The first embryonic cells generated have the ability to differentiate into any type of cell in the body and, as such, are called totipotent, meaning each has the capacity to divide, differentiate, and develop into a new organism. As cell proliferation progresses, three major cell lineages are established within the embryo. As explained in a later chapter, each of these lineages of embryonic cells forms the distinct germ layers from which all the tissues and organs of the human body eventually form. Each germ layer is identified by its relative position: ectoderm (ecto- = “outer”), mesoderm (meso- = “middle”), and endoderm (endo- = “inner”). The types of tissues and organs associated with the each of the three germ layers. Note that epithelial tissue originates in all three layers, whereas nervous tissue derives primarily from the ectoderm and muscle tissue from mesoderm.
The two broad categories of tissue membranes in the body are (1) connective tissue membranes, which include synovial membranes, and (2) epithelial membranes, which include mucous membranes, serous membranes, and the cutaneous membrane, in other words, the skin.
The three basic types of cell-to-cell junctions are tight junctions, gap junctions, and anchoring junctions.
Simple epithelial tissue is organized as a single layer of cells and stratified epithelial tissue is formed by several layers of cells.
(a) In the lining of the small intestine, columnar epithelium cells are interspersed with goblet cells. (b) The arrows in this micrograph point to the mucous-secreting goblet cells.
A stratified epithelium consists of several stacked layers of cells. This epithelium protects against physical and chemical wear and tear. The stratified epithelium is named by the shape of the most apical layer of cells, closest to the free space. Stratified squamous epithelium is the most common type of stratified epithelium in the human body. The apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The top layer may be covered with dead cells filled with keratin. Mammalian skin is an example of this dry, keratinized, stratified squamous epithelium. The lining of the mouth cavity is an example of an unkeratinized, stratified squamous epithelium. Stratified cuboidal epithelium and stratified columnar epithelium can also be found in certain glands and ducts, but are uncommon in the human body. Another kind of stratified epithelium is transitional epithelium, so-called because of the gradual changes in the shapes of the apical cells as the bladder fills with urine. It is found only in the urinary system, specifically the ureters and urinary bladder. When the bladder is empty, this epithelium is convoluted and has cuboidal apical cells with convex, umbrella shaped, apical surfaces. As the bladder fills with urine, this epithelium loses its convolutions and the apical cells transition from cuboidal to squamous. It appears thicker and more multi-layered when the bladder is empty, and more stretched out and less stratified when the bladder is full and distended. summarizes the different categories of epithelial cell tissue cells.
Exocrine glands are classified by their structure.
(a) In merocrine secretion, the cell remains intact. (b) In apocrine secretion, the apical portion of the cell is released, as well. (c) In holocrine secretion, the cell is destroyed as it releases its product and the cell itself becomes part of the secretion.
These glands secrete oils that lubricate and protect the skin. They are holocrine glands and they are destroyed after releasing their contents. New glandular cells form to replace the cells that are lost
Fibroblasts produce this fibrous tissue. Connective tissue proper includes the fixed cells fibrocytes, adipocytes, and mesenchymal cells.
This is a loose connective tissue that consists of fat cells with little extracellular matrix. It stores fat for energy and provides insulation.
This is a loose connective tissue made up of a network of reticular fibers that provides a supportive framework for soft organs.
(a) Dense regular connective tissue consists of collagenous fibers packed into parallel bundles. (b) Dense irregular connective tissue consists of collagenous fibers interwoven into a mesh-like network. From top,
Cartilage is a connective tissue consisting of collagenous fibers embedded in a firm matrix of chondroitin sulfates. (a) Hyaline cartilage provides support with some flexibility. The example is from dog tissue. (b) Fibrocartilage provides some compressibility and can absorb pressure. (c) Elastic cartilage provides firm but elastic support. From top,
The cell body of a neuron, also called the soma, contains the nucleus and mitochondria. The dendrites transfer the nerve impulse to the soma. The axon carries the action potential away to another excitable cell.
Nervous tissue is made up of neurons and neuroglia. The cells of nervous tissue are specialized to transmit and receive impulses
The skin is composed of two main layers: the epidermis, made of closely packed epithelial cells, and the dermis, made of dense, irregular connective tissue that houses blood vessels, hair follicles, sweat glands, and other structures. Beneath the dermis lies the hypodermis, which is composed mainly of loose connective and fatty tissues.
The epidermis of thick skin has five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in the different layers of the epidermis originate from basal cells located in the stratum basale, yet the cells of each layer are distinctively different.
This stained slide shows the two components of the dermis—the papillary layer and the reticular layer. Both are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
The relative coloration of the skin depends of the amount of melanin produced by melanocytes in the stratum basale and taken up by keratinocytes.
Moles range from benign accumulations of melanocytes to melanomas. These structures populate the landscape of our skin.
Individuals with vitiligo experience depigmentation that results in lighter colored patches of skin. The condition is especially noticeable on darker skin.
Hair follicles originate in the epidermis and have many different parts.
The nail is an accessory structure of the integumentary system.
Eccrine glands are coiled glands in the dermis that release sweat that is mostly water.
During strenuous physical activities, such as skiing (a) or running (c), the dermal blood vessels dilate and sweat secretion increases (b). These mechanisms prevent the body from overheating. In contrast, the dermal blood vessels constrict to minimize heat loss in response to low temperatures (b)
Acne is a result of over-productive sebaceous glands, which leads to formation of blackheads and inflammation of the skin.
The cranium completely surrounds and protects the brain from non-traumatic injury.
Bones are classified according to their shape.
A typical long bone shows the gross anatomical characteristics of bone.
The periosteum forms the outer surface of bone, and the endosteum lines the medullary cavity.
This cross-section of a flat bone shows the spongy bone (diploë) lined on either side by a layer of compact bone.
The surface features of bones depend on their function, location, attachment of ligaments and tendons, or the penetration of blood vessels and nerves.
Four types of cells are found within bone tissue. Osteogenic cells are undifferentiated and develop into osteoblasts. When osteoblasts get trapped within the calcified matrix, their structure and function changes, and they become osteocytes. Osteoclasts develop from monocytes and macrophages and differ in appearance from other bone cells.
(a) This cross-sectional view of compact bone shows the basic structural unit, the osteon. (b) In this micrograph of the osteon, you can clearly see the concentric lamellae and central canals.
Spongy bone is composed of trabeculae that contain the osteocytes. Red marrow fills the spaces in some bones.
Normal leg bones are relatively straight, but those affected by Paget’s disease are porous and curved.
Diagram of Blood and Nerve Supply to Bone
Blood vessels and nerves enter the bone through the nutrient foramen.
Intramembranous ossification follows four steps. (a) Mesenchymal cells group into clusters, and ossification centers form. (b) Secreted osteoid traps osteoblasts, which then become osteocytes. (c) Trabecular matrix and periosteum form. (d) Compact bone develops superficial to the trabecular bone, and crowded blood vessels condense into red marrow.
Endochondral ossification follows five steps. (a) Mesenchymal cells differentiate into chondrocytes. (b) The cartilage model of the future bony skeleton and the perichondrium form. (c) Capillaries penetrate cartilage. Perichondrium transforms into periosteum. Periosteal collar develops. Primary ossification center develops. (d) Cartilage and chondrocytes continue to grow at ends of the bone. (e) Secondary ossification centers develop. (f) Cartilage remains at epiphyseal (growth) plate and at joint surface as articular cartilage.
The epiphyseal plate is responsible for longitudinal bone growth.
Progression from Epiphyseal Plate to Epiphyseal Line
As a bone matures, the epiphyseal plate progresses to an epiphyseal line. (a) Epiphyseal plates are visible in a growing bone. (b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone.
Compare healthy bone with different types of fractures: (a) closed fracture, (b) open fracture, (c) transverse fracture, (d) spiral fracture, (e) comminuted fracture, (f) impacted fracture, (g) greenstick fracture, and (h) oblique fracture.
The healing of a bone fracture follows a series of progressive steps: (a) A fracture hematoma forms. (b) Internal and external calli form. (c) Cartilage of the calli is replaced by trabecular bone. (d) Remodeling occurs.
Graph Showing Relationship Between Age and Bone Mass
Bone density peaks at about 30 years of age. Women lose bone mass more rapidly than men.
The body regulates calcium homeostasis with two pathways; one is signaled to turn on when blood calcium levels drop below normal and one is the pathway that is signaled to turn on when blood calcium levels are elevated.
The axial skeleton supports the head, neck, back, and chest and thus forms the vertical axis of the body. It consists of the skull, vertebral column (including the sacrum and coccyx), and the thoracic cage, formed by the ribs and sternum. The appendicular skeleton is made up of all bones of the upper and lower limbs.
The skull consists of the rounded brain case that houses the brain and the facial bones that form the upper and lower jaws, nose, orbits, and other facial structures.
An anterior view of the skull shows the bones that form the forehead, orbits (eye sockets), nasal cavity, nasal septum, and upper and lower jaws.
The lateral skull shows the large rounded brain case, zygomatic arch, and the upper and lower jaws. The zygomatic arch is formed jointly by the zygomatic process of the temporal bone and the temporal process of the zygomatic bone. The shallow space above the zygomatic arch is the temporal fossa. The space inferior to the zygomatic arch and deep to the posterior mandible is the infratemporal fossa.
The bones of the brain case surround and protect the brain, which occupies the cranial cavity. The base of the brain case, which forms the floor of cranial cavity, is subdivided into the shallow anterior cranial fossa, the middle cranial fossa, and the deep posterior cranial fossa.
A lateral view of the isolated temporal bone shows the squamous, mastoid, and zygomatic portions of the temporal bone.
External and Internal Views of Base of Skull
(a) The hard palate is formed anteriorly by the palatine processes of the maxilla bones and posteriorly by the horizontal plate of the palatine bones. (b) The complex floor of the cranial cavity is formed by the frontal, ethmoid, sphenoid, temporal, and occipital bones. The lesser wing of the sphenoid bone separates the anterior and middle cranial fossae. The petrous ridge (petrous portion of temporal bone) separates the middle and posterior cranial fossae.
This view of the posterior skull shows attachment sites for muscles and joints that support the skull.
Shown in isolation in (a) superior and (b) posterior views, the sphenoid bone is a single midline bone that forms the anterior walls and floor of the middle cranial fossa. It has a pair of lesser wings and a pair of greater wings. The sella turcica surrounds the hypophyseal fossa. Projecting downward are the medial and lateral pterygoid plates. The sphenoid has multiple openings for the passage of nerves and blood vessels, including the optic canal, superior orbital fissure, foramen rotundum, foramen ovale, and foramen spinosum.
This midline view of the sagittally sectioned skull shows the nasal septum.
The unpaired ethmoid bone is located at the midline within the central skull. It has an upward projection, the crista galli, and a downward projection, the perpendicular plate, which forms the upper nasal septum. The cribriform plates form both the roof of the nasal cavity and a portion of the anterior cranial fossa floor. The lateral sides of the ethmoid bone form the lateral walls of the upper nasal cavity, part of the medial orbit wall, and give rise to the superior and middle nasal conchae. The ethmoid bone also contains the ethmoid air cells.
The three nasal conchae are curved bones that project from the lateral walls of the nasal cavity. The superior nasal concha and middle nasal concha are parts of the ethmoid bone. The inferior nasal concha is an independent bone of the sku
The maxillary bone forms the upper jaw and supports the upper teeth. Each maxilla also forms the lateral floor of each orbit and the majority of the hard palate.
The mandible is the only moveable bone of the skull.
Seven skull bones contribute to the walls of the orbit. Opening into the posterior orbit from the cranial cavity are the optic canal and superior orbital fissure.
The nasal septum is formed by the perpendicular plate of the ethmoid bone and the vomer bone. The septal cartilage fills the gap between these bones and extends into the nose.
The paranasal sinuses are hollow, air-filled spaces named for the skull bone that each occupies. The most anterior is the frontal sinus, located in the frontal bone above the eyebrows. The largest are the maxillary sinuses, located in the right and left maxillary bones below the orbits. The most posterior is the sphenoid sinus, located in the body of the sphenoid bone, under the sella turcica. The ethmoid air cells are multiple small spaces located in the right and left sides of the ethmoid bone, between the medial wall of the orbit and lateral wall of the upper nasal cavity.
The hyoid bone is located in the upper neck and does not join with any other bone. It provides attachments for muscles that act on the tongue, larynx, and pharynx.
The adult vertebral column consists of 24 vertebrae, plus the sacrum and coccyx. The vertebrae are divided into three regions: cervical C1–C7 vertebrae, thoracic T1–T12 vertebrae, and lumbar L1–L5 vertebrae. The vertebral column is curved, with two primary curvatures (thoracic and sacrococcygeal curves) and two secondary curvatures (cervical and lumbar curves).
Abnormal Curvatures of the Vertebral Column
(a) Scoliosis is an abnormal lateral bending of the vertebral column. (b) An excessive curvature of the upper thoracic vertebral column is called kyphosis. (c) Lordosis is an excessive curvature in the lumbar region of the vertebral column.
Osteoporosis is an age-related disorder that causes the gradual loss of bone density and strength. When the thoracic vertebrae are affected, there can be a gradual collapse of the vertebrae. This results in kyphosis, an excessive curvature of the thoracic region.
A typical vertebra consists of a body and a vertebral arch. The arch is formed by the paired pedicles and paired laminae. Arising from the vertebral arch are the transverse, spinous, superior articular, and inferior articular processes. The vertebral foramen provides for passage of the spinal cord. Each spinal nerve exits through an intervertebral foramen, located between adjacent vertebrae. Intervertebral discs unite the bodies of adjacent vertebrae.
The bodies of adjacent vertebrae are separated and united by an intervertebral disc, which provides padding and allows for movements between adjacent vertebrae. The disc consists of a fibrous outer layer called the anulus fibrosus and a gel-like center called the nucleus pulposus. The intervertebral foramen is the opening formed between adjacent vertebrae for the exit of a spinal nerve.
A typical cervical vertebra has a small body, a bifid spinous process, transverse processes that have a transverse foramen and are curved for spinal nerve passage. The atlas (C1 vertebra) does not have a body or spinous process. It consists of an anterior and a posterior arch and elongated transverse processes. The axis (C2 vertebra) has the upward projecting dens, which articulates with the anterior arch of the atlas.
A typical thoracic vertebra is distinguished by the spinous process, which is long and projects downward to overlap the next inferior vertebra. It also has articulation sites (facets) on the vertebral body and a transverse process for rib attachment.
Lumbar vertebrae are characterized by having a large, thick body and a short, rounded spinous process.
The sacrum is formed from the fusion of five sacral vertebrae, whose lines of fusion are indicated by the transverse ridges. The fused spinous processes form the median sacral crest, while the lateral sacral crest arises from the fused transverse processes. The coccyx is formed by the fusion of four small coccygeal vertebrae.
Weakening of the anulus fibrosus can result in herniation (protrusion) of the nucleus pulposus and compression of a spinal nerve, resulting in pain and/or muscle weakness in the body regions supplied by that nerve.
The anterior longitudinal ligament runs the length of the vertebral column, uniting the anterior sides of the vertebral bodies. The supraspinous ligament connects the spinous processes of the thoracic and lumbar vertebrae. In the posterior neck, the supraspinous ligament enlarges to form the nuchal ligament, which attaches to the cervical spinous processes and to the base of the skull.
Thoracic vertebrae have superior and inferior articular facets on the vertebral body for articulation with the head of a rib, and a transverse process facet for articulation with the rib tubercle.
The thoracic cage is formed by the (a) sternum and (b) 12 pairs of ribs with their costal cartilages. The ribs are anchored posteriorly to the 12 thoracic vertebrae. The sternum consists of the manubrium, body, and xiphoid process. The ribs are classified as true ribs (1–7) and false ribs (8–12). The last two pairs of false ribs are also known as floating ribs (11–12).
The bones of the newborn skull are not fully ossified and are separated by large areas called fontanelles, which are filled with fibrous connective tissue. The fontanelles allow for continued growth of the skull after birth. At the time of birth, the facial bones are small and underdeveloped, and the mastoid process has not yet formed.
The pectoral girdle consists of the clavicle and the scapula, which serve to attach the upper limb to the sternum of the axial skeleton.
The isolated scapula is shown here from its anterior (deep) side and its posterior (superficial) side.
The humerus is the single bone of the upper arm region. It articulates with the radius and ulna bones of the forearm to form the elbow joint.
The ulna is located on the medial side of the forearm, and the radius is on the lateral side. These bones are attached to each other by an interosseous membrane.
The eight carpal bones form the base of the hand. These are arranged into proximal and distal rows of four bones each. The metacarpal bones form the palm of the hand. The thumb and fingers consist of the phalanx bones.
This radiograph shows the position of the bones within the hand. Note the carpal bones that form the base of the hand
The carpal tunnel is the passageway by which nine muscle tendons and a major nerve enter the hand from the anterior forearm. The walls and floor of the carpal tunnel are formed by the U-shaped grouping of the carpal bones, and the roof is formed by the flexor retinaculum, a strong ligament that anteriorly unites the bones.
During tight gripping—compare (b) to (a)—the fourth and, particularly, the fifth metatarsal bones are pulled anteriorly. This increases the contact between the object and the medial side of the hand, thus improving the firmness of the grip.
Falls or direct blows can result in fractures of the surgical neck or shaft of the humerus. Falls onto the elbow can fracture the distal humerus. A Colles fracture of the distal radius is the most common forearm fracture.
The pelvic girdle is formed by a single hip bone. The hip bone attaches the lower limb to the axial skeleton through its articulation with the sacrum. The right and left hip bones, plus the sacrum and the coccyx, together form the pelvis.
The adult hip bone consists of three regions. The ilium forms the large, fan-shaped superior portion, the ischium forms the posteroinferior portion, and the pubis forms the anteromedial portion.
The posterior sacroiliac ligament supports the sacroiliac joint. The sacrospinous ligament spans the sacrum to the ischial spine, and the sacrotuberous ligament spans the sacrum to the ischial tuberosity. The sacrospinous and sacrotuberous ligaments contribute to the formation of the greater and lesser sciatic foramens.
The female pelvis is adapted for childbirth and is broader, with a larger subpubic angle, a rounder pelvic brim, and a wider and more shallow lesser pelvic cavity than the male pelvis.
The femur is the single bone of the thigh region. It articulates superiorly with the hip bone at the hip joint, and inferiorly with the tibia at the knee joint. The patella only articulates with the distal end of the femur.
The Q-angle is a measure of the amount of lateral deviation of the femur from the vertical line of the tibia. Adult females have a larger Q-angle due to their wider pelvis than adult males.
The tibia is the larger, weight-bearing bone located on the medial side of the leg. The fibula is the slender bone of the lateral side of the leg and does not bear weight.
The bones of the foot are divided into three groups. The posterior foot is formed by the seven tarsal bones. The mid-foot has the five metatarsal bones. The toes contain the phalanges.
Limb buds are visible in an embryo at the end of the seventh week of development (embryo derived from an ectopic pregnancy)
Clubfoot This photograph shows a baby with a clubfoot.Clubfoot is a common deformity of the ankle and foot that is present at birth. Most cases are corrected without surgery, and affected individuals will grow up to lead normal, active lives. (credit: James W. Hanson)
The suture joints of the skull are an example of a synarthrosis, an immobile or essentially immobile joint.
A multiaxial joint, such as the hip joint, allows for three types of movement: anterior-posterior, medial-lateral, and rotational.
Fibrous joints form strong connections between bones. (a) Sutures join most bones of the skull. (b) An interosseous membrane forms a syndesmosis between the radius and ulna bones of the forearm. (c) A gomphosis is a specialized fibrous joint that anchors a tooth to its socket in the jaw.
The fontanelles of a newborn’s skull are broad areas of fibrous connective tissue that form fibrous joints between the bones of the skull.
Synovial joints allow for smooth movements between the adjacent bones. The joint is surrounded by an articular capsule that defines a joint cavity filled with synovial fluid. The articulating surfaces of the bones are covered by a thin layer of articular cartilage. Ligaments support the joint by holding the bones together and resisting excess or abnormal joint motions.
Bursae are fluid-filled sacs that serve to prevent friction between skin, muscle, or tendon and an underlying bone. Three major bursae and a fat pad are part of the complex joint that unites the femur and tibia of the leg.
The six types of synovial joints allow the body to move in a variety of ways. (a) Pivot joints allow for rotation around an axis, such as between the first and second cervical vertebrae, which allows for side-to-side rotation of the head. (b) The hinge joint of the elbow works like a door hinge. (c) The articulation between the trapezium carpal bone and the first metacarpal bone at the base of the thumb is a saddle joint. (d) Plane joints, such as those between the tarsal bones of the foot, allow for limited gliding movements between bones. (e) The radiocarpal joint of the wrist is a condyloid joint. (f) The hip and shoulder joints are the only ball-and-socket joints of the body.
Osteoarthritis of a synovial joint results from aging or prolonged joint wear and tear. These cause erosion and loss of the articular cartilage covering the surfaces of the bones, resulting in inflammation that causes joint stiffness and pain.
Synovial joints give the body many ways in which to move. (a)–(b) Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist, metacarpophalangeal, metatarsophalangeal, and interphalangeal joints. (c)–(d) Anterior bending of the head or vertebral column is flexion, while any posterior-going movement is extension. (e) Abduction and adduction are motions of the limbs, hand, fingers, or toes in the coronal (medial–lateral) plane of movement. Moving the limb or hand laterally away from the body, or spreading the fingers or toes, is abduction. Adduction brings the limb or hand toward or across the midline of the body, or brings the fingers or toes together. Circumduction is the movement of the limb, hand, or fingers in a circular pattern, using the sequential combination of flexion, adduction, extension, and abduction motions. Adduction/abduction and circumduction take place at the shoulder, hip, wrist, metacarpophalangeal, and metatarsophalangeal joints. (f) Turning of the head side to side or twisting of the body is rotation. Medial and lateral rotation of the upper limb at the shoulder or lower limb at the hip involves turning the anterior surface of the limb toward the midline of the body (medial or internal rotation) or away from the midline (lateral or external rotation).
(g) Supination of the forearm turns the hand to the palm forward position in which the radius and ulna are parallel, while forearm pronation turns the hand to the palm backward position in which the radius crosses over the ulna to form an "X." (h) Dorsiflexion of the foot at the ankle joint moves the top of the foot toward the leg, while plantar flexion lifts the heel and points the toes. (i) Eversion of the foot moves the bottom (sole) of the foot away from the midline of the body, while foot inversion faces the sole toward the midline. (j) Protraction of the mandible pushes the chin forward, and retraction pulls the chin back. (k) Depression of the mandible opens the mouth, while elevation closes it. (l) Opposition of the thumb brings the tip of the thumb into contact with the tip of the fingers of the same hand and reposition brings the thumb back next to the index finger.
The atlantoaxial joint is a pivot type of joint between the dens portion of the axis (C2 vertebra) and the anterior arch of the atlas (C1 vertebra), with the dens held in place by a ligament.
The temporomandibular joint is the articulation between the temporal bone of the skull and the condyle of the mandible, with an articular disc located between these bones. During depression of the mandible (opening of the mouth), the mandibular condyle moves both forward and hinges downward as it travels from the mandibular fossa onto the articular tubercle.
The glenohumeral (shoulder) joint is a ball-and-socket joint that provides the widest range of motions. It has a loose articular capsule and is supported by ligaments and the rotator cuff muscles.
(a) The elbow is a hinge joint that allows only for flexion and extension of the forearm. (b) It is supported by the ulnar and radial collateral ligaments. (c) The annular ligament supports the head of the radius at the proximal radioulnar joint, the pivot joint that allows for rotation of the radius.
(a) The ball-and-socket joint of the hip is a multiaxial joint that provides both stability and a wide range of motion. (b–c) When standing, the supporting ligaments are tight, pulling the head of the femur into the acetabulum.
(a) The knee joint is the largest joint of the body. (b)–(c) It is supported by the tibial and fibular collateral ligaments located on the sides of the knee outside of the articular capsule, and the anterior and posterior cruciate ligaments found inside the capsule. The medial and lateral menisci provide padding and support between the femoral condyles and tibial condyles.
A strong blow to the lateral side of the extended knee will cause three injuries, in sequence: tearing of the tibial collateral ligament, damage to the medial meniscus, and rupture of the anterior cruciate ligament.
The talocrural (ankle) joint is a uniaxial hinge joint that only allows for dorsiflexion or plantar flexion of the foot. Movements at the subtalar joint, between the talus and calcaneus bones, combined with motions at other intertarsal joints, enables eversion/inversion movements of the foot. Ligaments that unite the medial or lateral malleolus with the talus and calcaneus bones serve to support the talocrural joint and to resist excess eversion or inversion of the foot.
The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle.
Bundles of muscle fibers, called fascicles, are covered by the perimysium. Muscle fibers are covered by the endomysium.
A skeletal muscle fiber is surrounded by a plasma membrane called the sarcolemma, which contains sarcoplasm, the cytoplasm of muscle cells. A muscle fiber is composed of many fibrils, which give the cell its striated appearance.
The sarcomere, the region from one Z-line to the next Z-line, is the functional unit of a skeletal muscle fiber.
At the NMJ, the axon terminal releases ACh. The motor end-plate is the location of the ACh-receptors in the muscle fiber sarcolemma. When ACh molecules are released, they diffuse across a minute space called the synaptic cleft and bind to the receptors.
Narrow T-tubules permit the conduction of electrical impulses. The SR functions to regulate intracellular levels of calcium. Two terminal cisternae (where enlarged SR connects to the T-tubule) and one T-tubule comprise a triad—a “threesome” of membranes, with those of SR on two sides and the T-tubule sandwiched between them.
A cross-bridge forms between actin and the myosin heads triggering contraction. As long as Ca++ ions remain in the sarcoplasm to bind to troponin, and as long as ATP is available, the muscle fiber will continue to shorten.
Ca++ ions are pumped back into the SR, which causes the tropomyosin to reshield the binding sites on the actin strands. A muscle may also stop contracting when it runs out of ATP and becomes fatigued.
The Sliding Filament Model of Muscle Contraction
When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap completely.
(a) The active site on actin is exposed as calcium binds to troponin. (b) The myosin head is attracted to actin, and myosin binds actin at its actin-binding site, forming the cross-bridge. (c) During the power stroke, the phosphate generated in the previous contraction cycle is released. This results in the myosin head pivoting toward the center of the sarcomere, after which the attached ADP and phosphate group are released. (d) A new molecule of ATP attaches to the myosin head, causing the cross-bridge to detach. (e) The myosin head hydrolyzes ATP to ADP and phosphate, which returns the myosin to the cocked position.
(a) Some ATP is stored in a resting muscle. As contraction starts, it is used up in seconds. More ATP is generated from creatine phosphate for about 15 seconds. (b) Each glucose molecule produces two ATP and two molecules of pyruvic acid, which can be used in aerobic respiration or converted to lactic acid. If oxygen is not available, pyruvic acid is converted to lactic acid, which may contribute to muscle fatigue. This occurs during strenuous exercise when high amounts of energy are needed but oxygen cannot be sufficiently delivered to muscle. (c) Aerobic respiration is the breakdown of glucose in the presence of oxygen (O2) to produce carbon dioxide, water, and ATP. Approximately 95 percent of the ATP required for resting or moderately active muscles is provided by aerobic respiration, which takes place in mitochondria.
During isotonic contractions, muscle length changes to move a load. During isometric contractions, muscle length does not change because the load exceeds the tension the muscle can generate.
Muscle mass is reduced as muscles atrophy with disuse.
Intercalated discs are part of the cardiac muscle sarcolemma and they contain gap junctions and desmosomes.
Smooth muscle tissue is found around organs in the digestive, respiratory, reproductive tracts and the iris of the eye.
The dense bodies and intermediate filaments are networked through the sarcoplasm, which cause the muscle fiber to contract.
A series of axon-like swelling, called varicosities or “boutons,” from autonomic neurons form motor units through the smooth muscle.
The biceps brachii flex the lower arm. The brachoradialis, in the forearm, and brachialis, located deep to the biceps in the upper arm, are both synergists that aid in this motion.
The skeletal muscles of the body typically come in seven different general shapes.
On the anterior and posterior views of the muscular system above, superficial muscles (those at the surface) are shown on the right side of the body while deep muscles (those underneath the superficial muscles) are shown on the left half of the body. For the legs, superficial muscles are shown in the anterior view while the posterior view shows both superficial and deep muscles.
Many of the muscles of facial expression insert into the skin surrounding the eyelids, nose and mouth, producing facial expressions by moving the skin rather than bones.
(a) The extrinsic eye muscles originate outside of the eye on the skull. (b) Each muscle inserts onto the eyeball.
The muscles that move the lower jaw are typically located within the cheek and originate from processes in the skull. This provides the jaw muscles with the large amount of leverage needed for chewing.
Tongue muscles can be extrinsic or intrinsic. Extrinsic tongue muscles insert into the tongue from outside origins, and the intrinsic tongue muscles insert into the tongue from origins within it. The extrinsic muscles move the whole tongue in different directions, whereas the intrinsic muscles allow the tongue to change its shape (such as, curling the tongue in a loop or flattening it).
The anterior muscles of the neck facilitate swallowing and speech. The suprahyoid muscles originate from above the hyoid bone in the chin region. The infrahyoid muscles originate below the hyoid bone in the lower neck.
The superficial and deep muscles of the neck are responsible for moving the head, cervical vertebrae, and scapulas.
The large, complex muscles of the neck and back move the head, shoulders, and vertebral column.
(a) The anterior abdominal muscles include the medially located rectus abdominis, which is covered by a sheet of connective tissue called the rectus sheath. On the flanks of the body, medial to the rectus abdominis, the abdominal wall is composed of three layers. The external oblique muscles form the superficial layer, while the internal oblique muscles form the middle layer, and the transverses abdominus forms the deepest layer. (b) The muscles of the lower back move the lumbar spine but also assist in femur movements.
The diaphragm separates the thoracic and abdominal cavities.
The external intercostals are located laterally on the sides of the body. The internal intercostals are located medially near the sternum. The innermost intercostals are located deep to both the internal and external intercostals.
The pelvic floor muscles support the pelvic organs, resist intra-abdominal pressure, and work as sphincters for the urethra, rectum, and vagina.
Muscles That Position the Pectoral Girdle
The muscles that stabilize the pectoral girdle make it a steady base on which other muscles can move the arm. Note that the pectoralis major and deltoid, which move the humerus, are cut here to show the deeper positioning muscles.
(a, c) The muscles that move the humerus anteriorly are generally located on the anterior side of the body and originate from the sternum (e.g., pectoralis major) or the anterior side of the scapula (e.g., subscapularis). (b) The muscles that move the humerus superiorly generally originate from the superior surfaces of the scapula and/or the clavicle (e.g., deltoids). The muscles that move the humerus inferiorly generally originate from middle or lower back (e.g., latissiumus dorsi). (d) The muscles that move the humerus posteriorly are generally located on the posterior side of the body and insert into the scapula (e.g., infraspinatus).
The muscles originating in the upper arm flex, extend, pronate, and supinate the forearm. The muscles originating in the forearm move the wrists, hands, and fingers.
The intrinsic muscles of the hand both originate and insert within the hand. These muscles provide the fine motor control of the fingers by flexing, extending, abducting, and adducting the more distal finger and thumb segments.
The large and powerful muscles of the hip that move the femur generally originate on the pelvic girdle and insert into the femur. The muscles that move the lower leg typically originate on the femur and insert into the bones of the knee joint. The anterior muscles of the femur extend the lower leg but also aid in flexing the thigh. The posterior muscles of the femur flex the lower leg but also aid in extending the thigh. A combination of gluteal and thigh muscles also adduct, abduct, and rotate the thigh and lower leg.
The muscles along the dorsal side of the foot (a) generally extend the toes while the muscles of the plantar side of the foot (b, c, d) generally flex the toes. The plantar muscles exist in three layers, providing the foot the strength to counterbalance the weight of the body. In this diagram, these three layers are shown from a plantar view beginning with the bottom-most layer just under the plantar skin of the foot (b) and ending with the top-most layer (d) located just inferior to the foot and toe bones.
The muscles of the anterior compartment of the lower leg are generally responsible for dorsiflexion, and the muscles of the posterior compartment of the lower leg are generally responsible for plantar flexion. The lateral and medial muscles in both compartments invert, evert, and rotate the foot.
The structures of the PNS are referred to as ganglia and nerves, which can be seen as distinct structures. The equivalent structures in the CNS are not obvious from this overall perspective and are best examined in prepared tissue under the microscope.
(a) The nucleus of an atom contains its protons and neutrons. (b) The nucleus of a cell is the organelle that contains DNA. (c) A nucleus in the CNS is a localized center of function with the cell bodies of several neurons, shown here circled in red
This drawing of the connections of the eye to the brain shows the optic nerve extending from the eye to the chiasm, where the structure continues as the optic tract. The same axons extend from the eye to the brain through these two bundles of fibers, but the chiasm represents the border between peripheral and central.
Somatic, Autonomic, and Enteric Structures of the Nervous System
Somatic structures include the spinal nerves, both motor and sensory fibers, as well as the sensory ganglia (posterior root ganglia and cranial nerve ganglia). Autonomic structures are found in the nerves also, but include the sympathetic and parasympathetic ganglia. The enteric nervous system includes the nervous tissue within the organs of the digestive tract.
The major parts of the neuron are labeled on a multipolar neuron from the CNS.
Unipolar cells have one process that includes both the axon and dendrite. Bipolar cells have two processes, the axon and a dendrite. Multipolar cells have more than two processes, the axon and two or more dendrites.
Three examples of neurons that are classified on the basis of other criteria. (a) The pyramidal cell is a multipolar cell with a cell body that is shaped something like a pyramid. (b) The Purkinje cell in the cerebellum was named after the scientist who originally described it. (c) Olfactory neurons are named for the functional group with which they belong.
The CNS has astrocytes, oligodendrocytes, microglia, and ependymal cells that support the neurons of the CNS in several ways.
The PNS has satellite cells and Schwann cells.
Myelinating glia wrap several layers of cell membrane around the cell membrane of an axon segment. A single Schwann cell insulates a segment of a peripheral nerve, whereas in the CNS, an oligodendrocyte may provide insulation for a few separate axon segments
(1) The sensory neuron has endings in the skin that sense a stimulus such as water temperature. The strength of the signal that starts here is dependent on the strength of the stimulus. (2) The graded potential from the sensory endings, if strong enough, will initiate an action potential at the initial segment of the axon (which is immediately adjacent to the sensory endings in the skin). (3) The axon of the peripheral sensory neuron enters the spinal cord and contacts another neuron in the gray matter. The contact is a synapse where another graded potential is caused by the release of a chemical signal from the axon terminals. (4) An action potential is initiated at the initial segment of this neuron and travels up the sensory pathway to a region of the brain called the thalamus. Another synapse passes the information along to the next neuron. (5) The sensory pathway ends when the signal reaches the cerebral cortex. (6) After integration with neurons in other parts of the cerebral cortex, a motor command is sent from the precentral gyrus of the frontal cortex. (7) The upper motor neuron sends an action potential down to the spinal cord. The target of the upper motor neuron is the dendrites of the lower motor neuron in the gray matter of the spinal cord. (8) The axon of the lower motor neuron emerges from the spinal cord in a nerve and connects to a muscle through a neuromuscular junction to cause contraction of the target muscle.
Receptors in the skin sense the temperature of the water.
On the basis of the sensory input and the integration in the CNS, a motor response is formulated and executed.
Cell Membrane and Transmembrane Proteins
The cell membrane is composed of a phospholipid bilayer and has many transmembrane proteins, including different types of channel proteins that serve as ion channels.
When the ligand, in this case the neurotransmitter acetylcholine, binds to a specific location on the extracellular surface of the channel protein, the pore opens to allow select ions through. The ions, in this case, are cations of sodium, calcium, and potassium.
Voltage-gated channels open when the transmembrane voltage changes around them. Amino acids in the structure of the protein are sensitive to charge and cause the pore to open to the selected ion.
In certain situations, ions need to move across the membrane randomly. The particular electrical properties of certain cells are modified by the presence of this type of channel.
Graded potentials are temporary changes in the membrane voltage, the characteristics of which depend on the size of the stimulus. Some types of stimuli cause depolarization of the membrane, whereas others cause hyperpolarization. It depends on the specific ion channels that are activated in the cell membrane.
The synapse is a connection between a neuron and its target cell (which is not necessarily a neuron). The presynaptic element is the synaptic end bulb of the axon where Ca2+ enters the bulb to cause vesicle fusion and neurotransmitter release. The neurotransmitter diffuses across the synaptic cleft to bind to its receptor. The neurotransmitter is cleared from the synapse either by enzymatic degradation, neuronal reuptake, or glial reuptake.
(a) An ionotropic receptor is a channel that opens when the neurotransmitter binds to it. (b) A metabotropic receptor is a complex that causes metabolic changes in the cell when the neurotransmitter binds to it (1). After binding, the G protein hydrolyzes GTP and moves to the effector protein (2). When the G protein contacts the effector protein, a second messenger is generated, such as cAMP (3). The second messenger can then go on to cause changes in the neuron, such as opening or closing ion channels, metabolic changes, and changes in gene transcription.
Early Embryonic Development of Nervous System
The neuroectoderm begins to fold inward to form the neural groove. As the two sides of the neural groove converge, they form the neural tube, which lies beneath the ectoderm. The anterior end of the neural tube will develop into the brain, and the posterior portion will become the spinal cord. The neural crest develops into peripheral structures.
Primary and Secondary Vesicle Stages of Development
The embryonic brain develops complexity through enlargements of the neural tube called vesicles; (a) The primary vesicle stage has three regions, and (b) the secondary vesicle stage has five regions.
(a) Spina bifida is a birth defect of the spinal cord caused when the neural tube does not completely close, but the rest of development continues. The result is the emergence of meninges and neural tissue through the vertebral column. (b) Fetal myelomeningocele is evident in this ultrasound taken at 21 weeks.
The cerebrum is a large component of the CNS in humans, and the most obvious aspect of it is the folded surface called the cerebral cortex.
The cerebral cortex is divided into four lobes. Extensive folding increases the surface area available for cerebral functions.
Brodmann mapping of functionally distinct regions of the cortex was based on its cytoarchitecture at a microscopic level.
Frontal Section of Cerebral Cortex and Basal Nuclei
The major components of the basal nuclei, shown in a frontal section of the brain, are the caudate (just lateral to the lateral ventricle), the putamen (inferior to the caudate and separated by the large white-matter structure called the internal capsule), and the globus pallidus (medial to the putamen).
