Life. Every single living thing has something in common—do you know what that is? The clue is in the title! In this learning package you will learn all about cells—the parts and the functions of those parts. By learning about the basic building block of life, scientists, and you, can have a better understanding of the workings of your body and of all living things. You’ll understand what happens when all the parts are working well, and what can happen when a part malfunctions.
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations.
Kojima, Hajime --- Seidle, Troy --- Spielmann, Horst
Artificial Intelligence Applied to Medical Imaging and Computational Biology
Medical imaging and computational biology continuously pose new fundamental medical and biological questions that often give rise to novel challenges in Artificial Intelligence. These research fields present an increasing need for the application of cutting-edge computational approaches that generally involve machine learning or computational intelligence techniques, which can effectively perform bioimage and biosignal processing in different clinical areas.
Leonardo Rundo, Carmelo Militello, Andrea (Tangherloni
MDPI - Multidisciplinary Digital Publishing Institute
Our goal is to present the key observations and unifying concepts upon which modern biology is based; it is not a survey of all biology! Once understood, these foundational observations and concepts should enable you to approach any biological process, from disease to kindness, from a scientific perspective. To understand biological systems we need to consider them from two complementary perspectives; how they came to be (the historic, that is, evolutionary) and how their structures, traits, and behaviors are produced (the mechanistic, that is, the physicochemical).
Biology for AP® Courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences
Biostratigraphic And Geological Significance Of Planktonic Foraminifera
Foraminifera are marine, free-living, amoeboid protozoa (in Greek, proto = first and zoa = animals). They are single-celled eukaryotes (organisms the cytoplasm of which is organized into a complex structure with internal membranes and contains a nucleus, mitochondria, chloroplasts, and Golgi bodies, see Fig. 1.1), and they exhibit animal-like (cf. plant-like) behaviour. Usually, they secrete an elaborate, solid carbonate skeleton (or test) that contains the bulk of the cell, but some forms accrete and cement tests made of sedimentary particles. The foraminiferal test is divided into a series of chambers, which increase in number during growth. In life, they exhibit extra-skeletal pseudopodia (temporary organic projections) and web-like filaments that can be granular, branched and fused (rhizopodia), or pencil-shaped and pointed (filopodia). The pseudopodia emerge from the cell body (see Plate 1.1 below) and enable bidirectional cytoplasmic flow that transports nutrients to the body of the cell (Baldauf, 2008). Foraminifera first appeared in the Cambrian with a benthic mode of life and, over the course of the Phanerozoic, invaded most marginal to fully marine environments. They diversified to exploit a wide variety of niches, including, from the Late Triassic or Jurassic, the planktonic realm. These planktonic forms are the focus of this book. Both living and fossil foraminifera come in a wide
Computational Biology: Genomes, Networks, Evolution
Concepts of Biology-1st Canadian Edition
In this survey text, directed at those not majoring in biology, we dispel the assumption that a little learning is a dangerous thing. We hope that by skimming the surface of a very deep subject, biology, we may inspire you to drink more deeply and make more informed choices relating to your health, the environment, politics, and the greatest subject that are all of us are entwined in, life itself.
We’ll begin with a brief introduction to the two main types of stem cells, embryonic and adult stem cells. We’ll then discuss stem cell potency. The second section “Stem cells in research and diseases management” will focus on the opportunities and roles of stem cells in diseases and medical research. Stem cells have a special position in contemporary biological sciences due to their unspecialized characteristics and continuous proliferation. We will focus in particular on the areas of diabetes and neuron regeneration.