The diencephalon is composed primarily of the thalamus and hypothalamus, which together define the walls of the third ventricle. The thalami are two elongated, ovoid structures on either side of the midline that make contact in the middle. The hypothalamus is inferior and anterior to the thalamus, culminating in a sharp angle to which the pituitary gland is attached.
The brain stem comprises three regions: the midbrain, the pons, and the medulla.
The cerebellum is situated on the posterior surface of the brain stem. Descending input from the cerebellum enters through the large white matter structure of the pons. Ascending input from the periphery and spinal cord enters through the fibers of the inferior olive. Output goes to the midbrain, which sends a descending signal to the spinal cord.
The cross-section of a thoracic spinal cord segment shows the posterior, anterior, and lateral horns of gray matter, as well as the posterior, anterior, and lateral columns of white matter
The blood supply to the brain enters through the internal carotid arteries and the vertebral arteries, eventually giving rise to the circle of Willis.
Blood drains from the brain through a series of sinuses that connect to the jugular veins.
The choroid plexus in the four ventricles produce CSF, which is circulated through the ventricular system and then enters the subarachnoid space through the median and lateral apertures. The CSF is then reabsorbed into the blood at the arachnoid granulations, where the arachnoid membrane emerges into the dural sinuses.
The cell bodies of sensory neurons, which are unipolar neurons by shape, are seen in this photomicrograph. Also, the fibrous region is composed of the axons of these neurons that are passing through the ganglion to be part of the dorsal nerve root (tissue source: canine)
The slide includes both a cross-section of the lumbar spinal cord and a section of the dorsal root ganglion (see also [link]) (tissue source: canine).
The structure of a nerve is organized by the layers of connective tissue on the outside, around each fascicle, and surrounding the individual nerve fibers (tissue source: simian).
Zoom in on this slide of a nerve trunk to examine the endoneurium, perineurium, and epineurium in greater detail (tissue source: simian).
The anatomical arrangement of the roots of the cranial nerves observed from an inferior view of the brain.
There are four main nerve plexuses in the human body. The cervical plexus supplies nerves to the posterior head and neck, as well as to the diaphragm. The brachial plexus supplies nerves to the arm. The lumbar plexus supplies nerves to the anterior leg. The sacral plexus supplies nerves to the posterior leg.
Receptor cell types can be classified on the basis of their structure. Sensory neurons can have either (a) free nerve endings or (b) encapsulated endings. Photoreceptors in the eyes, such as rod cells, are examples of (c) specialized receptor cells. These cells release neurotransmitters onto a bipolar cell, which then synapses with the optic nerve neurons.
The tongue is covered with small bumps, called papillae, which contain taste buds that are sensitive to chemicals in ingested food or drink. Different types of papillae are found in different regions of the tongue. The taste buds contain specialized gustatory receptor cells that respond to chemical stimuli dissolved in the saliva. These receptor cells activate sensory neurons that are part of the facial and glossopharyngeal nerves.
(a) The olfactory system begins in the peripheral structures of the nasal cavity. (b) The olfactory receptor neurons are within the olfactory epithelium. (c) Axons of the olfactory receptor neurons project through the cribriform plate of the ethmoid bone and synapse with the neurons of the olfactory bulb (tissue source: simian).
The external ear contains the auricle, ear canal, and tympanic membrane. The middle ear contains the ossicles and is connected to the pharynx by the Eustachian tube. The inner ear contains the cochlea and vestibule, which are responsible for audition and equilibrium, respectively.
A sound wave causes the tympanic membrane to vibrate. This vibration is amplified as it moves across the malleus, incus, and stapes. The amplified vibration is picked up by the oval window causing pressure waves in the fluid of the scala vestibuli and scala tympani. The complexity of the pressure waves is determined by the changes in amplitude and frequency of the sound waves entering the ear.
The three major spaces within the cochlea are highlighted. The scala tympani and scala vestibuli lie on either side of the cochlear duct. The organ of Corti, containing the mechanoreceptor hair cells, is adjacent to the scala tympani, where it sits atop the basilar membrane.
The hair cell is a mechanoreceptor with an array of stereocilia emerging from its apical surface. The stereocilia are tethered together by proteins that open ion channels when the array is bent toward the tallest member of their array, and closed when the array is bent toward the shortest member of their array.
a given region of the basilar membrane will only move if the incoming sound is at a specific frequency. Because the tectorial membrane only moves where the basilar membrane moves, the hair cells in this region will also only respond to sounds of this specific frequency. Therefore, as the frequency of a sound changes, different hair cells are activated all along the basilar membrane. The cochlea encodes auditory stimuli for frequencies between 20 and 20,000 Hz, which is the range of sound that human ears can detect. The unit of Hertz measures the frequency of sound waves in terms of cycles produced per second. Frequencies as low as 20 Hz are detected by hair cells at the apex, or tip, of the cochlea. Frequencies in the higher ranges of 20 KHz are encoded by hair cells at the base of the cochlea, close to the round and oval windows ([link]). Most auditory stimuli contain a mixture of sounds at a variety of frequencies and intensities (represented by the amplitude of the sound wave). The hair cells along the length of the cochlear duct, which are each sensitive to a particular frequency, allow the cochlea to separate auditory stimuli by frequency, just as a prism separates visible light into its component colors.
The standing sound wave generated in the cochlea by the movement of the oval window deflects the basilar membrane on the basis of the frequency of sound. Therefore, hair cells at the base of the cochlea are activated only by high frequencies, whereas those at the apex of the cochlea are activated only by low frequencies.
The maculae are specialized for sensing linear acceleration, such as when gravity acts on the tilting head, or if the head starts moving in a straight line. The difference in inertia between the hair cell stereocilia and the otolithic membrane in which they are embedded leads to a shearing force that causes the stereocilia to bend in the direction of that linear acceleration.
Rotational Coding by Semicircular Canals
Rotational movement of the head is encoded by the hair cells in the base of the semicircular canals. As one of the canals moves in an arc with the head, the internal fluid moves in the opposite direction, causing the cupula and stereocilia to bend. The movement of two canals within a plane results in information about the direction in which the head is moving, and activation of all six canals can give a very precise indication of head movement in three dimensions.
The eye is located within the orbit and surrounded by soft tissues that protect and support its function. The orbit is surrounded by cranial bones of the skull.
The extraocular muscles move the eye within the orbit.
The sphere of the eye can be divided into anterior and posterior chambers. The wall of the eye is composed of three layers: the fibrous tunic, vascular tunic, and neural tunic. Within the neural tunic is the retina, with three layers of cells and two synaptic layers in between. The center of the retina has a small indentation known as the fovea.
(a) All photoreceptors have inner segments containing the nucleus and other important organelles and outer segments with membrane arrays containing the photosensitive opsin molecules. Rod outer segments are long columnar shapes with stacks of membrane-bound discs that contain the rhodopsin pigment. Cone outer segments are short, tapered shapes with folds of membrane in place of the discs in the rods. (b) Tissue of the retina shows a dense layer of nuclei of the rods and cones.
The retinal molecule has two isomers, (a) one before a photon interacts with it and (b) one that is altered through photoisomerization.
Comparison of Color Sensitivity of Photopigments
Comparing the peak sensitivity and absorbance spectra of the four photopigments suggests that they are most sensitive to particular wavelengths.
Ascending Sensory Pathways of the Spinal Cord
The dorsal column system and spinothalamic tract are the major ascending pathways that connect the periphery with the brain.
Auditory Brain Stem Mechanisms of Sound Localization
Localizing sound in the horizontal plane is achieved by processing in the medullary nuclei of the auditory system. Connections between neurons on either side are able to compare very slight differences in sound stimuli that arrive at either ear and represent interaural time and intensity differences.
Connections between the vestibular system and the cranial nerves controlling eye movement keep the eyes centered on a visual stimulus, even though the head is moving. During head movement, the eye muscles move the eyes in the opposite direction as the head movement, keeping the visual stimulus centered in the field of view.
Segregation of Visual Field Information at the Optic Chiasm
Contralateral visual field information from the lateral retina projects to the ipsilateral brain, whereas ipsilateral visual field information has to decussate at the optic chiasm to reach the opposite side of the brain.
A cartoon representation of the sensory homunculus arranged adjacent to the cortical region in which the processing takes place.
Topographic Mapping of the Retina onto the Visual Cortex
The visual field projects onto the retina through the lenses and falls on the retinae as an inverted, reversed image. The topography of this image is maintained as the visual information travels through the visual pathway to the cortex.
Because of the interocular distance, which results in objects of different distances falling on different spots of the two retinae, the brain can extract depth perception from the two-dimensional information of the visual field.
From the primary visual cortex in the occipital lobe, visual processing continues in two streams—one into the temporal lobe and one into the parietal lobe.
The major descending tract that controls skeletal muscle movements is the corticospinal tract. It is composed of two neurons, the upper motor neuron and the lower motor neuron. The upper motor neuron has its cell body in the primary motor cortex of the frontal lobe and synapses on the lower motor neuron, which is in the ventral horn of the spinal cord and projects to the skeletal muscle in the periphery.
Connections of Parasympathetic Division of the Autonomic Nervous System
Neurons from brain-stem nuclei, or from the lateral horn of the sacral spinal cord, project to terminal ganglia near or within the various organs of the body. Axons from these ganglionic neurons then project the short distance to those target effectors.
The connection between autonomic fibers and target effectors is not the same as the typical synapse, such as the neuromuscular junction. Instead of a synaptic end bulb, a neurotransmitter is released from swellings along the length of a fiber that makes an extended network of connections in the target effector.
Comparison of Somatic and Visceral Reflexes
The afferent inputs to somatic and visceral reflexes are essentially the same, whereas the efferent branches are different. Somatic reflexes, for instance, involve a direct connection from the ventral horn of the spinal cord to the skeletal muscle. Visceral reflexes involve a projection from the central neuron to a ganglion, followed by a second projection from the ganglion to the target effector.
Stigmatization, discrimination and illness
“She was given her own plate, her own cup, everything of her own, even when she just touched a cloth then nobody wanted to touch it again.” (Halima, HIV-seropositive) The book sheds light on the profound influence of an HIV-seropositive diagnosis on the lives of women and their social environment in the United Republic of Tanzania. The author, a medical doctor and social anthropologist, tells the story of six Tanzanian HIV-seropositive women, focusing on their negotiation and perception of illness and disease. Furthermore, the high levels of discrimination and stigmatization in the context of HIV-seropositivity that they experience are presented in detail, weaving together the impacts of an HIV-seropositive diagnosis with results analyzed both from a Medical Anthropology and Public Health perspective. Despite a new era of antiretroviral treatment, available in Tanzania free of cost, that has given cause for hope in a change in how the disease is perceived, the book impressively underlines that being HIV-seropositive remains a great challenge and heavy burden for women in Tanzania.
Several bones that help form the walls of the nasal cavity have air-containing spaces called the paranasal sinuses, which serve to warm and humidify incoming air. Sinuses are lined with a mucosa. Each paranasal sinus is named for its associated bone: frontal sinus, maxillary sinus, sphenoidal sinus, and ethmoidal sinus. The sinuses produce mucus and lighten the weight of the skull.
Accounting may be defined as the process of analyzing, classifying, recording, summarizing, and interpreting business transactions. One of the key aspects of the process is keeping “running totals” of “things.” Examples of items a business might keep track of include the amount of cash the business currently has, what a company has paid for utilities for the month, the amount of money it owes, its income for the entire year, and the total cost of all the equipment it has purchased. You want to always have these running totals up to date so they are readily available to you when you need the information. It is similar to checking what your cash balance in the bank is when deciding if you have enough money to make a purchase with your debit card.
The roles of veterinarians in society range from clinician to researcher, food inspector to enlisted military officer. Critical to the educational training of all of these veterinarians is the fundamental understanding of basic anatomy, both gross and microscopic. The knowledge of normal anatomy provides the basis of both physiology as well as pathology. Relating gross (e.g. physical exam findings) or microscopic changes (e.g. surgical biopsy) to specific disease processes first requires firm knowledge of “normal”; hence, disease is detected as an alteration of normal! Teaching histology in the veterinary curriculum is the challenging process of conveying to the future veterinarian the clinical relevance of microscopic anatomy, which may not be inherently appreciable to the first-year veterinary student.
Business Ethics is designed to meet the scope and sequence requirements of the single-semester business ethics course. This title includes innovative features designed to enhance student learning, including case studies, application scenarios, and links to video interviews with executives, all of which help instill in students a sense of ethical awareness and responsibility.
Technical Project Management in Living and Geometric Order
Technical Project Management , Living, Geometric Order
This book is the result of a collaboration among the three instructors responsible for Technical Project Management, one of the ten required classes in the Master of Engineering Management (MEM) program at the University of Wisconsin-Madison. The Master of Engineering Management is a world-class online program, consistently ranked in the Top 10 by U.S. News & World Report. Unlike many self-paced, online degree programs, the Engineering Management program provides a collaborative learning opportunity in which students work together to complete actual projects from their workplaces, discuss weekly topics, and participate in weekly web conferences. All of the students in the MEM program are experienced engineers, working full-time as they complete their graduate studies. The course and this text are targeted to the interests and needs of such midcareer professionals, who value practical principles and guidance.
Jeffrey Russell, Wayne Pferdehirt, John Nelson
Introduction to Business covers the scope and sequence of most introductory business courses. The book provides detailed explanations in the context of core themes such as customer satisfaction, ethics, entrepreneurship, global business, and managing change. Introduction to Business includes hundreds of current business examples from a range of industries and geographic locations, which feature a variety of individuals. The outcome is a balanced approach to the theory and application of business concepts, with attention to the knowledge and skills necessary for student success in this course and beyond.
Lawrence Gitman ,Carl McDaniel, Amit Shah. Ad All
Introduction to Financial Accounting - First US Edition
Accounting is often called the language of business because it uses a unique vocabulary to communicate information to decision makers. In this chapter, we will discuss what financial accounting is and briefly introduce how financial information is communicated through financial statements. Then we will study how financial transactions are analyzed and reported on financial statements. Accounting is the process of identifying, measuring, recording, and communicating an organization’s economic activities to users. Users need information for decision making. Internal users of accounting information work for the organization and are responsible for planning, organizing, and operating the entity. The area of accounting known as managerial accounting serves the decision‐making needs of internal users.
Building Maintenance & Construction: Tools and Maintenance Tasks
Building Maintenance & Construction: Tools and Maintenance Tasks introduces and develops knowledge of basic building maintenance tools and materials, applied skills and techniques, industry health and safety tandards, and preventive maintenance and troubleshooting practices required by employers for entry-level positions in the building trades and facilities maintenance fields.
Operational Amplifiers & Linear Integrated Circuits: Theory and Application / 3E
Operational Amplifiers , Linear Integrated Circuits
Before we can begin our study of the operational amplifier, it is very important that certain background elements be in place. The purpose of this chapter is to present the very useful analysis concepts and tools associated with the decibel measurement scheme and the frequency domain. We will also be examining the differential amplifier that serves as the heart of most operational amplifiers. With a thorough working knowledge of these items, you will find that circuit design and analysis will proceed at a much quicker and more efficient pace. Consider this chapter as an investment in time, and treat it appropriately.
Semiconductor Devices: Theory and Application
Just as the late eighteenth through nineteenth centuries are known as the industrial age due to the rise of mechanization, the twentieth century can be referred to as the beginning of the electronic age. The first half of the century was dominated by electronic vacuum tubes that made possible devices such as radio, television, radar and long distance telephone. The technology of the vacuum tube was displaced mid-century by the introduction of solid-state semiconductors. The first working prototype transistor was invented at Bell Labs in 1947 by John Bardeen, Walter Brattain and William Shockley. This device, properly referred to as a point contact transistor, was quickly superseded by the bipolar junction transistor, a major topic of this text.
Electrical Engineering Technology .Mohawk Valley Community College
As you read A Primer on Sustainable Business, we challenge you to not think of sustainability as a program, an initiative, or an activity. Rather, sustainability is a mind-set, a philosophy, and worldview. Throughout each chapter, you are challenged to alter the way you view your job, the workplace, the business, and the world. Whether you are an executive, an entrepreneur, or an employee, A Primer on Sustainable Business will help you understand the big picture of what it means to be a sustainable business and will give you the information you need to begin your journey toward sustainability.
This eBook was written as the sequel to the eBook titled DC Circuits, which was written in 2016 by Chad Davis. This eBook covers Alternating Current (AC) circuit theory as well as a brief introduction of electronics. It is broken up into seven modules. Module 1 covers the basic theory of AC signals. Since only DC sources are used in the first eBook, details of AC signals such as sinusoidal waveforms (or sine waves), square waves, and triangle waves are provided. Module 2, titled AC Circuits Math Background, covers the mathematics background needed for solving AC circuit problems. The background material in Modules 1 and 2 are combined in Module 3 to solve circuits with AC sources that include resistors, inductors, and capacitors (RLC circuits).
Business 211 Introduction to Business Law
Lawhas different meanings as well as differentfunctions. Philosophers have considered issues of justice and law for centuries, and several different approaches, or schools of legal thought, have emerged. In this chapter, we will look at those different meanings and approaches andwill consider howsocial and political dynamics interact with the ideas that animate the various schools of legal thought. We will also look at typical sources of“positive law” in the United States and how some of those sources have priority over others, and we will set out some basic differences between the US legal system and other legal systems.
Introduction to Water Systems Technology
Water Systems and Technology is a program designed to provide the student with enough information to build a successful and lasting career in the water and wastewater industry. It is a program that has been developed by professionals within the industry and within academia. Upon successful completion of the program and after completing any required general education course work, the student can earn an Associate of Science degree in Water Systems Technology. In addition, each course provides supplemental course work hours required for renewal of existing certifications in the water and wastewater industries and many provide specialized training coursework to qualify students to take state certification exams. The program has several general topic course options, includes coursework related to waterworks mathematics, and has specialized courses covering water distribution, water treatment, and wastewater
This chapter presents a brief introduction on the water sources that are available for potable supply; detailed information is presented in Water 032 (Water Supply). Understanding the water sources used for potable application is important to appreciate the variety of contaminants that can be present in water, and assess their characteristics.
A water distribution system is nothing more than a network of components designed to deliver water from a source to a user. It can be thought of as an array of piping networks and various pieces of equipment taking water from one location and delivering it to another. As a comparison, the human body has a number of different “distribution” systems. The circulatory system for example distributes blood throughout the body through a series of organs. You can also look at our roadways as a “distribution system”. You leave your house and follow a path to a destination. In between are turns, signals, signs, etc. Understanding this general description of water distribution systems by no means undermines the complexity of delivering safe and reliable drinking water to consumers.
Water Treatment Plant Operation Processes I
A very finite amount of water on our planet (0.34%) is available to treat for human consumption. Knowing where the water comes from assists certified operators in treating raw source water to make it potable. Newer technology has been developed to treat salinized or salty water found in the ocean. These treatment methods are still extremely expensive and not widely accessible. Supplying water to the public is an extremely important function in society as water is the basic building block of life. Because water quality is of the utmost importance new regulations and water quality standards are continually changing and evolving to make sure the public has safe sources of drinking water. The first drinking water standards were signed into law by President Ford in 1974 and it was known as the Safe Drinking Water Act (SDWA). Throughout the text new concepts will be introduced and an acronym will be given and used subsequently. You are going to learn to love acronyms if you become a certified operator. We use them quite frequently!
Water Treatment and Plant Operation Processes II
The basic objective in the operation of drinking water treatment plants is to produce a drinking water that is safe and aesthetically pleasing at a reasonable cost with respect to capital as well as operation and maintenance. From a public health perspective, production of a safe drinking water is one that is free of harmful microorganisms and toxic materials, and this object is the first priority. It is also important to produce a high-quality, water that appeals to the consumer. Generally, the water must be clear, free of turbidity, colorless, and free of objectionable tastes and odors. Consumers also show a preference for water supplies that do not stain plumbing fixtures and clothes, do not corrode plumbing fixtures and piping, and do not leave scale deposits or spot glassware.
Proper wastewater treatment and disposal is essential for the vitality of a functioning society. Without it, a community’s environment can be severely polluted and the health of the public is at great risk. To better understand the relationship between wastewater treatment and water treatment and distribution, examine the urban water cycle (link). Like the typical hydrologic cycle, which shows the natural movement of water in the environment, the urban water cycle shows how water is moved in an urban environment. In some cases, as shown is FIG XX, (show detailed picture of typical community water/wastewater infrastructure) wastewater that has been treated by a wastewater treatment plant will be discharged back into a natural water body. Water from that water body will then be used by downstream communities as source water for their water treatment plants. If either of these two treatment facilities are not operating to current regulations and standards, public health is at risk. In addition, if the wastewater treatment facility is not operating properly there can also be additional environmental damage to the water body
The wastewater collection system is the network of pipes that convey the wastewater from households and business to a wastewater treatment facility. Each customer will have a lateral connected to the main sewer lines. In order to keep sediment from settling out in the collection system and causing a blockage the pipe is sloped to ensure a velocity of 2 ft/sec. A majority of the system will utilize the slope of the pipe and gravity so the water travels downhill. However, that is not always feasible and when needed a lift station will be installed. The lift station is comprised of a wet well where the wastewater is collected and pumps the water to a higher elevation where it can then resume to flow by gravity. The portion of the pressure pipe that is connected to the lift station is called a force main. The force main is always under pressure and the wastewater completely fills the pipe. Where a gravity sewer has minimal pressure and under normal conditions only about ⅓ of the pipe is filled with wastewater.
Answer: Financial accounting1 focuses on providing historical financial information to external users. External users are those outside the company, including owners (e.g., shareholders) and creditors (e.g., banks or bondholders). Financial accountants reporting to external users are required to follow U.S. Generally Accepted Accounting Principles (U.S. GAAP)2 , a set of accounting rules that requires consistency in recording and reporting financial information. This information typically summarizes overall company results and does not provide detailed information. Managerial accounting3 focuses on internal users—executives, product managers, sales managers, and any other personnel within the organization who use accounting information to make important decisions. Managerial accounting information need not conform with U.S. GAAP. In fact, conformance with U.S. GAAP may be a deterrent to getting useful information for internal decision-making purposes. For example, when establishing an inventory cost for one or more units of product (each jersey or hat produced at Sportswear Company), U.S. GAAP requires that production overhead costs, such as factory rent and factory utility costs, be included. However, for internal decision-making purposes, it might make more sense to include nonproduction costs that are directly linked to the product, such as sales commissions or administrative costs.
As we get started on our journey into the world of health and nutrition, our first focus will be to demonstrate that nutritional science is an evolving field of study, continually being updated and supported by research, studies, and trials. Once we establish this, your confidence will be strengthened in nutritional science to help guide your eating habits. Let’s begin with the story of hurry, curry, and worry: the story of H. pylori. Peptic ulcers are painful sores in the gastrointestinal tract and can cause symptoms of abdominal pain, nausea, loss of appetite, and weight loss. The cure for this ailment took some time for scientists to figure out. If your grandfather complained to his doctor of symptoms of peptic ulcer, he was probably told to avoid spicy foods, alcohol, and coffee, and to manage his stress.
Going green, green business, and sustainable business are topics on everyone’s mind. But what does all this mean exactly? A Primer on Sustainable Business answers that question and provides an introduction to the basics you need to know. We begin with an understanding of the background of the concept of sustainability and how it applies to the business world. In 1987, the Brundtland Commission put forth a “global agenda for change” with the purpose of “furthering the common understanding and common spirit of responsibility so clearly needed in a divided world.”Brundtland (1987). The report outlined the following description of sustainable development:
Kansas State University Human Nutrition Flexbook
The CK-12 foundation defines a flexbook as a “free and open source textbook platform where one can build and edit collaborative textbooks1 .” The FNDH 400 (formerly HN 400, department changed its name from Human Nutrition to Food, Nutrition, Dietetics and Health) Flexbook fits this definition, but I felt the name was particularly accurate due to the flexibility of Google Docs that it was built on. The flexbook is divided into 13 chapters with sections and subsections. These are numbered in such a way that the first number represents the chapter. A period separates the chapter from the section number, and another period is followed by the subsection number. The figures are non-copyrighted figures or I have made them myself in PowerPoint. The flexbook also contains links to articles, videos, and animations in Web Link boxes. These can be clicked to open the link, and urls for these resources are also provided at the end of the section or subsection.
The converting (or cancelling) of units is the most important concept in waterworks mathematics. You may be working with million gallons, cubic feet, acre feet, feet per second, gallons per minute, milligrams per liter, pounds per gallon, yard, ounce, parts per billion, etc., etc., etc. Units are the “driver” for problem solving in many waterworks math questions. The reason for this has to do with how processes are measured. For example, many water meters measure usage in hundred cubic feet. However, when Utility Managers report total usage by a class of customers it is typically expressed as acre feet or million gallons. Another example can be when dosage calculations are performed. Many times flow rates are measured as gallons per minute, but dosage computations require million gallons per day. These are just a couple of examples demonstrating the common conversion between units. In an introductory water mathematics course unit conversion is typically explained in a “unit by unit” break down. Here we are converting from cfs (cubic feet per sec) to gpm (gallon per minute).
You’re about to understand water demand and water supply more deeply. This understanding is going to change how you look at your water bill, grass in your yard and around town, and all those canals you see while driving around in California. Understanding the connection between demand and supply is critical to anyone working in the water industry today. Water demand is our need and use of water. Water supply refers to our sources of water. This textbook has three primary parts. In Part One, you will learn foundational concepts in water supply, including the water cycle, water management concepts, water rights and stakeholder concepts.
Principles of Accounting, Volume 2: Managerial Accounting
Principles of Accounting is designed to meet the scope and sequence requirements of a two-semester accounting course that covers the fundamentals of financial and managerial accounting. This book is specifically designed to appeal to both accounting and non-accounting majors, exposing students to the core concepts of accounting in familiar ways to build a strong foundation that can be applied across business fields. Each chapter opens with a relatable real-life scenario for today’s college student. Thoughtfully designed examples are presented throughout each chapter, allowing students to build on emerging accounting knowledge. Concepts are further reinforced through applicable connections to more detailed business processes. Students are immersed in the “why” as well as the “how” aspects of accounting in order to reinforce concepts and promote comprehension over rote memorization.
MITCHELL FRANKLIN, PATTY GRAYBEAL, DIXON COOPER,
You are probably asking yourself the question, "When and where will I use statistics?" If you read any newspaper, watch television, or use the Internet, you will see statistical information. There are statistics about crime, sports, education, politics, and real estate. Typically, when you read a newspaper article or watch a television news program, you are given sample information. With this information, you may make a decision about the correctness of a statement, claim, or "fact." Statistical methods can help you make the "best educated guess." Since you will undoubtedly be given statistical information at some point in your life, you need to know some techniques for analyzing the information thoughtfully. Think about buying a house or managing a budget. Think about your chosen profession. The fields of economics, business, psychology, education, biology, law, computer science, police science, and early childhood development require at least one course in statistics
ALEXANDER HOLMES, BARBARA ILLOWSKY, SUSAN DEAN,
This first general textbook An introduction to ontology engineering has as main aim to provide the reader with a comprehensive introductory overview of ontology engineering. A secondary aim is to provide hands-on experience in ontology development that illustrate the theory. The book is divided into three blocks: Block I: logic foundations for ontologies both regarding the languages (mainly First Order predicate Logic, Description Logics, and OWL) and automated reasoning. Block II: developing good ontologies with methods and methodologies, the top-down approach with foundational ontologies, and the bottom-up approach to extract as much useful content as possible from legacy material.
Business Information Systems: Design an App for That
nformation systems are the combination of people, information technology, and business processes to accomplish a business objective. Every information system (IS) has people, processes, and information technology. In fact, many IS professionals add most of their value working with people and processes. They manage the programmers but typically avoid programming themselves. We can represent an information system as a triangle with people, processes, and information technology (computers) on the three vertices. The three parts of an information system are often referred to as theinformation systems triangle. Consider the popular trend of letting the TV audience vote on some talent shows such as Dancing with the Stars. The voting is managed by a sophisticated information system. The voters are the people involved with the system. Voters can cast the votes by phone, by text, or by online poll—three different information technologies. A central server at ABC records and tallies the votes. The business processes include the phone, texting, and online procedures—how and when to cast votes, and rules limiting the number of votes from each household.
Raymond Frost, Jacqueline Pike, Lauren Kenyo, Sarah Pels,
Pipeline projects can be small jobs requiring only a few sticks of pipe. Or, they can be extensive jobs covering several miles or more. Regardless of the size of the job, it is important to properly plan. Preparing the pipe at the job site is an important aspect of job preparation. The pipe should be placed as close to the trench as possible. This makes it easier for the pipe to be accessed and placed into the trench. String the pipe on the opposite side of the trench as the dirt (spoils) that is being excavated and should be located away from traffic and heavy equipment. The bells should be located in the direction of installation and only enough pipe should be laid out for a days work. It is also important that the pipe is protected from rolling into the trench or away from the job site.
Water Systems and Technology is a program designed to provide the student with enough information to build a successful and lasting career in the water and wastewater industry. It is a by professionals within the industry and within academia. Upon successful completion of the program and after completing any required general education course work, the student can earn an Associate of Science degree in Water Systems Technology. In addition, each course provides supplemental course work hours required for renewal of existing certifications in the water and wastewater industries and many provide specialized training coursework to qualify students to take state certification exams. The program has several general topic course options, includes coursework related to waterworks mathematics, and has specialized courses covering water distribution, water treatment, and wastewater.
https://www.canyons.edu/Offices/DistanceLearning/OER/Documents/Water%20020%20Text%20- 203rd%20Edition%20(2).pdf
The field of Urogynaecology has expanded dramatically over the past decade with the advent of a number of new medical and surgical treatment modalities. The evidence base on pelvic floor dysfunction has also grown extensively. This multi-contributor text will prove invaluable to gynecology, urology and surgery registrars and specialists. Physiotherapists and nurses working in the field of Urogynaecology will also find it extremely useful.
Home health services are those which are provided within the comforts of the home setting to help people avoid hospitalization or skilled nursing facility placement while they recover from illness, injury, or disability. Home health care may also be provided to people who suffer from chronic illnesses, those who have cognitive or physical disabilities or those who have been diagnosed with a terminal illness. Home Health Aide and Personal Care Aide are two of the fastest growing occupations. This text will provide you with the background necessary to begin working toward a career in the home care field.
Middle Mediastinum and Heart - Anatomy and Dissection Guide
The anatomy shown in this video is based off of the UBC MEDD 411 gross anatomy checklist.
Hypothalamus and Limbic System - UBC Neuroanatomy - Season 1 - Ep 4
Dr. Claudia Krebs, Tamara Bodnar, Parker Holman, Dr. Joanne Weinberg
UBC Medicine - Educational Media published via YouTube.com
In this video, I demonstrate the surgeon's knot and the square knot and give some general beginner tips on how to suture.
Lifelong Nursing published via YouTube.com
This video shows the first stage of the production of a cast gold crown for a damaged tooth. The crown is made on the model (See Videos 2 and 3) using wax, which will be replaced by molten gold in the lost wax casting process. The technique of making the wax template and adjusting it to fit the model accurately is shown. Courtesy of Dr Christopher Stokes and Dr Duncan Wood
Dr Christopher Stokes and Dr Duncan Wood
School of Clinical Dentistry, The University of Sheffield.
Creative Commons
This video shows the second stage of the production of a cast gold crown for a damaged tooth. The wax template of the tooth is sprued using wax wire, then invested in a refractory investment material. The video shows the mould being heated to both expand it and prevent against thermal shock. A centrifugal casting process is shown, using an electrical furnace for melting the gold.
This video shows the final stage of the production of a cast gold crown for a damaged tooth. The gold casting is cooled and removed from the mould. Sand blasting, an acid bath and then a series of abrasive burs are used to trim and finish the casting before a final polish is applied.
MCQs in Oral and Maxillofacial Surgery - Local and General Anesthetics
Oral and Maxillofacial Surgery MCQs - Local and General Anesthetics Practice these MCQs for MDS entrance preparation in AIIMS, COMEDK, AIPG, PGI, BHU, etc. Also useful for ADA, NBDE, NDEB and other dental board exams. Please Share and Subscribe to Support us.
Dentosphere : World of Dentistry published via YouTube.com
Creative Commons License .
This is the first lecture in the Bioinformatics for Cancer Genomics 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Trevor Pugh from the Princess Margaret Cancer Centre. For tutorials and lecture slides for this workshop, please visit bioinformaticsdotca.github.io.
http://incompetech.com/music/royalty-...
Breast Cancer Eliminated Using Keshe Technologies - Demo by Dr.Rodrigo Vildosola
Dr. Rodrigo Vildosola explains his method for treating breast cancer using Keshe Plasma Technologies. He gives an example of how he used this with one of his patients with stunning results. Warning: The video contains graphic images of a medical nature.
This is a tutorial/lecture on Drug Formulations. We cover some topics important for classes such as Biochemistry and Pharmacology.
TheSalmonellaPlace published via YouTube.com
Coming Off Psychiatric Drugs: A Harm Reduction Approach to Medication Withdrawal | Will Hall
Psychiatric medications can sometimes be very useful, but there is often little information or guidance when the risks and harm start to outweigh the benefits. Will Hall provides an introductory overview of how to come off psychiatric medication. Will Hall is a survivor of a schizophrenia diagnosis who today works as a therapist and teaches internationally on mental diversity, including psychiatric medication. This video provides some basic guidance for anyone considering reducing or coming off psychiatric medications and their supporters, and is discussed in greater detail in the Harm Reduction Guideto Coming Off Psychiatric Drugs.
Will Hall published via YouTube.com
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of esophageal cancer, including etiology, epidemiology, screening, pathology, staging, and treatment.
University of Massachusetts Medical School
As we get started on our journey into the world of health and nutrition, our first focus will be to demonstrate that nutritional science is an evolving field of study, continually being updated and supported by research, studies, and trials.
Pharmacokinetics/ADME Of Drugs | Pharmacology Online Lecture-1 | For Upcoming D.Pharm & B.Pharm Exam
In this video , we have discussed about PHARMACOKINETICS OF DRUGS - ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION (ADME) IN BRIEF. Watch the video till the end to get complete information regarding pharmacokinetics of drugs. Topic discussed in the video :- Pharmacokinetics - the branch of pharmacology concerned with the movement of drugs within the body, the time course of its absorption, bioavailability, distribution, metabolism, and excretion or sometimes described as what the body does to a drug. It include four steps:- Absorption, Distribution, Metabolism, Excretion.
LEARNINGPHARMACY.IN published via YouTube.com
Food as Medicine: Preventing and Treating the Most Common Diseases with Diet
This is Dr. Greger's 2015 live presentation. Dr. Greger has scoured the world's scholarly literature on clinical nutrition and developed this new presentation based on the latest in cutting-edge research exploring the role diet may play in preventing, arresting, and even reversing some of our leading causes of death and disability. Subscribe to Dr. Greger’s free nutrition newsletter and get the Evidence-Based Eating Guide: A Healthy Living Resource from Dr. Greger and NutritionFacts.org.
Nutrition Facts.org published via YouTube.com
This is the first lecture in the Bioinformatics of Genomic Medicine 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Michael Brudno from the Hospital for Sick Children. For tutorials and lecture slides for this workshop, please visit bioinformaticsdotca.github.io.
Bioinformatics Dot Ca published via YouTube.com
Introduction to Financial Accounting Adapted for U.S. GAAP
AccounƟng involves a process of collecƟng, recording, and reporƟng a business’s economic acƟviƟes to users. It is oŌen called the language of business because it uses a unique vocabulary to communicate informaƟon to decision makers. To understand accounƟng, we first look at the basic forms of business organizaƟons. The concepts and principles that provide the foundaƟon for financial accounƟng are then discussed. With an emphasis on the corporate form of business organizaƟon, we will examine how we communicate to users of financial informaƟon using financial statements. Finally, we will review how financial transacƟons are analyzed and then reported on financial statements.
Henry Dauderis, David Annand, Donna L. Marchand
PROJECT MANAGEMENT, INSTRUCTIONAL DESIGNERS
Professional Web Accessibility Auditing Made Easy
Digital accessibility skills are in high demand, as the world becomes more aware of barriers in digital content that prevent some people from participating in a digital society. These are essential skills for web developers, and essential knowledge for organizations that want to ensure their web content is reaching the broadest audience possible.
Teaching the strategic management course can be a challenge for many professors. In most business schools, strategic management is a “capstone” course that requires students to draw on insights from various functional courses they have completed (such as marketing, finance, and accounting) in order to understand how top executives make the strategic decisions that drive whether organizations succeed or fail. Although students have taken these functional courses, many students have very little experience with major organizational choices.
Principles of Management is designed to meet the scope and sequence requirements of the introductory course on management. This is a traditional approach to management using the leading, planning, organizing, and controlling approach. Management is a broad business discipline, and the Principles of Management course covers many management areas such as human resource management and strategic management, as well behavioral areas such as motivation. No one individual can be an expert in all areas of management, so an additional benefit of this text is that specialists in a variety of areas have authored individual chapters.
The Delft Sand, Clay & Rock Cutting Model
This book gives an overview of cutting theories for the cutting of sand, clay and rock as applied in dredging engineering. In dredging engineering in general sand, clay and rock are excavated with buckets of bucket ladder dredges, cutter heads of cutter suction dredges, dredging wheels of wheel dredges, drag heads of trailing suction hopper dredges, clamshells, backhoes and other devices. Usually the blades have a width much larger than the layer thickness of the cut (2D process) and the blade angles of these devices are not too large in the range of 30°-60°. Although clamshells and backhoes may have blade angles around 90°when they start cutting. Other devices like drill bits of oil drilling devices,blades of tunnel boring machines,ice berg scour and the bull dozer effect in front of a drag head may have cutting angles larger than 90°. In such a case a different cutting mechanismis encountered, the so called wedge mechanism
HYDRAULICS AND ELECTRICAL CONTROL OF HYDRAULIC SYSTEMS
Differentiate between fluid power systems and mechanical or electrical systems Differentiate between hydraulic and pneumatic systems with respect to the fluid medium employed, characteristics, capacity, performance, and cleanliness Describe a basic fluid power system in terms of power conversion. Describe the role of a prime mover like a motor or internal combustion engine in a fluid power system.Draw the schematic symbol for a motor and internal combustion engine. Describe the role of a pump in a fluid power system. Draw the schematic symbol for a pump and reservoir.Describe what properties pressure, flow rate, and valve position influence in a fluid power system. Describe Pascal’s Law and the formula used to relate force, pressure, and area.Describe the role of an actuator in a fluid power system. Draw the schematic symbol for a cylinder and hydraulic motor.
Principles of Accounting Volume 1 Financial Accounting
Principles of Accounting is designed to meet the scope and sequence requirements of a two-semester accounting course that covers the fundamentals of financial and managerial accounting. Due to the comprehensive nature of the material, we are offering the book in two volumes. This book is specifically designed to appeal to both accounting and non-accounting majors, exposing students to the core concepts of accounting in familiar ways to build a strong foundation that can be applied across business fields. Each chapter opens with a relatable real-life scenario for today’s college student. Thoughtfully designed examples are presented throughout each chapter, allowing students to build on emerging accounting knowledge. Concepts are further reinforced through applicable connections to more detailed business processes. Students are immersed in the “why” as well as the “how” aspects of accounting in order to reinforce concepts and promote comprehension over rote memorization.
Building information - representationand management
Building information,, representationand management
This book is about the foundations and principles of building information, its representation and management. It does not tell you which software or policies to choose for representing buildings and managing the resulting information. In fact, the book argues that one should not start with practical steps before fully understanding the reasoning behind any such choice. The basis of this reasoning comprises the structure of information and of the representations that contain it, the purposes of managing information in the context of these representations and the processes in which the representations are used; in a nutshell, how information relates to a specific domain. Without adequate reasoning that takes into account all syntactic, semantic and pragmatic aspects, adopting one software or another, implementing one practical measure or another simply subjugates information processing to some prescriptive or proscriptive framework that may be unproductive, incompatible or inappropriate for the domain.
Digital Circuit Projects: An Overview of Digital Circuits Through Implementing Integrated Circuits - Second Edition
Digital circuits, often called Integrated Circuits or ICs, are the central building blocks of a Central Processing Unit (CPU). To understand how a computer works, it is essential to understand the digital circuits which make up the CPU. This text introduces the most important of these digital circuits; adders, decoders, multiplexers, D flip-flops, and simple state machines. What makes this textbook unique is that it puts the ability to understand these circuits into the hands of anyone, from hobbyists to students studying Computer Science. This text is designed to teach digital circuits using simple projects the reader can implement. But unlike most lab manuals used in classes in Digital Circuits or Computer Organization classes, this textbook is designed to remove the barrier of a laboratory infrastructure needed in a face-to-face environment at a college or university. This textbook is designed to be used by the reader to create the circuits in their own homes. The textbook is free. The cost of the kits needed to do the labs is reasonable.
This textbook and its accompanying spreadsheet templates were designed with and for students wanting a practical and easy-to-follow guide for developing a business plan. It follows a unique format that both explains what to do and demonstrates how to do it.
Introduction To MIPS Assembly Language Programming
This book was written to introduce students to assembly language programming in MIPS. As with all assembly language programming texts, it covers basic operators and instructions, subprogram calling, loading and storing memory, program control, and the conversion of the assembly language program into machine code. However this book was not written simply as a book on assembly language programming. The larger purpose of this text is to show how concepts in Higher Level Languages (HLL), such as Java or C/C++, are represented in assembly. By showing how program constructs from these HLL map into assembly, the concepts will be easier to understand and use when the programmer implements programs in languages like Java or C/C++. Concepts such as references and variables, registers, binary and Boolean operations, subprogram execution, memory types (heap, stack, and static), and array processing are covered to clarify the decisions made when implementing HLL. Program control is presented using a mapping from structured programs in pseudo code to help students understand structured programming, and why it exists. Memory access in assembly is presented to high light the difference between references (pointers) and values, and how these impact HLL.
1. A variety of different malignancies fall into the category of “Head and. Neck Cancers”. This chapter focuses on upper aerodigestive tract cancer. 2. Tobacco and alcohol use and human papillomavirus infection are common causes of head and neck cancers. 3. Most head and neck cancers are squamous cell carcinomas. 4. Treatment of head and neck cancers commonly requires some combination of surgery, radiation, and chemotherapy. Close cooperation between otolaryngologists, radiation oncologists, and medical oncologists is mandatory for successful treatment of these cancers. 5. Preservation of organ function in addition to cure of cancer, is an important goal of treatment. 6. Any patient with persistent symptoms of sore throat, hoarseness, difficulty swallowing or an enlarged cervical lymph node should be evaluated for possible head and neck cancer.
James Liebmann, MD, Ali Akalin MD, PhD., Liana Puscas, MD, MHS., Andrew Chen MD., Richard S. Pieters, MD
Metastatic Extramammary Paget's Disease: Pathogenesis and Novel Therapeutic Approach
Metastatic Extramammary Paget's Disease, Pathogenesis and Novel Therapeutic Approach
Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.
Clinical Procedures for Safer Patient Care
British Columbia Institute of Technology (BCIT)
Essentials of Nutrition: A Functional Approach! This book is written for students who are not majoring in nutrition, but want to learn about the fundamental aspects of nutrition and how it applies to their own lives. We have written this book with the assumption that you have little or no prior knowledge of college level chemistry, biology, or physiology. But that does not mean it’s not scientific! Nutrition is a science-based discipline, so all the material included is backed up by rigorous scientific research, but it is presented in a clear, easy-to-understand fashion without requiring a background in science.
Brehe’s Grammar Anatomy makes grammar accessible to general and specialist readers alike. This book provides an in-depth look at beginner grammar terms and concepts, providing clear examples with limited technical jargon. Whether for academic or personal use, Brehe’s Grammar Anatomy is the perfect addition to any resource library.
Organizational Behavior. The text presents the theory, concepts, and applications with particular emphasis on the impact that individuals and groups can have on organizational performance and culture. An array of recurring features engages students in entrepreneurial thinking, managing change, using tools/technology, and responsible management; furthermore, the unique chapter on Social Media and Communication contextualizes the importance and implications of various platforms and communications methods.
Intimate Communities . Wartime Healthcare and the Birth of Modern China, 1937–1945
When China’s War of Resistance against Japan began in July 1937, it sparked an immediate health crisis throughout China. In the end, China not only survived the war but emerged from the trauma with a more cohesive population. Intimate Communities argues that women who worked as military and civilian nurses, doctors, and midwives during this turbulent period built the national community, one relationship at a time. In a country with a majority illiterate, agricultural population that could not relate to urban elites’ conceptualization of nationalism, these women used their work of healing to create emotional bonds with soldiers and civilians from across the country. These bonds transcended the divides of social class, region, gender, and language. “Nicole Elizabeth Barnes demonstrates remarkable insights into some of the most well-known figures in healthcare in wartime China—and introduces many previously unknown—providing pointed character analyses while also connecting individual experiences to larger sociopolitical trends across the tumultuous wartime landscape.” SONYA GRYPMA, PhD, RN, author of China Interrupted: Japanese Internment and the Reshaping of a Canadian Missionary Community “Not only a major contribution to the histories of medicine, gender, emotion, and nationalism, but even more importantly, it opens up exciting horizons by making visible and exploring the surprising entanglements between them all.” SEAN HSIANG-LIN LEI, author of Neither Donkey nor Horse: Medicine in the Struggle over China’s Modernity
Building Green . Environmental Architects and the Struggle for Sustainability in Mumbai
Building Green explores the experience of environmental architects in Mumbai, one of the world’s most populous and population-dense urban areas and a city iconic for its massive informal settlements, extreme wealth asymmetries, and ecological stresses. Under these conditions, what does it mean to learn, and try to practice, so-called green design? By tracing the training and professional experiences of environmental architects in India’s first graduate degree program in Environmental Architecture, Rademacher shows how environmental architects forged sustainability concepts and practices and sought to make them meaningful through engaged architectural practice. The book’s focus on practitioners offers insights into the many roles that converge to produce this emergent, critically important form of urban expertise. At once activists, scientists, and designers, the environmental architects profiled in Building Green act as key agents of urban change whose efforts in practice are shaped by a complex urban development economy, layered political power relations, and a calculus of when, and how, their expert skills might be operationalized in service of a global urban future.
Migrating into Financial Markets : How Remittances Became a Development Tool
We understand very little about the billions of dollars that flow throughout the world from migrants back to their home countries. In this rigorous and illuminating work, Matt Bakker, an economic sociologist, examines how these migrant remittances—the resources of some of the world’s least affluent people—have come to be seen in recent years as a fundamental contributor to development in the migrant?sending states of the global south. This book analyzes how the connection between remittances and development was forged through the concrete political and intellectual practices of policy entrepreneurs within a variety of institutional settings, from national government agencies and international development organizations to nongovernmental policy foundations and think tanks.
The Environmental Impact of Sieben Linden Ecovillage
Environmental impact assessment is widely taught and researched, but rarely covers both lifestyle and building construction in a town or neigh-bourhood. This book provides a broad assessment of the environmental impact of the ecovillage Sieben Linden in Germany. The ecovillage was founded in 1997 and has a population of over one hundred people. This book shows how raising the awareness of individuals and adopting a consistent way of community living can be environmentally friendly. This applies both to everyday practices and the way the houses in the ecovillage are built. The tools used to measure the impact are Ecological Footprint and Carbon Footprint methodologies, making use of indicators such as Primary Energy Intensity and Global Warming Potential. Despite the diffi culties encountered by using standardised methodologies, these research tools provide an overall assessment and have allowed comparisons with selected, similar cases and general values from statistic sources.
Bocco, Andrea; Gerace , Martina; Pollini, Susanna
Governing Extractive Industries : Politics, Histories, Ideas
The large-scale extraction of minerals, hydrocarbons, and other natural resources1has long been central to national economies and the global economy. This has been the case in colonial and post-colonial economies alike, and the harnessing of such resources continues to feature prominently in the economic development strategies of many countries. The economic significance of resource extraction can be quantified through data on percentage contribution of oil, gas, and mining to GDP, exports, foreign direct investment, and the public budget (Mosley, 2017). In contrast, the contributions of extractive industries to ‘development’ and ‘inclusive development’ are more uncertain, not least because definitions of these terms differ based on the degree to which analysts emphasize goals of poverty and income inequality, environmental justice, gender equity, or human and citizenship rights. Even those advocating for the role of extractives in economic development and poverty reduction recognize that results have often been ambiguous (Davis, 2009).
Undergraduate Diagnostic Imaging Fundamentals
Diagnostic Imaging principles and concepts are augmented by the presentation of images for common clinical conditions. Guiding principles related to minimizing radiation exposure and requesting the most appropriate imaging examination are addressed.Static images are enhanced by the ability to access images stored and displayed on an Html-5 compatible, Dicom image viewer that simulates a simple Picture Archive and Communication system (PACS). Users can also access other imaging from the Dicom viewer (ODIN), beyond the basic curriculum provided, to further advance their experience with viewing diagnostic imaging pathologies.
In dredging, production estimating is carried out mainly with analytical physical models of the different dredging processes. Slurry transport of settling slurries and cutting processes in sand, clay and rock are already covered in two other books by the author. Other processes like hopper sedimentation and erosion, water jet fluidization, cutter head spillage, pump/pipeline dynamics and clamshell dredging are covered in this Special Topics Edition. New topics may be added in the near future
The goal of this book is to improve your logical-reasoning skills. These skills are also called "critical thinking skills." They are a complex weave of abilities that help you get someone's point, generate reasons for your own point, evaluate the reasons given by others, decide what or what not to do, decide what information to accept or reject, explain a complicated idea, apply conscious quality control as you think, and resist propaganda. Your most important critical thinking skill is your skill at making judgments─not snap judgments that occur in the blink of an eye, but those that require careful reasoning.
3D City Models and urban information: Current issues and perspectives
Many urban or environmental models are defined with the objective of helping practitioners and stakeholders in their decision-making processes. Models which represent in three dimensions the geometric elements of a city are called 3D city models. These models are increasingly used in different cities and countries for an intended wide range of applications beyond mere visualisation. Indeed, unlike maps and drawings, 3D visualisation reflects a view of the environment that a lot of people are familiar with and acts as a communication tool. Non geometrical data (such as social, historic or acoustic data or statistics, for example) can be associated to urban geometrical objects (such as buildings or streets) that can be represented and visualized in 3D, leading to a localization as well as a better understanding of these data. By associating a domain (energy consumption, air quality, etc.) to these 3D models, we obtain richer 3D representations that can be used for simulations and reasoning (visual reasoning).
Νear-Earth space is the region that extends from the middle atmosphere up to the outer radiation belts. This region is of significant interest because of its potentially undesired effects on human life and on technological systems, whose understanding, modeling and prediction require continuous scientific exploration and advances. Consequently, a number of observing systems have been set up to acquire observations from the near-Earth space, producing a wealth of diverse types of data which still need to be homogenized and organized in order to become widely accessible. The exploitation of multi-instrument data from a large number of distributed observing sites is the requirement for accurate predictions of the near-Earth space environment. As the near-Earth space is part of the complex Sun-Earth system, supporting data from the Sun, the interplanetary medium but also from the upper and lower layers of the atmosphere, are needed to drive near-Earth prediction models.
The Precision Medicine Initiative, which was instituted by President Barack Obama on January 20, 2015, highlighted the importance that advances in genomics and related “-omic” approaches have made to science and medicine, and it set the stage for their federally funded and mandated integration into the delivery of health care. Whether these advances comprise large-scale approaches, such as The Cancer Genome Atlas, which provides a modern classification of cancers based on molecular profiles, or genealogy initiatives, which seek to trace the movement of our early ancestors out of Africa, genomic technology has taken us closer to developing targeted therapies and a refined understanding of our evolutionary journey.
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
t Quantitative four-dimensional (4D) image reconstruction methods with respiratory and cardiac motion compensation are an active area of research in ECT imaging, including SPECT and PET. They are the extensions of three-dimensional (3D) statistical image reconstruction methods with iterative algorithms that incorporate accurate models of the imaging process and provide significant improvement in the quality and quantitative accuracy of the reconstructed images as compared to that obtained from conventional analytical image reconstruction methods. The new 4D image reconstruction methods incorporate additional models of the respiratory and cardiac motion of the patient to reduce image blurring due to respiratory motion and image noise of the cardiac-gated frames of the 4D cardiac-gated images.
The core of the present study is an investigation on eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in reference works such as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice1 , as well as a growing awareness of health issues (Pirohakul-Wallis 2014: 3-4), favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole.
Innovative Medicine : Basic Research and Development
Reactive oxygen species (ROS) are an intricate part of normal cellular physiology. In excess, however, ROS can damage all three major classes of acromolecules and compromise cell via bility. We briefl y discuss the physiology of ROS but focus on the mechanisms cells use to preserve redox homeostasis upon oxidative stress, with particular emphasis on glycolysis. ROS inhibits multiple glycolytic enzymes, including glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase M2, and phosphofructokinase-1. Consistently, glycolytic inhibition promotes fl ux into the oxidative arm of the pentose phosphate pathway to generate NADPH. NADPH is critically important, as it provides the reducing power that fuels the protein-based antioxidant systems and recycles oxidized glutathione. The unique ability of pyruvate kinase M2 inhibition to promote serine synthesis in the context of oxidative stress is also discussed.
Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto
Our species has always used plants as medicines, during our 200,000 year existence. This is made obvious by the plant medicines found in mummy burials, around the world, dating back thousands of years. Human beings evolved using plant medicines to stay alive. This has resulted in a genetic selection in which those who were healed by plant medicines and survived were able to pass on their genes. Modern humans must continue to use plant medicines. When a Traditional Healer is asked how her people learned how to use a specific plant medicine, the answer is usually that God taught them. Each of us has a spiritual sense that can be used to seek answers [1]. Finding a new plant medicine involves fasting, praying, and spending as much as four days with the plant that will become a new medicine [2]. Traditional Healers are still the major or only source of healthcare for many regions of the world. The loss of Traditional Healers in some areas has resulted in major changes in healthcare, sometimes to the detriment of the people [3,4]. Since Traditional Healers may be religious leaders also, they provide moral direction for the community. The displacement of traditional religious beliefs has been detrimental in some regions
Drug-Diagnostics Co-Development in Oncology
The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen-receptor modulator tamoxifen was developed in the 1970s for the treatment of breast cancer, data on estrogen-receptor status were correlated with the treatment outcome. Based on a phase II study performed in patients with advanced breast cancer, published in 1976, the investigators concluded:“a high degree of correlation between response and positive estrogen-receptor assay suggests the value of the diagnostic test as a means to select patients for tamoxifen treatment” (1). Despite the fact that this conclusion was drawn nearly 40 years ago, the adaptation of the drug-diagnostic co-development model has been relatively slowand it is only within the last decade that it has gained widespread acceptance.
Machine Learning with Radiation Oncology Big Data
Half of all cancer patients may receive radiotherapy as part of their treatment. With the wealth of diverse data generated every day in the clinic, the radiation oncology community possesses a unique advantage in harnessing these massive data with the predictive power of machine learning methods for the beneﬁt of millions of cancer patients undergoing radiotherapy worldwide. In this Research Topic “Machine Learning with Radiation Oncology Big Data,” a wide range of clinical applications involving various machine learning algorithms have been described and demonstrated, with the hope of ushering in more widespread applications of artiﬁcial intelligence in medicine, particularly in cancer radiotherapy in order to achieve a truly individualized radiation oncology and an evidence-based learning healthcare system.
The Impact of Systems Medicine on Human Health and Disease
Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties.
Homeostasis and Allostasis of Thyroid Function
Alterations of thyroid function, especially hypothyroidism, are exceptionally common conditions. Studies from several developed countries revealed the prevalence of subclinical and overt hypothyroidism to be between 5 and 15 % and between 1 and 10%, respectively. Diagnosis and treatment of (overt or subclinical) hypothyroidism are considered to be easy tasks, since thyrotropin (TSH) concentration mirrors the supply with thyroid hormones and is therefore accepted as a biomarker for both diagnosis and dose calibration for substitution therapy.
Johannes W. Dietrich, John E. M. Midgley, Rudolf Hoermann
Mind-Body Medicine in Children and Adolescents
The field of mind-body medicine holds significant promise for children and adolescents. Growing recognition of the intricate connections between thought, emotion, and physiology highlights the need for new therapies that leverage inner resources and offer non-invasive treatment options. Modern imaging techniques such as functional magnetic resonance imaging (fMRI) have advanced our understanding and appreciation of how the mind-body therapies can benefit health, increasing confidence in their use and propelling them into the mainstream of medicine. Mind-body therapies have special value in addressing pain, fear, and stress that accompanies many pediatric medical encounters. Some of the mind-body therapies such as mindfulness, have their roots in ancient traditions and are now being used routinely in the practice of pediatric integrative medicine, an emerging field focused on preventive health that blends conventional and evidence-based complementary therapies
MDPI - Multidisciplinary Digital Publishing Institute
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease
The Research Defence Society (RDS) was founded in 1908 by Dr Stephen Paget, son of the eminent Victorian surgeon, Sir James Paget. Its role was to defend scientists conducting medical research using animals and to inform the public about the importance of animal experimentation. In its first year it attracted a membership of 2000 which included scientists in the pharmaceutical industry, in academia and in research institutes. Past presidents of the Society include such distinguished figures as Lord Perry of Walton and Sir William Paton.
Secondary Analysis of Electronic Health Records
While wonderful new medical discoveries and innovations are in the news every day, healthcare providers continue to struggle with using information. Uncertainties and unanswered clinical questions are a daily reality for the decision makers who provide care. Perhaps the biggest limitation in making the best possible decisions for patients is that the information available is usually not focused on the specific individual or situation at hand. For example, there are general clinical guidelines that outline the ideal target blood pressure for a patient with a severe infection. However, the truly best blood pressure levels likely differ from patient to patient, and perhaps even change for an individual patient over the course of treatment. The ongoing computerization of health records presents an opportunity to overcome this limitation.
Innovative Radiopharmaceuticals in Oncology and Neurology
Personalized medicine is presented as the future of patient care. Nuclear Medicine will play a major role in the selection of patients for targeted therapies and in early therapy assessment with the investigation of phenotypes and functions using sensitive and specific SPECT and PET imaging techniques and theranostic approaches. Nuclear Medicine is already a key in the development of new therapies and targeted radionuclide therapy provides efficacious treatment modalities against cancer. An incredible amount of innovation is related to the use of a variety of radionuclides, new or improved multimodality imaging devices, and numbers of recently marketed radiopharmaceuticals in all medical domains and particularly cardiology, neurology, and oncology.
Rabies Symptoms, Diagnosis, Prophylaxis and Treatment
Rabies is an acute, progressive, incurable viral encephalitis found throughout the world. Despite being one of the oldest recognized pathogens, its impact remains substantial in public health, veterinary medicine, and conservation biology. Thus, it is Essential to apply existing tools and to seek new methods to improve upon prevention, control, selective variant elimination, and treatment efforts. Advances in diagnosis, vaccinology, pathobiology, and related research techniques continue to afford enhanced insights on rabies. Although rabies is not a candidate for eradication, the results of these innovative communications provide further knowledge to deﬁne a more optimal approach to understanding and managing this complex infectious disease of nature on a global basis in a One Health context.
Charles Rupprecht (Ed.), Bernhard Dietzschold (Ed.)
Appropriate mathematical tools and methodologies are critical for ensuring robust and reliable computational model predictions based on medical and healthcare data in the era of the digital health revolution (Duggal et al., 2018). Patient-speciﬁc approaches are being increasingly pursued, with simulations benchmarked by clinical data (e.g., brain activity recordings; Breakspear, 2017) obtained in non-invasive manner on individual level (e.g., resting state; Spetsieris et al., 2015). Precision Medicine, although not a new concept, is gaining momentum (Hodson, 2016) powered by the ever increasing volume of patients data (Colijn et al.). Quantifying patient similarity is an important challenge that is critical in predicting patients’ disease trajectories (Sharafoddini et al., 2017). In an opinion article (Brown) patient similarity concept has been introduced as a paradigm shift in optimizing personalisation of patient care.
Krasimira Tsaneva-Atanasova, Vanessa Diaz-Zuccarini
Fundamentals of Microwave and RF Design enables mastery of the essential concepts required to cross the barriers to a successful career in microwave and RF design. Extensive treatment of scattering parameters, that naturally describe power flow, and of Smith-chart-based design procedures prepare the student for success. The emphasis is on design at the module level and on covering the whole range of microwave functions available. The orientation is towards using microstrip transmission line technologies and on gaining essential mathematical, graphical and design skills for module design proficiency. This book is derived from a multi volume comprehensive book series, Microwave and RF Design, Volumes 1-5, with the emphasis in this book being on presenting the fundamental materials required to gain entry to RF and microwave design.
North Carolina State University Libraries
Microwave and RF Design: Radio Systems is a circuits- and systems-oriented approach to modern microwave and RF systems. Sufficient details at the circuits and sub-system levels are provided to understand how modern radios are implemented. Design is emphasized throughout. The evolution of radio from what is now known as 0G, for early radio, through to 6G, for sixth generation cellular radio, is used to present modern microwave and RF engineering concepts. Two key themes unify the text: 1) how system-level decisions affect component, circuit and subsystem design; and 2) how the capabilities of technologies, components, and subsystems impact system design. This book is suitable as both an undergraduate and graduate textbook, as well as a career-long reference book.
Microwave and RF Design: Transmission Lines
Microwave and RF Design: Transmission Lines builds on the concepts of forward- and backward-traveling waves. Many examples are included of advanced techniques for analyzing and designing transmission line networks with microstrip lines primarily used in design examples. Coupled-lines are an important functional element in microwave circuits, and circuit equivalents of coupled lines are introduced as fundamental building blocks in design. The text and examples introduce the often hidden design requirements of mitigating parasitic effects and eliminating unwanted modes of operation.
Microwave and RF Design: Networks presents the tools and techniques required to analyze and design microwave and RF circuits. Because of the finite speed of light, microwave circuits must be considered to be spatially distributed and so there is not a single ground. As such metrics that can be used to describe power flow are of most use. The topics covered include scattering parameters, signal flow graphs, and Smith charts. Acquiring expertise in these is the biggest barriers to a successful career in microwave and RF engineering
Microwave and RF Design: Modules focuses on the design of systems based on microwave modules. The use of modules has become increasingly important in RF and microwave engineering for rapidly realizing high performance microwave systems. When integration is ultimately to be used, building a system up using modules provides a rapid means of prototyping and testing system concepts. A wide variety of RF modules including amplifiers, local oscillators, switches, circulators, isolators, phase detectors, frequency multipliers and dividers, phase-locked loops, and direct digital synthesizers are considered. Detailed design strategies for synthesizing filters based on parallel coupled lines are presented. The reader will gain an appreciation of design by synthesis.
Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation
In recent years, there has been vast improvement in the survival of solid organ grafts. Improved immunosuppression has resulted in efficient control of cell-mediated immune responses and has also mitigated the effects of HLA mismatching between the recipient and the grafted organ. ntibodymediated rejection (AMR) however still remains a clinical challenge and the identification of donorspecific HLA antibodies pretransplant are a mandatory requirement for successful grafting. Accurate and sensitive HLA antibody identification has been made possible by the introduction of solid phase assays such as the Luminex bead based platform for antibody testing. Despite this advancement in detecting and understanding the role of HLA antibodies in rejection, many questions still require answers in order to maximize the outcome in solid organ transplantation. Many of these aspects are dealt with efficiently in this excellent series of papers addressing the role of antibodies in solid organ rejection. This collection of reviews, some including new findings, by world leaders in their particular
Narinder K. Mehra --- Ajay Kumar Baranwal --- Brian D. Tait
Natural Antibodies in Health and Disease
Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition,
Ana Maria Hernandez , Nichol E. Holodick
Ontogeny and Phylogeny of Brain Barrier Mechanisms
Norman R. Saunders , Helen B. Stolp, Shane A. Liddelow
Sensory Hair Cell Death and Regeneration
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as agin g, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of hese hair cells lead to deficits in hearing and balance, and in ammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells.
Michael E. Smith , Andrew K. Groves, Allison B. Coffin
Breaking the cycle: Attacking the malaria parasite in the liver
Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular eﬀector mechanisms capable of eliminating Plasmodium from the liver. However, malaria liver stage immunity is complex. The anatomic site of priming of naive Plasmodium-speciﬁc CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may in fact determine the speciﬁcity of the eﬀector CD8 T cells. The participation of particular antigenpresenting cells (Corradin and Levitskaya, 2014) and tissue signatures that inﬂuence the activation of intrahepatic CD8 T cells against malaria sporozoites (Morrot and Rodrigues, 2014) are still incompletely understood. Similarly, how eﬀector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.
Ute Frevert, Urszula Krzych , Thomas L. Richie
Lyme Disease: Recent Advances and Perspectives
he interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging.
Tanja Petnicki Ocwieja, - Catherine A Brissette
NK Cell Subsets in Health and Disease: New Developments
Under physiological conditions, the distribution /intensity of the surface markers CD56 and CD16 (FcγRIII) defines two subsets of NK lymphocytes: the CD56bright/CD16neg-dim (generally referred to as CD56bright) population that make up about 10% of blood NK cells in adults and the CD56dim/CD16bright (generally referred to as CD56dim) cells that comprise for about 90% of circulating NK cells. CD56bright NK cells exert only marginal cytotoxic capacity but are higly proficient in production of cytokines such as interferon IFN-γ, TNF-α and GM-CSF. Because of this property, CD56bright NK cells have been generally referred to as regulatory NK cells.
Emanuela Marcenaro, - Luigi D. Notarangelo ,- Jordan S. Orange --- Eric Vivier
Applications of STEM (Science, Technology, Engineering and Mathematics) tools in microbiology of infectious diseases
Science, technology, engineering, and mathematical (STEM) tools and approaches are expected to become a critical component for the prevention, control, and eradication of animal diseases at a global scale in the near future. In the last decades the amount of information that is being generated in all scientific disciplines, including microbiological studies applied to infectious diseases, has increased exponentially, becoming a problem in itself due to the lack of tools and expertise to analyze data. The formulation and parameterization of such a body of empirical knowledge combined with theoretical knowledge into mathematical models
Drug-induced hypersensitivity reactions play a prominent role among adverse drug effects, and constitute a major health problem. It has been suggested that up to 6% of all hospital admissions are related to these reactions. Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions.
The first human tumor virus was discovered in the middle of the last century by Anthony Epstein, Bert Achong and Yvonne Barr in African pediatric patients with Burkitt’s lymphoma. To date, seven viruses -EBV, KSHV, high-risk HPV, MCPV, HBV, HCV and HTLV1- have been consistently linked to different types of human cancer, and infections are estimated to account for up to 20% of all cancer cases worldwide. Viral oncogenic mechanisms generally include: generation of genomic instability, increase in the rate of cell proliferation, resistance to apoptosis, alterations in DNA repair mechanisms and cell polarity changes, which often coexist with evasion mechanisms of the antiviral immune response. Viral agents also indirectly contribute to the development of cancer mainly through immunosuppression or chronic inflammation, but also through chronic antigenic stimulation
Enhancing Soil Health to Mitigate Soil Degradation
This research editorial is intended to establish the context and provide a broad overview for the Special Issue of Sustainability entitled “Enhancing Soil Health to Mitigate Soil Degradation” that was initiated in 2014 to document both the magnitude and global revalence of soil degradation. Our goals for the Special Issue were to: (1) help illustrate various factors contributing to the problem of soil degradation; (2) identify past and current impacts of soil degradation in countries around the world; and (3) suggest soil health strategies that could be used to protect our fragile soil resources. As our global population marches steadily toward projections of 9.5 billion in 2050, natural and human induced soil degradation, if not mitigated, will undoubtedly increase the potential for negative impacts such as disease and malnutrition.
Douglas L. Karlen (Ed.) ,- Charles W. Rice (Ed.)
The Transcriptional Regulation of Memory
The formation of human memories involves a series of complicated biochemical processes many of which are not fully understood. However, recent data implicate several families of transcription factors that appear critically important in the regulation of memory. For example, CREB, NF-kB, AP-1, Egr, and C/EBP ...The formation of human memories involves a series of complicated biochemical processes many of which are not fully understood. However, recent data implicate several families of transcription factors that appear critically important in the regulation of memory. For example, CREB, NF-kB, AP-1, Egr, and C/EBP families are emerging as key transcriptional regulators of synaptic plasticity and long term memory.
Benedict C. Albensi , Jelena Djordjevic
Advances in Hydro-Meteorological Monitoring
This book presents a reprint of the Special Issue of the journal Water dedicated to “Advances in Hydro-Meteorological Monitoring”. As we planned, as editors, this Special Issue aimed to shed light on the more recent advances in ground observations and remote sensing products, as well as on the benefit that comes from the integration of technological innovation and the development of new ideas in hydrology science. This original objective was achieved, and in the eleven papers collected here the readers can appreciate theoretical and applied contributions dealing with the development and comparison of different monitoring procedures based on ground and satellite data. The papers are arranged with a process-oriented criterion that follows the hydrologic cycle. Starting from soil moisture monitoring from satellites and in-situ, we move to pan evaporimeter measurements. Runoff measurement using advanced methods from both satellites and in the field are then addressed. Three papers are dedicated to rainfall measurement and spatial representation and the two final papers address the problem of systematic errors in snow precipitation measurement and the design of snow measurement networks
Tommaso Moramarco (Ed.) -, Roberto Ranzi (Ed.)
Dynamics of decision making: from evidence to preference and belief
At the core of the many debates throughout cognitive science concerning how decisions are made are the processes governing the time course of preference formation and decision. From perceptual choices, such as whether the signal on a radar screen indicates an enemy missile or a spot on a CT scan indicates a tumor, to cognitive value-based decisions, such as selecting an agreeable flatmate or deciding the guilt of a defendant, significant and everyday decisions are dynamic over time. Phenomena such as decoy effects, preference reversals and order effects are still puzzling researchers
Marius Usher -, Konstantinos Tsetsos -, Erica Yu -, David A. Lagnado
Danger Signals Triggering Immune Response and Inflammation
The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial or mesenchymal) and injured tissue. Some endogenous danger signals are heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular-matrix breakdown products such as hyaluronan fragments, neuromediators and cytokines like the interferons (IFNs).
Abdulraouf Ramadan --- Walter G. Land --- Sophie Paczesny
So-called altered states of consciousness (ASC) are an intriguing, still under-researched topic, with profound neuropsychological and epistemological implications. In the last few decades there has been increasing multidisciplinary interest in consciousness and ASC, a term encompassing a wide range of pathological and non-pathological conditions, including dreaming, near-death experiences (NDEs), hypnagogic states, hallucinogenic experiences, epileptic seizures, psychotic symptoms, coma, and minimally conscious states
Platelets as immune cells in physiology and immunopathology
Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells—which all specialists consider at the time being—are they immune cells? The issue that platelets participate in immunity is no longer debated; however, the issue that they are key cells in immunity is challenged. It has even been proposed a couple of years ago that platelets can present antigen to T-lymphocytes by using their HLA class I molecules. No one has the same functional definition of platelets. The ‘Frontiers Research Topic’- coordinators’ own view is that platelets are primarily repairing cells, what they do in deploying tools of physiological inflammation.
Drug Development for Parasite-Induced Diarrheal Diseases
One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease
Computers and Games for Mental Health and Well-Being
Recent years have seen important developments in the computer and game industry, including the emergence of the concept of serious games. It is hypothesized that tools such as games, virtual reality, or applications for smartphones may foster learning, enhance motivation, promote behavioral change, support psychotherapy, favor empowerment, and improve some cognitive functions. Computers and games may create supports for training or help people with cognitive, emotional, or behavioral change.
Medical Geology: Impacts of the Natural Environment on Public Health
B. anthracis infections in wildlife and livestock have been recognized as a critically important disease in the United States for over 200 years. Historical data on environmental, weather/climate and geographical factors that influence the occurrence of these infections are well known and include; (1) warm seasons during dry periods that follow moderate to heavy precipitation events (weather/climate); (2) regions containing post-flood organic detritus and/or short dry grazing grasses (environmental); and (3) topological lows, such as waterholes or riverbanks, calcareous and alluvial soils with elevated nutrient content and pH values greater than 6.0 (geology). Other geological factors that may influence B. anthracis outbreak occurrence, as noted through in vivo or in vitro observations, are elevated phosphate (which results in higher protective antigen production), magnesium, sodium, copper, zinc (needed for lethal factor production) and manganese (typically found in very low concentrations in calcareous soils and needed for gene regulation of exotoxins and antibiotics) [1–5].
Metals Challenged by Neutron and Synchrotron Radiation
In the past one and a half decades, neutron and synchrotron radiation techniques have come to the forefront as an excellent set of tools for the wider investigation of material structures and properties [1,2], becoming available to a large user community. This holds especially true for metals, which are a fascinating class of materials with both structural and functional applications. With respect to these application classes, metals are used to engineer bridges and automotive engines as well as to exploit magnetic and electric properties in computer storage, optics, and electronics. Both neutron sources and synchrotrons are large user facilities of quantum-beam installations [3] with the implementation of a common accelerator or nuclear reactor-based source, often serving over 50 beamlines simultaneously and even more end stations. Up to a few thousand experiments are undertaken yearly, utilizing specialized beam conditions, sample environments, and detection systems. Their variations range across spectroscopy, diffraction, small-angle scattering, and inelastic scattering for sample sizes ranging from nanometers to meters. Examples of such installations can be found in the Topical Collection Facilities of Metals’ sister journal Quantum Beam Science [3].
Handbook of Life Course Health Development
A critical mass of research linking early life events, experiences, and exposures with adult health conditions is delineating the developmental origins of many common chronic diseases. This emerging body of life course health development (LCHD) research specifies the complex adaptive processes by which both adversity and opportunity are integrated into developing biobehavioral systems. It is also challenging long-held views about origins and etiology of health and disease. There is a growing momentum among practitioners and policymakers to “connect the dots” between this rapidly expanding evidence base and the related practices and policies that are implemented within the fields of medicine, public health, nursing, mental health, education, urban planning, community development, social welfare, and others.
Development and Application of Herbal Medicine from Marine Origin
Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research.
Cloud-Based Benchmarking of Medical Image Analysis
This book presents the VISCERAL project benchmarks for analysis and retrieval of 3D medical images (CT and MRI) on a large scale, which used an innovative cloud-based evaluation approach where the image data were stored centrally on a cloud infrastructure and participants placed their programs in virtual machines on the cloud. The book presents the points of view of both the organizers of the VISCERAL benchmarks and the participants.The book is divided into five parts. Part I presents the cloud-based benchmarking and Evaluation-as-a-Service paradigm that the VISCERAL benchmarks used. Part II focuses on the datasets of medical images annotated with ground truth created in VISCERAL that continue to be available for research.
Allan Hanbury , - Henning Müller , - Georg Langs
Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book
his open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
Role of health economic data in policy making and reimbursement of new medical technologies
An accelerated growth of health spending began in the 1960s exceeding the historical 4% GDP threshold. This phenomenon was noticed early on in mature market economies led by the US and during the following decades spread to many global regions. Health policy makers became increasingly exposed to new harsh challenges in the uneasy task to provide universal health coverage and decent equity of access to the medical services. Among the most prominent demand-side issues are population aging, rise of non-communicable diseases and growing patient expectations.
Mihajlo (Michael) Jakovljevic -, Tetsuji Yamada
Drugs quality control (Theoretical foundation and practical application): The Coursebook
The Course book presents the basics of drugs quality control in accordance with regulatory documents (pharmacopoeia of Europe, USA, Japan, Russia) and new data from current scientific periodicals, monographs The features of the physical, spectral and chemical quality control of medicines according to the indicators «identification», «tests» and «assay» are described in detail. Part II presents a workbook, which includes questions for the self-control of the material studied and tasks for a laboratory workshop. The Course book contains reference material and samples of pharmacopoeial articles. The Course book is designed for students of the specialty «Pharmacy».
A Laboratory Guide to Clinical Hematology
This is eBook will be constantly updated, edited, and reviewed as new emerging information arises.
Calcium Signaling in Human Health and Diseases
Intracellular Ca2+ signals regulate a myriad of cellular functions, ranging from short-term responses, such as excitation-contraction coupling and stimulus-secretion coupling, to long-term processes, such as proliferation, gene expression, differentiation, motility, synaptic plasticity, programmed cell death (or apoptosis), and metabolism. It is, therefore, not surprising that any derangement of the multifaceted Ca2+ toolkit that shapes the elevation in intracellular Ca2+ concentration ([Ca2+]i) may lead to severe pathological disorders, including cancer, chronic heart failure, epileptic and neurodegenerative disorders, immunodeficiency, and developmental defects. An increase in [Ca2+]i is shaped by the concerted interaction among the components of an extremely versatile network of channels, transporters, pumps, and buffers that can be uniquely assembled by each cell type to generate intracellular Ca2+ signals with spatio-temporal properties precisely tailored to regulate specific functions.