: The effect of germinated Superhongmi, a reddish brown pigmented rice cultivar, on the glucose profile and bone turnover in the postmenopausal-like model of ovariectomized rats was determined. The ovariectomized Sprague-Dawley rats were randomly divided into three dietary groups (n = 10): normal control diet (NC) and normal diet supplemented with non-germinated Superhongmi (SH) or germinated Superhongmi (GSH) rice powder. After eight weeks, the SH and GSH groups showed significantly lower body weight, glucose and insulin concentrations, levels of bone resorption markers and higher glycogen and 17-β-estradiol contents than the NC group. The glucose metabolism improved through modulation of adipokine production and glucose-regulating enzyme activities. The GSH rats exhibited a greater hypoglycemic effect and lower bone resorption than SH rats. These results demonstrate that germinated Superhongmi rice may potentially be useful in the prevention and management of postmenopausal hyperglycemia and bone turnover imbalance.
Traditionally, nutritional supplements were limited to essential vitamins and minerals. However, in recent years, scientists have identified several biologically active compounds from plant and animal foods having beneficial health effects.
Effect of Processing on Sensory Quality and Bioactive Components in Food Products
In order to obtain high-quality food products, we need to control them from their origin. This ranges from the crops themselves to the reception of raw materials at the factory. The effect of industrial processing on the final quality of food is an essential factor that can guarantee its acceptance for sale, thus avoiding the losses that a rejected or withdrawn product could cause a company. In addition, preserving the integrity of bioactive ingredients during food processing is a challenge in the agri-food industry.
Antonio José Pérez-López, Luis Noguera-Artiaga
Endocrine System and Influence on Behavior - Part 1
Created by Ryan Scott Patton. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/behavior/biological-basis-of-behavior-ner/v/endocrine-system-and-influence-on-behavior-part-2?utm_source=YT&utm_medium=Desc&utm_campaign=mcat Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/behavior/biological-basis-of-behavior-ner/v/modern-ways-of-studying-the-brain?utm_source=YT&utm_medium=Desc&utm_campaign=mcat MCAT on Khan Academy: Go ahead and practice some passage-based questions! About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Endocrine System and Influence on Behavior Part 2
Created by Ryan Scott Patton. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/behavior/human-development/v/egg-sperm-and-fertilization?utm_source=YT&utm_medium=Desc&utm_campaign=mcat Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/behavior/biological-basis-of-behavior-ner/v/endocrine-system-and-influence-on-behavior-part-1?utm_source=YT&utm_medium=Desc&utm_campaign=mcat MCAT on Khan Academy: Go ahead and practice some passage-based questions! About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/maternal-changes-in-pregnancy?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/reproductive-cycle-graph-luteal-phase?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Standard YouTube License This video represents licensed content on YouTube, meaning that the content has been claimed by a YouTube content partner.
Open Educational Resource (OER) Unsyiah adalah satu satu Portal yang dikembangkan oleh Perpustakaan Universitas Syiah Kuala. OER Unsyiah berbasis Open Acces untuk siapa saja dan di mana saja. Bahkan Kami juga akan menerima kontribusi yang ingin ikut berpartisipasi dalam OER Unsyiah: http://uilis.unsyiah.ac.id/oer/contribution. Di sini, Kami menyediakan berbagai bentuk Course, seperti Textbook, Video, Audio, dan sebagainnya dengan berbagai bidang materi yang bervariasi. Namun, yang perlu diketahui bahwa OER Unsyiah berLisensi Creative Commons. Nah, bagi yang berkenan atau ingin mempelajari berbagai bidang materi mari kunjungi link UPT. Perpustakaan Unsyiah: http://uilis.unsyiah.ac.id/oer/ http://uilis.unsyiah.ac.id/ http://uilis.unsyiah.ac.id/oer/ https://www.facebook.com/groups/pustaka.unsyiah/ https://www.youtube.com/channel/UCvOxlI8WMHLUWuPTD80jNUw https://www.instagram.com/upt_perpustakaan_unsyiah/?hl=en
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The word biology means, "the science of life", from the Greek bios, life, and logos, word or knowledge. Therefore, Biology is the science of Living Things. That is why Biology is sometimes known as Life Science.