Calibration/Validation of Visible Infrared Imaging Radiometers and Applications
The success of the Suomi National Polar-orbiting Partnership (NPP) brings us into a new era of global daily Earth observations, ranging from the faintest light of human settlements and air glows, to the dramatic events of hurricanes and forest fires, as well as the subtle changes in the planet Earth which we call home. At the heart of all satellite applications, calibration/validation of the instrument measurements and derived products is essential. Satellite product calibration and validation have become increasingly more important and challenging, in order to meet the stringent requirements for accurate and quantitative data for numerical weather prediction, climate change detection, and environmental intelligence. Validation is required not only for the satellite measurements, but also for all geophysical retrievals, including aerosols, cloud properties, radiation budget, sea surface temperature, ocean color, active fire, albedo, snow and ice, vegetation, as well as nightlights from human settlements
Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because women’s health care has its own unique challenges, the intersection between cancer care delivery and women’s health is to be examined in this Frontiers in Oncology issue.
Cancer Metabolism: Molecular Targeting and Implications for Therapy
“Metabolic reprogramming” is one of the hallmarks of cancer, and is exemplified by distinctive biochemical alterations which include enhanced glucose uptake, aerobic glycolysis and glutamine-metabolism. Clinically, the prominent feature of altered metabolism, (i.e.) rapid glucose utilization, has already been exploited to diagnose majority of solid malignancies using PET/CT imaging. In the light of recent research it has become evident that cancer-specific metabolic shift complements pro-survival and anti-apoptotic events during unfavorable conditions such as nutrient-deprivation and therapeutic challenges.
Carbon Fibers and Their Composite Materials
To achieve good mechanical properties of carbon ﬁbre-reinforced polycarbonate composites, the ﬁbre-matrix adhesion must be dialled to an optimum level. The electrolytic surface treatment of carbon ﬁbres during their production is one of the possible means of adapting the surface characteristics of the ﬁbres. The production of a range of tailored ﬁbres with varying surface treatments (adjusting the current, potential, and conductivity) was followed by contact angle, inverse gas chromatography and X-ray photoelectron spectroscopy measurements, which revealed a signiﬁcant increase in polarity and hydroxyl, carboxyl, and nitrile groups on the ﬁbre surface. Accordingly, an increase in the ﬁbre-matrix interaction indicated by a higher interfacial shear strength was observed with the single ﬁbre pull-out force-displacement curves
Catalytic soot oxidation by platinum on sintered metal filters. Influence of the platinum quantity, particle size and location, and investigation of the platinum-soot contact
The great challenge for next years concerning the emission of diesel engines is to develop diesel particle filters (DPF) with catalytic regeneration systems. This work is focused on the global understanding of the diesel soot oxidation on sintered metal filters (SMF). Platinum is studied as reference catalyst. The first objective is to determine which of platinum quantity, platinum particle size, or platinum location exhibits the preponderant influence on the catalytic.
Influence of elevated temperatures up to 100 °C on the mechanical properties of concrete
Experiments to characterize the effects of moisture content and temperature on the mechanical properties of concrete were conducted. Based on these experiments, a new overall material model capable of predicting the mechanical behaviour of concrete subject to elevated temperatures up to 100 °C was developed. The material model estimates the time, temperature and moisture dependency of the compressive and tensile strength, creep and shrinkage of concrete.
Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-3 FA-enriched oral nutritional supplement (ONS) providing 2.0 g of eicosapentaenoic acid (EPA) and 1.0 g of docosahexaenoic acid (DHA) per day or a standard ONS for seven days before surgery. On the day of operation, there was a significant increase in the production of leukotriene B5 (LTB5) (p < 0.01) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p < 0.01), a significant decrease in the production of leukotriene B4 (LTB4) (p < 0.01) and a trend for a decrease in the production of 5-hydroxyeicosatetraenoic acid (5-HETE) (p < 0.1) from stimulated neutrophils in the active group compared with controls. There was no association between LTB4 values and postoperative complications. In conclusion, oral n-3 FA exerts anti-inflammatory effects in surgical patients, without reducing the risk of postoperative complications.
Modern societies cannot function without information and communications technology (ICT) systems. When ICT systems such as electronic government (e-government) systems, e-payment infrastructures, and mobile phone networks fail,users can still access alternative systems based on older technologies, but these alternatives are rapidly disappearing. E-government services are introduced on the Web to improve services to citizens and to free up the human resources needed to tackle the increasing health care requirements of aging populations.
Molecular computing and bioinformatics are two important interdisciplinary sciences that study molecules and computers. Molecular computing is a branch of computing that uses DNA, biochemistry, and molecular biology hardware, instead of traditional silicon-based computer technologies. Research and development in this area concerns theory, experiments, and applications of molecular computing. The core advantage of molecular computing is its potential to pack vastly more circuitry onto a microchip than silicon will ever be capable of—and to do it cheaply. Molecules are only a few nanometers in size, making it possible to manufacture chips that contain billions—even trillions—of switches and components.
Advances in Virtual Agents and Affective Computing for the Understanding and Remediation of Social Cognitive Disorders
Recent advances in computer technologies and research now enable to simulate realistic social interaction thanks to the use of increasingly complex computer models. Virtual agents reproducing both human appearance and expressive behaviors are now available for supporting affective interactions with users. Two deeply intertwined fields of knowledge already benefit from such innovations concerning virtual agents and affective computing: psychiatry and social neurosciences
Modern cities cannot be imagined without traffic lights controlling the road network. To handle the network's changing demands efficiently, the signal plan specification needs to be shifted from the design time to the run-time of a signal system. The generic observer/controller architecture proposed for Organic Computing facilitates this shift. A two-levelled learning mechanism optimises signal plans on-line while a distributed coordination mechanism establishes green waves in the road network.
Anatomy and Plasticity in Large-Scale Brain Models
Supercomputing facilities are becoming increasingly available in neuroscience, predominantly for simulating the dynamics of electrical activity propagating through neuronal circuits. On today's most advanced supercomputers, large-scale models can be simulated with up to a billion of neurons. However, merely further increasing the number of neurons and synapses will not be sufficient to create biologically realistic full-scale brain models.
The Google Earth Engine (GEE) is a cloud computing platform designed to store and process huge data sets (at petabyte-scale) for analysis and ultimate decision making [1]. Following the free availability of Landsat series in 2008, Google archived all the data sets and linked them to the cloud computing engine for open source use. The current archive of data includes those from other satellites, as well as Geographic Information Systems (GIS) based vector data sets, social, demographic, weather, digital elevation models, and climate data layers.
Multi-agent systems (MAS) allow and promote the development of distributed and intelligent applications in complex and dynamic environments. Applications of this kind have a crucial role in our everyday life, as witnessed by the broad range of domains they are deployed to—such as manufacturing, management sciences, e-commerce, biotechnology, etc. Despite heterogeneity, those domains share common requirements such as autonomy, structured interaction, mobility, and openness—which are well suited for MAS. Therein, in fact, goal-oriented processes can enter and leave the system dynamically and interact with each other according to structured protocols
Image analysis is playing a very essential role in numerous research areas in the fields of science and technology, ranging from medical imaging to the computer science of automatic vision. Being involved in several applications, which are mainly based on a constant innovation of technologies, image analysis always requires different approaches and new algorithms, including continual upgrades and improvements of existing methods. Accordingly, the range of the analyses in which it is engaged can be considered as wide as the prospective future technologies.
Flexible Electronics: Fabrication and Ubiquitous Integration
Flexible Electronics platforms are increasingly used in the fields of sensors, displays, and energy conversion with the ultimate goal of facilitating their ubiquitous integration in our daily lives. Some of the key advantages associated with flexible electronic platforms are: bendability, lightweight, elastic, conformally shaped, nonbreakable, roll-to-roll manufacturable, and large-area. To realize their full potential, however, it is necessary to develop new methods for the fabrication of multifunctional flexible electronics at a reduced cost and with an increased resistance to mechanical fatigue
This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types.
Nano/Micro-Assisted Regenerative Medicine
Regenerative medicine is an emerging multidisciplinary field that aims to repair and restore the normal functions of tissues and organs damaged by aging, disease, injury, or congenital disorders. The basic concept of "Nano/Micro-Assisted Regenerative Medicine" is to use advanced nano/micro-technologies, either alone or in combination with specific cells, such as stem cells, to replace, enhance, or regenerate damaged or diseased human tissues or organs.
The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets.
The Poetics and Politics of Alzheimer’s Disease Life-Writing
The introduction gives an overview on sociopolitical and research-related developments regarding dementia, and attempts explanations for why the interest in dementia of critical scholarship continues to be very limited and particularly focused on caregiver accounts. It illustrates that an understanding of the obvious neglect of dementia patient narratives sheds some light onto the ethical implications and challenges of critically reading such narratives: these narratives seem least of all fit to match classical survivor illness literature, and serious impairment in the ability to tell or understand stories has been taken as motivation to neglect patient narratives.
This collection of papers describes the recent development of travel health and vaccination services delivered by pharmacists. It is the first dedicated collection of its type and provides a template for the continued growth of pharmacy practice in this area. The articles examine and report on aspects of such services in the UK, US, Canada, Australia, Switzerland, and South Africa, which will provide useful insight for those in other countries developing such pharmacy-based services.
Galectins in Cancer and Translational Medicine
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell “glycome” in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well.Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs.
Anatomy Quizbook: for students studying or intending to study medicine
Anatomy Quizbook is an interactive learning book that will help students and tutors – indeed anyone interested in anatomy – learn, test and improve their knowledge of the human body.Readers are presented with carefully selected questions and diagrams addressing core learning in clinically-relevant anatomy. This selective rather than exhaustive approach will especially suit time-poor scholars. Regular self-testing will also ensure a robust and strategic understanding of the subject matter.In this first Volume, you can develop your knowledge of fundamental anatomy, including clinically-relevant terminology and the significant parts and operation of thethorax focusing on the heart, lungs, and associated bones, muscles, nerves, blood and lymphatic vessels.abdomen exploring the stomach, intestines, pancreas, liver, gallbladder, kidneys, spleen and their supporting structures (muscles, nerves, blood and lymphatic vessels).pelvis examining the bones, ligaments, vessels and nerves of the pelvic region, the features of male and female pelves, and the major digestive and excretory organs (colon, rectum, bladder and urethra).Whilst developed primarily for students who are studying, or intend to study, medicine, the Anatomy Quizbook will reward all readers who seek to explore and learn about the workings of the human body
Principles and Practice of Case-based Clinical Reasoning Education
Practice of Case-based Clinical Reasoning
This volume describes and explains the educational method of Case-Based Clinical Reasoning (CBCR) used successfully in medical schools to prepare students to think like doctors before they enter the clinical arena and become engaged in patient care. Although this approach poses the paradoxical problem of a lack of clinical experience that is so essential for building proficiency in clinical reasoning, CBCR is built on the premise that solving clinical problems involves the ability to reason about disease processes. This requires knowledge of anatomy and the working and pathology of organ systems, as well as the ability to regard patient problems as patterns and compare them with instances of illness scripts of patients the clinician has seen in the past and stored in memory
White Paper on Joint Replacement: Status of Hip and Knee Arthroplasty Care in Germany
This White Paper details the status of hip and knee arthroplasty care in Germany. Hip and knee replacements are amongst the most frequently performed procedures and usually become necessarily due to age-related wear of the joint, osteoarthritis and fractures of the femoral neck. In light of demographic change, demands with regard to standards of care and the procedures are likely to rise.This book addresses people involved in shaping and representing the healthcare system from a variety of fields including medical professions, health insurances and health sciences as well as journalists and patient representatives.
Technologies for Development: From Innovation to Social Impact
This open access book presents 18 case studies that explore current scientific and technological efforts to address global development issues, such as poverty, from a holistic and interdisciplinary point of view, putting actual impacts at the centre of its analysis. It illustrates the use of technologies for development in various fields of research, such as humanitarian action, medical and information and communication technology, disaster risk-reduction technologies, habitat and sustainable access to energy. The authors discuss how innovative technologies, such as unmanned aerial vehicles for disaster risk reduction, crowdsourcing humanitarian data, online education and ICT-based medical technologies can have significant social impact.
Compartment syndrome is a complex physiologic process with significant potential harm, and though an important clinical problem, the basic science and research surrounding this entity remains poorly understood. This unique open access book fills the gap in the knowledge of compartment syndrome, re-evaluating the current state of the art on this condition. The current clinical diagnostic criteria are presented, as well as the multiple dilemmas facing the surgeon. Pathophysiology, ischemic thresholds and pressure management techniques and limitations are discussed in detail.
X-Ray Contrast Media: Overview, Use and Pharmaceutical Aspects
This open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspects of X-ray contrast media. The overall goal of this book is to provide a comprehensive overview relevant for the optimal use of x-ray contrast media covering next to the historic development, their structure and properties also practical information for handling of contrast media, and explanation of the relevant risks during use and measures for prevention and treatment of potential side effects
Designed as an easy-to-use, practical guide to tumors of the eye, lids, and orbit, this open access book comprehensively addresses surgical treatment and management of diseases related to ophthalmic oncology. Surgical Ophthalmic Oncology: A Collaborative Open Access Reference is an ideal reference for general ophthalmologists, surgeons, fellows and trainees around the world who encounter these diseases in the care of their patients. Notably, this book includes considerations for those ophthalmologists offering subspecialty care in environments with limited access to advanced technology and instrumentation.
Clinical Text Mining: Secondary Use of Electronic Patient Records
This open access book describes the results of natural language processing and machine learning methods applied to clinical text from electronic patient records.It is divided into twelve chapters. Chapters 1-4 discuss the history and background of the original paper-based patient records, their purpose, and how they are written and structured. These initial chapters do not require any technical or medical background knowledge.
Consideration of Abiotic Natural Resources in Life Cycle Assessments
The book contains a collection of articles dealing with how the extraction of mineral resources can be considered in environmental analyses such as Life Cycle Assessment (LCA). The consumption of resources, e.g., metals, is increasing strongly worldwide. This is associated with more energy use; environmental pollution; and social, economic, and political consequences. An increase is also expected for the coming decades. At the same time, modern products and technologies, even in the field of renewable energies, require a large number of critical raw materials. A crucial question here is the exhaustibility of natural resources.
Habitats and Biota of the Gulf of Mexico: Before the Deepwater Horizon Oil Spill: Volume 1: Water Quality, Sediments, Sediment Contaminants, Oil and Gas Seeps, Coastal Habitats, Offshore Plankton and Benthos, and Shellfish
The Gulf of Mexico is an open and dynamic marine ecosystem rich in natural resources but heavily impacted by human activities, including agricultural, industrial, commercial and coastal development. The Gulf of Mexico has been continuously exposed to petroleum hydrocarbons for millions of years from natural oil and gas seeps on the sea floor, and more recently from oil drilling and production activities located in the water near and far from shore. Major accidental oil spills in the Gulf are infrequent; two of the most significant include the Ixtoc I blowout in the Bay of Campeche in 1979 and the Deepwater Horizon Oil Spill in 2010. Unfortunately, baseline assessments of the status of habitats and biota in the Gulf of Mexico before these spills either were not available, or the data had not been systematically compiled in a way that would help scientists assess the potential short-term and long-term effects of such events
Neutron and Synchrotron radiation methods have matured to become powerful techniques for the study of a vast range of materials, including metals. The characterization methods comprise the categories of diffraction, spectroscopy and imaging, which themselves can alter greatly in detail, to include hundreds of variants, problems and sample environments. In a similar way, their applications to metals and hard condensed matter materials cover disciplines spanning engineering, physics, chemistry, materials science and their derivatives such as geology, energy storage, etc.
Perspectives on European Earthquake Engineering and Seismology: Volume 2
Sustainable Manufacturing: Challenges, Solutions and Implementation Perspectives
General and Civil Engineering --- Materials
This edited volume presents the research results of the Collaborative Research Center 1026 “Sustainable manufacturing - shaping global value creation”. The book aims at providing a reference guide of sustainable manufacturing for researchers, describing methodologies for development of sustainable manufacturing solutions. The volume is structured in four chapters covering the following topics: sustainable manufacturing technology, sustainable product development, sustainable value creation networks and systematic change towards sustainable manufacturing. The target audience comprises both researchers and practitioners in the field of sustainable manufacturing, but the book may also be beneficial for graduate students.
Following the Fukushima nuclear accident, a large volume of monitoring data has been collected about the soil, air, dust, and seawater, along with data about an immense number of foods supplied to the market. Little is known, however, about the effect of radioactive fallout on agriculture, information about which is vital. Although more than 80% of the damaged area is related to agriculture, in situ information specifically for agriculture is scarce. This book provides data about the actual movement and accumulation of radioactivity in the ecological system—for example, whether debris deposited on mountains can be a cause of secondary contamination, under what conditions plants accumulate radioactive cesium in their edible parts, and how radioactivity is transferred from hay to milk.
Marginality: Addressing the Nexus of Poverty, Exclusion and Ecology
This book takes a new approach on understanding causes of extreme poverty and promising actions to address it. Its focus is on marginality being a root cause of poverty and deprivation. “Marginality” is the position of people on the edge, preventing their access to resources, freedom of choices, and the development of capabilities. The book is research based with original empirical analyses at local, national, and local scales; book contributors are leaders in their fields and have backgrounds in different disciplines.
Joachim von Braun --- Franz W. Gatzweiler
Model-Driven Development and Operation of Multi-Cloud Applications: The MODAClouds Approach
This book summarizes work being undertaken within the collaborative MODAClouds research project, which aims to facilitate interoperability between heterogeneous Cloud platforms and remove the constraints of deployment, portability, and reversibility for end users of Cloud services. Experts involved in the project provide a clear overview of the MODAClouds approach and explain how it operates in a variety of applications. While the wide spectrum of available Clouds constitutes a vibrant technical environment, many early-stage issues pose specific challenges from a software engineering perspective
Sustainable Land Use and Rural Development in Southeast Asia: Innovations and Policies for Mountainous Areas
This book is based on the findings of a long-term (2000-2014) interdisciplinary research project of the University of Hohenheim in collaboration with several universities in Thailand and Vietnam. Titled Sustainable Land Use and Rural Development in Mountainous Areas in Southeast Asia, or the Uplands Program, the project aims to contribute through agricultural research to the conservation of natural resources and the improvement of living conditions of the rural population in the mountainous regions of Southeast Asia.
Environmental Sciences --- General and Civil Engineering --- Geology --
This book compares the lessons learned from a wetland-perspective approach to the changing climate and the requirements of the Water Framework Directive (WFD) with regard to environmental conservation. Examples from Germany and Poland are discussed due to the efficiency of their respective implementations of water conservation policies. Although the general scientific interest in specific issues such as wetlands, climate change, nature conservation and the WFD enjoy a well established position in international environmental research, these four elements are rarely considered together due to the complexity of the processes, biased scenarios of global change and subjective policy background.
Reflections on the Fukushima Daiichi Nuclear Accident: Toward Social-Scientific Literacy and Engineering Resilience
This book focuses on nuclear engineering education in the post-Fukushima era. It was edited by the organizers of the summer school held in August 2011 in University of California, Berkeley, as part of a collaborative program between the University of Tokyo and UC Berkeley. Motivated by the particular relevance and importance of social-scientific approaches to various crucial aspects of nuclear technology, special emphasis was placed on integrating nuclear science and engineering with social science.
Biodiversity of Vegetable Crops, A Living Heritage
Intensive agriculture has generally resulted in higher productivity, but also in a trend towards decreasing levels of agro-biodiversity, which represents a key point in ensuring the adaptability and resilience of agro-ecosystems in the global challenge to produce more and better food in a sustainable way. The biodiversity of vegetable crops includes genetic diversity—both as species diversity (interspecific diversity) and as a diversity of genes within a species (intraspecific diversity) with regard to the vegetable varieties grown—and the diversity of agro-ecosystems (agro-biodiversity). T
Bioeconomy: Shaping the Transition to a Sustainable, Biobased Economy
This book defines the new field of "Bioeconomy" as the sustainable and innovative use of biomass and biological knowledge to provide food, feed, industrial products, bioenergy and ecological services. The chapters highlight the importance of bioeconomy-related concepts in public, scientific, and political discourse. Using an interdisciplinary approach, the authors outline the dimensions of the bioeconomy as a means of achieving sustainability.
Protocols for Pre-Field Screening of Mutants for Salt Tolerance in Rice, Wheat and Barley
This book offers effective, low-cost and user-friendly protocols for the pre-field selection of salt-tolerant mutants in cereal crops. It presents simple methods for measuring soil salinity, including soil sampling and the analysis of water-soluble salts, and describes a detailed, but simple, screening test for salt tolerance in rice, wheat and barley seedlings, which uses hydroponics. The protocols are devised for use by plant breeders and can be easily accommodated into breeding practice.
Changing Land Use, Changing Livelihoods: Smallholders Today
his book brings together eleven works by scholars within and beyond geography, to argue the case for a continued engagement with smallholder agricultural studies. The research detailed is largely empirical and draws on a wide spectrum of mixed qualitative and quantitative methodologies. The case studies cover a range of geographic locations, including Brazil, Burkina Faso, South Africa, Botswana, Malawi, Madagascar, Vietnam, and the USA, with greatest emphasis in sub-Saharan Africa.
Claudia A. Radel (Ed.) --- Jacqueline M. Vadjunec (Ed.)
Power Transformer Diagnostics, Monitoring and Design Features
Power transformers are key components in electric power distribution and transmission systems, and it is essential that they function properly for many years. With increasing age, there are potential risks of extremely high monetary losses due to unexpected failures and outages. A simple solution would be to replace all aging and risky transformers at once with new ones. Such an approach is obviously not a fiscally realistic solution. The main objectives are to extend their service life and optimize their performance through increased availability.
Issouf Fofana, Ph.D. ing. Chairholder (Ed.)
Micro/Nano Devices for Chemical Analysis
Since the concept of micro total analysis systems (µ-TAS) has been advocated, various kinds of micro/nano devices have been developed by researchers in many fields, such as in chemistry, chemical engineering, mechanical engineering, electric engineering, biology, and medicine, among others. The analytical techniques for small sample volumes, using the micro/nano devices, heavily impacted the fields of biology, medicine and biotechnology, as well as analytical chemistry.
Manabu Tokeshi (Ed.) --- Kiichi Sato (Ed.)
Active technological development has fuelled rapid growth in the number of Unmanned Aerial Vehicle (UAV) platforms being deployed around the globe. Novel UAV platforms, UAV-based sensors, robotic sensing and imaging techniques, the development of processing workflows, as well as the capacity of ultra-high temporal and spatial resolution data, provide both opportunities and challenges that will allow engineers and scientists to address novel and important scientific questions in UAV and sensor design, remote sensing and environmental monitoring.T
Felipe Gonzalez Toro (Ed.) --- Antonios Tsourdos (Ed.)
ctive technological development has fuelled rapid growth in the number of Unmanned Aerial Vehicle (UAV) platforms being deployed around the globe. Novel UAV platforms, UAV-based sensors, robotic sensing and imaging techniques, the development of processing workflows, as well as the capacity of ultra-high temporal and spatial resolution data, provide both opportunities and challenges that will allow engineers and scientists to address novel and important scientific questions in UAV and sensor design, remote sensing and environmental monitoring.
Geomorphometry is the science of quantitative terrain characterization and analysis, and has traditionally focused on the investigation of terrestrial and planetary landscapes. However, applications of marine geomorphometry have now moved beyond the simple adoption of techniques developed for terrestrial studies, driven by the rise in the acquisition of high-resolution seafloor data and by the availability of user-friendly spatial analytical tools. Considering that the seafloor represents 71% of the surface of our planet, this is an important step towards understanding the Earth in its entirety.This volume is the first one dedicated to marine applications of geomorphometry.
Lucieer, Vanessa --- Dolan, Margaret --- Lecours, Vincent
Two-Dimensional Electronics - Prospects and Challenges
During the past 10 years, two-dimensional materials have found incredible attention in the scientific community. The first two-dimensional material studied in detail was graphene, and many groups explored its potential for electronic applications. Meanwhile, researchers have extended their work to two-dimensional materials beyond graphene. At present, several hundred of these materials are known and part of them is considered to be useful for electronic applications.
UAV or Drones for Remote Sensing Applications
The rapid development and growth of unmanned aerial vehicles (UAVs) as a remote sensing platform, as well as advances in the miniaturization of instrumentation and data systems, have resulted in an increasing uptake of this technology in the environmental and remote sensing science communities.Although tough regulations across the globe may still limit the broader use of UAVs, their use in precision agriculture, ecology, atmospheric research, disaster response biosecurity, ecological and reef monitoring, forestry, fire monitoring, quick response measurements for emergency disaster, Earth science research, volcanic gas sampling, monitoring of gas pipelines, mining plumes, humanitarian observations and biological/chemo-sensing tasks continues to increase.
Felipe Gonzalez Toro and Antonios Tsourdos (Eds.)
Open-source electronics are becoming very popular, and are integrated with our daily educational and developmental activities. At present, the use open-source electronics for teaching science, technology, engineering, and mathematics (STEM) has become a global trend. Off-the-shelf embedded electronics such as Arduino- and Raspberry-compatible modules have been widely used for various applications, from do-it-yourself (DIY) to industrial projects. In addition to the growth of open-source software platforms, open-source electronics play an important role in narrowing the gap between prototyping and product development. Indeed, the technological and social impacts of open-source electronics in teaching, research, and innovation have been widely recognized.
A topic of utmost importance in civil engineering is finding optimal solutions throughout the life cycle of buildings and infrastructural objects, including their design, manufacturing, use, and maintenance. Operational research, management science, and optimization methods provide a consistent and applicable groundwork for engineering decision-making. These topics have received the interest of researchers and, after a rigorous peer-review process, eight papers have been published in this Special Issue.
Engineering Dielectric Liquid Applications
Dielectric liquids are used as impregnates of solid insulations or filling products in many kinds of equipment, such as transformers (power, rectifier, distribution, traction, furnace, potential, current), resistors, reactors, capacitors, cables, bushings, circuit breakers, tap changers, and thyristor cooling in power electronics, etc. Their role is paramount in the sense that their presence is one of the fundamental conditions for the proper functioning of such equipment. Similar to blood in the human body, dielectric liquids hold the responsibility of maintaining the entire equipment.
The Emerging Discipline of Quantitative Systems Pharmacology
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research.
Structural Health Monitoring (SHM) of Civil Structures
At the current time of writing, the American Society of Civil Engineers (ASCE) has awarded American infrastructure a grade of D+, meaning poor and at risk. Part of the reason for the low grade is due to the rapid deterioration of structural integrity and the inability of most places to safely meet future demands. Deficiencies in these areas may be remediated by advancements in structural health monitoring (SHM) technologies that provide sensing systems to automatically and economically diagnose structural integrity.
Gangbing Song (Ed.) --- Chuji Wang (Ed.) --- Bo Wang (Ed.)
General and Civil Engineering --- Technology (General)
Power electronics technology is still an emerging technology, and it has found its way into many applications, from renewable energy generation (i.e., wind power and solar power) to electrical vehicles (EVs), biomedical devices, and small appliances, such as laptop chargers. In the near future, electrical energy will be provided and handled by power electronics and consumed through power electronics; this not only will intensify the role of power electronics technology in power conversion processes, but also implies that power systems are undergoing a paradigm shift, from centralized distribution to distributed generation. Today, more than 1000 GW of renewable energy generation sources (photovoltaic (PV) and wind) have been installed, all of which are handled by power electronics technology.
Blaabjerg, Frede --- Dragicevic, Tomislav --- Davari, Pooya
Power electronics technology is still an emerging technology, and it has found its way into many applications, from renewable energy generation (i.e., wind power and solar power) to electrical vehicles (EVs), biomedical devices, and small appliances, such as laptop chargers. In the near future, electrical energy will be provided and handled by power electronics and consumed through power electronics; this not only will intensify the role of power electronics technology in power conversion processes, but also implies that power systems are undergoing a paradigm shift, from centralized distribution to distributed generation.
Allergy and Immunology --- Medicine (General)
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation.
Fulfilling the Promise of Technology Transfer
Manufactures --- Chemical Engineering --- Business and Management --- Political Science
Universities and research institutes are increasingly expected to contribute to society by creating innovation from the returns of their research results and the establishment of new technologies. Toward that goal, Keio University in Japan held an international symposium titled “Fulfilling the Promise of Technology Transfer: Fostering Innovation for the Benefit of Society.” From that symposium the following contents are included in the present volume: 1) A showcase of ideas and case studies to promote future creation of innovation by universities and research institutes worldwide, including information on the R&D value chain, licensing, income generation, start-ups and mechanisms to encourage entrepreneurship, and the changing role of universities in fostering innovation. 2) Introduction of active research projects that aim to productize successful research results on an international level. For example, the book includes results of research on stem cell technologies and regenerative medicine as well as the realization and application of polymer photonics and the development of the core technology of polymer photonics. 3) Case studies from the U.K. in developing industry–academia collaboration with various business partners ranging from start-ups and spinout companies to large enterprises. 4) Reports of the achievements of the technological transfer activities at Keio University supported by the 5-year public fund, with suggestions for future prospects.
Epigenetics of B Cells and Antibody Responses
Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states.
Rangeland Systems: Processes, Management and Challenges
This book provides an unprecedented synthesis of the current status of scientific and management knowledge regarding global rangelands and the major challenges that confront them. It has been organized around three major themes. The first summarizes the conceptual advances that have occurred in the rangeland profession. The second addresses the implications of these conceptual advances to management and policy. The third assesses several major challenges confronting global rangelands in the 21st century.
Presenting very high surface-to-volume ratio, relatively simple processability and low cost, graphene and graphene-related materials were soon identified as promising nanofillers for polymer matrixes. Reports have shown notorious property enhancements for graphene-polymer composites (GPC) at very low filler loadings. Uses of GPC in varied fields, such as energy, electronics, catalysis, separation and purification, biomedicine, aerospace, tribology, etc., have been demonstrated and, in some cases, put into industrial practice. However, challenges still exist
Sustainable Smart Cities and Smart Villages Research
a. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[There is ever more research on smart cities and new interdisciplinary approaches proposed on the study of smart cities. At the same time, problems pertinent to communities inhabiting rural areas are being addressed, as part of discussions in contigious fields of research, be it environmental studies, sociology, or agriculture. Even if rural areas and countryside communities have previously been a subject of concern for robust policy frameworks, such as the European Union’s Cohesion Policy and Common
Miltiadis D. Lytras (Ed.) --- Anna Visvizi (Ed.)
Groundwater Contamination and Remediation
This Special Issue of Water brings together 10 studies on groundwater contamination and remediation. Common themes include practical techniques for plume identification and delineation, the central role of subsurface processes, the pervasiveness of non-Fickian transport, and the importance of bacterial communities in the broader context of biogeochemistry.
Timothy D. Scheibe (Ed.) --- David C. Mays (Ed.)
Understanding and Managing Emerald Ash Borer Impacts on Ash Forests
The emerald ash borer (EAB) is rapidly spreading throughout Eastern North America and devastating ecosystems where ash is a component tree. This rapid and sustained loss of ash trees has already resulted in ecological impacts on both terrestrial and aquatic ecosystems and is projected to be even more severe as EAB invades ash dominated wetlands of the western Great Lakes region. We propose a Special Issue that will address current research documenting ecological impacts of EAB in forest ecosystems, as well as management approaches to mitigate those impacts.
Randall K. Kolka (Ed.) --- Anthony D’Amato (Ed.) --- Nam Jin Noh (Ed.) --- Brian J. Palik (Ed.) --- et al.
Optical Methods in Sensing and Imaging for Medical and Biological Applications
General and Civil Engineering --- Medicine (General) --- Therapeutics
The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject.
Dragan Indjin (Ed.) --- Željka Cvejić (Ed.) --- Małgorzata Jędrzejewska-Szczerska (Ed.)
Electromagnetic Technologies for Medical Diagnostics. Fundamental Issues, Clinical Applications and Perspectives
The content of this Special Issue will highlight papers exploring non-commutative Fourier harmonic analysis, spectral properties of aperiodic order, the hypoelliptic heat equation, and the relativistic heat equation in the context of Information Theory and Geometric Science of Information
Advanced Asphalt Materials and Paving Technologies
There has been significant research progress in the area of pavement materials and paving technologies in the past decade. This includes the use of warm mix asphalt technologies, rubber asphalt, bio asphalt, nanomaterial applications, new construction technologies, innovative concrete materials, as well as the application of mechanistic–empirical pavement design. With all these developments, a collection of peer-reviewed articles with the theme of advanced asphalt materials and paving technologies is necessary for industry, researchers, government agencies, and other stakeholders.
Zhanping You (Ed.) --- Qingli Dai (Ed.) --- Feipeng Xiao (Ed.)
Advances in Integrated Energy Systems Design, Control and Optimization
In the face of climate change and resource scarcity, energy supply systems are on the verge of a major transformation, which mainly includes the introduction of new components and their integration into the existing infrastructures, new network configurations and reliable topologies, optimal design and novel operation schemes, and new incentives and business models. This revolution is affecting the current paradigm and demanding that energy systems be integrated into multi-carrier energy hubs. It is highly increasing the interactions between today’s energy systems at various scales and future intelligent energy systems, which are able to incorporate an increasing amount renewable energy sources.
Josep M. Guerrero (Ed.) --- Amjad Anvari-Moghaddam (Ed.)
Technology (General) --- General and Civil Engineering --- Environmental Engineering
The Special Issue on Advances in Water Distribution Networks (WDNs) explores four important topics of research in the framework of WDNs, namely simulation and optimization modelling, topology and partitioning, water quality, and service effectiveness. With regard to the first topic, the following aspects are addressed: pressure-driven formulations, algorithms for the optimal location of control valves to minimize leakage, the benefits of water discharge prediction for the remote real time control of valves, and transients generated by pumps operating as turbines. In the context of the second topic, a topological taxonomy of WDNs is presented, and partitioning methods for the creation of district metered areas are compared.
Aeroacustic and Vibroacoustic Advancement in Aerospace and Automotive Systems
The purpose of this special issue is to highlight the latest advances in vibroacoustics and aeroacoustics applied to aerospace and automotive industries. In proposing this wide topic, we wanted to give scientists and engineers the opportunity to publish their studies of current interest, both in the theoretical and experimental fields of vibration, sound generation, and radiation; and passive and active noise control approaches, which can be of interest for assessing vibroacoustics characteristics of aerospace and automotive vehicles
Roberto Citarella (Ed.) --- Luigi Federico (Ed.)
This Special Issue is focused on breakthrough developments in the field of biosensors, as well as on the current scientific progress in biomedical signal processing. The papers address innovative solutions in assistance robotics based on bioelectrical signals, including the following: affordable biosensor technology, affordable assistive-robotics devices, new techniques in myoelectric control, and advances in brain–machine interfacing.
Fernando Torres (Ed.) --- Santiago Puente (Ed.) --- Andrés Ubeda (Ed.)
The subject of this book is ""Biofuel and Bioenergy Technology"". It aims to publish high-quality review and research papers, addressing recent advances in biofuel and bioenergy. State-of-the-art studies of advanced techniques of biorefinery for biofuel production are also included. Research involving experimental studies, recent developments, and novel and emerging technologies in this field are covered.
Chen, Wei-Hsin --- Lee, Keat Teong --- Ong, Hwai
Zavadskas, Edmundas Kazimieras --- Antuchevi?ien?, Jurgita --- Bausys,
Control and Nonlinear Dynamics on Energy Conversion Systems
The ever-increasing need for higher efficiency, smaller size, and lower cost make the analysis, understanding, and design of energy conversion systems extremely important, interesting, and even imperative. One of the most neglected features in the study of such systems is the effect of the inherent nonlinearities on the stability of the system. Due to these nonlinearities, these devices may exhibit undesirable and complex dynamics, which are the focus of many researchers. Even though a lot of research has taken place in this area during the last 20 years, it is still an active research topic for mainstream power engineers.
Iu, Herbert Ho-Ching --- El Aroudi, Abdelali
The Delft Sand, Clay and Rock Cutting Model
Sand, clay and rock have to be excavated for a variety of purposes, such as dredging, trenching, mining (including deep sea mining), drilling, tunnel boring and many other applications. Many excavations take place on dry land, but they are also frequently required in completely saturated conditions, and the methods necessary to accomplish them consequently vary widely. This book provides an overview of cutting theories. It begins with a generic model, valid for all types of soil (sand, clay and rock), and continues with the specifics of dry sand, water-saturated sand, clay, atmospheric rock and hyperbaric rock
Sustainable Living with Environmental Risks
We are not free from environmental risks that accompany the development of human societies. Modern economic development has accelerated environmental pollution, caused loss of natural habitats, and modified landscapes. These environmental changes have impacted natural systems: water and heat circulation, nutrient cycling, and biodiversity. These changes in natural systems degrade ecosystem services and subsequently increase environmental risks for humans. Environmental risks, therefore, are not only human health risks by pollution, climatic anomalies and natural disasters, but also degradation of ecosystem services on which most people are relying for their lives.
Nobuhiro Kaneko --- Shinji Yoshiura --- Masanori Kobayashi
Design and Applications of Coordinate Measuring Machines
Coordinate measuring machines (CMMs) have been conventionally used in industry for 3-dimensional and form-error measurements of macro parts for many years. Ever since the first CMM, developed by Ferranti Co. in the late 1950s, they have been regarded as versatile measuring equipment, yet many CMMs on the market still have inherent systematic errors due to the violation of the Abbe Principle in its design. Current CMMs are only suitable for part tolerance above 10 μm. With the rapid advent of ultraprecision technology, multi-axis machining, and micro/nanotechnology over the past twenty years, new types of ultraprecision and micro/nao-CMMs are urgently needed in all aspects of society
Development and Application of Optical Coherence Tomography (Oct)
This special feature issue has been initiated to celebrate the 25th anniversary of Optical Coherence Tomography (OCT). In OCT, broad bandwidth light is used in order to produce cross sectional images of turbid and translucent samples with high axial resolution (in the order of a few µm). The imaging speed of OCT can be as high as several millions of depth scans (A-scans) per second which allows for various applications in different fields. This special feature issue consists of three overview papers covering OCT angiography, polarization-sensitive OCT and dental applications of OCT. Additional applications and the latest developments in OCT are covered in nine research papers.
Development and Application of Nonlinear Dissipative Device in Structural Vibration Control
This book entitled Development and Application of Nonlinear Dissipative Device in Structural Vibration Control contains contributions that focus on the development and application of innovative nonlinear dissipative systems that mitigate the potentially catastrophic effects of extreme loading by incorporating new materials or effective mechanical control technologies. Moreover, new nonlinear analytical methods for distinctive vibrating structures under different excitations are also highlighted in this book.
Zheng Lu (Ed.) --- Tony Yang (Ed.) --- Ying Zhou (Ed.) --- Angeliki Papalou (Ed.)
Technology (General) --- General and Civil Engineering
Geomorphometry is the science of quantitative terrain characterization and analysis, and has traditionally focused on the investigation of terrestrial and planetary landscapes. However, applications of marine geomorphometry have now moved beyond the simple adoption of techniques developed for terrestrial studies, driven by the rise in the acquisition of high-resolution seafloor data and by the availability of user-friendly spatial analytical tools. Considering that the seafloor represents 71% of the surface of our planet, this is an important step towards understanding the Earth in its entirety
Advances in Welding Metal Alloys, Dissimilar Metals and Additively Manufactured Parts
General and Civil Engineering --- Materials --- Mining and Metallurgy
Welding technology has been taken for granted as a mature and established technology for too long. However, many new welding technologies have been included among the alternatives to joining materials. They come both from the areas of fusion and solid-state welding. Moreover, a recent approach has offered one more alternative. This is hybrid welding, which couples two or more welding sources in a cooperative or synergic welding mode.
Aluminium is the world’s most abundant metal and is the third most common element, comprising 8% of the Earth’s crust. The versatility of aluminium makes it the most widely used metal after steel. By utilising various combinations of their advantageous properties such as strength, lightness, corrosion resistance, recyclability, and formability, aluminium alloys are being employed in an ever-increasing number of applications. In the recent decade, a rapid new development has been made in production of aluminium alloys, and new techniques of casting, forming, welding, and surface modification, have been evolved to improve the structural integrity of aluminium alloys.
First-Principles Approaches to Metals, Alloys, and Metallic Compounds
Mining and Metallurgy --- Chemistry (General)
Current fundamental electronic-structure theory allows for the accurate prediction and characterization of elemental metals adopting any allotropic structure, intermetallic compounds, and other metal-rich phases. From an engineering perspective, there is a need for structural materials that are suitable for mechanical and civil engineering as well as energy production and conversion. While different microstructural features influence the macroscopic behaviour, quantum-mechanical simulation may enormously accelerate and guide the entire development process since atomistic modelling allows for the generation of structural models and the calculation of enthalpies and other free energies as a function of pressure and temperature
Hydrometallurgy, which involves the use of aqueous solutions for the recovery of metals from ores, concentrates, and recycled or residual material, plays an integral role in the multi-billion dollar minerals processing industry. There are numerous hydrometallurgical process technologies used for recovering metals, such as: agglomeration; leaching; solvent extraction/ion exchange; metal recovery; and remediation of tailings/waste. Modern hydrometallurgical routes to extract metals from their ores are faced with a number of issues related to both the chemistry and engineering aspects of the processes involved.
Suresh Bhargava --- Mark Pownceby --- Rahul Ram
Shape memory alloys (SMAs) have special property of the shape memory effect. After thermal treatment above the martensitic transition temperature, the alloys come back to the original shape when the alloys heat again after having cooled it to the temperature that is lower than the martensitic transition temperature. By means of this property, many industrial parts and systems were produced. This Special Issue "Shape Memory Alloys 2017" is constructed articles reporting new and progressive research results, as well as reviews of particular classes of fundamental physics of the materials and their applications of SMAs.
This edited volume contains the selected papers presented at the scientific board meeting of the German Cluster of Excellence on “Integrative Production Technology for High-Wage Countries”, held in November 2014. The topical structure of the book is clustered in six sessions: Integrative Production Technology, Individualised Production, Virtual Production Systems, Integrated Technologies, Self-Optimising Production Systems and Human Factors in Production Technology.
The Tohoku University Graduate School of Dentistry first introduced the concept of “Interface Oral Health Science”, designed to establish and maintain healthy oral cavities, which are home to a number of mixed systems. Included in those systems are: (1) host tissues such as teeth, mucosa, muscle and bone, (2) parasites and microorganisms cohabiting the surfaces of the oral cavity and (3) biomaterials that are used for the rehabilitation of oral functions. In addition, (4) these systems are subject to severe and complex mechanical forces.
Keiichi Sasaki --- Osamu Suzuki --- Nobuhiro Takahashi
Safer Healthcare: Strategies for the Real World
Pharmacy and materia medica --- Medicine (General) --- Biotechnology -
The authors of this book set out a system of safety strategies and interventions for managing patient safety on a day-to-day basis and improving safety over the long term. These strategies are applicable at all levels of the healthcare system from the frontline to the regulation and governance of the system. There have been many advances in patient safety, but we now need a new and broader vision that encompasses care throughout the patient’s journey. The authors argue that we need to see safety through the patient’s eyes, to consider how safety is managed in different contexts and to develop a wider strategic and practical vision in which patient safety is recast as the management of risk over time.
Beyond Safety Training: Embedding Safety in Professional Skills
This book investigates why, despite more and more resources devoted to safety training, expectations are not entirely met, particularly in the industrial sectors that have already achieved a high safety level. It not only reflects the most precious viewpoints of experts from different disciplines, different countries, with experiences in various industrial fields at the cutting edge of theories and practices in terms of safety, professionalization and their relationships
Agriculture (General) --- Plant Sciences
Souleymane Bado --- Brian P. Forster --- Abdelbagi M.A. Ghanim --- Joanna Jankowicz-Cieslak --- et al.
Cyril Mauffrey --- David J. Hak --- Murphy P. Martin III
his open access book is an overview on CT/X-ray contrast media designed for radiologists and other medical specialists who use contrast media in imaging and interventional procedures as well as related scientists on the use and pharmaceutical aspects of X-ray contrast media. The overall goal of this book is to provide a comprehensive overview relevant for the optimal use of x-ray contrast media covering next to the historic development, their structure and properties also practical information for handling of contrast media, and explanation of the relevant risks during use and measures for prevention and treatment of potential side effects
Ocean-Atmosphere Interactions of Gases and Particles
Business and Management --- General and Civil Engineering --- Materials --- Geography
The oceans and atmosphere interact through various processes, including the transfer of momentum, heat, gases and particles. In this book leading international experts come together to provide a state-of-the-art account of these exchanges and their role in the Earth-system, with particular focus on gases and particles. Chapters in the book cover: i) the ocean-atmosphere exchange of short-lived trace gases; ii) mechanisms and models of interfacial exchange (including transfer velocity parameterisations); iii) ocean-atmosphere exchange of the greenhouse gases carbon dioxide, methane and nitrous oxide; iv) ocean atmosphere exchange of particles and v) current and future data collection and synthesis efforts.
Medicine (General) --- Pharmacy and materia medica
his Open Access book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively new and emerging area. There are few practical training resources for public health practitioners, especially resources which include discussion of realistic cases which are likely to arise in the practice of public health.
Barrett, D.H --- Ortmann, L.H --- Dawson, A --- Saenz, C --- et al.
Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
his volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration
Toshio Nakanishi --- Roger R. Markwald --- H.Scott Baldwin --- Bradley B. Keller --- et al.
Cosmic Ray Neutron Sensing: Estimation of Agricultural Crop Biomass Water Equivalent
This open access book provides methods for the estimation of Biomass Water Equivalent (BEW), an essential step for improving the accuracy of area-wide soil moisture by cosmic-ray neutron sensors (CRNS). Three techniques are explained in detail: (i) traditional in-situ destructive sampling, (ii) satellite based remote sensing of plant surfaces, and (iii) biomass estimation via the use of the CRNS itself. The advantages and disadvantages of each method are discussed along with step by step instructions on proper procedures and implementation.
Ammar Wahbi --- Lee Heng --- Gerd Dercon
Counteracting Urban Heat Island Effects in a Global Climate Change Scenario
Urban heat islands are a new type of microclimatic phenomenon that causes a significant increase in the temperature of cities compared to surrounding areas. The phenomenon has been enforced by the current trend towards climate change. Although experts consider urban heat islands an urgent European Union public health concern, there are too few policies that address it. The EU carried out a project to learn more about this phenomenon through pilot initiatives. The pilots included feasibility studies and strategies for appropriately altering planning rules and governance to tackle the problem of urban heat islands.
General and Civil Engineering --- Materials -
Designing Sustainable Energy for All: Sustainable Product-Service System Design Applied to Distributed Renewable Energy
This open access book addresses the issue of diffusing sustainable energy access in low- and middle-income contexts. Access to energy is one of the greatest challenges for many people living in low-income and developing contexts, as around 1.4 billion people lack access to electricity. Distributed Renewable Energy systems (DRE) are considered a promising approach to address this challenge and provide energy access to all. However, even if promising, the implementation of DRE systems is not always straightforward. The book analyses, discusses and classifies the promising
Carlo Vezzoli --- Fabrizio Ceschin --- Lilac Osanjo --- Mugendi K. M’Rithaa --- et al.
Designing Sustainable Technologies, Products and Policies
This open access book provides insight into the implementation of Life Cycle approaches along the entire business value chain, supporting environmental, social and economic sustainability related to the development of industrial technologies, products, services and policies; and the development and management of smart agricultural systems, smart mobility systems, urban infrastructures and energy for the built environment.
Enrico Benetto --- Kilian Gericke --- Mélanie Guiton
Contemporary Bioethics: Islamic Perspective
This book combines Islamic textual analysis with juridical methodology to engage dominant secular bioethics in the Muslim healthcare institutions. It integrates Islamic textual resources with medical information in order to provide careful analyses of the political, economic and cultural terrains that are necessary for bioethicists to effectively promote social justice
Mohammed Ali Al-Bar --- Hassan Chamsi-Pasha
High Density Lipoproteins: From Biological Understanding to Clinical Exploitation
Manufactures --- Electrical and Nuclear Engineering
this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
Arnold von Eckardstein --- Dimitris Kardassis
Autonomous Driving: Technical, Legal and Social Aspects
This book takes a look at fully automated, autonomous vehicles and discusses many open questions: How can autonomous vehicles be integrated into the current transportation system with diverse users and human drivers? Where do automated vehicles fall under current legal frameworks? What risks are associated with automation and how will society respond to these risks? How will the marketplace react to automated vehicles and what changes may be necessary for companies? Experts from Germany and the United States define key societal, engineering, and mobility issues related to the automation of vehicles.
Markus Maurer --- J. Christian Gerdes --- Barbara Lenz --- Hermann Winner
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
Rudolf Jaenisch --- Feng Zhang --- Fred Gage
Business and Management --- Economics --- Manufactures
This book reflects the current state of discussion about agricultural and rural finance in developing and transition countries. It provides insight into specific themes, such as commodity value chains, farm banking and risk management in agricultural banking, structured finance, crop insurance, mobile banking and how to increase effectiveness in rural finance. Case studies illustrate various aspects of agricultural and rural finance in developing economies. The book is based on one of the yearly financial Sector Development Symposia held by the KfW Development Bank.
Freshwater Microplastics: Emerging Environmental Contaminants?
This volume focuses on microscopic plastic debris, also referred to as microplastics, which have been detected in aquatic environments around the globe and have accordingly raised serious concerns. The book explores whether microplastics represent emerging contaminants in freshwater systems, an area that remains underrepresented to date. Given the complexity of the issue, the book covers the current state-of-research on microplastics in rivers and lakes, including analytical aspects, environmental concentrations and sources, modelling approaches, interactions with biota, and ecological implications.
This is a lab manual for a college-level human anatomy course. Mastery of anatomy requires a fair amount of memorization and recall skills. The activities in this manual encourage students to engage with new vocabulary in many ways, including grouping key terms, matching terms to structures, recalling definitions, and written exercises. Most of the activities in this manual utilize anatomical models, and several dissections of animal tissues and histological examinations are also included. Each unit includes both pre- and post-lab questions and six lab exercises designed for a classroom where students move from station to station. The vocabulary terms used in each unit are listed at the end of the manual and serve as a checklist for practicals.
Non-Vitamin K Antagonist Oral Anticoagulants: A Concise Guide
Surgery --- Medicine (General) --- Biotechnology --- Therapeutics --- Cardiovascular
This book is an essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.
urgical infections are caused by the breakdown of the equilibrium existing between organisms and the host. This may occur after a breach in a protective surface, as occurs after surgical trauma, changes in host resistance, or particular characteristics of the organism. The possible outcomes are abscess formation, local spread with/without tissue death, distant spread or resolution. A surgical infection is an infection requiring operative treatment (excision or drainage), and occupies an unvascularized space in tissue, or may occur in an operated site. Common examples of the former group are furuncles and carbuncles, hollow viscus inflammations, such as appendicitis, cholecystitis, and most abscesses. The latter group comprises all surgical site infections.
Evangelos P. Misiakos --- Konstantinos George Tsalis
this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.
Universities and research institutes are increasingly expected to contribute to society by creating innovation from the returns of their research results and the establishment of new technologies. Toward that goal, Keio University in Japan held an international symposium titled “Fulfilling the Promise of Technology Transfer: Fostering Innovation for the Benefit of Society.” From that symposium the following contents are included in the present volume: 1)
Biotechnologies for Plant Mutation Breeding: Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries.
Joanna Jankowicz-Cieslak --- Thomas H. Tai --- Jochen Kumlehn --- Bradley J. Till
The Sustainability of Agro-Food and Natural Resource Systems in the Mediterranean Basin
Pharmacy and materia medica --- Nutrition and Food Sciences --
This book is focused on the challenges to implement sustainability in diverse contexts such as agribusiness, natural resource systems and new technologies. The experiences made by the researchers of the School of Agricultural, Forestry, Food and Environmental Science (SAFE) of the University of Basilicata offer a wide and multidisciplinary approach to the identification and testing of different solutions tailored to the economic, social and environmental characteristics of the region and the surrounding areas.
The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models
Pharmacy and materia medica --- Physiology
Infogest' (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (including food scientists, gut physiologists and nutritionists)
Kitty Verhoeckx --- Paul Cotter --- Iván López-Expósito --- Charlotte
Responsible Innovation: Ethics, Safety and Technology
This textbook is based on the MOOC Responsible Innovation offered by the TU Delft. It provides a framework to reflect on the ethics and risks of new technologies. How can we make sure that innovations do justice to social and ethical values? How can we minimize (unknown)risks?
Actuarial and Financial Risks in Life Insurance, Pensions and Household Finance
The recent regulatory changes, together with the increasing awareness of the variety of sources of uncertainty that affect the activities of insurance and pension funds, have generated increasing attention towards insurance risk management theory and practice. Against this background, this Special Issue collects relevant contributions on a variety of issues encompassing longevity risk modelling, solvency requirements, risk management, and risk sharing
Benchmarking Eventually Consistent Distributed Storage Systems
Cloud storage services and NoSQL systems typically offer only ""Eventual Consistency"", a rather weak guarantee covering a broad range of potential data consistency behavior. The degree of actual (in-)consistency, however, is unknown. This work presents novel solutions for determining the degree of (in-)consistency via simulation and benchmarking, as well as the necessary means to resolve inconsistencies leveraging this information.
The rapidly growing world population and increasingly dense settlements demand ever-larger and more complex buildings from today's engineers. In comparison to this technological progress, a building's equipment for emergency evacuation has been hardly developed further. This work presents a concept for a building evacuation system based on mobile devices. Furthermore, various algorithms for route planning with mobile devices and for indoor localization of mobile devices are addressed.
A Celebration of the Ties That Bind Us: Connections Between Actuarial Science and Mathematical Finance
The articles in this volume are contributed by scholars who are not only experts in areas of Actuarial Science (AS) and Mathematical Finance (MF), but also those who present diverse perspectives from both industry and academia. Topics from multiple areas, such as Stochastic Modeling, Credit Risk, Monte Carlo Simulation, and Pension Valuation, among others, that were maybe thought to be the domain of one type of risk manager, are shown time and again to have deep value to other areas of risk management as well.
Science and Technology Governance and Ethics: A Global Perspective from Europe, India and China
This book analyzes the possibilities for effective global governance of science in Europe, India and China. Authors from the three regions join forces to explore how ethical concerns over new technologies can be incorporated into global science and technology policies. The first chapter introduces the topic, offering a global perspective on embedding ethics in science and technology policy. Chapter Two compares the institutionalization of ethical debates in science, technology and innovation policy in three important regions: Europe, India and China. The third chapter explores public perceptions of science and technology in these same three regions.
Miltos Ladikas --- Sachin Chaturvedi --- Yandong Zhao --- Dirk Stemerding
Ship and Offshore Structure Design in Climate Change Perspective
This book summarizes results of longstanding research and scientific contributions from many projects and relevant working groups. It collects and evaluates wind and wave climate projections under changing climate having design needs and marine safety in focus. Potential impact of projected climate change in met-ocean conditions on ships and offshore structures is discussed and illustrated by an example of the expected wave climate change on tanker design.
Elzbieta Maria Bitner-Gregersen --- Lars Ingolf Eide --- Torfinn Hørte --- Rolf Skjong
We are not free from environmental risks that accompany the development of human societies. Modern economic development has accelerated environmental pollution, caused loss of natural habitats, and modified landscapes. These environmental changes have impacted natural systems: water and heat circulation, nutrient cycling, and biodiversity. These changes in natural systems degrade ecosystem services and subsequently increase environmental risks for humans.
Dynamic Capacity Control in Air Cargo Revenue Management
This book studies air cargo capacity control problems. The focus is on analyzing decision models with intuitive optimal decisions as well as on developing efficient heuristics and bounds. Three different models are studied: First, a model for steering the availability of cargo space on single legs. Second, a model that simultaneously optimizes the availability of both seats and cargo capacity. Third, a decision model that controls the availability of cargo capacity on a network of flights.
Dynamics of Long-Life Assets: From Technology Adaptation to Upgrading the Business Model
The editors present essential methods and tools to support a holistic approach to the challenge of system upgrades and innovation in the context of high-value products and services. The approach presented here is based on three main pillars: an adaptation mechanism based on a broad understanding of system dependencies; efficient use of system knowledge through involvement of actors throughout the process; and technological solutions to enable efficient actor communication and information handling.
Stefan N. Grösser --- Arcadio Reyes-Lecuona --- Göran Granholm
This Special Issue is devoted to the econometric analysis of income inequality and income distributions. Given the recent surge of inequality research, this Special Issue seeks to combine both theoretical and applied contributions which advance the econometric analysis of income inequality and income distributions. Possible topics include, but are not limited to, statistical inference for inequality measurement, inequality measurement with complex survey data, parametric or nonparametric modeling of income distributions, statistical decomposition methodology, methods to investigate the determinants of distributional change, causal inference in inequality measurement, and applications of such methods to substantive research questions in different fields of economics.
Martin Biewen (Ed.) --- Emmanuel Flachaire (Ed.)
Economics of Distributed Storage Systems : an economic analysis of arbitrage-maximizing storage systems at the end consumer level
Increasing the shares of Renewable Energy Sources (RES) and Distributed Energy Resources (DER) is one of the most important levers in many countries to cope with the environmental, political, and economic challenges of future energy supply. The underlying research question of this thesis is whether Distributed Storage Systems (DSS) at the end consumer level can economically foster the integration of intermittent and non-dispatchable resources by providing demand-side flexibility.
Universities and research institutes are increasingly expected to contribute to society by creating innovation from the returns of their research results and the establishment of new technologies. Toward that goal, Keio University in Japan held an international symposium titled “Fulfilling the Promise of Technology Transfer: Fostering Innovation for the Benefit of Society.” From that symposium the following contents are included in the present volume: 1) A showcase of ideas and case studies to promote future creation of innovation by universities and research institutes worldwide, including information on the R&D value chain, licensing, income generation, start-ups and mechanisms to encourage entrepreneurship, and the changing role of universities in fostering innovation. 2) Introduction of active research projects that aim to productize successful research results on an international level.
Since the 2008 financial crisis, modeling of the extreme values of financial risk has become important. Postgraduate programs and PhD research programs in mathematical finance are cropping up in nearly every university. Additionally, many conferences are being held annually on the topic of extreme financial risk. The aim of this Special Issue is to provide a collection of papers from leading experts in the area of extreme financial risk
Saralees Nadarajah (Ed.) --- Stephen Chan (Ed.)
Indicator-based Sustainability Assessment of the German Energy System and its Transition
The energy transition not only has an impact on technical infrastructures but also leads to socio-economic changes. To evaluate the sustainability aspects of the German Energiewende, the authors have developed a monitoring system which includes 45 indicators and their corresponding target values for 2020, 2030, and 2050 as well as a rating system for the year 2020 based on a distance-to-target approach and traffic color lights.
Rösch, ChristineBräutigam, Klaus-RainerKopfmüller, JürgenStelzer,, et al
Information Management and Market Engineering. Vol. II
The research program Information Management and Market Engineering focuses on the analysis and the design of electronic markets. Taking a holistic view of the conceptualization and realization of solutions, the research integrates the disciplines business administration, economics, computer science, and law. Topics of interest range from the implementation, quality assurance, and advancement of electronic markets to their integration into business processes and legal frameworks.
Dreier, Thomas Krämer, Jan Studer, Rudi Weinhardt, Christof [Hrsg.]
Information Management and Market Engineering. [Vol. I]
The research program �Information Management and Market Engineering� focuses on the analysis and the design of electronic markets. Taking a holistic view of the conceptualization and realization of solutions, the research integrates the disciplines business administration, economics, computer science, and law. Topics of interest range from the implementation, quality assurance, and further development of electronic markets to their integration into business processes, innovative business models, and legal frameworks.
Innovation in General Purpose Technologies : How Knowledge Gains when It Is Shared
This book tackles the different aspects of the creation and transmission of knowledge in the context of the characteristics of a general purpose technology. Nanotechnology is investigated as showcase example. Particular emphasis is put on the role of the composition of knowledge as well as the corresponding knowledge spillovers on the one hand and on the concrete impact of collaboration and knowledge sharing in innovator networks on the other hand.
Innovations in Quantitative Risk Management
Quantitative Finance; Game Theory, Economics, Social and Behav. Sciences; Finance/Investment/Banking; Actuarial Sciences
Kathrin Glau --- Matthias Scherer --- Rudi Zagst
Intelligent Business Process Optimization for the Service Industry
The company's sustainable competitive advantage derives from its capacity to create value for customers and to adapt the operational practices to changing situations. Business processes are the heart of each company. Therefore process excellence has become a key issue. This book introduces a novel approach focusing on the autonomous optimization of business processes by applying sophisticated machine learning techniques such as Relational Reinforcement Learning and Particle Swarm Optimization.
Managing Elevated Risk: Global Liquidity, Capital Flows, and Macroprudential Policy - An Asian Perspective
This book discusses the risks and opportunities that arise in Emerging Asia given the context of a new environment in global liquidity and capital flows. It elaborates on the need to ensure financial and overall economic stability in the region through improved financial regulation and other policy measures to minimize the emergent risks. "Managing Elevated Risk: Global Liquidity, Capital Flows, and Macroprudential Policy - An Asian Perspective" also explores the range of policy options that may be deployed to address the impact of global liquidity on domestic financial and socio-economic conditions including income inequality.
Market engineering. A structured design process for electronic markets
In this book, the author provides a complete process for electronic markets design together with the required en-gineering methods. As such the book is unique applying tech-niques from engineering design to modern Information Systems and Economics. Mr. Neumann succeeds in presenting a generic but coherent approach that is an indispensable aid in designing markets.
Microfinance, EU Structural Funds and Capacity Building for Managing Authorities: A Comparative Analysis of European Convergence Regions
In recent years, the European Commission has attached increasing importance to the use of financial engineering instruments rather than traditional grant-based financing for the microcredit sector, considering these to be the most efficient option available.This book presents a study of capacity building and structural funds in public managing authorities for the microcredit sector. It presents two surveys to highlight the strengths and weaknesses of the managing authorities' capacity building. The first survey investigates the authorities' need for and interests in capacity building activities, assessing the areas in which capacity building support is needed, and explores the different types of support offered.
Light and light based technologies have played an important role in transforming our lives via scientific contributions spanned over thousands of years. In this book we present a vast collection of articles on various aspects of light and its applications in the contemporary world at a popular or semi-popular level. These articles are written by the world authorities in their respective fields. This is therefore a rare volume where the world experts have come together to present the developments in this most important field of science in an almost pedagogical manner. This volume covers five aspects related to light.
Mohammad D. Al-Amri --- Mohamed El-Gomati --- M. Suhail Zubairy
Modeling and Selection of Software Service Variants
Providers and consumers have to deal with variants of software services, which are alternative instances of a services design, implementation, deployment, or operation. This work develops the service feature modeling language to represent software service variants and a suite of methods to select variants for development or delivery. An evaluation describes the systems implemented to make use of service feature modeling and its application to two real-world use cases.
Moral Reasoning at Work: Rethinking Ethics in Organizations
Moral dilemmas are a pervasive feature of working life. Moral Reasoning at Work offers a fresh perspective on how to live with them. How do we cope with situations where no matter what we decide to do, something will be wrong? How do we live with the moral dissonance between what we are tempted to do and what is in line with our moral convictions? What can organizations do to establish a foundation for responsible decision-making and conduct? This book combines research streams from ethics and moral psychology using extensive experience of sessions of moral reasoning with leaders and employees in organizations.
Ontology Alignment using Biologically-inspired Optimisation Algorithms
It is investigated how biologically-inspired optimisation methods can be used to compute alignments between ontologies. Independent of particular similarity metrics, the developed techniques demonstrate anytime behaviour and high scalability. Due to the inherent parallelisability of these population-based algorithms it is possible to exploit dynamically scalable cloud infrastructures - a step towards the provisioning of Alignment-as-a-Service solutions for future semantic applications.
Organic Service-Level Management in Service-Oriented Environments
Dynamic service-oriented environments (SOEs) are characterised by a large number of heterogeneous service components that are expected to support the business as a whole. The present work provides a negotiation-based approach to facilitate automated and multi-level service-level management in an SOE, where each component autonomously arranges its contribution to the whole operational goals. Evaluation experiments have shown an increased responsiveness and stability of an SOE in case of changes.
Performance and Behavior of Family Firms
Family involvement characterizes a large number of firms around the world and is thought to significantly impact their strategies, behavior, and performance. Family involvement occurs when a family exerts control over the firm through ownership and management. When family involvement leads to intentions to pursue particularistic goals and strategies, controlling families are more likely to exert a significant influence on firm strategies, behavior, and performance. Indeed, intentions imply that a firm’s strategic behaviors will be oriented toward preserving the economic and socioemotional value of the firm for the family in the long term.
Poverty Reduction Policies and Practices in Developing Asia
This book looks at the major policy challenges facing developing Asia and how the region sustains rapid economic growth to reduce multidimensional poverty through socially inclusive and environmentally sustainable measures. Asia is facing many challenges arising from population growth, rapid urbanization, provision of services, climate change and the need to redress declining growth after the global financial crisis. This book examines poverty and related issues and aims to advance the development of new tools and measurement of multidimensional poverty and poverty reduction policy analysis.
Almas Heshmati --- Esfandiar Maasoumi --- Guanghua Wan
Process Measurement in Business Process Management : Theoretical Framework and Analysis of Several Aspects
Process measurement deals with the quantification of business process models using process model metrics. This book presents a theoretical framework for the prediction of external process model attributes (as, for example, error-proneness and understandabiltiy) based on internal (structural) attributes. The properties of proposed metrics are analyzed. A visualization technique for metric values is introduced and metrics for process model understandability and granularity are evaluated.
Production cost models with regard to liberalised electricity markets
This book makes a contribution to the formulation and implementation of production cost models for the modelling of liberalized electricity markets by addressing issues associated with the level of detail in the representation of the underlying power system, the accuracy of the results and the modelling effort. To this end a production cost model was formulated and applied to estimate the short-run marginal cost of the power systems of three important European electricity markets.
Promoting Social Dialogue in European Organizations: Human Resources Management and Constructive Conflict Management
This volume focuses on describing the social dialogue system in organizations from an Human Resources Management perspective. Based on the NEIRE model for industrial relations, key factors are determined contributing to creative social dialogue in European organizations. Actual data from surveys and interviews from more than 700 CEO and HR managers in eleven European countries give insights in the experiences with and expectations of employers of social dialogue. The volume offers a comprehensive introduction to the historical context and current situation in social dialogue in these countries.
Martin C Euwema --- Lourdes Munduate --- Patricia Elgoibar --- Erica Pender --- et al.
Quality in Design and Execution of Engineering Practice
Quality in Design and Execution of Engineering Practice is about quality management focused at fitness for purpose, rather than compliance with specifications, rules and regulations. The focus on getting execution in line with fitness for purpose is supported by a classification of seven different categories of quality, defined by their relevance for purpose, compliance with specifications, and actual execution. This classification facilitates decision making on desirable exemptions from specifications in the interest of both buyer and supplier. The author offers guidelines for quality management in different types of business units: License Giver, License Taker, Jobber and Consultant.
Global Business Strategy: Multinational Corporations Venturing into Emerging Markets
This book presents theories and case studies for corporations in developed nations, including Japan, for designing strategies to maximize opportunities and minimize threats in business expansion into developing nations. The case studies featured here focus on Asia, including China and India, and use examples of Japanese manufacturers. Five case studies are provided, including Hitachi Construction Machinery and Shiseido in China and Maruti Suzuki in India. These cases facilitate the reader’s understanding of the business environments in emerging economies.
Financial Risk Measurement is a challenging task, because both the types of risk and the techniques evolve very quickly. This book collects a number of novel contributions to the measurement of financial risk, which address either non-fully explored risks or risk takers, and does so in a wide variety of empirical contexts.
Risk Measures with Applications in Finance and Economics
Risk measures play a vital role in many subfields of economics and finance. It has been proposed that risk measures could be analysed in relation to the performance of variables extracted from empirical real-world data. For example, risk measures may help inform effective monetary and fiscal policies and, therefore, the further development of pricing models for financial assets such as equities, bonds, currencies, and derivative securities.A Special Issue of “Risk Measures with Applications in Finance and Economics” will be devoted to advancements in the mathematical and statistical development of risk measures with applications in finance and economics.
Role and dynamics of 'Late-comers' in the global technology competition
Faster developing cycles and economic developments created many emerging economies in the 20th century. For sustainable economic growth, however, the construction and constant preservation of a profound knowledge base and technological pool is crucial. Brazil, China, India and Russia, experienced constant high economic growth rates and begun to evolve to solid economies which are challenging the established players. This book consists of a profound empirical analysis of these emerging economies.
Stochastics of Environmental and Financial Economics
These Proceedings offer a selection of peer-reviewed research and survey papers by some of the foremost international researchers in the fields of finance, energy, stochastics and risk, who present their latest findings on topical problems. The papers cover the areas of stochastic modeling in energy and financial markets; risk management with environmental factors from a stochastic control perspective; and valuation and hedging of derivatives in markets dominated by renewables, all of which further develop the theory of stochastic analysis and mathematical finance.
Strategic power plant investment planning under fuel and carbon price uncertainty
The profitability of power plant investments depends strongly on uncertain fuel and carbon prices. In this doctoral thesis, we combine fundamental electricity market models with stochastic dynamic programming to evaluate power plant investments under uncertainty. The application of interpolation-based stochastic dynamic programming and approximate dynamic programming allows us to consider a greater variety of stochastic fuel and carbon price scenarios compared to other approaches
Subject-Oriented Business Process Management
Activities performed in organizations are coordinated via communication between the people involved. The sentences used to communicate are naturally structured by subject, verb, and object. The subject describes the actor, the verb the action and the object what is affected by the action. Subject-oriented Business Process Management (S-BPM) as presented in this book is based on this simple structure which enables process-oriented thinking and process modeling. S-BPM puts the subject of a process at the center of attention and thus deals with business processes and their organizational environment from a new perspective, meeting organizational requirements in a much better way than traditional approaches.
Albert Fleischmann --- Werner Schmidt --- Christian Stary --- Stefan Obermeier --- et al.
The dynamically changing world economy, in an era of intensive development and globalization, creates new needs in both the theoretical models of management and in the practical discussion related to the perception of business. Because of new economic phenomena related to the crisis, there is a need for the design and operationalization of innovative business models for companies. Due to the fact that in times of crisis, the principles of strategic balance are particularly important; these business models can be sustainable business models. Moreover, it is essential to skillfully use different methods and concepts of management to ensure the continuity of business. It seems that sustainable business models, in their essence, can support companies' effectiveness and contribute to their stable, sustainable functioning in the difficult, ever-changing market
The concept of sustainability is important for companies both in the case of SMEs and worldwide multinational companies. Some key factors to help a company achieve its sustainability objectives are based on human resource management. Sustainable human resource management is a typical cross-functional task that becomes increasingly important at the strategic level of a company. Industry 4.0 technologies, Internet of Things, and competitive demands, as signs of globalization, have led to significant changes across the organizational structures and human resource strategies of companies.
Innovations in Derivatives Markets: Fixed Income Modeling, Valuation Adjustments, Risk Management, and Regulation
his book presents 20 peer-reviewed chapters on current aspects of derivatives markets and derivative pricing. The contributions, written by leading researchers in the field as well as experienced authors from the financial industry, present the state of the art in: • Modeling counterparty credit risk: credit valuation adjustment, debit valuation adjustment, funding valuation adjustment, and wrong way risk. • Pricing and hedging in fixed-income markets and multi-curve interest-rate modeling. •
Kathrin Glau --- Zorana Grbac --- Matthias Scherer --- Rudi Zagst
How can the Web be made situation-aware? Event processing is a suitable technology for gaining the necessary real-time results. The Web, however, has many users and many application domains. Thus, we developed multi-schema friendly data models allowing the re-use and mix from diverse users and application domains. Furthermore, our methods describe protocols to exchange events on the Web, algorithms to execute the language and to calculate access rights.
Managing the Complexity of Critical Infrastructures: A Modelling and Simulation Approach
This book summarizes work being pursued in the context of the CIPRNet (Critical Infrastructure Preparedness and Resilience Research Network) research project, co-funded by the European Union under the Seventh Framework Programme (FP7). The project is intended to provide concrete and on-going support to the Critical Infrastructure Protection (CIP) research communities, enhancing their preparedness for CI-related emergencies, while also providing expertise and technologies for other stakeholders to promote their understanding and mitigation of the consequences of CI disruptions, leading to enhanced resilience.
Roberto Setola --- Vittorio Rosato --- Elias Kyriakides --- Erich Rome
Governance for Drought Resilience: Land and Water Drought Management in Europe
This book presents the findings of a team of scientists and practitioners who have been working on the project “Benefits of Governance in Drought Adaptation” (in short: the DROP project), which is included in the European Union’s INTERREG IVB NWE programme. The DROP governance team developed a Governance Assessment Tool (GAT), which allows the governance setting of a given region for planning and realizing drought adaptation measures to be assessed
Hans Bressers --- Nanny Bressers --- Corinne Larrue
High Mountain Conservation in a Changing World
This book aims to provide case studies and a general view of the main processes involved in the ecosystem shifts occurring in the high mountains, and to analyse the implications for nature conservation. Although case studies from the Pyrenees are preponderant, conclusions are aimed at any mountain range surrounded by highly populated lowland areas. The chapters give emphasis to approaches from environmental geography, functional ecology, biogeography, and paleoenvironmental reconstructions.
Jordi Catalan --- Josep M Ninot --- M. Mercè Aniz
Evolution, Monitoring and Predicting Models of Rockburst: Precursor Information for Rock Failure
This open access book focuses on investigating predicting precursor information and key points of rockburst in mining engineering through laboratory experiment, theoretical analysis, numerical simulation and case studies. Understanding the evolution patterns for the microstructure instability of rock is a prerequisite for rockburst prediction. The book provides a guide for readers seeking to understand the evolution patterns for the microstrucure of rock failure, the predicting key point of rock failure and the rockburst predicting model.
Innovative Medicine: Basic Research and Development
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”.
Kazuwa Nakao --- Nagahiro Minato --- Shinji Uemoto
The aim of this book is to document for the first time the dimensions and requirements of effective integrated groundwater management (IGM). Groundwater management is a formidable challenge, one that remains one of humanity’s foremost priorities. It has become a largely non-renewable resource that is overexploited in many parts of the world. In the 21st century, the issue moves from how to simply obtain the water we need to how we manage it sustainably for future generations, future economies, and future ecosystems. The focus then becomes one of understanding the drivers and current state of the groundwater resource, and restoring equilibrium to at-risk aquifers.
Anthony J. Jakeman --- Olivier Barreteau --- Randall J. Hunt --- Jean-Daniel Rinaudo --- et al.
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers
Methods for Measuring Greenhouse Gas Balances and Evaluating Mitigation Options in Smallholder Agriculture
This book provides standards and guidelines for quantifying greenhouse gas emissions and removals in smallholder agricultural systems and comparing options for climate change mitigation based on emission reductions and livelihood trade-offs. Globally, agriculture is directly responsible for about 11% of annual greenhouse gas (GHG) emissions and induces an additional 17% through land use change, mostly in developing countries. Farms in the developing countries of sub-Saharan Africa and Asia are predominately managed by smallholders, with 80% of land holdings smaller than ten hectares.
Todd S. Rosenstock --- Mariana C. Rufino --- Klaus Butterbach-Bahl --- Lini Wollenberg --- et al.
Nature-Based Solutions to Climate Change Adaptation in Urban Areas: Linkages between Science, Policy and Practice
This book brings together research findings and experiences from science, policy and practice to highlight and debate the importance of nature-based solutions to climate change adaptation in urban areas. Emphasis is given to the potential of nature-based approaches to create multiple-benefits for society. The expert contributions present recommendations for creating synergies between ongoing policy processes, scientific programmes and practical implementation of climate change and nature conservation measures in global urban areas.
Nadja Kabisch --- Horst Korn --- Jutta Stadler --- Aletta Bonn
This in-depth survey of salutogenesis shows the breadth and strengths of this innovative perspective on health promotion, health care, and wellness. Background and historical chapters trace the development of the salutogenic model of health, and flesh out the central concepts, most notably generalized resistance resources and the sense of coherence, that differentiate it from pathogenesis. From there, experts describe a range of real-world applications within and outside health contexts, from positive psychology to geriatrics, from small towns to corrections facilities, and from school and workplace to professional training.
Maurice B. Mittelmark --- Shifra Sagy --- Monica Eriksson --- Georg F. Bauer --- et al.
Hormones, Metabolism and the Benefits of Exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism.