BI101 Course Description: Adaptations of BI101 vary in theme. BI101A is a survey course that introduces the discipline of cellular biology, exploring topics including the cellular basis of life, cell structure and function and the metabolic processes that affect cells. BI101 introduces students to biology as a scientific discipline and engages students in the process of scientific discovery. All BI101 courses are equivalent; only one can be used to fulfill degree requirements. BI101, BI102 and BI103 are non-sequential and can be taken in any order. Students considering majors in science or preprofessional health occupations are advised to eventually take BI211, B1212 and BI213.
The book contains the substance of the lectures and partly of the practices of the subject of ‘Genetics and Genomics’ held in Semmelweis University for medical, pharmacological and dental students. The book does not contain basic genetics and molecular biology, but rather topics from human genetics mainly from medical point of views. Some of the 15 chapters deal with medical genetics, but the chapters also introduce to the basic knowledge of cell division, cytogenetics, epigenetics, developmental genetics, stem cell biology, oncogenetics, immunogenetics, population genetics, evolution genetics, nutrigenetics, and to a relative new subject, the human genomics and its applications for the study of the genomic background of complex diseases, pharmacogenomics and for the investigation of the genome environmental interactions. As genomics belongs to sytems biology, a chapter introduces to basic terms of systems biology, and concentrating on diseases, some examples of the application and utilization of this scientific field are also be shown. The modern human genetics can also be associated with several ethical, social and legal issues. The last chapter of this book deals with these issues. At the end of each chapter there are questions, with which the readers can ascertain whether they understood and/or learned the chapter. Because it is an e-book, some terms and definitions has a hyperlink for more detailed explanations in the World Wide Web. Besides university students, the book is also recommended to all those who are interested in modern medical genetics and genomics and want to be up-to date in these subjects.
Genetics of human populations: evolutionary and epidemiological applications
The present thesis deals with a deep analysis of the genetic structure of extant human worldwide populations, with a special focus on the Mediterranean. Different genetic markers, 18 Alu insertions and 367 single nucleotide polymorphisms (SNPs), were analysed for the first time in general populations and Bedouins from Jordan. The same SNPs were also genotyped in a consistent set of samples from the Mediterranean Basin. Specifically, Alu markers were used to assess the genetic diversity within Jordan and to define the relationships across present-day Middle Eastern, North African, and European populations. While SNPs located in the top coronary artery disease (CAD) risk regions (1p13, 1q41, 9p21, and 10q11) were used to explore the genetic variation and the LD patterns across 19 populations from Europe, Middle East and North Africa, together with Asian and African samples from the 1000 Genomes Project. Furthermore, Tunisian and Moroccan case-control samples were used to test for the first time the applicability of European GWAS results in these four genomic regions to North African populations. Finally, simulated genomic data were used to evaluate the consistency of association results across European, Asian and Sub-Saharan African case-control samples. Neutral and CAD risk markers pointed out a low but significant geographic structure in the Mediterranean area. As a particular case in the Mediterranean context, Bedouins and general population from Jordan showed statistical differences (p=0.038). The genetic heterogeneity detected is likely related to the fact that urban areas have been subject to several external influences but Bedouins have preserved their own genetic background because of their nomadic and isolated lifestyle. The general patterns of genetic variation observed in the four CAD risk regions analysed are in agreement with the genetic structure generated by demographic processes. Despite this fact, the present work also identified potential signals of positive and balancing selection in some specific risk markers and haplotypes. Actually, potential signatures of positive selection in the 9p21 region and of balancing selection in 9p21 and 10q11 have been observed. The regions under positive or balancing selection are shared across continents but the specific markers under selection are, in some cases, continent-specific. Results from the association study in North Africa revealed significant association signals in the four genomic regions analysed in Moroccan and Tunisian samples confirming the trans-ethnic importance of these genomic regions for the risk of CAD. However, in the meta-analyses performed with the North African case-control samples, only the 9p21 and 10q11 regions showed association signals and none of the North African risk SNPs was associated with CAD in Europe. These arguments suggest the existence of continent-specific CAD risk variants in these chromosomal regions. Significant differences in the LD and in the haplotype patterns confirm the heterogeneity in the genomic structure between North Africans and Europeans. In addition, differences in the LD structure persist even across Europeans, North Africans, Asians, and Sub-Saharan Africans. Finally, the simulation study highlighted an overall consistency in effect direction across populations of different ancestry, specially between Europeans and Asians. Because simulations assumed no actual differences in genetic effect size between populations and because the rate of between-population effect size differences generated by our study was considerably lower than the rate reported from empirical studies using real data, our study supports the existence of real differences in the genetic risk architecture of complex traits between populations. In general, this study confirmed that a substantial fraction of association signals are shared across people of different ancestries. However, some discrepancies in the effect size across populations highlighted the importance of accounting for population structure in association studies.