This book collects 4 keynote and 15 theme lectures presented at the 2nd European Conference on Earthquake Engineering and Seismology (2ECEES), held in Istanbul, Turkey, from August 24 to 29, 2014. The conference was organized by the Turkish Earthquake Foundation - Earthquake Engineering Committee and Prime Ministry, Disaster and Emergency Management Presidency under the auspices of the European Association for Earthquake Engineering (EAEE) and European Seismological Commission (ESC).
Plant Selection for Bioretention Systems and Stormwater Treatment Practices
As cities develop, more land is converted into impervious surfaces, which do not allow water to infiltrate. Careful urban planning is needed to ensure that the hydrologic cycle and water quality of the catchment areas are not affected. There are techniques that can attenuate peak flow during rain events and reduce the amount of metals, nutrients, and bacteria that enter the urban water cycle.
William F. Hunt --- Bill Lord --- Benjamin Loh --- Angelia Sia
Self-Reported Population Health: An International Perspective based on EQ-5D
The EQ-5D instrument, as a standardized, cross-culturally validated measure of self-assessed health has a hugely important role in understanding population health within and across countries. Over the past two decades a wealth of international population health survey data have been accumulated by the EuroQol Group from research conducted in many countries across four continents. One of the success factors of the EQ-5D instruments has been the easy availability of national or international sets of EQ-5D data, as well as clear explanations and guidance for users.
Agota Szende --- Bas Janssen --- Juan Cabases
This open access book describes the results of natural language processing and machine learning methods applied to clinical text from electronic patient records. It is divided into twelve chapters. Chapters 1-4 discuss the history and background of the original paper-based patient records, their purpose, and how they are written and structured. These initial chapters do not require any technical or medical background knowledge. The remaining eight chapters are more technical in nature and describe various medical classifications and terminologies such as ICD diagnosis codes, SNOMED CT, MeSH, UMLS, and ATC.
Cognitive Supervision for Robot-Assisted Minimally Invasive Laser Surgery
This thesis lays the groundwork for the automatic supervision of the laser incision process, which aims to complement surgeons’ perception of the state of tissues and enhance their control over laser incisions. The research problem is formulated as the estimation of variables that are representative of the state of tissues during laser cutting. Prior research in this area leveraged numerical computation methods that bear a high computational cost and are not straightforward to use in a surgical setting.
Ecological Risk Assessment for Chlorpyrifos in Terrestrial and Aquatic Systems in North America
This book attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.
MARE-WINT: New Materials and Reliability in Offshore Wind Turbine Technology
This book provides a holistic, interdisciplinary overview of offshore wind energy, and is a must-read for advanced researchers. Topics, from the design and analysis of future turbines, to the decommissioning of wind farms, are covered. The scope of the work ranges from analytical, numerical and experimental advancements in structural and fluid mechanics, to novel developments in risk, safety & reliability engineering for offshore wind.The core objective of the current work is to make offshore wind energy more competitive, by improving the reliability, and operations and maintenance (O&M) strategies of wind turbines.
Wiesław Ostachowicz --- Malcolm McGugan --- Jens-Uwe Schröder-Hinrichs --- Marcin Luczak
Satellite Earth Observations and Their Impact on Society and Policy
he result of a workshop bringing together an international advisory board of experts in science, satellite technologies, industry innovations, and public policy, this book addresses the current and future roles of satellite Earth observations in solving large-scale environmental problems. The book showcases the results of engaging distinct communities to enhance our ability to identify emerging problems and to administer international regimes created to solve them. It also reviews the work of the Policy and Earth Observation Innovation Cycle (PEOIC) project, an effort aimed at assessing the impact of satellite observations on environmental policy and to propose a mission going forward that would launch an “innovation cycle”.
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field.
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book.
Akinori Akaike --- Shun Shimohama --- Yoshimi Misu
This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Caws, Maxine --- Marais, Ben --- Heemskerk, Dorothee --- Farrar, Jeremy
Infogest' (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (including food scientists, gut physiologists and nutritionists). The network gathers 70 partners from academia, corresponding to a total of 29 countries.
Kitty Verhoeckx --- Paul Cotter --- Iván López-Expósito --- Charlotte Kleiveland --- et al.
This book compares the lessons learned from a wetland-perspective approach to the changing climate and the requirements of the Water Framework Directive (WFD) with regard to environmental conservation. Examples from Germany and Poland are discussed due to the efficiency of their respective implementations of water conservation policies
This publication addresses the global challenges of food and water security in a rapidly changing and complex world. The essays highlight the links between bio-physical and socio-cultural processes, making connections between local and global scales, and focusing on the everyday practices of eating and drinking, essential for human survival. Written by international experts, each contribution is research-based but accessible to the general public.
Peter Jackson --- Walter E.L. Spiess --- Farhana Sultana
Resilience: A New Paradigm of Nuclear Safety: From Accident Mitigation to Resilient Society Facing Extreme Situations
This book summarizes presentations and discussions from the two-day international workshop held at UC Berkeley in March 2015, and derives questions to be addressed in multi-disciplinary research toward a new paradigm of nuclear safety. The consequences of the Fukushima Daiichi nuclear accident in March 2011 have fuelled the debate on nuclear safety: while there were no casualties due to radiation, there was substantial damage to local communities.
Joonhong Ahn --- Franck Guarnieri --- Kazuo Furuta
Non-Equilibrium Social Science and Policy: Introduction and Essays on New and Changing Paradigms in Socio-Economic Thinking
The overall aim of this book, an outcome of the European FP7 FET Open NESS project, is to contribute to the ongoing effort to put the quantitative social sciences on a proper footing for the 21st century. A key focus is economics, and its implications on policy making, where the still dominant traditional approach increasingly struggles to capture the economic realities we observe in the world today - with vested interests getting too often in the way of real advances. Insights into behavioral economics and modern computing techniques have made possible both the integration of larger information sets and the exploration of disequilibrium behavior.
Jeffrey Johnson --- Andrzej Nowak --- Paul Ormerod --- Bridget Rosewell --- et al.
Abiotic Stress Effects on Performance of Horticultural Crops
Horticultural crop yield and quality depend on genotype, environmental conditions, and production management. In particular, adverse environmental conditions may greatly affect crop performance, reducing crop yield by 50%–70%. Abiotic stresses such as cold, heat, drought, flooding, salinity, nutrient deficiency, and ultraviolet radiation affect multiple physiological and biochemical mechanisms in plants as they attempt to cope with the stress conditions. However, different crop species can have different sensitivities or tolerances to specific abiotic stresses
Francini, Alessandra --- Sebastiani, Luca
Acoustic and Elastic Waves: Recent Trends in Science and Engineering
The present Special Issue intends to explore new directions in the field of acoustics and ultrasonics. The interest includes, but is not limited to, the use of acoustic technology for condition monitoring of materials and structures. Topics of interest (among others): • Acoustic emission in materials and structures (without material limitation)
Dimitrios G. Aggelis (Ed.) --- Nathalie Godin (Ed.)
Acupuncture – Basic Research and Clinical Application
This book focuses on the investigation, development, and modernization of acupuncture in basic research settings as well as in clinical applications. The book contains 13 chapters reporting the latest evidence-based results of acupuncture research and exploring acupuncture in general. Altogether, 44 authors from all over the world contributed to this book.
Adaptive Catchment Management and Reservoir Operation
River catchments and reservoirs play a central role in water security, food supply, flood risk management, hydropower generation, and ecosystem services; however, they are now under increasing pressure from population growth, economic activities, and changing climate means and extremes in many parts of the world. Adaptive management of river catchments and reservoirs requires an in-depth understanding of the impacts of future uncertainties and thus the development of robust, sustainable solutions to meet the needs of various stakeholders and the environment.
Fu, Guangtao --- Ni, Guangheng --- Zhang, Chi
Additive Manufacturing Technologies and Applications
The present Special Issue proposes articles in the area of Additive Manufacturing with particular attention to the different employed technologies and the several possible applications. The main investigated technologies are the Selective Laser Sintering (SLS) and the Fused Deposition Modelling (FDM). These methodologies, combined with the Computer Aided Design (CAD), provide important advantages. Numerical, analytical and experimental knowledge and models are proposed to exploit the potential advantages given by 3D printing for the production of modern systems and structures in aerospace, mechanical, civil and biomedical engineering fields.
Salvatore Brischetto (Ed.) --- Paolo Maggiore (Ed.) --- Carlo Giovanni Ferro (Ed.)
Advanced Applications for Smart Energy Systems Considering Grid-Interactive Demand Response
This book covers applied research on smart energy systems, smart grids, smart energy homes, smart energy products and services, and the advanced applications thereof, in the context of demand response and grid interactions. In particular, this book is focused on interdisciplinary research results that combine technical, social, environmental, and economic aspects of smart energy systems and smart energy products
Advanced DSP Techniques for High-Capacity and Energy-Efficient Optical Fiber Communications
The rapid proliferation of the Internet has been driving communication networks closer and closer to their limits, while available bandwidth is disappearing due to an ever-increasing network load. Over the past decade, optical fiber communication technology has increased per fiber data rate from 10 Tb/s to exceeding 10 Pb/s. The major explosion came after the maturity of coherent detection and advanced digital signal processing (DSP).
Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems
The overall objective of this Special Issue is to improve knowledge on developing and using advanced simulation tools in water supply and distribution systems. The final aim is to propose a suitable framework supporting insightful hydraulic mechanisms to help the decision-making processes of water utility managers and practitioners. Contributions to this Special Issue, exploring new research avenues on urban hydraulics and hydroinformatics, will be of great value for both Academia and those water utility stakeholders.
Manuel Herrera (Ed.) --- Silvia Meniconi (Ed.) --- Stefano Alvisi (Ed.) --- Joaquín Izquierdo (Ed.)
Advanced Memristor Modeling: Memristor Circuits and Networks
The investigation of new memory schemes, neural networks, computer systems, and many other improved electronic devices is very important for the future generation’s electronic circuits and for their widespread application in all the areas of industry. In this respect, the analysis of new efficient and advanced electronic elements and circuits is an essential field of highly developed electrical and electronic engineering. The resistance-switching phenomenon, observed in many amorphous oxides, has been investigated since 1970 and is a promising technology for constructing new electronic memories.
Advances in Airborne Lidar Systems and Data Processing
Presented to audience as “Airborne Laser Systems and Data Processing”, this book collects the papers in the Remote Sensing special issue “ Airborne Laser Scanning” (November 2016) and several other papers selected from recent, previous Remote Sensing issues. We were approached by Remote Sensing late 2015 to edit a special issue on Lidar remote sensing. After some literature review and careful thinking, we selected the theme for the special issue as “Airborne Laser Scanning”. Having this focus in mind, we made a call for papers and spread it well over Internet and social media. In the meantime, a number of leading experts in their fields were reached out for contribution.
Catalyst deactivation, the loss over time of catalytic activity and/or selectivity, is a problem of great and continuing concern in the practice of industrial catalytic processes. Costs to industry for catalyst replacement and process shutdown total tens of billions of dollars per year. While catalyst deactivation is inevitable for most processes, some of its immediate, drastic consequences may be avoided, postponed, or even reversed. Accordingly, there is considerable motivation to better understand catalyst decay and regeneration
Calvin H. Bartholomew (Ed.) --- Morris D. Argyle (Ed.)
The book presents research papers addressing a wide range of environmental topics: water and wastewater treatment and management, soil degradation and conservation, sediment pollution control, environmental impacts of technologies, life cycle analysis (LCA), air quality and indoor environment, and advanced environmental materials. The contributions provide novel and significant scientific results and advanced applications in the field of environmental engineering and provide an integrated view of the trends in solving the problems associated with the achievement of sustainability.
Adriana Estokova (Ed.) --- Magdalena Balintova (Ed.)
Advances in Groundwater Flow and Solute Transport: Pushing the Hidden Boundary
In recent decades, the study of groundwater flow and solute transport has advanced into new territories that are beyond conventional theories, such as Darcy’s law and Fick’s law. The studied media have changed from permeable porous and fractured ones to much less permeable ones, such as clay and shale. The studied pore sizes have also changed from millimetres to micro-meters or even nano-meters.
Zhan, Hongbin --- Wang, Quanrong --- Wen, Zhang
Advances in Micro-Bioreactor Design for Organ Cell Studies
Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or using bioreactors for the production of biologics. This book highlights these issues with a strong focus on new engineering design.
Advances in Multi-Sensor Information Fusion: Theory and Applications 2017
The information fusion technique can integrate a large amount of data and knowledge representing the same real-world object and obtain a consistent, accurate and useful representation of that object. The data may be independent or redundant, and can be obtained by different sensors at the same time or at different times. A suitable combination of investigative methods can substantially increase the profit of information in comparison with that from a single sensor. Multi-sensor information fusion has been a key issue in sensor research since the 1970s and it has been applied in many fields, such as geospatial information systems, business intelligence, oceanography, discovery science, intelligent transport systems, wireless sensor networks, etc.
Xue-Bo Jin (Ed.) --- Shuli Sun (Ed.) --- Hong Wei (Ed.) --- Feng-Bao Yang (Ed.)
Application of Artificial Neural Networks in Geoinformatics
Recently, a need has arisen for prediction techniques that can address a variety of problems by combining methods from the rapidly developing field of machine learning with geoinformation technologies such as GIS, remote sensing, and GPS. As a result, over the last few decades, one particular machine learning technology, known as artificial neural networks, has been successfully applied to a wide range of fields in science and engineering. In addition, the development of computational and spatial technologies has led to the rapid growth of geoinformatics, which specializes in the analysis of spatial information.
Application of Bioinformatics in Cancers
This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future.
Applications of Computational Intelligence to Power Systems
Electric power systems around the world are changing in terms of structure, operation, management and ownership due to technical, financial, and ideological reasons. Power systems keep on expanding in terms of geographical areas, asset additions, and the penetration of new technologies in generation, transmission, and distribution. The conventional methods for solving the power system design, planning, operation, and control problems have been extensively used for different applications, but these methods suffer from several difficulties, thus providing suboptimal solutions.
Applications of Remote Sensing/ GIS in Water Resources and Flooding Risk Managements
Remote sensing and GIS play critical roles in water resource and flood inundation mapping and risk management. Remote sensing provides data sources for mapping water resources (snow and glaciers, water bodies, soil moisture and groundwater), measuring hydrological fluxes (ET, precipitation and river discharge), and monitoring drought and flooding inundation, while GIS provides the best tools for water resources, drought and flooding risk management and for setting up hydrologic models, inputting data processing and output analyses and visualizations
Hongjie Xie (Ed.) --- Xianwei Wang /Ed.)
Applications of Semiconductor Optical Amplifiers
ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Semiconductor optical amplifiers (SOAs) are considered a key enabling technology for the design and implementation of photonic circuits, subsystems, and networks. Owing to the attractive features of low power consumption, compactness, broad gain bandwidth and ability for integration with affordable cost, SOAs enjoy continuous popularity as core versatile devices within the optical communications research and industrial sector for the accomplishment of critical and indispensable tasks at fundamental and system-oriented level.
Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes
Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake.
Lluis Serra-Majem (Ed.) --- Mariela Nissensohn (Ed.)
Modern robotic technologies have enabled robots to operate in a variety of unstructured and dynamically-changing environments, in addition to traditional structured environments. Robots have, thus, become an important element in our everyday lives. One key approach to develop such intelligent and autonomous robots is to draw inspiration from biological systems. Biological structure, mechanisms, and underlying principles have the potential to provide new ideas to support the improvement of conventional robotic designs and control.
Toshio Fukuda (Ed.) --- Fei Chen (Ed.) --- Qing Shi (Ed)
Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development
Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area.
Compared to conventional chemical technologies and other similar industrial processes, bioprocesses represent a more sustainable and environmentally-friendly alternative for the production of fuels and platform chemicals. In biorefineries, different kinds of feedstocks, such as biomass or lignocellulosic materials in general, can be used and fermented by microorganisms
Biodiversity and Conservation in Forests
Global forest communities cover only about 30% of land areas, but they provide important ecosystem services, such as watershed protection, carbon sequestration, and oxygen production, as well as renewable forest products for human subsistence and markets. Forests also support the majority of the world’s terrestrial biodiversity. Although land conversion for agriculture and pastureland has historically resulted in fragmentation and declining forested areas, forests worldwide are now experiencing change at an unprecedented rate due to various anthropogenic activities and growing human populations.
Intensive agriculture has generally resulted in higher productivity, but also in a trend towards decreasing levels of agro-biodiversity, which represents a key point in ensuring the adaptability and resilience of agro-ecosystems in the global challenge to produce more and better food in a sustainable way. The biodiversity of vegetable crops includes genetic diversity—both as species diversity (interspecific diversity) and as a diversity of genes within a species (intraspecific diversity) with regard to the vegetable varieties grown—and the diversity of agro-ecosystems (agro-biodiversity).
Renna, Massimiliano --- Santamaria, Pietro --- Signore, Angelo --- Montesano, Francesco Fabiano --- et al.
BioEnergy and BioChemicals Production from Biomass and Residual Resources
Research and technology developments in bioenergy and biochemical production systems are of the utmost importance for the development of next generation, highly efficient biomass conversion concepts, maximizing the total energy and chemical output. The utilization of non-conventional biomasses and unexploited residual resources (e.g., agriculture and agroindustry wastes), innovative solutions for online monitoring and process control, novel biochemical pathways, microbial platforms and reactor technologies are key issues to be addressed.
Dimitar Karakashev (Ed.) --- Yifeng Zhang (Ed.)
The Biology and Treatment of Myeloid Leukaemias
There has been an observed decrease in the global mortality from cancer, mostly atributable to improved, particularly early, detection and prevention. For many carcinomas and leukaemias in adults, once the disease has reached a certain stage there are no therapies that are able to erradicate the cancer cells and cure patients. There has been progress in the treatment of acute myeloid leukaemia (AML) and remissions are achievable; however, the presence of chemoresistent blast cells leads to most patients relapsing, and relapse is difficult to treat and thus patients die due to their disease
Geoffrey Brown (Ed.) --- Ewa Marcinkowska (Ed.)
Biomass for Energy Country Specific Show Case Studies
In many domestic and industrial processes, vast percentages of primary energy are produced by the combustion of fossil fuels. Apart from diminishing the source of fossil fuels and the increasing risk of higher costs and energy security, the impact on the environment is worsening continually. Renewables are becoming very popular, but are, at present, more expensive than fossil fuels, especially photovoltaics and hydropower. Biomass is one of the most established and common sources of fuel known to mankind, and has been in continuous use for domestic heating and cooking over the years, especially in poorer communities.
Biotechnological Applications of Phage and Phage-Derived Proteins
Phages have shown a high biotechnological potential with numerous applications. The advent of high-resolution microscopy techniques aligned with omic and molecular tools have revealed innovative phage features and enabled new processes that can be further exploited for biotechnological applications in a wide variety of fields. The high-quality original articles and reviews presented in this Special Issue demonstrate the incredible potential of phages and their derived proteins in a wide range of biotechnological applications for human benefit.
Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent.
Cancer Biomarkers and Targets in Digestive Organs
Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets.
Climate change is one of the main threats to modern society. This phenomenon is associated with an increase in greenhouse gas (GHGs, mainly carbon dioxide—CO2) emissions due to anthropogenic activities. The main causes are the burning of fossil fuels and land use change (deforestation). Climate change impacts are associated with risks to basic needs (health, food security, and clean water), as well as risks to development (jobs, economic growth, and the cost of living).
Carbon, Nitrogen and Phosphorus Cycling in Forest Soils
The majority of carbon stored in the soils of the world is stored in forests. The refractory nature of some portions of forest soil organic matter also provides the slow, gradual release of organic nitrogen and phosphorus to sustain long term forest productivity. Contemporary and future disturbances, such as climatic warming, deforestation, short rotation sylviculture, the invasion of exotic species, and fire, all place strains on the integrity of this homeostatic system of C, N, and P cycling.
Catalysts Deactivation, Poisoning and Regeneration
Catalyst lifetime represents one of the most crucial economic aspects in industrial catalytic processes, due to costly shutdowns, catalyst replacements, and proper disposal of spent materials. Not surprisingly, there is considerable motivation to understand and treat catalyst deactivation, poisoning, and regeneration, which causes this research topic to continue to grow. The complexity of catalyst poisoning obviously increases along with the increasing use of biomass/waste-derived/residual feedstocks and with requirements for cleaner and novel sustainable processes.
Chemical and Molecular Approach to Tumor Metastases
Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies.
Gianni Sava (Ed.) --- Alberta Bergamo (Ed.)
Clean Energy and Fuel (Hydrogen) Storage
Clean energy and fuel storage are often required for both stationary and automotive applications. Some of these clean energy and fuel storage technologies currently under extensive research and development include hydrogen storage, direct electric storage, mechanical energy storage, solar–thermal energy storage, electrochemical (batteries and supercapacitors), and thermochemical storage. The gravimetric and volumetric storage capacity, energy storage density, power output, operating temperature and pressure, cycle life, recyclability, and cost of clean energy or fuel storage are some of the factors that govern efficient energy and fuel storage technologies for potential deployment in energy harvesting (solar and wind farms) stations and onboard vehicular transportation
Climate Change Mitigation and Adaptation—ZEMCH 2016
This book explores the current issues around sustainable design and energy efficiency within the construction industry in both developed and developing countries. Sustainable housing; thermal comfort; daylighting; low-income housing; green roofs; energy efficient retrofitting and photovoltaic façades are some of the subjects discussed in the book.
Climate Variability and Climate Change Impacts on Land Surface, Hydrological Processes and Water Management
During the last several decades, Earth´s climate has undergone significant changes due to anthropogenic global warming, and feedbacks to the water cycle. Therefore, persistent efforts are required to improve our understanding of hydrological processes and to engage in efficient water management strategies that explicitly consider changing environmental conditions. The twenty-four contributions in this book have broadly addressed topics across
Zhang, Yongqiang --- Li, Hongxia --- Reggiani, Paolo
This reprint book ‘Communication in Pharmacy Practice’ is launched to help improve communication practices by increasing knowledge of different aspects of communication in pharmacy practice. The book consists of recently published research articles and illustrates that pharmacy communication is a research subject that is investigated globally and from many perspectives. The overall pharmacy communicational themes investigated and discussed in this book are as follows: Communication between health care professionals; communication between pharmacists and patients in the context of both prescription and over-the-counter (OTC) medicines; and factors impacting communication
Sofia Kälvemark Sporrong (Ed.) --- Susanne Kaae (Ed.)
The educational system leading up to the pharmacy degree, student training, and the continuing personal development of pharmacists are being more and more mapped to the competences pharmacists require to provide the relevant safe and efficient pharmaceutical services to meet the health needs of patients. This book draws on the experience of experts involved in the develoment of competence training for pharmacy education and training in Europe, North America, and Australia. It discusses the philosophy and implications of such an approach, as well as the production and development of models, and their application to existing courses.
Computational Methods of Multi-Physics Problems
This book offers a collection of six papers addressing problems associated with the computational modeling of multi-field problems. Some of the proposed contributions present novel computational techniques, while other topics focus on applying state-of-the-art techniques in order to solve coupled problems in various areas including the prediction of material failure during the lithiation process, which is of major importance in batteries; efficient models for flexoelectricity, which require higher-order continuity; the prediction of composite pipes under thermomechanical conditions; material failure in rock; and computational materials design.
Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease
Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features.
Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade.
Hwang, Tsong-Long --- Sung, Ping-Jyun --- Liaw, Chih-Chuang
his Special Issue of Nutrients, entitled "DHA for Optimal Health", consists of evidence-based original research or reviews of the scientific literature. Manuscripts focus on the evidence that underpins dietary requirements throughout the lifespan (from in-utero to the elderly) for optimal brain function and/or prevention (or treatment) of disease.
Diagnosis and Management of Pediatric Diseases
A screenshot of some the most rapidly evolving fields in Neonatology and Pediatrics with articles reviewing some metabolic dysregulations as well as non-oncologic diseases that may occur in infancy, childhood, youth. The illustrative material with original photographs and drawings highlighting some pathogenetic concepts are keystones of this book.
Diagnosis and Treatment of Thoracic Outlet Syndrome
Thoracic outlet syndrome (TOS) is a spectrum of disorders resulting from the compression of the neurovascular structures within the thoracic outlet. The three main subtypes of TOS are defined by the anatomic structure affected by the extrinsic compression. In the most common subtype—neurogenic TOS—the brachial plexus is compressed and symptoms include pain, arm paresthesias, and sometimes weakness. Venous TOS is characterized by the compression of the subclavian vein and its resultant thrombosis. Arterial TOS is the least common and is distinguished by the compression of the subclavian artery and the development of aneurysms or stenoses with distal embolization.
Julie Ann Freischlag (Ed.) --- Natalia O. Glebova (Ed.)
Diagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain.
The purpose of these books is to have an updated systematic overview examining, in detail, the functional role of different diets and dietary components in maintaining glucose homeostasis and preventing long-term complications. The first book includes experimental evidence from preclinical research, whereas the second book provides studies in the clinical scenario.
Dietary intake in children is not only associated with current and future health, but also with behavior and learning. Especially during early childhood and throughout the school-age years, adequate food and nutrient intake to support brain development and function are critical. Data on the effect of sugar intake on children’s activity levels, or their ability to focus on cognitive tasks, are mixed. Overall, more research into nutrition and children’s behavior is needed to address the questions: How does behavior affect children’s nutrition and how does nutrition affect children’s behavior?
Design and analysis of a content-based image retrieval system
The automatic retrieval of images according to the similarity of their content is a challenging task with many application fields. In this book the automatic retrieval of images according to human spontaneous perception without further effort or knowledge is considered. A system is therefore designed and analyzed. Methods for the detection and extraction of regions and for the extraction and comparison of color, shape, and texture features are also investigated.
Design for Stability in Transport Logistics - Definition, Concepts and Evaluation
Lean management describes a set of methods combined with a management philosophy which aims at eliminating waste in logistics processes. In production logistics, lean is already widespread and applied successfully. Research has shown that lean also works in a warehousing environment. In transport logistics, lean is still at a low level of maturity in both research and practice. This work contributes to closing this gap by introducing Heijunka leveling to transport logistics.
Determining Cycle Times for Packing in Distribution Centres
Scope of this work is to determine cycle time formulas for packing in distribution centres. No such formulas exist today, even if it is the second most important process after picking. Based on examining packing, morphological boxes showing time influencing parameters are derived. The most significant parameters are identified using analysis of variance (ANOVA). Cycle times are determined and applied to cases. These prove that the formulas can be used to calculate the time required for packing.
Discrete time analysis of batch processes in material flow systems
Scope of this work is the development of appropriate models for the evaluation of batch processes in material flow systems. The presented analytical methods support the long range planning in an early planning stage, in which capacities are determined to minimize the facility costs under the condition of cycle time targets.
Discrete Time Analysis of Multi-Server Queueing Systems in Material Handling and Service
In this doctoral thesis, performance parameters of multi-server queueing systems are estimated under general stochastic assumptions. We present an exact calculation method for the discrete time distribution of the number of customers in the queueing system at the arrival moment of an arbitrary customer. The waiting time distribution and the sojourn time distribution are estimated exactly, as well. For the calculation of the inter departure time distribution, we present an approximation method.
Distributed Transformers for Broadband Monolithic Millimeter-Wave Integrated Power Amplifiers
This work presents methods and techniques to optimize and implement distributed magnetic transformers for their application in matching networks of Monolithic Millimeter-wave Integrated Circuits (MMICs). It describes strategies for the efficiency and bandwidth optimization of the transformers and demonstrates their potential based on an optimized transformer geometry as well as two MMIC power amplifiers.
Divertor Development for a Future Fusion Power Plant
Nuclear fusion is considered as a future source of sustainable energy supply. Since the H-mode discovery in ASDEX experiment ""Divertor I"" in 1982, the divertor has been an integral part of all modern tokamaks and stellarators. The major goal of this thesis is to develop a feasible divertor design for a fusion power plant to be built after ITER. The thesis describes the approach in the conceptual development of a helium-cooled divertor and the methods of verification and validation of the design.
ECG Imaging of Ventricular Activity in Clinical Applications
ECG imaging was performed in humans to reconstruct ventricular activation patterns and localize their excitation origins. The precision of the non-invasive reconstructions was evaluated against invasive measurements and found to be in line with the state-of-the-art literature. Statistics were produced for various excitation origins and reveal the beat-to-beat robustness of the imaging method.
ECG Based Analysis of the Ventricular Repolarisation in the Human Heart
ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de Pointes. Especially drug induced effects on the repolarisation processes are in focus, since some non-cardiac drugs have been associated with sudden cardiac death in the 1990s. The analysis of the ventricular repolarisation using a set of parameters depicting the morphology of the T-wave is introduced in this work. Therefore, new methods of fully automatic patient-specific QRS detection, beat classification and precise T-wave delineation are presented.
Electrofiltration of Biopolymers : Spatially Distributed Process Analysis
In biotechnology the current downstream processing trends are directed towards integrated, faster and more effective processes. Electrofiltration is a hybrid method which is a combination of membrane filtration and electrophoresis in a dead-end process. Spatially distributed process analysis together with the applicability of electrofiltration for technically important biopolymers such as PHB, chitosan and hyaluronic acid enables the implementation of the technology into industry.
Financial markets and public information
The last decades have seen dramatic changes in trading technology and the way that financial markets operate. As trading technology advances, news providers have kept pace and deliver news to market participants around the world within fractions of a second using electronic systems. Currently, most news is still interpreted by humans but news providers have started to offer newswire products with machine learning systems that specifically cater to algorithmic traders. In practice, newswire messagesmake up a major part of the public information set available to investors.
Finite Element Method (FEM) Model and Performance Analysis of Solid Oxide Fuel Cells
This work presents a numerical FEM framework, capable of predicting SOFC performance under technically relevant, planar stack contacting conditions. A high level of confidence in the model predictions is supplied by using exclusively experimentally determined material/kinetic parameters and by a comprehensive validation. The presented model aids SOFC stack development by pre-evaluating possible material choices and design combinations for cells/interconnectors without any experimental effort.
Flow control : theoretical concept of absolute instability
At the 37th Prandtl memorial lecture on Regions of Viccous Flow, H.Oertel 1994 developed for the first time the stability theory of local perturbations in boundary layers and wake flows, as well as their practical application in the flow control of vehicle flows and the boundary layer of civil aircraft wings.This work presents how the stability theory concept of absolute instability has advanced and proven in practice in the last 15 years in terms of the efficient flow control.
Fluid Flow and Heat Transfer in Cellular Solids
To determine the characteristics and properties of cellular solids for an application, and to allow a systematic practical use by means of correlations and modelling approaches, we perform experimental investigations and develop numerical methods. In view of coupled multi-physics simulations, we employ the phase-field method. Finally, the applicability is demonstrated exemplarily for open-cell metal foams, providing qualitative and quantitative comparison with experimental data.
Formation of Intracardiac Electrograms under Physiological and Pathological Conditions
This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.
The formation of patterns in subaqueous sediment
This book investigates the formation of subaqueous patterns by means of high-fidelity numerical simulations which resolve all the relevant scales of the flow and the sediment bed. This is required to provide a space- and time-resolved information on the flow field and the sediment bed. Secondly, detailed analysis of the generated data allows to address the different governing mechanisms involved in the formation of patterns as well as to access the validity of various existing models.
Forward and inverse problems of electrocardiography : clinical investigations
The non-invasive reconstruction of cardiac activity can significantly improve the quality of cardiac diagnostics. Two major approaches are considered. The model-based method consists in the optimization of an electrophysiological cardiac model until the measured and simulated ECGs are similar. The inverse problem of electrocardiography is solved to compute the cardiac sources distributions from body surface potential maps. The results and their interpretation are shown for several patients.
High Performance Light Water Reactor : Design and Analyses
The High Performance Light Water Reactor is a nuclear reactor concept of the 4th generation which is cooled and moderated with supercritical water. The concept has been worked out by a consortium of European partners, co-funded by the European Commission. It features a once through steam cycle, a pressure vessel type reactor, and a compact containment with pressure suppression pool. The conceptual design enables to assess its feasibility, its safety features and its economic potential.
Schulenberg, ThomasStarflinger, Jörg [Hrsg.]
High Temperature Superconductor Cable Concepts for Fusion Magnets
Three concepts of high temperature superconductor cables carrying kA currents (RACC, CORC and TSTC) are investigated, optimized and evaluated in the scope of their applicability as conductor in fusion magnets. The magnetic field and temperature dependence of the cables is measured; the thermal expansion and conductivity of structure, insulation and filling materials are investigated. High temperature superconductor winding packs for fusion magnets are calculated and compared with corresponding low temperature superconductor cases.
The impact of interfaces on the performance of organic photovoltaic cells
Organic photovoltaic is an attractive technology to solve future energy supply scenarios. To further increase the potential of this technology novel absorber materials and interface materials have to be developed. In this work the paramount importance of interface materials for efficient as well as stable organic photovoltaic cells and modules is demonstrated. The general requirements of interface materials are elaborated and properties of a novel interface material which meets the demands are investigated experimentally and by simulations.
Improving the Spectral Bandwidth of Superconducting Nanowire Single-Photon Detectors (SNSPDs)
This work presents a comprehensive investigation of the influence of geometry-dependent factors on performance metrics of superconducting single-photon detectors. With fundamental knowledge, main investigations are focused to extend the spectral bandwidth and to enhance the detection efficiency, especially in infrared range. The developed technology of single-spiral detectors and unconventional electron-beam lithography allows to improve the performance of superconducting detectors.
Dreier, ThomasStuder, RudiWeinhardt, Christof [Hrsg.]
Geothermal Energy: Delivering on the Global Potential
After decades of being largely the preserve of countries in volcanic regions, the use of geothermal energy—for both heat and power applications—is now expanding worldwide. This reflects its excellent low-carbon credentials and its ability to offer baseload and dispatchable output - rare amongst the mainstream renewables. Yet uptake of geothermal still lags behind that of solar and wind, principally because of (i) uncertainties over resource availability in poorly-explored reservoirs and (ii) the concentration of full-lifetime costs into early-stage capital expenditure (capex).
Abstract Microtechnology has changed our world since the last century, when silicon microelectronics revolutionized sensor, control and communication areas, with applications extending from domotics to automotive, and from security to biomedicine. The present century, however, is also seeing an accelerating pace of innovation in glassy materials; as an example, glass-ceramics, which successfully combine the properties of an amorphous matrix with those of micro- or nano-crystals, offer a very high flexibility of design to chemists, physicists and engineers, who can conceive and implement advanced microdevices.
Righini, Giancarlo --- Righini, Nicoletta
Global Indigeneities and the Environment
Global Indigeneities and the Environment—covering fields from American Indian Studies, anthropology, communications, ethnoecology, ethnomusicology, geography, global studies, history, and literature, the purpose of the Special Issue is to give new understandings of the concept of global indigeneities and to showcase some of the most promising work in the field to date.
Karen L. Thornber (Ed.) --- Tom Havens (Ed.)
Gluten Related Disorders: People Shall not Live on Bread Alone
Once upon a time, gluten was not part of the human diet, and therefore, there were no gluten-related disorders. With the advent of agriculture 10,000 years ago, the introduction of gluten-containing grains in the human diet created conditions for human diseases related to gluten exposure. These diseases, including celiac disease, non-celiac gluten sensitivity, and wheat allergy, have distinct pathophysiological mechanisms, serological markers, and long-term treatments, but similar, often overlapping clinical presentations.
In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD.
Grain-based Foods: Processing, Properties, and Heath Attributes
The Special Issue aims to provide a complete exploration of the scientific principles related to processing, fermentation/malting, and nutrition of cereal grains. It also describes their physical and chemical characteristics and explains how these properties relate to health and nutritional value of the final grain-based products. Indeed, while grains remain the world’s largest food yield—with more than 2.4 billion metric tons produced annually—consumer demands are on the rise for grain products sustainable from an environmental, social and economic viewpoint, in order to meet the growing demand for healthy and nutritious foods.
Emanuele Zannini (Ed.) --- Raffaella di Cagno (Ed.)
Heat and Mass Transfer in Building Energy Performance Assessment
The building industry is influenced by many factors and trends reflecting the current situation and developments in social, economic, technical, and scientific fields. One of the most important trends seeks to minimize the energy demand. This can be achieved by promoting the construction of buildings with better thermal insulating capabilities of their envelopes and better efficiency in heating, ventilation, and air conditioning systems.
Robert Černý Sciprofile link ,Ákos Lakatos Sciprofile link andVáclav Kočí Sciprofile link (Eds.)
Heat Transfer Processes in Oscillatory Flow Conditions
Heat exchange processes in steady flows have been studied extensively over the last two hundred years, and are now a part of undergraduate syllabi in most engineering courses. However, heat transfer processes in oscillatory flow conditions are still not very well understood. Their importance is well recognized in applications including Stirling machines, thermoacoustic engines, and refrigerators or pulsed-tube coolers in cryogenics.
Watershed hydrology is driven by climate forcing, near ground surface characteristics, and human activities, addressing a wide spectrum of environmental and water resource problems regarding both scientific-driven questions and practical engineering issues. This book collates watershed problems and solutions from around the world covering diverse climate types. These cases show complex interactions between hydrological processes and environmental conditions and scientific methods for understanding the hydrological regime and management of human activities.
Christopher J. Duffy (Ed.) --- Xuan Yu (Ed.)
Human and Animal Sensitivity: How Stock-People and Consumer Perception Can Affect Animal Welfare
This book presents cross-discipline studies covering aspects ranging from animal science to social/consumer sciences and psychology, with the aim to collect and disseminate information promoting the continuous enhancement of animal welfare by improving stakeholders’ perception of animal welfare. Although animal welfare is about how the animals perceive the surrounding environment, the actual welfare of the animals is dependent on how the stakeholders perceive and weigh animal welfare.
World Green Building Council suggests that health, well-being and productivity should be the next chapter for green building. There is an obvious shift of green building movement from technology-centric towards human-centric, which culminates in recent WELL Building Standard, focusing exclusively on human health and wellness. This special issue aims to push forward the research, discourse and practice of green building towards more human-oriented design solutions.
Humidity Sensors. Advances in Reliability, Calibration and Application
Humidity detection has deep significance for the scientific research surrounding medical care and human performance, and the industrial development of agriculture, geography and automated instruments. This special issue aims to showcase some of the advancements in humidity sensor design and calibration, and its applications. The selected papers cover a variety of humidity sensor-related topics including material science, chemistry and industrial engineering.