Montage edited from the lecture slides of the Human Biology Core Faculty, including Professors Bill Durham, Richard Klein, Katherine Preston, William Talbot, Bill Scheidel, Margaret Fuller, Anne Fernald, David Lyons, Roland Nusse, Laura Carstensen, Paul Fisher, Craig Heller, Joe Nation, and Laurence Baker
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This course uses the basic principles of biology and earth science as a context for understanding environmental policies and resource management practices. Our planet is facing unprecedented environmental challenges, from oil spills to global climate change. In ENSC 1000, you will learn about the science behind these problems; preparing you to make an informed, invaluable contribution to Earth’s future. I hope that each of you is engaged by the material presented and participates fully in the search for, acquisition of, and sharing of information within our class.
Malaria parasites are highly species specific. No animal reservoir for human malaria parasites.Malaria: Plasmodium Species of Human Disease
This Microbiology textbook, adapted from the Boundless version, is intended to provide health care professionals with a working knowledge of infectious disease. Much of the book is devoted to the structure/function relationships in pathogenic microorganisms and how these relationships are expressed in host-parasite interactions. The text also examines Microbial diseases of specific organ systems as well as host response mechanisms.
Microbiology is designed to cover the scope and sequence requirements for the single-semester Microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications of microbiology in healthcare professions. The pedagogical features of Microbiology make the material interesting and accessible to students while maintaining the career-application focus and scientific rigor inherent in the subject matter.
This is a brief overview of the production of monoclonal antibodies (mAb), also known as hybridoma technology. Design inspired by Salman Khan. Special thanks to Professor DeMasi @ MCPHS University. Davidson College's website on mAbs: http://www.bio.davidson.edu/molecular/MolStudents/01rakarnik/mab.html#Prep Diagram of mAb production from the National Academies Press: http://www.nap.edu/openbook.php?record_id=9450&page=9 Software: SmoothDraw 4, CamStudio, and Premiere Pro CS6 Hardware: Bamboo CTH-460, Logitech microphone
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The GEO Handbook on Biodiversity Observation Networks
This book is based on the collective knowledge of the GEO BON network of volunteers, working towards the establishment of a global, sustainable observation system for monitoring changes in biodiversity. As such, a great number of colleagues have contributed their time and energy towards the production of this handbook and huge thanks go to all of them. Chapter 6 acknowledges information obtained from the World Register of Marine Species (WoRMS), the European Ocean Biogeographic Information System (EurOBIS) and Marine Regions, which are supported by data and infrastructure provided by VLIZ as part of the Flemish contribution to LifeWatch, and is funded by the Hercules Foundation. Also thanks to Chap. 6 team: Jan Mees, Francisco Hernandez and Pieter Provoost (IOC) for being very helpful in accessing data from OBIS.