McCarthy, Peter W. --- Liu, Zhuofu --- Cascioli, Vincenzo
Craig M. Jensen --- Etsuo Akiba --- Hai-Wen Li
Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential
Antimicrobial peptides are key defense molecules adopted by all life forms to prevent infection. They also have other beneficial effects such as boosting immune response, anticancer, and wound healing. The antiviral effects of antimicrobial peptides have laid the foundations for developing new agents to combat seasonal Flu, HIV-1, RSV, Zika, and Ebola. This eBook is constructed to systematically deal with antimicrobial peptides from a variety of natural sources, including fungi, plants, and animals (insects, fish, amphibians, birds, and reptiles).
Impact of Bioactive Peptides on Human Health
Food-derived bioactive peptides or dietary peptides are increasingly becoming recognized as major food compounds for human health promotion, which prevent the occurrence of chronic diseases through their impacts on the gastrointestinal, cardiovascular, immune, and nervous systems. Further bioactive peptide discoveries are essential for maintaining human health and commercial development in the area of functional foods and nutraceuticals.
Innovation Issues in Water, Agriculture and Food
In a worldwide context of ever-growing competition for water and land, climate change, droughts and man-made water scarcity, and less-participatory water governance, agriculture faces the great challenge of producing enough food for a continually increasing population. In this line, this book provides a broad overview of innovation issues in the complex water–agriculture–food nexus, thus also relative to their interconnections and dependences. Issues refer to different spatial scales, from the field or the farm to the irrigation system or the river basin.
Cameira, Maria do Rosario --- Pereira, Luis Santos
Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis
The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility
Locatelli, Marcello --- Carradori, Simone --- Mocan, Andrei
Innovative Technologies and Services for Smart Cities
A smart city is a modern technology-driven urban area which uses sensing devices, information, and communication technology connected to the internet of things (IoTs) for the optimum and efficient utilization of infrastructures and services with the goal of improving the living conditions of citizens. Increasing populations, lower budgets, limited resources, and compatibility of the upgraded technologies are some of the few problems affecting the implementation of smart cities. Hence, there is continuous advancement regarding technologies for the implementation of smart cities.
The Insecticidal Bacterial Toxins in Modern Agriculture
Increased awareness about environmental adverse effects of human activities has prompted the use of insecticides with low impact on systems associated to agriculture. Currently, the most successful biological products are based on protein toxins from the bacterial species Bacillus thuringiensis. Because of the remarkable properties of these proteins, their encoding genes were introduced into farming species (the so called Bt-crops), in such a way, that these plants are self-protected against some key insect pests.
Juan Ferré (Ed.) --- Baltasar Escriche (Ed.)
Integral Transforms and Operational Calculus
Researches and investigations involving the theory and applications of integral transforms and operational calculus are remarkably wide-spread in many diverse areas of the mathematical, physical, chemical, engineering and statistical sciences.
Integrated Role of Nutrition and Physical Activity for Lifelong Health
As computer and space technologies have been developed, geoscience information systems (GIS) and remote sensing (RS) technologies, which deal with the geospatial information, have been rapidly maturing. Moreover, over the last few decades, machine learning techniques including artificial neural network (ANN), deep learning, decision tree, and support vector machine (SVM) have been successfully applied to geospatial science and engineering research fields.
Integration of 2D Materials for Electronics Applications
Two-dimensional (2D) materials and their vertical/lateral heterostructures are currently the subject of massive research interests, both for fundamental science and for technological applications in diverse fields, such as electronics, optoelectronics, quantum metrology, spintronics, membranes, energy conversion/storage, and sensing. Integration of 2D materials within real device structures currently represents the main challenge to move from the laboratory stage to industrial applications, especially in the fields of electronics/optoelectronics.
Filippo Giannazzo (Ed.) --- Samuel Lara Avila (Ed.) --- Jens Eriksson (Ed.) --- Sushant Sonde (Ed.)
Interface Circuits for Microsensor Integrated Systems
this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Recent advances in sensing technologies, especially those for Microsensor Integrated Systems, have led to several new commercial applications. Among these, low voltage and low power circuit architectures have gained growing attention, being suitable for portable long battery life devices. The aim is to improve the performances of actual interface circuits and systems, both in terms of voltage mode and current mode, in order to overcome the potential problems due to technology scaling and different technology integrations.
Giuseppe Ferri (Ed.) --- Vincenzo Stornelli (Ed.)
Kernel Methods and Hybrid Evolutionary Algorithms in Energy Forecasting
The development of kernel methods and hybrid evolutionary algorithms (HEAs) to support experts in energy forecasting is of great importance to improving the accuracy of the actions derived from an energy decision maker, and it is crucial that they are theoretically sound. In addition, more accurate or more precise energy demand forecasts are required when decisions are made in a competitive environment. Therefore, this is of special relevance in the Big Data era. These forecasts are usually based on a complex function combination. These models have resulted in over-reliance on the use of informal judgment and higher expense if lacking the ability to catch the data patterns.
Landscape Urbanism and Green Infrastructure
This volume examines the applicability of landscape urbanism theory in contemporary landscape architecture practice by bringing together ecology and architecture in the built environment. Using participatory planning of green infrastructure and application of nature-based solutions to address urban challenges, landscape urbanism seeks to reintroduce critical connections between natural and urban systems. In light of ongoing developments in landscape architecture, the goal is a paradigm shift towards a landscape that restores and rehabilitates urban ecosystems.
Life Cycle Assessment on Green Building Implementation
Greenhouse-gas emissions have become one of the most impacting environmental issues in today’s society. A rapidly increasing trend in global CO2emissions particularly since the early nineties (23.64% since 1990) has led to the generation of about 50,000 million tons of CO2–equivalent (eqv) worldwide in 2010. According to mainstream climate experts, the increasing concentration of greenhouse-gases is having a warming effect on the world climate. To slow down global warming, there is a global focus on reducing greenhouse-gas emissions
Liquid Crystal on Silicon Devices: Modeling and Advanced Spatial Light Modulation Applications
Liquid Crystal on Silicon (LCoS) has become one of the most widespread technologies for spatial light modulation in optics and photonics applications. These reflective microdisplays are composed of a high-performance silicon complementary metal oxide semiconductor (CMOS) backplane, which controls the light-modulating properties of the liquid crystal layer. State-of-the-art LCoS microdisplays may exhibit a very small pixel pitch (below 4 ?m), a very large number of pixels (resolutions larger than 4K), and high fill factors (larger than 90%). They modulate illumination sources covering the UV, visible, and far IR. LCoS are used not only as displays but also as polarization, amplitude, and phase-only spatial light modulators, where they achieve full phase modulation.
Machine Learning and Embedded Computing in Advanced Driver Assistance Systems (ADAS)
This book contains the latest research on machine learning and embedded computing in advanced driver assistance systems (ADAS). It encompasses research in detection, tracking, LiDAR
Machine Learning Techniques Applied to Geoscience Information System and Remote Sensing
As computer and space technologies have been developed, geoscience information systems (GIS) and remote sensing (RS) technologies, which deal with the geospatial information, have been rapidly maturing. Moreover, over the last few decades, machine learning techniques including artificial neural network (ANN), deep learning, decision tree, and support vector machine (SVM) have been successfully applied to geospatial science and engineering research fields. The machine learning techniques have been widely applied to GIS and RS research fields and have recently produced valuable results in the areas of geoscience, environment, natural hazards, and natural resources.
Machining—Recent Advances, Applications and Challenges
The Special Issue Machining—Recent Advances, Applications and Challenges is intended as a humble collection of some of the hottest topics in machining. The manufacturing industry is a varying and challenging environment where new advances emerge from one day to another. In recent years, new manufacturing procedures have retained increasing attention from the industrial and scientific community. However, machining still remains the key operation to achieve high productivity and precision for high-added value parts.
López de Lacalle, Luis Norberto --- Urbicain, Gorka
Magnesium is universally recognized as an essential nutrient for human life and health. Indeed, magnesium plays an important physiologic role in every organ of the human body. Disturbances of Mg homeostasis have been implicated in the pathophysiology of several diseases, and Mg supplementation has been evaluated in numerous large-scale clinical trials. The World Health Organization has listed magnesium as among those essential nutrients that are consumed in suboptimal amounts by the general population.
Federica Wolf (Ed.) --- Valentina Trapani (Ed.)
[Selective and quantitative detection of different kinds of biocomponents plays an important role in biomedical applications, clinical diagnostics, environmental monitoring, toxicology, regenerative medicine and drug delivery. Therefore, multidisciplinary area of magnetic biosensing have been extensively developed in recent years, aiming to create compact analytical devices for non-expensive and low time consuming analysis provided at the point of care by non-skilled personnel.
The desired properties of surface components include the improvement of different properties, such as aesthetic appearance, oxidation resistance, wear resistance, mechanical properties, electronic or electrical properties, thermal insulation, wear, triboemission and corrosion resistance through barriers. These properties can be enhanced using different methods, such as by adding a coating. Nevertheless, the bulk of the material or substrate cannot be considered independent of the surface treatment.
In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity.
Friedemann Honecker (Ed.) --- Sergey A. Dyshlovoy (Ed.)
Rösch, ChristineBräutigam, Klaus-RainerKopfmüller, JürgenStelzer, VolkerLichtner, PatrickFricke, Annika
Influence of fully miscible lubrication oil on flow boiling of CO? inside horizontal evaporator tubes
Flow boiling heat transfer, pressure drop and flow pattern of CO?-POE oil mixtures were experimentally investigated in smooth and micro-fin tubes. The POE oil used features full miscibility in the range of operation investigated. The experimental data was evaluated based on mixture properties, used to evaluate and improve established predictive methods. The knowledge obtained contributes to understanding the influence of oil, which is essential for achieving an efficient evaporator design.
Magnetization of High Temperature Superconducting Trapped-Field Magnets
High temperature superconducting (HTS) bulks and stacks of coated conductors can be magnetized to become trapped-field magnets that provide much stronger magnetic fields than those reachable with conventional permanent magnets. This work investigates the flux dynamics during the magnetization of HTS trapped-field magnets and proposes possible strategies to improve the trapped field produced by the pulsed field magnetization method that is promising for practical applications.
Mapping and Localization in Urban Environments Using Cameras
In this work we present a system to fully automatically create a highly accurate visual feature map from image data aquired from within a moving vehicle. Moreover, a system for high precision self localization is presented. Furthermore, we present a method to automatically learn a visual descriptor. The map relative self localization is centimeter accurate and allows autonomous driving.
Micromechanical Modeling and Simulation of Forming Processes
The deep drawing of an aluminum alloy used in the packaging industry for the beverage can manufacturing process is investigated. In this work, the effective constitutive behavior is based on a crystal plasticity model in combination with a non-linear Hashin-Shtrikman type homogenization scheme in which a reference stiffness controls the stress and strain fluctuations. The simulation results are compared to experiments in terms of deep drawing earing profiles, texture evolution, and localization.
Modeling of electrophysiology and tension development in the human heart
Comprehension of the beating of the human heart is important for cardiac research and will improve many clinical applications. Simulations based on models describing cardiac electro-mechanics can acquire insights into this behavior. This work focuses on the mathematical reconstruction of electrophysiology, excitation conduction, and tension development in the human heart on the cellular and the tissue level. The tissue models represent accurate anatomical shapes of the atria and the ventricles and incorporate electrophysiological heterogeneity and anisotropic conduction.
Modelling the human cardiac fluid mechanics
We present a virtual heart model simulating the flow in the left human ventricle and in the aorta. Because of the lack of in vivo structure data of the human ventricle, the active ventricle movement is given by a time-dependent ventricle model that is derived from in vivo image data of a nuclear spin MRT tomograph of a healthy human heart.
Modified mass-spring system for physically based deformation modeling
Mass-spring systems are considered the simplest and most intuitive of all deformable models. They are computationally efficient, and can handle large deformations with ease. But they suffer several intrinsic limitations. In this book a modified mass-spring system for physically based deformation modeling that addresses the limitations and solves them elegantly is presented. Several implementations in modeling breast mechanics, heart mechanics and for elastic images registration are presented.
Network Structures of Cargo Airlines - An Empirical and a Modelling Approach
The development of efficient air freight networks is an upcoming challenge. The present book approaches this problem for cargo airlines by characterising and classifying their network structures and by developing a model for an airline's strategic network design. The book provides results which are of value for airline professionals (network efficiency analysis), policy makers (policy impact assessment) and researchers (cargo airline network design model).
Numerical Haemodynamics in the Human Heart
The characteristic vortex formation in the ventricles is believed to be affected at an early stage of heart diseases. First, post-processing of patient-specific data has to be standardised. The chosen methods, a combination of Eulerian and Lagrangian techniques, are characterised by means of necessary spatial and temporal resolutions. Second, the goal is to find the best cost-benefit approach for modelling of the mitral valve, as it affects vortex formation and progression in the left ventricle.
Numerical Modeling of Stagnation Flows over Porous Catalytic Surfaces
In this book, stagnation flows on a catalytic porous plate is modeled one-dimensionally coupled with multi-step surface reaction mechanisms and molecular transport (diffusion and conduction) in the flow field and in the porous catalyst. Internal and external mass transfer limitations as well as possible reaction routes in the catalyst are investigated for CO oxidation, WGS reaction, partial and steam reforming of methane over Rh/Al?O?.
Optical antennas : linear and nonlinear excitation and emission
The linear and nonlinear resonance behaviour of optical antennas (metallic nanostructures showing resonance behaviour at optical frequencies) made of gold and aluminum using electron-beam lithography is investigated. Specifically, it is of interest how the emission behaviour is changed by the coupling of two antenna arms via a small gap. Experimental techniques applied include dark-field spectroscopy and two-photon luminescence.
Optically Powered Highly Energy-efficient Sensor Networks
In optically powered networks, both, communication signals and power for remotely located sensor nodes, are transmitted over an optical fiber. Key features of optically powered networks are node operation without local power supplies or batteries as well as operation with negligible susceptibility to electro-magnetic interference and to lightning. In this book, different kinds of optically powered devices and networks are investigated, and selected applications are demonstrated.
Optimization of Hot-Electron Bolometers for THz Radiation
Hot-electron bolometers are fast and low noise radiation detectors which can be used for many different applications. The aim of this work was to optimize the fabrication process of hot-electron bolometers and gain a deeper understanding of the underlying processes. To achieve this, the fabrication of the superconducting thin films was optimized and the superconducting properties of the films were analyzed. Detectors fabricated using the results showed a record value for the noise temperature.
Organic Semiconductor Lasers and Tailored Nanostructures for Raman Spectroscopy
This work presents the application of organic semiconductor distributed feedback laser as free-space excitation source in Raman spectroscopy. Surface-enhanced Raman scattering effect is exploited to improve the detection sensitivity. The SERS conditionis achiedved by using substrates consisting of gold-coated polymeric nanopillar arrays. The organic-laser-excited SERS measurements are applied to verify the concentration variation of biomolecule adenosine in aqueous solutions.
Photonic crystal slabs for low-cost biosensors
Biosensors are devices that utilize biological recognition elements to selectively detect and analyze specific biological and chemical analyte substances. In this work a technology platform for label-free optical biosensors based on surface-functionalized photonic crystal slabs is proposed. Using this technology platform, low-cost solutions for three biotechnical questions are presented.
Planning the Charging Infrastructure for Electric Vehicles in Cities and Regions
Planning the charging infrastructure for electric vehicles (EVs) is a new challenging task. This book treats all involved aspects: charging technologies and norms, interactions with the electricity system, electrical installation, demand for charging infrastructure, economics of public infrastructure provision, policies in Germany and the EU, external effects, stakeholder cooperation, spatial planning on the regional and street level, operation and maintenance, and long term spatial planning.
Process Simulation of Technical Precipitation Processes - The Influence of Mixing
This work develops and shows up methods to tackle multi-scale challenges in particle formation during precipitation crystallization. Firstly, molecular, micro- and meso-scale interactions in confined impinging jet mixers are investigated and simulatively predicted. Secondly, to build up on developed methods, macroscale as present for instance in stirred tank reactors is added to the considerations.
Production process design using Multi-Criteria Analysis
Intra- and inter-company production networks have gained increased importance in developed and industrialising countries. By reusing waste of industrial sites as a valuable input within the production network, material cycles can be closed and resource efficiency can be improved.In order to improve the performance of a production process, a detailed mapping of the mass and energy flows is the basis to understand which process characteristics are the main drivers for resource efficiency.The objective of this book is to develop an integrated multi-criteria decision support model for production process design.
Reactive Control of Turbulent Wall-Bounded Flows for Skin Friction Drag Reduction
The work presents an attempt to improve the understanding of reactive drag reducing control of near-wall turbulence with respect to limitations present in a realistic application scenario. The reference reactive control scheme of opposition control is studied using direct numerical simulation through the consideration of various application oriented restrictions, i.e. local control application, limited spatial and temporal resolution of the scheme, sensor noise and control elements arrangement.
Real-time Digital Signal Processing for Software-defined Optical Transmitters and Receivers
A software-defined optical Tx is designed and demonstrated generating signals with various formats and pulse-shapes in real-time. Special pulse-shapes such as OFDM or Nyquist signaling were utilized resulting in a highly efficient usage of the available fiber channel bandwidth. This was achieved by parallel data processing with high-end FPGAs. Furthermore, highly efficient Rx algorithms for carrier and timing recovery as well as for polarization demultiplexing were developed and investigated
The role of indicators in decisions of technology innovation
There are thousands of indicators produced to understand and govern our societies. Studies about the way indicators are used in technological innovation are significantly rare, despite the centrality of these decisions to promote growth in our technology-intensive civilization. This book presents what is known and what was discovered in a doctoral research, which analysed innovative business leaders, policymakers and public researchers responsible for technological innovations.
This book presents a process-oriented business modeling framework based on semantic technologies. The framework consists of modeling languages, methods, and tools that allow for semantic modeling of business motivation, business policies and rules, and business processes. Quality of the proposed modeling framework is evaluated based on the modeling content of SAP Solution Composer and several real-world business scenarios.
Soft Magnetic Composites in Novel Designs of Electrical Traction Machines
Nowadays, the manufacturing of electrical machines based on electrical steel laminations has been well established worldwide. Compared with the electrical steel, the soft magnetic composites (SMC) shows magnetic isotropy and lower eddy current losses. Thus, it becomes an important impulse promoting the development of new topologies of electrical machine. The application of SMC in the electrical traction machine for hybrid electrical vehicle or electrical vehicle has been researched in the work.
Stability of cooperation in the international climate negotiations - An analysis using cooperative game theory
International cooperation on greenhouse gas emission reductions is needed to avoid dangerous climate change. This work analyses the stability of global cooperation on climate change using cooperative game theory. Numerical and theoretical models are applied to evaluate the impact of several real-world properties. It is shown that the introduction of these properties into the game-theoretical model substantially affects the results and can make global climate cooperation unstable.
Sulfur-tolerant natural gas reforming for fuel-cell applications
An attractive simplification of PEM-FC systems operated with natural gas would be the use of a sulfur tolerant reforming catalyst, but such a catalyst has not been available thus far. In this work it is demonstrated that a tailor made rhodium catalyst retains useful activity for typical sulfur levels in the feed. A brief economic comparison showed however that this alternative process is still less economical than the traditional process employing removal of sulfur components by adsorption.
Surface wave driven molecular low pressure plasmas for general lighting
Nowadays, compact fluorescent lamps are widely-used in general lighting applications. However, they still struggle with acceptance problems due to the hazardous mercury, which serves as the radiant component inside the lamp. The presented work deals with the development of a mercury-free, electrodeless, low pressure plasma based on a molecular filling and driven by microwaves, which may represent a viable alternative to the conventional CFLs.
Timber Engineering - Principles for Design
This comprehensive book provides in-depth knowledge and understanding of design rules according to Eurocode 5. It is based on the first edition of the STEP (Structural Timber Education Programme) series, which was prepared in 1995 by about 50 authors from 14 European countries. The present work updates and extends the STEP compilation and is aimed at students, structural engineers and other timber structure professionals.
Tracking Extended Objects in Noisy Point Clouds with Application in Telepresence Systems
We discuss theory and application of extended object tracking. This task is challenging as sensor noise prevents a correct association of the measurements to their sources on the object, the shape itself might be unknown a priori, and due to occlusion effects, only parts of the object are visible at a given time. We propose an approach to track the parameters of arbitrary objects, which provides new solutions to the above challenges, and marks a significant advance to the state of the art.
Transient behaviour of ITER poloidal field coils
Transient voltages occur on the terminals of superconducting coils and may lead to internal over-voltages. The main objective of this work was to calculate the transient electrical behaviour and internal voltage distribution within the ITER poloidal field (PF) coils at four scenarios and was made using the PF 3 and PF 6 coils as examples. The calculated maximum voltages will be used for definition of amplitudes and voltage waveforms for the tests of the high-voltage insulation of the coils.
Tunable Diode-Laser Absorption Spectroscopy for Trace-Gas Measurements with High Sensitivity and Low Drift
This book discusses the mechanical and opto-electronic design of laser spectrometers for measuring two very important atmospheric gases, namely water vapor and its isotopic ratios, and formaldehyde. For measuring water vapor, shot-noise limited sensitivity has been achieved by a careful choice of system components and data processing. For measuring formaldehyde, a selective sample modulation exploiting the Stark effect has been used to greatly improve the sensitivity.
Turbulent open channel flow, sediment erosion and sediment transport
This thesis aims to contribute to a better understanding of turbulent open channel flow, sediment erosion and sediment transport. The thesis provides an analysis of high-fidelity data from direct numerical simulation of (i) open channel flow over an array of fixed spheres, (ii) open channel flow with mobile eroding spheres, (iii) open channel flow with sediment transport of many mobile spheres. An immersed boundary method is used to resolve the finite-size particles.
Two-Scale Thermomechanical Simulation of Hot Stamping
Hot stamping is a hot drawing process which takes advantage of the polymorphic steel behavior to produce parts with a good strength-to-weight ratio. For the simulation of the hot stamping process, a nonlinear two-scale thermomechanical model is suggested and implemented into the FE tool ABAQUS. Phase transformation and transformation induced plasticity effects are taken into account. The simulation results regarding the final shape and residual stresses are compared to experimental findings
Uncertainty handling in multi-attribute decision support for industrial risk management
The complexity of today's industrial production networks constitutes a new challenge for industrial risk and safety management. In order to handle potential risks to and emanating from industry and their respective impact on mankind as well as the environment, an integrated approach to industrial risk management is needed, since complex decision situations need to be resolved requiring input from diverse scientific disciplines and the consideration of various often conflicting criteria.
Usage Policies for Decentralised Information Processing
Owners impose usage restrictions on their information, which can be based e.g. on privacy laws, copyright law or social conventions. Often, information is processed in complex constellations without central control. In this work, we introduce technologies to formally express usage restrictions in a machine-interpretable way as so-called policies that enable the creation of decentralised systems that provide, consume and process distributed information in compliance with their usage restrictions.
Methods and Concepts for Designing and Validating Smart Grid Systems
Energy efficiency and low-carbon technologies are key contributors to curtailing the emission of greenhouse gases that continue to cause global warming. The efforts to reduce greenhouse gas emissions also strongly affect electrical power systems. Renewable sources, storage systems, and flexible loads provide new system controls, but power system operators and utilities have to deal with their fluctuating nature, limited storage capabilities, and typically higher infrastructure complexity with a growing number of heterogeneous components.
Strasser, Thomas --- Rohjans, Sebastian --- Burt, Graeme
Micro/Nano Materials for Clean Energy and Environment
The research center serves as a platform for researchers at both universities to conduct joint research in the targeted areas, and to meet regularly for information exchange, talent exchange, and knowledge mobilization, especially in the fields of micro/nano, energy, and environmental technologies. The center focuses on three main interests: micro/nano energy technology, micro/nano pollution control technology, and relevant fundamental research.
Micro/nanofluidic chips have found increasing applications in the analysis of chemical and biological samples over the past two decades. Electrokinetics has become the method of choice in these micro/nano-chips for transporting, manipulating and sensing ions, (bio)molecules, fluids and (bio)particles, etc., due to the high maneuverability, scalability, sensitivity, and integrability.
Microbial Community Modeling: Prediction of Microbial Interactions and Community Dynamics
It has the potential to resolve many issues in the realms of energy, food, human health, the environment, and biotechnology. Scientists are trying to understand, in a fundamental way, how microbes influence each other and how they organize into interaction networks. These are the keys to predicting and engineering community function and properties of the microbiome. In this regard, mathematical modeling and computational analysis play an increasing role. This book is a collection of contributions from lead scientists in the field.
Microfluidics for Cells and Other Organisms
Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.
Microscale Surface Tension and Its Applications
Building on advances in miniaturization and soft matter, surface tension effects are a major key to the development of soft/fluidic microrobotics. Benefiting from scaling laws, surface tension and capillary effects can enable sensing, actuation, adhesion, confinement, compliance, and other structural and functional properties necessary in micro- and nanosystems. Various applications are under development: microfluidic and lab-on-chip devices, soft gripping and manipulation of particles, colloidal and interfacial assemblies, fluidic/droplet mechatronics. The capillary action is ubiquitous in drops, bubbles and menisci, opening a broad spectrum of technological solutions and scientific investigations.
Lambert, Pierre --- Mastrangeli, Massimo
Microstructure and Mechanical Properties of Structural Metals and Alloys
The papers collected in this special issue clearly reflect the modern research trends in materials science. These fields of specific attention are high-Mn TWIP steels, high-Cr heat resistant steels, aluminum alloys, ultrafine grained materials including those developed by severe plastic deformation, and high-entropy alloys. The major portion of the collected papers is focused on the mechanisms of microstructure evolution and the mechanical properties of metallic materials subjected to various thermo-mechanical, deformation or heat treatments.
Middleware Solutions for Wireless Internet of Things
Bellavista, Paolo --- Giannelli, Carlo --- Das , Sajal K. --- Cao, Jiannong
Mineralogy of Quartz and Silica Minerals
The present book reports recent contributions from research in the field of quartz and other silica minerals. The various forms of silica (SiO2) represent important constituents of the Earth crust and play a central role in the composition of geological materials. In particular, quartz is widely used as a raw material in numerous industrial sectors. The knowledge of the formation and specific properties of SiO2 rocks and minerals is indispensable for the understanding and reconstruction of geological processes, as well as for specific technical applications.
Mitochondrial Dysfunction in Ageing and Diseases
The past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors. Impairment of the mitochondria may be caused by mutations or deletions in nuclear or mitochondrial DNA. Hallmarks of mitochondrial dysfunction include decreased ATP production, decreased mitochondrial membrane potential, swollen mitochondria, damaged cristae, increased oxidative stress, and decreased mitochondrial DNA copy number.
Mobile Mapping technologies have seen a rapid growth of research activity and interest in the last years, due to the increased demand of accurate, dense and geo-referenced 3D data. Their main characteristic is the ability of acquiring 3D information of large areas dynamically. This versatility has expanded their application fields from the civil engineering to a broader range (industry, emergency response, cultural heritage...), which is constantly widening.
Rodríguez-Gonzálvez, Pablo --- Nocerino, Erica --- Toschi, Isabella --- Chiang, Kai-Wei
Modeling and Practice of Erosion and Sediment Transport under Change
Climate and anthropogenic changes impact the conditions of erosion and sediment transport in rivers. Rainfall variability and, in many places, the increase of rainfall intensity have a direct impact on rainfall erosivity. Increasing changes in demography have led to the acceleration of land cover changes in natural areas, as well as in cultivated areas, and, sometimes, in degraded areas and desertified landscapes. These anthropogenized landscapes are more sensitive to erosion. On the other hand, the increase in the number of dams in watersheds traps a great portion of sediment fluxes, which do not reach the sea in the same amount, nor at the same quality, with consequences on coastal geomorphodynamics.
Mahé, Gil --- Aksoy, Hafzullah --- Meddi, Mohamed
Modeling and Simulation of Energy Systems
Energy Systems Engineering is one of the most exciting and fastest growing fields in engineering. Modeling and simulation plays a key role in Energy Systems Engineering because it is the primary basis on which energy system design, control, optimization, and analysis are based. This book contains a specially curated collection of recent research articles on the modeling and simulation of energy systems written by top experts around the world from universities and research labs, such as Massachusetts Institute of Technology, Yale University, Norwegian University of Science and Technology, National Energy Technology Laboratory of the US Department of Energy, University of Technology Sydney, McMaster University, Queens University, Purdue University, the University of Connecticut, Technical University of Denmark, the University of Toronto, Technische Universität Berlin, Texas A&M, the University of Pennsylvania, and many more.
This specialist edition features key innovations in the science and engineering of new grinding processes, abrasives, tools, machines, and systems for a range of important industrial applications. Topics written by invited, internationally recognized authors review the advances and present results of research over a range of well-known grinding processes. A significant introductory review chapter explores innovations to achieve high productivity and very high precision in grinding.
The Molecular and Cellular Basis for Parkinson's Disease
The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.
Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs.
Molecular Magnetism of Lanthanides Complexes and Networks
Over the last ten years a fresh air has been blowing in the field of molecular magnetism with the re-introduction of lanthanides ions as spin carriers in magnetic molecules. The strong magnetic moment and huge magnetic anisotropy of lanthanide ions has enabled significant breakthroughs in magnetic blocking temperature and related phenomena. The chemical versatility of these ions is also a strong asset as easy substitution among the lanthanides series enables isotropic, anisotropic or solid-solutions of magnetic molecules. Additionally, their outstanding luminescent properties are key features in rationalizing the single-molecule magnet (SMM) behavior and paving the way toward production of multifunctional materials.
Molecular Pharmacology and Pathology of Strokes
Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke.
Joen-Rong Sheu (Ed.) --- Howard Prentice (Ed.)
Molecular Science for Drug Development and Biomedicine
With the avalanche of biological sequences generated in the postgenomic age, molecular science is facing an unprecedented challenge, i.e., how to timely utilize the huge amount of data to benefit human beings. Stimulated by such a challenge, a rapid development has taken place in molecular science, particularly in the areas associated with drug development and biomedicine, both experimental and theoretical. The current thematic issue was launched with the focus on the topic of “Molecular Science for Drug Development and Biomedicine”, in hopes to further stimulate more useful techniques and findings from various approaches of molecular science for drug development and biomedicine.
Multifunctional Oxide-Based Materials: From Synthesis to Application
The book deals with novel aspects and perspectives in metal oxide and hybrid material fabrication.
Jesionowski, Teofil --- Ciesielczyk, Filip
Multiscale and Innovative Kinetic Approaches in Heterogeneous Catalysis
Kinetics and reactor modeling for heterogeneous catalytic reactions are prominent tools for investigating and understanding catalyst functionalities at nanoscale and the related rates of complex reaction networks. This book illustrates some examples related to the transformation of simple to more complex feedstocks, including different types of reactor designs, i.e., steady-state, transient plug flow reactors, and TAP reactors for which there is sometimes a strong gap in the operating conditions from ultra-high-vacuum to high-pressure conditions.
Nanoelectronic Materials, Devices and Modeling
As CMOS scaling is approaching the fundamental physical limits, a wide range of new nanoelectronic materials and devices have been proposed and explored to extend and/or replace the current electronic devices and circuits so as to maintain progress with respect to speed and integration density. The major limitations, including low carrier mobility, degraded subthreshold slope, and heat dissipation, have become more challenging to address as the size of silicon-based metal oxide semiconductor field effect transistors (MOSFETs) has decreased to nanometers, while device integration density has increased.
Nanogrids, Microgrids, and the Internet of Things (IoT): Towards the Digital Energy Network
Driven by new regulations, new market structures, and new energy resources, the smart grid has been the trigger for profound changes in the way that electricity is generated, distributed, managed, and consumed. The smart grid has raised the traditional power grid by using a two-way electricity and information flow to create an advanced, automated power supply network. However, these pioneering smart grid technologies must grow to adapt to the demands of the current digital society. In today’s digital landscape, we can access feasible data and knowledge that were merely inconceivable.
Nanostructure Based Sensors for Gas Sensing: from Devices to Systems
The development of solid state gas sensors based on microtransducers and nanostructured sensing materials is the key point in the design of portable measurement systems able to reach sensing and identification performance comparable with analytical ones. In such a context several efforts must be spent of course in the development of the sensing material, but also in the choice of the transducer mechanism and its structure, in the electrical characterization of the performance and in the design of suitable measurement setups.
Natural Compounds as New Cancer Treatments
Cancer remains one of the main causes of morbidity and mortality worldwide. Although many pharmacological and clinical advances have been made, there is a constant need for new molecules to improve the overall options for treatment. Natural compounds from animal, microbial, vegetal, or fungal origin represent countless sources of new compounds that can be used as anticancer drugs, provided their activity, bioavailability, and toxicity are adequate. This book aims to compile both original articles and reviews that cover the most recent advances in the use of natural compounds for cancer treatment, and provide new objectives and advice for future research in the field of biological activity of natural compounds.
Natural Products for Cancer Prevention and Therapy
This Special Issue book, “Natural Products for Cancer Prevention and Therapy”, is based on recent advances in natural products for cancer prevention and therapy. For this purpose, the authors of this book have been organizing a biennial international conference series. The first meeting (First International Conference on Natural Products for Cancer Prevention and Therapy) was held in Istanbul between 31 August and 2 September 2015, with the support and contribution of many valuable researchers in this field
Anupam Bishayee (Ed.) --- Mukerrem Betul Yerer-Aycan (Ed.)
Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia
This Special Issue focuses on recent research on the important emerging and neglected tropical diseases (NTDs) in South and South East Asia and Northern Australia. This region stretches from Afghanistan in the west to Papua New Guinea in the east, and includes the Indian subcontinent, mainland South-East Asia (Indo China), maritime South East Asia, and the tropical regions of Australia. Many of these areas are highly endemic for important NTDs and emerging infectious diseases including lymphatic filariasis, leprosy, soil-transmitted helminthiases (hookworm, Trichuris, Ascaris, and Strongyloides), food-borne trematodiases, schistosomiasis, dengue/chikungunya/zika, leptospirosis, meloidosis, scabies, trachoma, and yaws. Several of these diseases are targeted for elimination or enhanced control by the World Health Organization in the next 5 to 10 years, although some have chronic lasting sequelae needing lifelong management.
Patricia Graves (Ed.) --- Thewarach Laha (Ed.) --- Peter A. Leggat (Ed.) --- Khin Saw Aye (Ed.)
New Lipid Lowering Therapies for Cardiovascular and Metabolic Diseases: Lessons from the Past and Future Challenges
This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.
Noise and Vibration Control in the Built Environment
With global urbanization rapidly rising and the increasing need of high-quality built environments, the requirement of achieving improved sound quality, both for outdoor and indoor environments, has received a lot of attention. This Special Issue collection reflects the current state of the art, with 12 papers covering environmental acoustics; the influence of soundscapes on people’s behavior; soundscape pleasantness estimation; tranquility; perceived quality of sonic environments; sound and vibration-related health complaints concerning tramways; and the disturbance of construction machines; as well as in building and room acoustics, including natural ventilation-enabling façade noise control devices; the effect of external shading devices; rating method of airborne sound insulation; water supply and drainage noise, and the effect of diffusive surfaces in auditoria.
Non-destructive Testing of Materials in Civil Engineering
This book was proposed and organized as a means to present recent developments in the field of nondestructive testing of materials in civil engineering. For this reason, the articles highlighted in this editorial relate to different aspects of nondestructive testing of different materials in civil engineering—from building materials to building structures. The current trend in the development of nondestructive testing of materials in civil engineering is mainly concerned with the detection of flaws and defects in concrete elements and structures, and acoustic methods predominate in this field.
Novel Advances in Aquatic Vegetation Monitoring in Ocean, Lakes and Rivers
In recent decades, there has been an increase in the development of strategies for water ecosystem mapping and monitoring. Overall, this is primarily due to legislative efforts to improve the quality of water bodies and oceans. Remote sensing has played a key role in the development of such approaches—from the use of drones for vegetation mapping to autonomous vessels for water quality monitoring. Within the specific context of vegetation characterization, the wide range of available observations—from satellite imagery to high-resolution drone aerial imagery—has enabled the development of monitoring and mapping strategies at multiple scales (e.g., micro- and mesoscales).
Novel Biocomposite Engineering and Bio-Applications
The engineering and utilization of biocomposites is a research field of major scientific and industrial interest worldwide. The biocomposite area is extensive and spans from structured and solid biocomposites (e.g., reinforced bioabsorbable polymers), films (e.g., antimicrobial barriers), to soft biocomposites (e.g., use of alginates, collagen and nanocellulose as components in bioinks for 3D bioprinting). Key aspects in this respect are the appropriate engineering and production of biomaterials, nanofibres, bioplastics, their functionalization enabling intelligent and active materials, processes for effective manufacturing of biocomposites and the corresponding characterization for understanding their properties.
Novel Insights into Orbital Angular Momentum Beams: From Fundamentals, Devices to Applications
It is well-known by now that the angular momentum carried by elementary particles can be categorized as spin angular momentum (SAM) and orbital angular momentum (OAM). In the early 1900s, Poynting recognized that a particle, such as a photon, can carry SAM, which has only two possible states, i.e., clockwise and anticlockwise circular polarization states. However, only fairly recently, in 1992, Allen et al. discovered that photons with helical phase fronts can carry OAM, which has infinite orthogonal states.
Yue, Yang --- Huang, Hao --- Ren, Yongxiong --- Pan, Zhongqi --- et al.
Novel Pharmacological Inhibitors for Bacterial Protein Toxins
Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present.
This book was established after the 6th International Workshop on Numerical and Evolutionary Optimization (NEO), representing a collection of papers on the intersection of the two research areas covered at this workshop: numerical optimization and evolutionary search techniques. While focusing on the design of fast and reliable methods lying across these two paradigms, the resulting techniques are strongly applicable to a broad class of real-world problems, such as pattern recognition, routing, energy, lines of production, prediction, and modeling, among others.
Lara, Adriana --- Quiroz, Marcela --- Mezura-Montes, Efrén --- Schütze, Oliver
Nutraceuticals and the Skin: Roles in Health and Disease
he skin is the largest organ of the body and serves as a barrier between the inner and external environments. As such, any problems in the skin can have serious effects on systemic health and well-being. Several studies have established that both nutritional and dietary factors play an important role in the maintenance of normal skin integrity, and can execute a causative, preventative and/or treatment role in a number of skin related conditions.
Jean Christopher Chamcheu (Ed.) --- Deeba Nadeem Syed (Ed.) --- G. Kerr Whitfield (Ed.)
Infants are not just small adults; they have a complex set of nutrient requirements and interactions to account for the high metabolic rate, growth, immunological and cognitive development, etc. Each year there are 138 million births, including 30 million from the least developed countries, where health is most at risk. Nutrition during infancy establishes growth patterns and development which moderate short term and long term health and life expectancy. There is continuing progress in understanding the nutrient composition of breastmilk and the importance nutritious and timely complementary foods.