The Insecticidal Bacterial Toxins in Modern Agriculture
Agriculture has suffered enormous changes since the first human attempts to domesticate plants to obtain productive varieties which could become a constant source of food. Many developments have shaped current agricultural systems, especially those that led to extensive industrial monocultures. Concurrently with those, there are numerous other types of small scale agricultural systems with an important social and economic impact. The development of ecosystems with scarce plant varieties has favored the presence of specialized phytophagous that have evolved and adapted to plant species used in agriculture. Pest species share some biological traits, such as short generation cycles and large offsprings. Improvements in agriculture have led to a high production efficiency and the control of pests through different strategies. Modern agriculture seeks to evolve to more environmentally-friendly systems with little environmental impact and accessible to developing countries.
Juan Ferré (Ed.) , Baltasar Escriche (Ed.)
Clinical death is the medical term for cessation of blood circulation and breathing, the two necessary criteria to sustain human and many other organisms' lives. It occurs when the heart stops beating in a regular rhythm, a condition called cardiac arrest. The term is also sometimes used in resuscitation research. Stopped blood circulation has historically proven irreversible in most cases. Prior to the invention of cardiopulmonary resuscitation (CPR), defibrillation, epinephrine injection, and other treatments in the 20th century, the absence of blood circulation (and vital functions related to blood circulation) was historically considered the official definition of death. With the advent of these strategies, cardiac arrest came to be called clinical death rather than simply death, to reflect the possibility of post-arrest resuscitation. At the onset of clinical death, consciousness is lost within several seconds. Measurable brain activity stops within 20 to 40 seconds. Irregular gasping may occur during this early time period, and is sometimes mistaken by rescuers as a sign that CPR is not necessary. During clinical death, all tissues and organs in the body steadily accumulate a type of injury called ischemic injury. Most tissues and organs of the body can survive clinical death for considerable periods. Blood circulation can be stopped in the entire body below the heart for at least 30 minutes, with injury to the spinal cord being a limiting factor. Detached limbs may be successfully reattached after 6 hours of no blood circulation at warm temperatures. Bone, tendon, and skin can survive as long as 8 to 12 hours. The brain, however, appears to accumulate ischemic injury faster than any other organ. Without special treatment after circulation is restarted, full recovery of the brain after more than 3 minutes of clinical death at normal body temperature is rare. Usually brain damage or later brain death results after longer intervals of clinical death even if the heart is restarted and blood circulation is successfully restored. Brain injury is therefore the chief limiting factor for recovery from clinical death. Although loss of function is almost immediate, there is no specific duration of clinical death at which the non-functioning brain clearly dies. The most vulnerable cells in the brain, CA1 neurons of the hippocampus, are fatally injured by as little as 10 minutes without oxygen. However, the injured cells do not actually die until hours after resuscitation. This delayed death can be prevented in vitro by a simple drug treatment even after 20 minutes without oxygen. In other areas of the brain, viable human neurons have been recovered and grown in culture hours after clinical death. Brain failure after clinical death is now known to be due to a complex series of processes called reperfusion injury that occur after blood circulation has been restored, especially processes that interfere with blood circulation during the recovery period. Control of these processes is the subject of ongoing research. In 1990, the laboratory of resuscitation pioneer Peter Safar discovered that reducing body temperature by three degrees Celsius after restarting blood circulation could double the time window of recovery from clinical death without brain damage from 5 minutes to 10 minutes. This induced hypothermia technique is beginning to be used in emergency medicine. The combination of mildly reducing body temperature, reducing blood cell concentration, and increasing blood pressure after resuscitation was found especially effective—allowing for recovery of dogs after 12 minutes of clinical death at normal body temperature with practically no brain injury. The addition of a drug treatment protocol has been reported to allow recovery of dogs after 16 minutes of clinical death at normal body temperature with no lasting brain injury. Cooling treatment alone has permitted recovery after 17 minutes of clinical death at normal temperature, but with brain injury. Under laboratory conditions at normal body temperature, the longest period of clinical death of a cat (after complete circulatory arrest) survived with eventual return of brain function is one hour..... Input by Sofia Nelly
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