Colin Binns (Ed.) --- Mi Kyung Lee (Ed.) --- Masaharu Kagawa (Ed.)
Nutrients, Infectious and Inflammatory Diseases
Foodborne disease like salmonellosis and toxoplasmosis are amongst the most significant causes of hospitalization in the U.S. and globally. Gastrointestinal infections alter gut microbiomes and increase permeability to toxins. Various invasions by microbial, fungal, viral and parasitic agents stimulate inflammation, a defensive mechanism of the body’s immune system. Other stimuli include environmental stimuli, oxidative stress, aging and the physiological process. A long-lasting, persistent and excessive inflammatory response is a significant risk factor for developing various chronic inflammatory and infectious diseases.
The purpose of this Special Issue, “Nutrition and Allergic Diseases”, is to provide an overview of the role of nutrition in allergy. The prevalence of asthma, rhinitis, and food allergy has increased tremendously over the last few decades. Is there a role for nutrition to help managing this global challenge? This Special Issue touches upon the many aspects that relate to nutrition and allergy and focuses on two fundamental questions: 1) Can nutrition play a role in allergy prevention and induction? 2) Can nutrition play a role in managing allergies?
Joost van Neerven (Ed.) --- Huub Savelkoul (Ed.)
The development and treatment of cancer presents a complex interaction between tumor and host. Provision of nutrients not only enables the maintenance of nutritional status, but also provides substrates and signals for immunity, tumor metabolism and protection of the host from treatment toxicities. Fat is one dietary element that has been explored for its role in cancer development. While the bulk of these studies have been observational or experimental, the evidence assembled suggests that dietary lipids behave uniquely to prevent or promote cancers
Malnutrition in people with liver disease is a challenging issue due to its multifactorial nature, which includes hypermetabolism, increased energy needs, malabsorption, and anorexia. Despite advances in both assessment and management, correct nutritional support is still an often-unanswered need in the care of these patients to avoid poor outcomes. One of the central issues remains how to improve muscolar mass of sarcopenic chronically malnourished individuals with end stage liver diseases and cirrhosis, as only a correct nutritional assessment and subsequent nutritional handling may enhance quality of life and disease outcome.
Pietro Vajro (Ed.) --- Claudia Mandato (Ed.)
Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients. Added to this complexity is the distinction between maternal and fetal nutrition and the impact the placenta plays in nutrient metabolism and overall nutrient supply to the fetus.
Janna L. Morrison --- Timothy R.H. Regnault
Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients.
The One Health concept recognizes that the health of humans, animals, and their ecosystems are interconnected, and that a coordinated, collaborative, multidisciplinary, and cross-sectoral approach is necessary to fully understand and respond to potential or existing risks that originate at the animal–human–ecosystems interfaces. Thus, the One Health concept represents a holistic vision for addressing some of the complex challenges that threaten human and animal health, food safety, and the environments in which diseases flourish.
Open-source electronics are becoming very popular, and are integrated with our daily educational and developmental activities. At present, the use open-source electronics for teaching science, technology, engineering, and mathematics (STEM) has become a global trend. Off-the-shelf embedded electronics such as Arduino- and Raspberry-compatible modules have been widely used for various applications, from do-it-yourself (DIY) to industrial projects. In addition to the growth of open-source software platforms, open-source electronics play an important role in narrowing the gap between prototyping and product development
Optics and Spectroscopy for Fluid Characterization
All over the world, there is a huge and ever-increasing interest in the development and application of optical and spectroscopic techniques to characterize fluids in engineering and science. The large number of review articles that are frequently published in these areas is evidence of this. Recent examples have focused on applications of optical diagnostics to gas phase environments, liquids, and multiphase systems. A key feature of such light-based methods is that they are usually non-intrusive, and hence they do not notably affect the system under investigation.
Optimisation Models and Methods in Energy Systems
Challenging problems arise in all segments of energy industries—generation, transmission, distribution and consumption. Optimization models and methods play a key role in offering decision/policy makers better information to assist them in making sounder decisions at different levels, ranging from operational to strategic planning.
Physical Metallurgy of High Manganese Steels
The Special Issue ‘Physical Metallurgy of High Manganese Steels’ addresses the highly fascinating class of manganese-alloyed steels with manganese contents well above 3 mass%. The book gathers manuscripts from internationally recognized researchers with stimulating new ideas and original results. It consists of fifteen original research papers. Seven contributions focus on steels with manganese contents above 12 mass%. These contributions cover fundamental aspects of process-microstrcuture-properties relationships with processes ranging from cold and warm rolling over deep rolling to heat treatment.
Physiological Responses to Abiotic and Biotic Stress in Forest Trees
As sessile organisms, plants have to cope with a multitude of natural and anthropogenic forms of stress in their environment. Due to their longevity, this is of particular significance for trees. As a consequence, trees develop an orchestra of resilience and resistance mechanisms to biotic and abiotic stresses in order to support their growth and development in a constantly changing atmospheric and pedospheric environment.
Planning, Development and Management of Sustainable Cities
The concept of ‘sustainable urban development’ has been pushed to the forefront of policymaking and politics as the world wakes up to the impacts of climate change and the destructive effects of the Anthropocene. Climate change has emerged to be one of the biggest challenges faced by our planet today, threatening both built and natural systems with long-term consequences, which may be irreversible. While there is a vast body of literature on sustainability and sustainable urban development, there is currently limited focus on how to cohesively bring together the vital issues of the planning, development, and management of sustainable cities.
Yigitcanlar, Tan --- Kamruzzaman, Md. (Liton)
Plant medicines are the original medicines that humans have always used. Many people continue to use plant medicines today including teas, coffee, chocolate, ginger, and other medicines. Traditional medicine is based on plant medicines and is the primary form of medicine for many people throughout the world. The current volume discusses traditional medicines and presents various plant medicines that could be tested in clinical trials. Modern medicine continues to use many drugs that are derived from plants. The current work has much to teach modern medicine about the treatment of several diseases.
Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin.
Plant Nutrient Dynamics in Stressful Environments
The papers included in this special issue cover a broad range of aspects ranging from genetics and breeding to crop production in the field. Climate change, intensified agriculture, modifications of land use, or pollution are often accompanied by larger fluctuations including extreme events. The growing world’s population and nutrient deficiencies in agricultural products for human or animal nutrition, or pollutants in harvested products in some regions (quality of yield), are important points to be integrated in a comprehensive analysis aimed at supporting agriculture on the way into a challenging future.
Urs Feller (Ed.) --- Stanislav Kopriva (Ed.) --- Valya Vassileva (Ed.)
Plasma catalysis is gaining increasing interest for various gas conversion applications, such as CO2 conversion into value-added chemicals and fuels, N2 fixation for the synthesis of NH3 or NOx, methane conversion into higher hydrocarbons or oxygenates. It is also widely used for air pollution control (e.g., VOC
Plasma Processes for Renewable Energy Technologies
The use of renewable energy is an effective solution for the prevention of global warming. On the other hand, environmental plasmas are one of powerful means to solve global environmental problems on nitrogen oxides, (NOx), sulfur oxides (SOx), particulate matter (PM), volatile organic compounds (VOC), and carbon dioxides (CO2) in the atmosphere. By combining both technologies, we can develop an extremely effective environmental improvement technology. Based on this background, a Special Issue of the journal Energies on plasma processes for renewable energy technologies is planned.
Plasmonics is a rapidly developing field that combines fundamental research and applications ranging from areas such as physics to engineering, chemistry, biology, medicine, food sciences, and the environmental sciences. Plasmonics appeared in the 1950s with the discovery of surface plasmon polaritons. Plasmonics then went through a novel propulsion in the mid-1970s, when surface-enhanced Raman scattering was discovered. Nevertheless, it is in this last decade that a very significant explosion of plasmonics and its applications has occurred. Thus, this book provides a snapshot of the current advances in these various areas of plasmonics and its applications, such as engineering, sensing, surface-enhanced fluorescence, catalysis, and photovoltaic devices.
Polarimetric SAR Techniques and Applications
Polarimetry allows sensitivity to the structural and geometric properties of the scene, making it possible a more accurate identification and classification than non-polarimetric systems. Then, polarimetry makes possible new applications, especially in quantitative extraction of bio and geophysical variables. Also, the combination of polarimetry and interferometry allows also to explore the vertical structure of semi-transparent media, like crops and forests. SAR polarimetry is an active field of research in Earth observation. Besides the development of applications, researchers have also focused in theory or physical modelling to make SAR polarimetry an operational technique.
Carlos López-Martínez (Ed.) --- Juan Manuel Lopez-Sanchez (Ed.)
Polyamine Metabolism in Disease and Polyamine-Targeted Therapies
Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis
Roles of NF-κB in Cancer and Their Therapeutic Approaches
Although mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity.
Selected Problems in Fluid Flow and Heat Transfer
Fluid flow and heat transfer processes play an important role in many areas of science and engineering, from the planetary scale (e.g., influencing weather and climate) to the microscopic scales of enhancing heat transfer by the use of nanofluids; understood in the broadest possible sense, they also underpin the performance of many energy systems. This topical Special Issue of Energies is dedicated to the recent advances in this very broad field.
Agriculture requires technical solutions for increasing production while lessening environmental impact by reducing the application of agro-chemicals and increasing the use of environmentally friendly management practices. A benefit of this is the reduction of production costs. Sensor technologies produce tools to achieve the abovementioned goals. The explosive technological advances and developments in recent years have enormously facilitated the attainment of these objectives, removing many barriers for their implementation, including the reservations expressed by farmers.
Short Rotation Woody Crop Production Systems for Ecosystem Services and Phytotechnologies
While international efforts in the development of short rotation woody crops (SRWCs) have historically focused on the production of biomass for bioenergy, biofuels, and bioproducts, research and deployment over the past decade has expanded to include broader objectives of achieving multiple ecosystem services. In particular, silvicultural prescriptions developed for SRWCs have been refined to include woody crop production systems for environmental benefits such as carbon sequestration, water quality and quantity, and soil health.
Zalesny, Jr., Ronald S. --- Headlee, William L. --- Soolanayakanahally, Raju --- Richardson, Jim
Silicon-Based Nanomaterials: Technology and Applications
Silicon has been proven to be remarkably resilient as a commercial electronic material. The microelectronics industry has harnessed nanotechnology to continually push the performance limits of silicon devices and integrated circuits. Rather than shrinking its market share, silicon is displacing “competitor” semiconductors in domains such as high-frequency electronics and integrated photonics. There are strong business drivers underlying these trends; however, an important contribution is also being made by research groups worldwide, who are developing new configurations, designs, and applications of silicon-based nanoscale and nanostructured materials.
Smart machines, Remote Sensing, Precision Farming, Processes, Mechatronic, Materials and Policies for Safety and Health Aspects
The introduction of "smart machines" for agricultural operations will allow several advantages, such as an increase in their efficiencies, a reduction in environmental impacts and a reduction of work injuries. There are partially- and fully-automatic devices for most aspects of agricultural functions, from seeding and planting to harvesting and postharvesting, from spraying to livestock management, and so on The objectives of this book are: study of man–machine dialogue systems; analysis on towed or carried machines: forestry chippers, manure spreaders, round balers and others; safety and health management system design and engineering
Andrea Colantoni (Ed.) --- Danilo Monarca (Ed.) --- Massimo Cecchini (Ed.) --- Vincenzo Laurendi (Ed.) --- et al.
Smart Sensors for Structural Health Monitoring
Smart sensors are technologies designed to facilitate the monitoring operations. For instance, power consumption can be minimized through on-board processing and smart interrogation algorithms, and state detection enhanced through collaboration between sensor nodes. Applied to structural health monitoring, smart sensors are key enablers of sparse and dense sensor networks capable of monitoring full-scale structures and components. They are also critical in empowering operators with decision making capabilities.
Ubertini, Filippo --- Laflamme, Simon --- Li, Jian
Smart Textiles Production: Overview of Materials, Sensor and Production Technologies for Industrial Smart Textiles
The research field of smart textiles is currently witnessing a rapidly growing number of applications integrating intelligent functions in textile substrates. With an increasing amount of new developed product prototypes, the number of materials used and that of specially designed production technologies are also growing. This book is intended to provide an overview of materials, production technologies, and product concepts to different groups concerned with smart textiles. It will help designers to understand the possibilities of smart textile production, so that they are enabled to design this type of products
Inga Gehrke, Vadim Tenner, Volker Lutz, David Schmelzeisen and Thomas Gries
With the advent of disruptive digital technologies, companies are facing unprecedented challenges and opportunities. Advanced manufacturing systems are of paramount importance in making key enabling technologies and new products more competitive, affordable, and accessible, as well as for fostering their economic and social impact. The manufacturing industry also serves as an innovator for sustainability since automation coupled with advanced manufacturing technologies have helped manufacturing practices transition into the circular economy
Soil Water Conservation. Dynamics and Impact
Human needs like food and clean water are directly related to good maintenance of healthy and productive soils. A good understanding of human impact on the natural environment is therefore necessary to preserve and manage soil and water resources. This knowledge is particularly important in semi-arid and arid regions, where the increasing demands on limited water supplies require urgent efforts to improve water quality and water use efficiency. It is important to keep in mind that both soil and water are limited resources.
Keesstra, Saskia --- Di Prima, Simone --- Castellini, Mirko --- Pirastru, Mario
Solar Energy Applications in Houses, Smart Cities and Microgrids
Five papers were selected for this Special Issue, with three relating to solar energy applications in houses, smart cities, and microgrids; one studying the relationship between the smart city model and the concept of energy sustainability; and one addressing the following two topics: the lack of effectiveness of detection algorithms based on the voltage/frequency displacement concept under voltage-controlled inverters and the applicability limits of others based on the impedance measurement (IM).
Deficiencies in these areas may be remediated by advancements in structural health monitoring (SHM) technologies that provide sensing systems to automatically and economically diagnose structural integrity. In a sense, SHM technologies will help pave the way to intelligent structures that are able to detect damage by themselves and even warn occupants of any danger due to impending structural failure. Engineering sensors and developing smart algorithms for SHM often involves the close collaboration of a surprisingly large breadth of specialties.
Structure and Mechanical Properties of Transition Group Metals, Alloys, and Intermetallic Compounds
The aim of this Special Issue is to present the latest theoretical and experimental achievements concerning the mechanisms of microstructural change in metallic materials subject to different processing methods, and their effect on mechanical properties. It is my pleasure to present a series of compelling scientific papers written by scientists from the community of transition group metals, alloys, and intermetallic compounds.
Sustainability in Construction Engineering
The concept of sustainability has been expanding to all areas of economic activity, including construction. The Special Issue “Sustainability in Construction Engineering” provided a possibility for researchers to disseminate their new ideas and findings related to sustainable decisions in construction engineering as a complex discipline that involves designing, planning, construction and management of infrastructures. The topics raised interest of researchers all over the world and the current Special Issue received a great number of submissions from different institutions, countries and continents.
Edmundas Kazimieras Zavadskas (Ed.) --- Jonas Šaparauskas (Ed.) --- Jurgita Antuchevičienė (Ed.)
Sustainable Agriculture–Beyond Organic Farming
The current conception of organic farming is the result of nearly a century of intellectual thought and dialogue, field observations and experiences, systematic experimentation, and codification of rules. Debates on the future viability of organic farming often focus on its capacity to produce sufficient food to meet the demands of a growing human population. Yet any thorough examination of the pros and cons of alternative farming approaches should consider much more—for example the side effects on soil, water and air; energy and land-use efficiency; global warming potential; conservation of biodiversity; waste generation and recycling; farmer and community well-being; animal welfare; and the capacity to function and meet demands long into the future.
The dynamically changing world economy, in an era of intensive development and globalization, creates new needs in both the theoretical models of management and in the practical discussion related to the perception of business. Because of new economic phenomena related to the crisis, there is a need for the design and operationalization of innovative business models for companies. Due to the fact that in times of crisis, the principles of strategic balance are particularly important; these business models can be sustainable business models. Moreover, it is essential to skillfully use different methods and concepts of management to ensure the continuity of business.
The dynamically changing world economy, in an era of intensive development and globalization, creates new needs in both the theoretical models of management and in the practical discussion related to the perception of business. Because of new economic phenomena related to the crisis, there is a need for the design and operationalization of innovative business models for companies. Due to the fact that in times of crisis, the principles of strategic balance are particularly important; these business models can be sustainable business models.
This Special Issue of Sustainability reports on recent research aiming to make the freight transport sector more sustainable. The sector faces significant challenges in different domains of sustainability, including the reduction of greenhouse gas emissions and the management of health and safety impacts. In particular, the intention to decarbonise the sector’s activities has led to a strong increase in research efforts—this is also the main focus of the Special Issue. Sustainable freight transport operations represent a significant challenge with multiple technical, operational, and political aspects.
Human development has made remarkable social and economic progress possible for most of us but has also entailed a range of serious impacts on natural resources, local communities and the economy at multiple scales. Thus, achieving sustainable territorial management that combines healthy and prosperous societies with the long-term maintenance of biodiversity and productive ecosystem services remains the biggest challenge of our modern world. This Special Issue seeks to collect a coherent set of studies on techniques and experiences (case studies) aimed at increasing the environmental, social, economic &/or institutional sustainability of landscapes and seascapes from a range of geographic and socioeconomic contexts.
David Rodr´ıguez-Rodr´ıguez (Ed.) --- Javier Mart´ınez-Vega (Ed.)
This book presents interesting samples of theoretical and practical advances of symmetry in multidisciplinary engineering applications. It covers several applications, such as accessibility and traffic congestion management, path planning for mobile robots, analysis of shipment service networks, fault diagnosis methods in electrical circuits and electrical machines, geometrical issues in architecture, geometric modeling and virtual reconstruction, design of noise detectors, filters, and segmentation methods for image processing, and cyclic symmetric structures in turbomachinery applications, to name but a few.
Montoya, Francisco G. --- Baños Navarro, Raúl
Teenage Reproductive Health: Pregnancy, Contraception, Unsafe Abortion, Fertility
Maternal mortality is still globally high and reducing it is a top priority. Teenage pregnancies have more complications and are also unwanted in many cases. This contributes to the high maternal mortality with both obstetric complications and burden of unsafe abortion. Additionally, many teenagers live in areas with heavy pollution that affects the mother and the unborn child. Global public health is a very important issue that aims to prevent disease, prolong life, and promote physical, mental and social well-being.
Thermal and Electro-thermal System Simulation
With increasing power levels and power densities in electronics systems, thermal issues are becoming more and more critical. The elevated temperatures result in changing electrical system parameters, changing the operation of devices, and sometimes even the destruction of devices. To prevent this, the thermal behavior has to be considered in the design phase. This can be done with thermal end electro-thermal design and simulation tools
Thin Films for Energy Harvesting, Conversion, and Storage
Efficient clean energy harvesting, conversion, and storage technologies are of immense importance for the sustainable development of human society. To this end, scientists have made significant advances in recent years regarding new materials and devices for improving the energy conversion efficiency for photovoltaics, thermoelectric generation, photoelectrochemical/electrolytic hydrogen generation, and rechargeable metal ion batteries.
Chen, Zhong --- Tang, Yuxin --- Zhao, Xin
Tissue Engineering and Regenerative Nanomedicine
This book focus on the most recent advances related to the design and processing methods of different nanobiomaterials, films, and fibers; surface functionalization strategies, including biological performance assessment and cytocompatibility; and their applications in tissue engineering strategies
Oliveira, Joaquim Miguel --- Reis, Rui L.
Toward a Sustainable Agriculture: Farming Practices and Water Use
Globally, the agri-food sector has a major role to play in ensuring food security and economic development, especially for lower income countries. In the increasingly demanding context of environmental risk, exacerbated by climate change, and of environmental degradation, agricultural producers are faced with the challenge to meet the demand of the agri-food sector to feed growing populations in a sustainable manner while still trying to make ends meet. Toward a Sustainable Agriculture: Farming Practices and Water Use
Towards Sustainable Global Food Systems. Conceptual and Policy Analysis of Agriculture, Food and Environment Linkages
One of the major knowledge challenges in the domain of Resilient and Sustainable Food Systems refers to the integration of perspectives on consumption, patterns that support public health, inclusive value chains, and environmentally sustainable food production. While there is a long record of the analysis of separate interventions, this special issue generates integrated insights, provides cross-cutting perspectives, and outlines practical and policy solutions that address these global challenges.<false,>
Toxins in Drug Discovery and Pharmacology
Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology for their own biological purposes by producing venoms that contain a structural and functional diversity of neurotoxins.
Traditional and Innovative Approaches in Seismic Design
This special issue collects selected papers about a wide range of innovative applications in earthquake engineering. These studies were presented during the 2nd Edition of the International Workshop “Traditional and Innovative Approaches in Seismic Engineering”, held in Pisa in March 2017. The topics refer to the investigation of traditional and innovative materials for earthquake engineering applications: masonry, reinforced concrete, steel, structural glass and timber. In particular, advanced analytical and numerical analyses are described for considering effects of strength and material irregularities and rocking behavior under seismic excitations on historic buildings and industrial facilities
Linda Giresini (ed.) --- Francesca Taddei
Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed.
Arpad Szallasi (Ed.) --- Susan M. Huang (Ed.)
Transmucosal Absorption Enhancers in the Drug Delivery Field
Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption.
Casettari, Luca --- Maher, Sam --- Illum, Lisbeth
Transport of Fluids in Nanoporous Materials
Fluid transport in narrow pores is central to the design and optimization of nanoporous materials in industrial applications, such as catalysis, nanofluids, electrochemical batteries, and membrane separation. However, due to the strong potential field in nanopores, conventional models and methods have become inadequate for predicting the transport behavior of molecules confined in the pore space. In addition, the inherent complexity of the pore structure in nanomaterials requires consideration of local or nanoscale transport at the single pore level, and averaging over the macroscale, which further impedes the application and validation of the formulated mechanical models
Suresh K. Bhatia (Ed.) --- David Nicholson (Ed.) --- Xuechao Gao (Ed.) --- Guozhao Ji (Ed.)
Trends in Catalytic Wet Peroxide Oxidation Processes
This book gives an overview of the state of the art in Catalytic Wet Peroxide Oxidation research for the treatment of industrial and urban wastewaters and provides novel solutions to overcome the current challenges of this technology. These solutions include tailoring of the catalysts to exploit the use of additional energy sources and oxidants. The collected papers illustrate the high versatility of this low-cost technology, easily adaptable to any kind of wastewater, either polluted by high-loaded recalcitrant organics in industrial wastewaters or by emerging pollutants at microconcentration levels in urban waters.
Quintanilla, Asuncion --- Munoz, Macarena
Tribological Performance of Artificial Joints
Joint replacement is a very successful medical treatment. However, the survivorship of the implants could be adversely affected due to the loss of materials in the form of particles or ions as the bearing surfaces articulate against earch other. The consequent tissue and immune response to the wear products, remain one of the key factors of their failure. Tribology has been defined as the science and technology of interacting surfaces in relative motion and all related wear products (e.g., particles, ions, etc.).
The Special Issue on Tribology and Surface Engineering includes nine research articles and one review article. It concerns a very important problem of resistance to wear and shaping the properties of the surface layers of different materials by different methods and technologies. The topics of the presented research articles include reactive direct current magnetron sputtering of silicon nitrides on implants, laser surface modification of aeroengine turbine blades, laser micro-texturing of titanium alloy to increase the tribological characteristics, electroplating of Cu–Sn composite coatings incorporated with Polytetrafluoroethylene (PTFE) and TiO2 particles, arc spraying of self-lubricous coatings, high velocity oxygen fuel (HVOF) spraying and gas nitriding of stainless steel coatings, HVOF spraying composite WC-Co coatings, testing of coatings deposited by physical vapour deposition (PVD), and also analysis of material removal and surface creation in wood sanding. The special issue provides valuable knowledge based on theoretical and empirical study in the field of coating technologies, as well as characterization of coatings, and wear phenomena.
Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment.
The Tumor Microenvironment of High Grade Serous Ovarian Cancer
The Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distinct components in particular, and the role of the TME in the context of disease recurrence and development of chemoresistance.
M. Sharon Stack (Ed.) --- Kenneth P. Nephew (Ed.) --- Joanna E. Burdette (Ed.) --- Anirban K. Mitra (Ed.)
Turbulence in River and Maritime Hydraulics
Understanding of the role of turbulence in controlling transport processes is of paramount importance for the preservation and protection of aquatic ecosystems, the minimization of the deleterious consequences of anthropogenic activity, and the successful sustainable development of river and maritime areas. In this context, the present Special Issue collects 15 papers which provide a representation of the present understanding of turbulent processes and their effects in river and maritime environments.
Mossa, Michele --- Termini, Donatella --- Davies, Peter A.
The first two-dimensional material studied in detail was graphene, and many groups explored its potential for electronic applications. Meanwhile, researchers have extended their work to two-dimensional materials beyond graphene. At present, several hundred of these materials are known and part of them is considered to be useful for electronic applications.
This open access Nursing Pharmacology textbook is designed for entry-level undergraduate nursing students. It explains basic concepts of pharmacology and describes common medication classes. This book is not intended to be used as a drug reference book, but direct links are provided to DailyMed, which provides trustworthy information about marketed drugs in the United States.
Chippewa Valley Technical College, Eau Claire, WI
This open source textbook is derived from many sources, initially from the Principles of Management by Carpenter, Bauer, and Erdogan, but there is abundant new content as well. It is published under a Creative Commons license and as such there is no charge ever for this textbook. The most important change from 1e is that static content was removed to make room for student-generated dynamic content. Throughout the book look for the names of contributing students in the red colored example boxes. As the term progresses, you will see new examples appear as fellow students research and summarize topics for current events, all are curated by the instructor.
AC Electrical Circuit Analysis: A Practical Approach
theory and practical application of analysis of AC electrical circuits. It assumes familiarity with DC circuit analysis. If you have not studied DC circuit analysis, it is strongly recommended that you read the companion OER text, DC Electrical Circuit Analysis before continuing. Both texts are offered free of charge under a Creative Commons non-commercial, share-alike with attribution license. For your convenience, along with the free pdf and odt files, print copies are available at a very modest charge. Check my web sites for links. This text is based on the earlier Workbook for AC Electrical Circuits, which it replaces. The original expository text has been greatly expanded and includes many examples along with computer simulations. For the convenience of those who used the Workbook, many of the problem sets are the same, with some re-ordering depending on the chapter.
DC Electrical Circuit Analysis: A Practical Approach
elcome to DC Electrical Circuit Analysis, an open educational resource (OER). The goal of this text is to introduce the theory and practical application of analysis of DC electrical circuits. It is offered free of charge under a Creative Commons non-commercial, share-alike with attribution license. For your convenience, along with the free pdf and odt files, print copies are available at a very modest charge. Check my web sites for links. This text is based on the earlier Workbook for DC Electrical Circuits, which it replaces. The original expository text has been greatly expanded and includes many examples along with computer simulations. For the convenience of those who used the Workbook, many of the problem sets are the same, with some re-ordering depending on the chapter.
This book was created for an undergraduate Introduction to Industrial Engineering course at The University of Texas at Arlington (UTA). The chapters give an overview of the profession and an introduction to some of the tools used by industrial engineers in industry. There are interactive content exercises included at the end of most chapters. This interactive content aims to engage students in the content as they are reading. The book will continue to revised and updated with new information as it becomes necessary.
Large Animal Surgery – Supplemental Notes
This textbook includes basic principles of large animal surgery and anesthesia, how to apply those principles to cases and situations, and discover ways of finding answers when you don’t remember the information, are presented with cases that aren’t “textbook” and/or things don’t go as planned.
University of Minnesota Libraries Publishing
Financial Management for Small Businesses: Financial Statements & Present Value Models
This book is for those whose financial management focus is on small businesses. For you, we adapt the traditional financial management themes emphasized in corporate financial management courses to meet the needs of small businesses. Many financial managers of small businesses come from farms or agribusinesses. Others are interested in working for or starting businesses in the food or retail sectors. In most cases, these businesses aren’t organized as C-corporations impacting things like taxes, depreciation, and legal requirements around compiling and reporting financial data. They are rarely publicly traded which creates unique constraints to raising debt and equity capital and calculating required risk-adjusted returns.
Lindon J. Robinson, Steven D. Hanson, J. Roy Black,
This Open Access book, building on research initiated by scholars from the Leiden-Delft-Erasmus Centre for Global Heritage and Development (CHGD) and ICOMOS Netherlands, presents multidisciplinary research that connects water to heritage. Through twenty-one chapters it explores landscapes, cities, engineering structures and buildings from around the world. It describes how people have actively shaped the course, form and function of water for human settlement and the development of civilizations, establishing socio-economic structures, policies and cultures; a rich world of narratives, laws and practices; and an extensive network of infrastructure, buildings and urban form.
This open access book presents a comprehensive and up-to-date collection of knowledge on the state of crowdfunding research and practice. It considers crowdfunding models and their different manifestations across a variety of geographies and sectors, and explores the perspectives of fundraisers, backers, platforms, and regulators. Gathering insights from a wide range of influential researchers in the field, the book balances concepts, theory, and case studies. Going beyond previous research on crowdfunding, the contributors also investigate issues of community, sustainability, education, and ethics
Shneor, Rotem --- Zhao, Liang --- Flåten, Bjørn-Tore
The papers presented in this open access book address diverse challenges in decarbonizing energy systems, ranging from operational to investment planning problems, from market economics to technical and environmental considerations, from distribution grids to transmission grids, and from theoretical considerations to data provision concerns and applied case studies. While most papers have a clear methodological focus, they address policy-relevant questions at the same time. The target audience therefore includes academics and experts in industry as well as policy makers, who are interested in state-of-the-art quantitative modelling of policy relevant problems in energy systems
Bertsch, Valentin --- Ardone, Armin --- Suriyah, Michael --- Fichtner, Wolf --- et al.
Advances in Pharma Business Management and Research
This open access book presents a unique collection of practical examples from the field of pharma business management and research. It covers a wide range of topics such as: 'Brexit and its Impact on pharmaceutical Law - Implications for Global Pharma Companies', 'Implementation of Measures and Sustainable Actions to Improve Employee's Engagement', 'Global Medical Clinical and Regulatory Affairs (GMCRA)', and 'A Quality Management System for R&D Project and Portfolio Management in a Pharmaceutical Company'. The chapters are summaries of master’s theses by "high potential" Pharma MBA students from the Goethe Business School, Frankfurt/Main, Germany, with 8-10 years of work experience and are based on scientific know-how and real-world experience.
Schweizer, Lars --- Dingermann, Theodor --- Russe, Otto Quintus --- Jansen, Christian
This edited volume contains the selected papers presented at the scientific board meeting of the German Cluster of Excellence on “Integrative Production Technology for High-Wage Countries”, held in November 2014. The topical structure of the book is clustered in six sessions: Integrative Production Technology, Individualised Production, Virtual Production Systems, Integrated Technologies, Self-Optimising Production Systems and Human Factors in Production Technology. The Aachen perspective on a holistic theory of production is complemented by conference papers from external leading researchers in the fields of production, materials science and bordering disciplines.
Perspectives on European Earthquake Engineering and Seismology: Volume 1
This book collects 5 keynote and 15 topic lectures presented at the 2nd European Conference on Earthquake Engineering and Seismology (2ECEES), held in Istanbul, Turkey, from August 24 to 29, 2014. The conference was organized by the Turkish Earthquake Foundation - Earthquake Engineering Committee and Prime Ministry, Disaster and Emergency Management Presidency under the auspices of the European Association for Earthquake Engineering (EAEE) and European Seismological Commission (ESC). The book’s twenty state-of-the-art papers were written by the most prominent researchers in Europe and address a comprehensive collection of topics on earthquake engineering, as well as interdisciplinary subjects such as engineering seismology and seismic risk assessment and management.
Advancing the Science of Cancer in Latinos
This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos – the largest, youngest, and fastest-growing minority group in the United States – are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress.
Ramirez, Amelie G. --- Trapido, Edward J.
Achieving the Paris Climate Agreement Goals
This open access book presents detailed pathways to achieve 100% renewable energy by 2050, globally and across ten geographical regions. Based on state-of-the-art scenario modelling, it provides the vital missing link between renewable energy targets and the measures needed to achieve them. Bringing together the latest research in climate science, renewable energy technology, employment and resource impacts, the book breaks new ground by covering all the elements essential to achieving the ambitious climate mitigation targets set out in the Paris Climate Agreement. For example, sectoral implementation pathways, with special emphasis on differences between developed and developing countries and regional conditions, provide tools to implement the scenarios globally and domestically
Advancing Culture of Living with Landslides: Volume 1 ISDR-ICL Sendai Partnerships 2015-2025
This volume contains peer-reviewed papers from the Fourth World Landslide Forum organized by the International Consortium on Landslides (ICL), the Global Promotion Committee of the International Programme on Landslides (IPL), University of Ljubljana (UL) and Geological Survey of Slovenia in Ljubljana, Slovenia from May 29 to June 2, 2017. The complete collection of papers from the Forum is published in five full-color volumes.
Kyoji Sassa --- Matjaž Mikoš --- Yueping Yin
Agricultural Implications of the Fukushima Nuclear Accident (III)
This open access book presents the findings from on-site research into radioactive cesium contamination in various agricultural systems affected by the Fukushima Daiichi Nuclear Power Plant accident in March 2011. This third volume in the series reports on studies undertaken at contaminated sites such as farmland, forests, and marine and freshwater environments, with a particular focus on livestock, wild plants and mushrooms, crops, and marine products in those environments. It also provides additional data collected in the subsequent years to show how the radioactivity levels in agricultural products and their growing environments have changed with time and the route by which radioactive materials entered agricultural products as well as their movement between different components (e.g., soil, water, and trees) within an environmental system (e.g., forests).
Nakanishi, Tomoko M. --- O`Brien, Martin --- Tanoi, Keitaro
AiREAS: Sustainocracy for a Healthy City
Medicine (General) ---, Environmental Technology
This book describes the coming about and first results of the AiREAS "healthy city" cooperative in the city of Eindhoven and Province of North Brabant in the Netherlands. AiREAS is an initiative focused on the multidisciplinary co-creation of healthy cities using the core human value of human health and air quality as guiding principle for profound regional innovation. The unique group process that followed uses the complexity of the city of Eindhoven as living lab.
Animals and the Shaping of Modern Medicine
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological. Each chapter analyses an important episode in which animals changed and were changed by medicine.
Woods, Abigail --- Bresalier, Michael --- Cassidy, Angela --- Mason Dentinger, Rachel
This open access book revisits common notions on how to select and recruit the right employees. It reveals that the secret of successful individuals and teams lies in a combination of talent and four important performance indicators, offering an innovative approach that companies can fruitfully adopt. Bas Kodden has studied key performance indicators among over 1,100 executives, senior staff and professionals, including 50 CEOs from leading Dutch companies. His findings put the present recruitment and selection procedures used by many prominent companies in a new light.
Belly-Rippers, Surgical Innovation and the Ovariotomy Controversy
This open access book looks at the dramatic history of ovariotomy, an operation to remove ovarian tumours first practiced in the early nineteenth century. Bold and daring, surgeons who performed it claimed to be initiating a new era of surgery by opening the abdomen. Ovariotomy soon occupied a complex position within medicine and society, as an operation which symbolised surgical progress, while also remaining at the boundaries of ethical acceptability. This book traces the operation’s innovation, from its roots in eighteenth-century pathology, through the denouncement of those who performed it as ‘belly-rippers’, to its rapid uptake in the 1880s, when ovariotomists were accused of over-operating.
This open access book presents a comprehensive analysis of biofuel use strategies from an interdisciplinary perspective using sustainability science. This interdisciplinary perspective (social science-natural science) means that the strategies and policy options proposed will have significant impacts on the economy and society alike. Biofuels are expected to contribute to reducing greenhouse gas emissions, revitalizing economies in agricultural communities and alleviating poverty.
Takeuchi, Kazuhiko --- Shiroyama, Hideaki --- Saito, Osamu --- Matsuura, Masahiro
This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows.
The Discipline of Organizing: 4th Professional Edition
We organize things, we organize information, we organize information about things, and we organize information about information. But even though “organizing” is a fundamental and ubiquitous challenge, when we compare these activities their contrasts are more apparent than their commonalities. We propose to unify many perspectives about organizing with the concept of an Organizing System, defined as an intentionally arranged collection of resources and the interactions they support.
This book has been created for students and all individuals who work with children and families (e.g., educators, parents, caregivers, direct support workers, etc.) in diverse contexts. It is imperative to understand how and what factors may influence child outcomes across the lifespan. Therefore, key concepts related to parenting, child-rearing, care-giving, and parenting education are outlined in this textbook to provide historical, theoretical, and practical perspectives across vast settings and developmental domains.
This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner.
Makarov, Sergey --- Horner, Marc --- Noetscher, Gregory
This open access book describes modern applications of computational human modeling in an effort to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields. Readers working on any application that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest models and techniques available to assess a given technology’s safety and efficacy in a timely and efficient manner.
Makarov, Sergey N. --- Noetscher, Gregory M. --- Nummenmaa, Aapo
A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans. ; Supports further investigation by summarizing state of the art in the field of Buruli ulcer research Enriches understanding of epidemiology of Buruli ulcer in different geographic regions Reviews exhaustively the characteristics of Mycobacterium ulcerans disease
This open access volume is the first academic book on the controversial issue of including spiritual care in integrated electronic medical records (EMR). Based on an international study group comprising researchers from Europe (The Netherlands, Belgium and Switzerland), the United States, Canada, and Australia, this edited collection provides an overview of different charting practices and experiences in various countries and healthcare contexts. Encompassing case studies and analyses of theological, ethical, legal, healthcare policy, and practical issues, the volume is a groundbreaking reference for future discussion, research, and strategic planning for inter- or multi-faith healthcare chaplains and other spiritual care providers involved in the new field of documenting spiritual care in EMR.
This open access book contributes to the creation of a cyber ecosystem supported by blockchain technology in which technology and people can coexist in harmony. Blockchains have shown that trusted records, or ledgers, of permanent data can be stored on the Internet in a decentralized manner. The decentralization of the recording process is expected to significantly economize the cost of transactions. Creating a ledger on data, a blockchain makes it possible to designate the owner of each piece of data, to trade data pieces, and to market them. This book examines the formation of markets for various types of data from the theory of market quality proposed and developed by M. Yano. Blockchains are expected to give data itself the status of a new production factor.
Yano, Makoto --- Dai, Chris --- Masuda, Kenichi --- Kishimoto, Yoshio